Cardiovascular Research Volume 105 No. 2 1 February 2015 EDITORIAL Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis M. Li and E. Hirsch 129 ORIGINAL ARTICLES Integrative physiology and pathophysiology Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension ¨l, M. Harhun, Y. Dyskina, V. Lehen’kyi, A. Jama, Z.-L. Lu, D. Gordienko, O. Povstyan, K. Sukhanova, M. Raphae R. Skryma, and N. Prevarskaya 131 Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function A.M. Wengrowski, X. Wang, S. Tapa, N.G. Posnack, D. Mendelowitz, and M.W. Kay 143 Cardiac biology and remodelling 151 Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy ˚ .B. Gustafsson, and N.H. Purcell C. Moc, A.E. Taylor, G.P. Chesini, C.M. Zambrano, M.S. Barlow, X. Zhang, A 160 1 21 Na ions as spatial intracellular messengers for co-ordinating Ca cardiomyocytes P. Swietach, K.W. Spitzer, and R.D. Vaughan-Jones signals during pH heterogeneity in 171 Renalase is a novel target gene of hypoxia-inducible factor-1 in protection against cardiac ischaemia– reperfusion injury M. Du, K. Huang, D. Huang, L. Yang, L. Gao, X. Wang, D. Huang, X. Li, C. Wang, F. Zhang, Y. Wang, M. Cheng, Q. Tong, G. Qin, K. Huang, and L. Wang 182 Uncoupling protein 3 mediates H2O2 preconditioning-afforded cardioprotection through the inhibition of MPTP opening Y. Chen, J. Liu, Y. Zheng, J. Wang, Z. Wang, S. Gu, J. Tan, Q. Jing, and H. Yang 192 Independent roles of the priming and the triggering of the NLRP3 inﬂammasome in the heart S. Toldo, E. Mezzaroma, M.D. McGeough, C.A. Pen ˜a, C. Marchetti, C. Sonnino, B.W. Van Tassell, F.N. Salloum, N.F. Voelkel, H.M. Hoffman, and A. Abbate 203 Vascular biology Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation B. Trachet, R.A. Fraga-Silva, A. Piersigilli, A. Tedgui, J. Sordet-Dessimoz, A. Astolfo, C. Van der Donckt, P. Modregger, M.F.M. Stampanoni, P. Segers, and N. Stergiopulos For information about purchasing a copy of this issue and for the current issue price, please go to: http://www.oxfordjournals.org/our_journals/cardiovascres/access_purchase/single_issues.html 213 Downloaded from by guest on February 6, 2015 Deﬁciency of ﬁlamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction ¨ merovic, and ¨nros, B. Redfors, C¸ C¸il, D. Pazooki, R. Salimi, E. Larsson, A.-X. Zhou, E. O S. Bandaru, J. Gro ¨rek L.M. Akyu Ion channels and arrhythmias Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains ´, C. Ronchi, M. Rocchetti, C. Moreno, A. de la Cruz, A. Oliveras, S.R. Kharche, M. Guizy, N. Comes, T. Stary ´, G. Loussouarn, A. Zaza, S. Severi, A. Felipe, and C. Valenzuela I. Baro 223 Downloaded from by guest on February 6, 2015