ADME/TOX® 2009年3月改定 ＜測定項目および測定単価表＞ 測定系 Adenosine 番号 サブタイプ レセプター 単価 1 A1 Rat brain 4,000 2 A2 Rat striatum 4,000 3 Transporter Guinea pig brain 4,000 4 A1 Rat recombinant 8,000 5 A3 Rat recombinant 8,000 6 A1 Human recombinant 8,000 7 A2a Human recombinant 8,000 8 A2b Human recombinant 8,000 9 薬物 濃度 例数 注 A3 Human recombinant 8,000 10 Transporter Human 8,000 11 α1 (Non-Selective) Rat brain 4,000 12 α1A Rat salivary glands 4,000 13 α1B Rat liver 4,000 14 α2 (Non-Selective) Rat cerebral cortex 4,000 15 β (Non-Selective) Rat brain 4,000 16 β1 Rat cerebral cortex 4,000 17 β2 Rat lung 4,000 18 α1A Rat recombinant 8,000 19 α1D Rat recombinant 8,000 20 α2C Rat recombinant 8,000 21 α１A Human recombinant 8,000 22 α1B Human recombinant 8,000 23 α2A Human recombinant 8,000 24 α2B Human recombinant 8,000 25 α2C Human recombinant 8,000 26 β1 Human recombinant 8,000 27 β2 Human recombinant 8,000 28 β3 Human Non-recombinant 8,000 注 29 CRLR+RAMP2 Human recombinant 8,000 注 30 CRLR+RAMP3 Human recombinant 8,000 注 31 AR Rat prostate 4,000 32 AR Rat recombinant 8,000 33 AT2 Mouse recombinant 8,000 注 34 AT1 Human recombinant 8,000 注 35 AT2 Human recombunant 8,000 注 Apelin 36 APJ Human recombinant 8,000 注 Benzodiazepine 37 BZ bovine cerebrum 8,000 38 B1 Human recombinant 8,000 39 B2 Human recombinant 8,000 40 BR (Non-Selective) Rat brain 4,000 注 41 BB1 Human recombinant 8,000 注 42 BB2 Human recombinant 8,000 注 43 BB3 Human recombinant 8,000 注 44 CALR Rat brain 4,000 注 45 Type L , Benzothiazepine Rat cerebral cortex 4,000 46 Type L , Dihydropyridine Rat cerebral cortex 4,000 47 Type L , Phenylalkylamine Rat cerebral cortex 4,000 48 Type N Rat brain 4,000 49 CB1 Mouse recombinant 8,000 50 CB1 Human recombinant 8,000 51 CB2 Human recombinant 8,000 Adrenergic Adrenomedulin Androgen Angiotensin Bradykinin Bombesin Calcitonin Ca ｃhannel Cannabinoid 注 注 注 ADME/TOX® ＜測定項目および測定単価表＞ 測定系 CGRP Chemoattractant Chemokine CCK CRF Cl channel Dopamine EGF 番号 サブタイプ 52 CGRP 53 CRLR+RAMP1 54 C3a 55 C5a 56 Endothelin GABA 単価 薬物 濃度 例数 8,000 注 Human recombinant 8,000 注 Human recombinant 8,000 注 Human recombinant 8,000 注 C5a （variant） Human recombinant 8,000 注 57 CXCR1 Human recombunant 8,000 注 58 CXCR2 Human recombinant 8,000 注 59 CXCR3 Human recombinant 8,000 注 60 CXCR4 Human recombinant 8,000 注 61 CXCR6 Human recombinant 8,000 注 62 CX3CR1 Human recombinant 8,000 注 63 CCR1 Human recombinant 8,000 注 64 CCR2b Human recombinant 8,000 注 65 CCR3 Human recombinant 8,000 注 66 CCR6 Human recombinant 8,000 注 67 CCR7 Human recombinant 8,000 注 68 CCR8 Human recombinant 8,000 注 69 CCR9 Human recombinant 8,000 注 70 CCR10 Human recombinant 8,000 注 71 XCR1 Human recombinant 8,000 注 72 A Human recombinant 8,000 注 73 B Human recombinant 8,000 注 74 CRF1 Human recombinant 8,000 注 75 CRF2 Human recombinant 8,000 注 Rat brain 4,000 注 4,000 76 77 D1 Rat striatum 78 D2 Rat striatum 4,000 79 D2 Mouse recombinant 8,000 80 D3 Rat recombinant 8,000 81 D1 Human recombinant 8,000 82 D1A Human recombinant 8,000 83 D2 Human recombinant 8,000 84 D2 short Human recombinant 8,000 85 D2 long Human recombinant 8,000 86 D3 Human recombinant 8,000 87 D4 Human recombinant 8,000 88 D4.2 Human recombinant 8,000 89 D4.4 Human recombinant 8,000 90 D4.7 Human recombinant 8,000 91 D5 Human recombinant 8,000 92 Transporter Human recombinant 8,000 93 EGF Human Non-recombinant 8,000 Rat uterus 4,000 94 Estrogen