2nd MetroMRT Scientific Workshop 21-22 May 2014 - Headquarters of LNE Workshop Agenda Wednesday 21st May 13:30 Welcome 13:40 Presentation of Laboratoire National Henri Becquerel (CEA/LNHB) Laboratoire national de métrologie et d’essais (LNE) L. de Carlan (Head of CEA/LNHB) 1, rue Gaston Boissier 75724 Paris Cedex 15 14:00 MetroMRT project presentation V. Smyth (NPL), Project coordinator http://www.lne.eu/en/lne_glance/access-maps.asp MetroMRT – Metrology for molecular radiation therapy 1 session: Calculation codes and applications in ionizing radiation metrology MetroMRT is a joint research project (JRP) within the European Metrology Research Programme (EMRP). It brings together expertise in ionizing radiation metrology and nuclear medicine research. The main goal is to address the problem of determining the radiation dose to individual patients who are undergoing molecular radiotherapy (MRT), also known as targeted radionuclide therapy, or nuclear medicine therapy. Chairman: B. Zimmerman (NIST) The consortium consists of 6 National Metrology Institutes (NPL, CEA/LNHB, CMI, ENEA-INMRI, PTB, VSL) and about 20 clinical research centres from 8 countries. The st project began on 1 June 2012 and is running for 3 years. http://projects.npl.co.uk/metromrt/ st 14:20 Calculation of beta spectra X. Mougeot (CEA/LNHB) 15:05 Monte Carlo code PENELOPE F. Salvat (University of Barcelona) 15:50 Coffee break 16:20 Simulation of ionization chamber for radionuclide metrology M.N. Amiot (CEA/LNHB) General theme of the scientific workshop 16:55 V. Ivantchenko (CERN) nd The 2 scientific workshop aims at bringing together metrology institutes and clinical research institutions to discuss about calculation codes (beta spectra, image reconstruction, Monte Carlo simulation, etc.) applied in the fields covered by the MetroMRT project (ionizing radiation metrology, quantitative imaging, dosimetry). Applications and limitations (in terms of biases or uncertainties) of these codes will be addressed during oral presentations and round tables. Monte Carlo code Geant4 17:40 Intercomparison exercise of Monte Carlo codes for the modelling of a medical linear accelerator M. Le Roy (CEA/LNHB) 18:05 Round Table st 18:30 End of 1 session 15:45 Thursday 22nd May nd 2 Coffee break Dosimetry in molecular therapy, clinical aspects and practical implementations 16:15: session: Dosimetry L. Ferrer (University of Nantes) Chairman: M. Bardiès (INSERM – Toulouse) 9:00 Geant4-DNA: overview and use in micro and nano dosimetry C. Villagrasa (IRSN) 9:45 Optimisation of treatment planning using 3D personalised Monte 90 Carlo dosimetry: application to Y-microspheres therapy A. Petitguillaume (IRSN) 10:30 Coffee break 11:00 From microscopic to macroscopic scale dosimetry M. Bardiès (INSERM – Toulouse) 11:45 Optimization of treatment planning using 3D personalised dosimetry based on convolution methods I. Gardin (CHB – Rouen) 12:30 Round Table 13:00 End of 2 nd session and Lunch rd 3 session: Quantitative Imaging Chairman: M. D’Arienzo (ENEA-INMRI). 14:15 Quantitative imaging for dosimetry study: potential and limitations I. Buvat (Paris 7 and Paris 11 Universities) 15:00 Bremsstrahlung imaging for molecular radiotherapy M. Ljungberg (Lund University) 17:00 Round Table 17:30 End of 3 session and of the workshop rd