Status: Recruiting study participants A Research Study Designed to Determine the Rate of New HIV Infections Among Men Who Have Sex With Men In Urban Cities Sponsor: Philippine Council for Health Research and Development, Department of Science and Technology Collaborator: Research Institute for Tropical Medicine, Department of Health Information provided by Dr. Rossana A. Ditangco, MD, Research Institute for (Responsible Party): Tropical Medicine RITM Institutional Review 2011-29-0 Board Protocol Number : Purpose There is very little information on how fast HIV is spreading among men who have sex with men in urban cities, specifically in Metro Manila. In this study, participants will undergo HIV antibody testing every 3 months for 3 to 5 years to find out the proportion that will acquire new HIV infection during the study period. Participants will also be tested and treated for other sexually transmitted infections. Every follow up visit, participants will be provided with HIV prevention education and commodities. Condition MSM unknown HIV status or HIV negative during last test Study Type: Intervention HIV antibody test every 3 months for 3 to 5 years Cohort observational Study Design: Endpoint Classification: sero-conversion Primary Purpose: HIV incidence Official Title: Incidence of HIV in a cohort of men who have sex with men in Metro Manila Further study details as provided by the Research Institue for Troipical Medicine : Primary Outcome Measures: HIV sero-conversion Enrollment: 620 participants Study Start Date: November 15, 2013 Study Completion Date: December 2017 Primary Completion Date: December 2017 (Final data collection date for primary outcome measure) Detailed Description: In recent years, a significant increase in the number of new HIV infections are being observed and majority of new HIV infections are being reported among young men who have sex with men (MSM) from highly urbanized areas in the country. There is no concrete data on the incidence of HIV among MSM that could better describe the burden of disease and assess the impact of on-going interventions. Implementing a cohort study on the incidence of HIV will not only help describe the current rates of infections among MSM but will also provide the research infrastructure for future research on molecular epidemiology of HIV and pathogenesis that are the backbone of vaccine, treatment and other prevention research. The primary objective of this research is to determine the incidence of HIV in a cohort of men who have sex with men (MSM) in Metro Manila. Other objectives are to describe the characteristics, behaviors, practices, knowledge, attitude and perception on HIV of MSM and factors associated with HIV. The Informed Consent Document contains all the required elements of informed consent as required by the institutional and ethical review board of RITM. The consent clearly states that this is research, participation is voluntary, and participants’ record and data will be protected to ensure confidentiality, that participants will be informed of the results of tests for sexually transmitted infections and appropriate management will be given and in case of positive HIV tests results, they will be immediately referred to RITM for HIV management. During each follow- up visit, participants will be provided with HIV prevention education and commodities. The participants will not incur cost with their participation, and that the laboratory tests that are part of the study (screening for STIs and HIV) are free and they will be provided with reasonable amount to cover their transportation expense for the follow up visits. Eligibility Ages Eligible for Study: Genders Eligible for Study: Accepts Healthy Volunteers: 18 Years and older Male Yes Criteria  Inclusion Criteria: 1. MSM who had anal or oral sex in the past 12 months  2. 18 years old and above  3. resides within Metro Manila  4. willing to follow-up every 3 months for 3 to 5 years Exclusion Criteria:  known HIV infected or had a confirmed positive HIV antibody test  Contacts and Locations Ms. Nikka Martinez or Ms. Hazel Macato # 09178261994, 3538922 Locations Philippines, Metro Manila RITM Satellite Clinic/The Love yourself Hub 1850 Leon Guinto St. Malate Manila Sponsors and Collaborators Philippine Council for Health Research and Development, Department of Science and Technology Research Institute for Tropical Medicine, Department of Health Investigators Principal Investigator: Rossana A. Ditangco,MD Research Institute for Tropical Medicine