レセプター Human recombinant 注 95 α Human recombinant 8,000 96 β Human recombinant 8,000 97 ETA Human recombinant 8,000 注 98 ETB Human recombinant 8,000 注 99 GABA A (Agonist Site) Rat cerebellum 4,000 100 GABA A (BZ Central) Rat brain 4,000 101 GABA A (BZ Peripheral) Rat heart 4,000 102 Chloride Channel Rat cerebral cortex 4,000 103 GABA B Rat cerebellum 4,000 104 Transporter Rat cerebral cortex 4,000 ADME/TOX® ＜測定項目および測定単価表＞ 測定系 番号 サブタイプ レセプター 単価 薬物 濃度 例数 105 GABA B1a Human recombinant 8,000 106 GABA B1b Human recombinant 8,000 107 GABA B1a + R2 Human recombinant 8,000 108 GABA B1b + R2 Human recombinant 8,000 109 GAL1 Human receptor 8,000 注 110 GAL2 Human receptor 8,000 注 111 GAL3 Human recombinant 8,000 注 112 GIP Human recombinant 8,000 注 New 113 GLP-1 Human recombinant 8,000 注 New 114 glucagon Human recombinant 8,000 注 Rat liver 4,000 GABA Galanin Glucagon Glucocorticoid Human recombinant 8,000 117 Non-Selective Rat cerebral cortex 4,000 118 AMPA Rat cerebral cortex 4,000 119 Kainate Rat brain 4,000 120 NMDA (Agonist site) Rat cerebral cortex 4,000 121 NMDA (Glycine site) Rat cerebral cortex 4,000 122 NMDA (Phencyclidine site) Rat cerebral cortex 4,000 123 NMDA (Polyamine site) Rat cerebral cortex 4,000 124 MGluR3 Human recombinant 8,000 125 MGluR7 Human recombinant 8,000 Glycine 126 Strychnine sensitive Rat spinal cord 4,000 GnRH 127 GnRH Human recombinant 8,000 128 H1 (Central) Guinea pig cerebellum 4,000 129 H1 (Peripheral) Guinea pig lung 4,000 130 H2 Rat cerebral cortex 4,000 131 H3 Rat brain 4,000 132 H2 Rat recombinant 8,000 133 H1 Human recombinant 8,000 134 H2 Human recombinant 8,000 135 H3 Human recombinant 8,000 136 H4 Human recombinant 8,000 137 Central Rat cerebral cortex 4,000 138 Peripheral Glutamate Histamine Imidazoline 116 IP3 139 Insulin 140 K ｃhannel Leukotriene Melanin-Concentration Hormone New 115 Melanocortin Melatonin 注 Rat kidney 4,000 Rat cerebellum 4,000 Rat liver 4,000 注 Rat cerebral cortex 4,000 注 141 KA 142 KATP Rat brain 4,000 143 Kv Rat brain 4,000 注 144 Skca Rat brain 4,000 注 145 hREG Human recombinant 8,000 注 146 B4 Guinea pig lung 8,000 147 C4 Guinea pig lung 8,000 148 D4 Guinea pig lung 8,000 149 CysLT1 Human recombinant 8,000 150 BLT1 Human recombinant 8,000 151 MCH1 Human recombinant 8,000 注 152 MCH2 Human recombinant 8,000 注 153 MC3 Mouse recombinant 8,000 注 154 MC5 Mouse recombinant 8,000 注 155 MC1 Human recombinant 8,000 注 156 MC3 Human recombinant 8,000 注 157 MC4 Human recombinant 8,000 注 158 MC5 Human recombinant 8,000 注 159 MT1 Human recombinant 8,000 注 160 MT2 Human recombinant 8,000 注 ADME/TOX® ＜測定項目および測定単価表＞ 測定系 番号 Motilin 161 MTL-R1 Monoamine 162 163 Muscarinic サブタイプ レセプター 単価 Human recombinant 8,000 Transporter Rabbit platelet 8,000 Non-Selective Rat cerebral cortex 4,000 164 M1 Rat cerebral cortex 4,000 165 M2 Rat cerebral cortex 4,000 166 M1 Mouse recombinant 8,000 167 M1 Human recombinant 8,000 168 M2 Human recombinant 8,000 169 M3 Human recombinant 8,000 170 M4 Human recombinant 8,000 171 M5 Human recombinant 8,000 Rat kidney 8,000 Rat brain 4,000 Mineralcorticoid 172 Na channel 173 薬物 濃度 例数 注 174 FPR1 Human recombinant 8,000 175 FPRL1 Human recombinant 8,000 注 176 NK1 Rat recombinant 8,000 注 177 NK2 Rat recombinant 8,000 178 NK1 Human recombinant 8,000 179 NK2 Human recombinant 8,000 180 NK3 Human recombinant 8,000 注 181 NMU1 （FM3） Human recombinant 8,000 注 182 