Presented DGN 2013 The effect of home-based

Presented DGN 2013
The effect of home-based physical activity training on patients with dementia and their
Vjera A. Holthoff, Kira Marschner, Maria Scharf, Shirin Meyer, Annette Werner, Rainer Koch,
Markus Donix
Department of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive
Neuropsychiatry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden,
01307 Dresden, Germany
DZNE, German Center for Neurodegenerative Diseases, Dresden, Germany
Department of Neuroradiology, Faculty of Medicine Carl Gustav Carus, Technische
Universität Dresden, 01307 Dresden, Germany
Background: The pilot study presented here is a randomized controlled trial (RCT) in patients
with mild to moderate AD still living at home and cared for by a family caregiver. Patients in
the intervention group completed a 12-week home-based physical activity training with a
movement trainer (Reck MOTOmed®) and were compared to patients treated as usual
Methods: Thirty patients (aged 72.4±4.3 years; 53% female) with mild to moderate AD
(MMSE score: 20.6±6.5 points), who met the NINCDS-ADRDA criteria and family caregivers
were randomly allocated to the TAU group or the 12-week home-based physical intervention
program. All participants underwent clinical testing at baseline, 12 and 24 weeks later. Next
to activities of daily living, cognitive and behavioural symptoms of dementia, motor skills,
physical fitness of the patients was measured and the quality of life in patients and carers as
well as caregiver burden. Patients in the intervention group trained 3 times a week for 30
minutes on a movement trainer (Reck MOTOmed®) controlled by a standardized software
activation program. Patients were considered to have successfully completed the
intervention if they trained for at least 75% of the time required by the protocol which was
recorded by the movement trainer. Patients in the control group received treatment-asusual (TAU) with the same monthly clinical visits and counselling by the treating physician.
The analyses based on linear models with autoregressive covariance structure for correlated
measures and multiple comparisons of means were Tukey adjusted.
Results: Analyses in the patients revealed significant effects in several domains, including
activities of daily living, behavior, executive function/language ability, motor skills and
quality of life. Analyses in the caregivers revealed significant effects in caregiver burden.
Conclusions: The data suggest that intensive home-based physical activity training is of
clinical benefit to patients with AD and to family caregivers.