Phibro Vaccines Phibro Vaccines poultry vaccination experts TM poultry vaccination experts TM TAbic® IB VAR206 Infectious Bronchitis live attenuated virus vaccine, variant 2 - 2006 isolate. Early and robust protection against IB variant 2 virus infections. Vaccine characteristics: The only solution to IB Variant 2 - TAbic® IB VAR206 live virus variant 2 vaccine of Infectious Bronchitis disease. The vaccine virus was attenuated from a field strain of IB which belongs to the unique genotype variant 2 IBV. Highly protective - TAbic® IB VAR206 provides early and robust protection against variant 2 field viruses found in the Middle East and in Turkey. Flexible application - TAbic® IB VAR206 can be administered by Eye drop, Coarse spray and Fine spray (Aerosol). Safe to use - TAbic® IB VAR206 is safe for Day-Old-Chicks by Coarse spray or Eye drop. Trials in SPF and commercial chickens have shown that TAbic® IB VAR206 is safe to the respiratory and urinary systems in broilers at all ages. Phibro Vaccines poultry vaccination experts TM TAbic ® IB VAR206 Application with ND vaccine - TAbic® IB VAR206 can be applied simultaneously with V.H. NDV live vaccine. Live IB variant 2 vaccine Tablet vaccine - TAbic® IB VAR206 is presented in convenient effervescent TABLET form and can be administered to chicken broilers at any age. Cost effective - TAbic® IB VAR206 protects the flock from the economic impact of the disease. www.phibro-vaccines.com The 1and only solution for variant 2 Infectious Bronchitis disease - variant 2 pathological signs: The disease in broilers is characterized by both respiratory and kidney lesions, that may occur as early as 14d of age. The damages include mortality of 10-25%, as well as losses due to secondary infections, treatment cost, poor performance and condemnations at slaughter. Protection from challenge in SPF chickens vaccinated at 1 and 14 days of age with IB VAR206 vaccine and challenged with homologous virulent field strain variant 2 100 Not-vaccinated and not-challenged 0 % Cilia Motility Enlarged swollen kidneys FJ807931 QX(K1583) DQ400359 IS/1201 QX DQ459474 YN05-01 Challenged with velogenic NDV Titer (HI) Survivability (%) V.H - ND vaccine 6.4a 100a V.H and TAbic® IB VAR206 6.06a 90a Not-vaccinated control 2b 0b Good protection from challenge with the virulent field IB variant 2 IS/1494/06 (SPF chickens vaccinated at 1d of age) % of protection after challenge with IS/1494/06 (Variant 2 virulent field strain) AF093795 IBV Variant 1 TAbic® IB VAR206 86a IBV IS/2006/08 V.H and TAbic® IB VAR206 86a Not-vaccinated control 7b AY279533 IS/885 S1 793B Nephropathogenic group AY091552 Israel/720/99 EU283057 Conn DQ664534 IBV Massachusetts 41 Mass Two vaccinations (1d&14d) of TAbic® IB VAR206 provide better protection from challenge with variant 2 virulent field strain (IS/1494/06) in comparison to two vaccinations with IB 793B or H120 vaccines. GQ154655 IBV H-120 95 100 X15832 D274 83 JX027070 IB VAR206 ABIC-PHIBRO EU780077 IBV IS/1494/06 S1 EU283055 Ark EU283063 Del 0.1 variant 2 % protection 80 IBV IS/373/09 ND IB variant 2 TAbic® V.H. TAbic® IB VAR206 Coarse spray Day 10-14 ND IB variant 2 TAbic® V.H. TAbic® IB VAR206 Coarse/Fine spray Day 13-17 IBD TAbic® M.B. DW Day 21-24 NDV TAbic® V.H. Aerosol spray Good protection from challenge with velogenic ND (SPF chickens vaccinated at 1d of age) Group Egypt Day 1 TAbic® IB VAR206 can be vaccinated simultaneously with ND V.H. live vaccine AF093793 IBV 4/91 attenuated JQ946056 IB VAR 233A ABIC-PHIBRO Route % protection, negative swabs Group Phylogenetic tree of IB strains and vaccines Brand Not-vaccinated and challenged 14 Tracheal plugs Vaccine 92 Gross pathology lesions of IB variant 2 (IS/1494/06) field strain Severe airsacculitis Age 100 97.3 IB VAR206 at 1 and 14 days of age Oviduct cysts TAbic® IB VAR206 recommended vaccination program for broilers: two vaccinations at 1 & 10-14 day of age. 70 60 40 20 5 0 H120+ 793B 793B+ 793B IB VAR206+ Not vacc and IB VAR206 challenged Unique features of TAbic® IB VAR206 Innovative TAbic® IB VAR206 is a live virus vaccine, in an effervescent tablet, sealed in sterile aluminum blister packaging. Easy to use TAbic® IB VAR206 tablets dissolve rapidly. The live virus disperses evenly in the diluent, resulting in a homogeneous clear suspension. User friendly TAbic® IB VAR206 is convenient, user friendly and safe to handle vaccine (No need for working tools, syringes or other equipment for vaccine preparation). Environmentally friendly TAbic® IB VAR206 is friendly to the environment; empty blisters are easily disposed of. No residues of contaminated vials. Convenient logistics Due to reduced size of each pack TAbic® IB VAR206 requires minimal storage volume, is light weight and easily transported.