www.ovg.ox.ac.uk - Oxford Vaccine Group

11th Immunisation Seminar
Thursday 20 March 2014
Richard Doll Building, Old Road Campus,
Roosevelt Drive, Headington, Oxford OX3 7LF
Time
Topic
Speaker
8.30 - 9.10
Coffee & registration
09.10 – 09.15
Welcome from the Chair
Recent changes to the schedule – resources available
Sarah Lang, Immunisation Advisor
Public Health England and OVG
09.15 – 09.35
Basic immunology – a refresher
Dr Elizabeth Clutterbuck, Senior Post Doctorate
Researcher, OVG
09.35 – 09.55
Shingles and other new vaccination programmes: the area
team perspective
Paula Jackson, Consultant in Public Health – Screening
and Immunisation, NHS England
09.55 – 10.25
This last year……
Helen Campbell, Senior Clinical Scientist
Public Health England
10.25 – 10.45
A parents perspective of meningococcal disease
Karen Crockatt, Member and Ambassador of
Meningitis Research Foundation
10.45 – 11.15
Coffee
11.15 – 11.30
Travel Update
Sarah Lang
11.30 – 11.50
OVG update
Prof Andrew J Pollard
Professor of Paediatric Infection and Immunity, OVG
11.50 – 12.20
Nonspecific effects of BCG vaccination
Dr David Porter, Clinical Lecturer,
Oxford University Hospitals NHS Trust
Research: How do we get from questions to answers?
Danielle Campbell, Senior Research Nurse, OVG
BCG and MenC study
Carrie White, Research Nurse, OVG
12.20 – 12.30
A participant’s perspective of clinical trials
Amy Letts
12.30 – 13.00
Ask the panel
Prof Andrew J Pollard (Chair) Sarah Lang, Dr Matthew
Snape, Prof Paul Heath
13.00 – 14.00
Lunch
14.00 – 14.20
Contraindications to live vaccines
Dr Dominic Kelly, Consultant in Vaccinology,
Oxford University Hospitals NHS Trust and OVG
14.20 - 14.30
The role of the JCVI: who are they and what do they do?
Prof Andrew J Pollard
14.30 – 14.50
How modelling informs vaccine decision making
Dr Caroline Trotter
University of Cambridge
14.50 – 15.15
Group B Strep vaccine development
Prof Paul Heath, Consultant Paediatric Diseases
St George’s, University of London
15.15 – 15.50
Should the licensed MenB vaccine be recommended for
routine use?
A debate
Prof Paul Heath and
Dr Matthew Snape, Consultant in Vaccinology and
General Paediatrics, OVG and Oxford University
Hospitals NHS Trust
15.50
Closing Remarks
www.ovg.ox.ac.uk
Speakers Biographies
Danielle Campbell joined the Oxford Vaccine Group in 2011 as a Paediatric Research Nurse. She obtained a
Bachelors of Science in Nursing in 2008 from McMaster University and a Diploma in Tropical Nursing from the
London School of Hygiene and Tropical Medicine in 2013. She currently works as a Senior Research Nurse
managing the adult clinical trials and as an Immunisation Advisor for VACCSline. Her background has been in
paediatric intensive care as well as tropical nursing in West Africa. She is keen to continue working in international
health in the developing world.
Helen Campbell is Senior Clinical Scientist in the Immunisation, Hepatitis and Blood Safety Department at Public
Health England.
Elizabeth Clutterbuck. I am a BRC and James Martin School funded Post Doctoral Researcher in the OVG lab,
mainly working on B cell studies based around the clinical trials. Prior to working in OVG I completed and MSc in
Immunology at Kings College London, followed by an 18 month post as a Guest Researcher in the Respiratory
Diseases Branch at CDC in Atlanta. I completed my PhD at OVG, finishing in 2008. My main focus now is on B cell
responses to vaccine antigens and I have developed assays to identify antigen specific B cells by ELISpot and Flow
Cytometry. This work has been applied to studies both in the UK and in Fiji where the data are being used to help
optimise pneumococcal vaccine schedules.
Karen Crockatt works as a Head of Procurement for a Private Healthcare Group. She trained as a nurse many years
ago specialising in Theatre and has held various operational management roles within the NHS and private sectors,
including Directorate Management, commissioning roles and Head of Procurement. She is an MRF trained
befriender and an Ambassador for the North West region of the charity. She is also a Trustee for
www.littlelegs.org.uk, the charity for children with congenital limb deficiencies or amputations of part of their legs
or feet. Her husband Nick is a European Director with a large medical devices company and is also an MRF
Ambassador. They have 2 children, Domenico aged 25 and Sofia aged 9. In February 2007, at the age of 2, Sofia
contracted meningococcal meningitis and septicaemia and as a result lost her left leg below the knee and sustained
severe damage to her right leg. She is now the first ever Junior Ambassador for the Meningitis Research
Foundation.
Paul Heath is a Professor and Honorary Consultant in Paediatric Infectious Diseases at St George’s, University of
London and Vaccine Institute in London, UK. His training in paediatrics and infectious diseases was at the Royal
Children’s Hospital, Melbourne, Australia, the John Radcliffe Hospital, Oxford and St George’s Hospital, London. His
particular research interests are in the epidemiology of vaccine preventable diseases, in clinical vaccine trials,
particularly in at-risk groups, and in perinatal infections.
