! Ȼ Ȼ ! ! Immunochemistry (ICT) ♫〇ရ ◊✲⏝ヨ⸆ Green FLIVO, Red FLIVO FLIVOઞტр๽ඥ 㻌䕔 ື≀䛛䜙⤌⧊䜢ྲྀ䜚ฟ䛩๓䛻 in vivo 䛷⣽⬊䛻ᶆ㆑䛩䜛䛣䛸䛻䜘䜚䚸䜰䞊䝔䜱䝣䜯䜽䝖䛺䜰䝫䝖䞊䝅䝇䛾䝅䜾䝘䝹䜢ᣠ䛖ྍ⬟ᛶ䜢పῶ䛷䛝䜎䛩䚹䕔 ᦬ฟᚋ䛾ฎ⌮䛾ᚲせ䛜䛒䜚䜎䛫䜣䚹⤌⧊䜢ྲྀ䜚ฟ䛧䛶┤䛠䛻⺯ග䝅䜾䝘䝹䜢ㄪ䜉䜛䛣䛸䛜䛷䛝䜎䛩䚹 ჹᄝళ 㻌䕔䛜䜣䛻ᑐ䛩䜛⸆๣䛾㛤Ⓨ䛺䛹䛷䚸⸆๣䛻䜘䜛⭘⒆⣽⬊䛾䜰䝫䝖䞊䝅䝇䜈䛾ㄏᑟ䜢 in vivo 䛻䛶䝰䝙䝍䝸䞁䜾䛩䜛䛾䛻᭷⏝䛷䛩䚹䕔䛣䛾ヨ⸆䛿⾑ᾮ⬻㛵㛛䜢㏻㐣䛩䜛䛯䜑䚸⚄⤒⣽⬊䛜䜰䝫䝖䞊䝅䝇䛾㐣⛬䛻䛒䜛䛛䜢 in vivo 䛷⡆༢䛻ㄪ䜉䜛䛣䛸䛜䛷䛝䜎䛩䚹 FAQs 㻌䕔 ᢞ୚䛾⤒㊰䛿䚸ᑿ㟼⬦䛛䜙䛾ὀධ䜢᥎ዡ䛧䛶䛔䜎䛩䚹ᐇ㦂䛻䜘䛳䛶䛿䚸┠ᶆ⤌⧊䛻㏆䛔㒊఩䜈ὀᑕ䛩䜛䛣䛸䛷‶㊊䛷䛝䜛⤖ᯝ䛜ᚓ䜙䜜䜛䛣䛸䜒䛒䜚䜎䛩䛜䚸⾑ὶ䛻䜘䜛㍺㏦䛜᭱䜒ຠ⋡䛜Ⰻ䛟䚸⭡⭍ᢞ୚䛿䛚䛩䛩䜑䛧䜎䛫䜣䚹䕔㻌ヨ⸆ᐜ㔞 (6 mice) 䛿1䝞䜲䜰䝹 ᙜ䜚䚸య㔜⣙30g䛾䝬䜴䝇6༉ศ䛻┦ᙜ䛧䜎䛩䚹䝷䝑䝖䛺䛹䚸䜘䜚኱䛝䛔 ື≀䛾ሙྜ䛿య㔜ẚ䜘䜚ィ⟬䛧䛶䛤౑⏝䛟䛰䛥䛔䚹䕔㻌ヨ⸆䛾ศᏊ㔞䛿䚸FAM-FLIVO (Green) = 692.4䚸SR-FLIVO (Red) = 873 䛷䛩䚹䕔ヨ⸆䛿⾑ᾮ⬻㛵㛛䚸⾑ᾮ⥙⭷㛵㛛䜢㏻㐣䛧䜎䛩䚹䕔㻌 ບ㉳Ἴ㛗䛿䚸㻳㼞㼑㼑㼚㻌㻲㻸㻵㼂㻻㻦㻌㻠㻤㻤㼚㼙㻘㻌㻾㼑㼐㻌㻲㻸㻵㼂㻻㻦㻌㻡㻡㻜㼚㼙䚸Ⓨග䠄㼑㼙㼕㼟㼟㼕㼛㼚䠅Ἴ㛗䛿䚸㻳㼞㼑㼑㼚㻌㻲㻸㻵㼂㻻㻦㻌㻡㻞㻜㼚㼙㻘㻌㻾㼑㼐㻌㻲㻸㻵㼂㻻㻦㻌㻡㻥㻜㻙㻢㻜㻜㼚㼙㻌䛾䝣䜱䝹䝍䞊䜢䛭䜜䛮䜜䛤౑⏝ୗ䛥䛔䚹䕔 ᦬ฟᚋ䛾⤌⧊䜢ᅛᐃ䛩䜛ሙྜ䛿䚸䝟䝷䝩䝹䝮䜰䝹䝕䝠䝗⣔䛾ᅛᐃᾮ䜢᥎ዡ䛧䜎䛩䚹㧗⃰ᗘ䛾䝯䝍䝜䞊䝹䜔䜶䝍䝜䞊䝹䛾౑⏝䛿䚸䝅䜾䝘䝹䛜ᛴ㏿䛻㏥Ⰽ䛩䜛䛾䛷䛚㑊䛡䛟䛰䛥䛔䚹 ࿪ऻ 㻌 1. Griffin RJ, Williams BW, Loren M, Bischof JC, Olin M, Lee BW, and Johnson G. Novel use of highly specific poly-caspase inhibitor for in vivo detection of apoptosis in tumors treated with vascular targeting agents. Poster presented at the American Association for Cancer Research, April 2006. 2. Griffin R, Williams BW, Olin M, Lowen M and Song CW. Thermoradiotherapy enhancement with anti-vascular strategy. Poster presented at the Radiation Research Society, October 17, 2005. 3. Morrow T, Paulson E. Diabetes-induced allodynia: correlation between behavioral intensity, duration of diabetes, and periaqueductal gray (PAG) activation. Poster presented at the Society for Neuroscience annual meeting, October 2006. 4. Olin M, Roy S, Peterson P and Moliter T. In vivo model for the detection of morphine-induced apoptosis. Poster presented at the Society of Neuroimmunology Pharmacology (SNIP), April, 2006. 䈜᭱᪂䛾౑⏝౛䛿䝯䞊䜹䞊䝩䞊䝮䝨䞊䝆㻌 www.immunochemistry.com 䜢䛤ぴ䛟䛰䛥䛔 ᄐ໚ས༞७ ߖૠ‫ݵ‬ଂ ი‫ۼ‬ౠ࿾फ़ࢄ୸Ȼ E-mail: [email protected] URL: www.ibl-japan.co.jp