Paula Jackson is employed by Public Health England as a Consultant in Public Health and is a Screening &
Immunisation Lead based with NHS England’s Thames Valley Area Team. Paula is currently responsible for adult
screening and immunisation programmes including the seasonal influenza vaccination programme and the shingles
vaccination programme. Paula has worked in the field of health promotion and public health for over twenty years
and has had the opportunity to provide public health leadership for screening and immunisation programmes in
Thames Valley over the last five years.
Dominic Kelly. I am a BRC consultant in paediatrics and vaccinology at the Children’s Hospital in Oxford where I
work in general paediatrics and paediatric infectious diseases. The rest of my time is committed to clinical and
immunology research in the field of childhood vaccines and vaccine preventable diseases as part of the Oxford
Vaccine Group.
Sarah Lang is an immunisation advisor for VACCSline at the Thames Valley Public Health England Centre. VACCSline
is an immunisation advice service jointly run by the PHE centre and the Oxford Vaccine Group, providing expert
advice to clinicians in all health care settings. Prior to joining VACCSline in 2007, Sarah spent many years working in
travel medicine in private travel clinics, occupational health and primary care. Sarah completed an MSc in Travel
Medicine in 2003 and is a founder member of the Faculty of Travel Medicine. Sarah has recently completed an MA
in Medical Education.
Amy Letts has been a participant in clinical trials.
Andrew J Pollard, FRCPCH PhD, is Professor of Paediatric Infection and Immunity at the University of Oxford,
Director of the Oxford Vaccine Group, James Martin Senior Fellow, Jenner Institute Investigator, Fellow of the
Infectious Disease Society of America, Fellow of St Cross College and Honorary Consultant Paediatrician at the
Children’s Hospital, Oxford, UK. He obtained his medical degree at St Bartholomew’s Hospital Medical School,
University of London in 1989 and trained in Paediatrics at Birmingham Children’s Hospital, UK, specialising in
Paediatric Infectious Diseases at St Mary’s Hospital, London, UK and at British Columbia Children’s Hospital,
Vancouver, Canada. He obtained his PhD at St Mary’s Hospital, London, UK in 1999 studying immunity to Neisseria
meningitidis in children and proceeded to work on anti-bacterial innate immune responses in children in Canada
before returning to his current position at the University of Oxford, UK in 2001. He chaired the UK’s NICE
meningitis guidelines development group, the NICE topic expert group developing quality standards for
management of meningitis and meningococcal septicaemia. He received the 2013 Bill Marshall Award of the
European Society for Paediatric Infectious Disease. He chairs the Department of Health’s Joint Committee on
Vaccination and Immunisation and the European Medicines Agency scientific advisory group on vaccines. He runs
one of the largest research groups in the UK that undertakes clinical trials in children and adults with 70 staff.
Current research activities include clinical trials of new and improved vaccines for children and adults, surveillance
of invasive bacterial diseases in children in Nepal, studies of cellular and humoral immune responses to
glycoconjugate and typhoid vaccines, development of serogroup B meningococcal vaccines and research on a
human challenge model of typhoid and paratyphoid. His publications include over 200 manuscripts and books on
various topics in paediatrics, infectious diseases, and high altitude medicine.
David Porter. I am an Academic Clinical Lecturer in Paediatric Infectious Diseases at the University of Oxford and
Honorary Registrar at the John Radcliffe Hospital. My medical and paediatric training was in Oxford, London and
Birmingham. I worked on trials of malaria vaccines in Oxford before undertaking a DPhil examining the immune
response to a new vaccine against tuberculosis. I am currently working on a study at the Oxford Vaccine Group,
funded by the Academy of Medical Sciences, examining the immunological effects of the BCG vaccine in healthy
UK infants.
Matthew Snape is Consultant in Vaccinology and General Paediatrics at the Oxford Radcliffe Hospitals NHS trust
and is an Honorary Senior Clinical Lecturer with the University of Oxford. After completing basic training in
paediatrics at the Royal Children's Hospital, Melbourne, he spent 18 months working in the paediatric intensive
care unit at St Mary's Hospital, London. While caring for children suffering overwhelming infections on this unit he
developed an interest in the prevention of these illnesses by immunisation. This led him to the Oxford Vaccine
Group, where he is currently the principal investigator on paediatric studies of meningococcal, pneumococcal,
influenza and Hepatitis B vaccines. He has co-authored over 50 articles related to these areas in journals such as
the Journal of the American Medical Association (JAMA), the British Medical Journal and the Lancet. He also
continues to work in both inpatient and outpatient general paediatrics at the John Radcliffe Hospital. Dr Snape’s
position is funded by the Oxford Partnership Biomedical Research Centre.
Caroline Trotter is an infectious disease epidemiologist at the University of Cambridge. Her research focuses on
the epidemiology and control of bacterial meningitis and other vaccine-preventable diseases. She uses a variety of
methods, including mathematical modelling and cost-effectiveness studies, to address questions relevant to
vaccine policy.
Carrie White obtained a BSc (hons) in adult nursing in 1993. She has a particular focus on working with children in
the community, previously working as a community nurse within a Health Visiting team in Bristol, and as a
community staff nurse in Sussex providing respite and outreach care for children with complex health needs. Carrie
joined the Oxford Vaccine Group in 2012 as a paediatric research nurse, where she is currently lead nurse on a
study researching the interaction between the BCG and the Meningococcal C immunisation.
We are grateful for support in the form of unrestricted educational grants provided by the
following companies, which makes this seminar possible:
GlaxoSmithKline has provided sponsorship towards the catering costs of this meeting but has had no input
into or influence over the agenda or content or selection of speakers. GSK staff will be present at the
Meeting and will have a stand promoting GSK products .

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