NMU2 （FM4） Human recombinant 8,000 注 183 NPFF1 Human recombinant 8,000 注 184 NPFF2 Human recombinant 8,000 注 185 NPY1 Human receptor (Non-recombinant) 8,000 注 186 NPY2 Human receptor (Non-recombinant) 8,000 注 187 NT1 Human recombunant 8,000 注 188 NT2 Human recombinant 8,000 注 189 Transporter Human recombinant 8,000 190 Ni Rat cerebral cortex 4,000 191 Ni Human receptor (Non-recombinant) 8,000 192 OX1 Human recombinant 8,000 注 193 OX2 Human recombinant 8,000 注 194 Non-Selective Rat cerebral cortex 4,000 New 195 δ Rat brain 4,000 New 196 κ Rat brain 4,000 New 197 μ Rat brain 4,000 198 δ Guinea pig brain 4,000 199 κ Guinea pig brain 4,000 200 μ Guinea pig brain 4,000 201 δ Mouse recombinant 8,000 202 κ Mouse recombinant 8,000 203 δ Human recombinant 8,000 204 κ Human recombinant 8,000 205 μ Human recombinant 8,000 206 ORL1 Human recombinant 8,000 Rat uterus 4,000 注 OT Human recombinant 8,000 注 Rabbit platelet 8,000 N-Formyl Peptide Neurokinin Neuromedin U Neuropeptide FF Neuropeptide Y Neurotensin Norepinephrine Nicotinic Orexin Opiate Oxytocin 207 208 New 注 PAF 209 PTH 210 PTH1 Human recombinant 8,000 211 Non-Selective Rabbit uterus 4,000 212 PR-B Human recombinant 8,000 213 PrRP Human recombinamt 8,000 注 214 PK1 Human recombinamt 8,000 注 215 PK2 Human recombinamt 8,000 注 Progesterone Prolactin Releasing Peptide Prokineticin 注 ADME/TOX® ＜測定項目および測定単価表＞ 測定系 Prostanoid New Protease-Activated Receptor 2 Relaxin Serotonin Sigma Somatostatin 番号 サブタイプ レセプター Human recombinant 単価 薬物 濃度 例数 216 CRTH2 8,000 217 DP Human recombinant 8,000 218 EP2 Human recombinant 8,000 219 EP3 Human recombinant 8,000 220 EP4 Human recombinant 8,000 221 PAR2 Human recombinant 8,000 注 222 RXFP3 Human recombinant 8,000 注 223 RXFP4 Human recombinant 8,000 注 224 5HT1 (Non-Selective) Rat striatum 4,000 225 5HT1A Rat cerebral cortex 4,000 226 5HT1B Rat brain 4,000 227 5HT2A Rat cerebral cortex 4,000 228 5HT4 Guinea pig striatum 4,000 229 5HT6 Rat recombinant 8,000 注 230 5HT7 Rat recombinant 8,000 注 231 5HT1A Human recombinant 8,000 232 5HT1B Human recombinant 8,000 233 5HT1D Human recombinant 8,000 234 5HT1E Human recombinant 8,000 235 5HT1F Human recombinant 8,000 236 5HT2A Human recombinant 8,000 237 5HT2B Human recombinant 8,000 238 5HT2C Human recombinant 8,000 239 5HT2C (edited) Human recombinant 8,000 240 5HT2C (non-edited) Human recombinant 8,000 241 5HT3 Human recombinant 8,000 242 5HT5A Human recombinant 8,000 注 243 5HT6 Human recombinant 8,000 注 244 5HT7 Human recombinant 8,000 注 245 Transporter Human recombinant 8,000 246 Non-Selective Guinea pig brain 4,000 247 σ1 Guinea pig brain 4,000 248 σ2 Guinea pig brain 4,000 249 SST1 Human recombinant 8,000 注 250 SST2a Human recombinant 8,000 注 251 SST3 Human recombinant 8,000 注 252 SST4 Human recombinant 8,000 注 253 SST5 Human recombinant 8,000 注 Guinea pig submaxillary 4,000 Human 8,000 注 注 Substance P 254 Testosterone 255 TRH 256 TRH1 Human recombinant 8,000 Thyroid hormone 257 TH Rat liver 8,000 注 258 UR2 （GPR14） Mouse recombinant 8,000 注 259 UR2 （GPR14） Human recombinant 8,000 注 260 V1 Rat liver 4,000 261 V2 Rat kidney 4,000 262 V1A Human recombinant 8,000 263 V1B Human recombinant 8,000 264 V2 Human recombinant 8,000 265 VIP Human recombinant 8,000 266 D3 Human recombinant 8,000 Urotensin Vasopressin Ｖasoactive intestinal polypeptide Vitamin 注 注 ADME/TOX® 弊社では，動物組織や発現蛋白を用いた，各種測定系をご準備させて頂いております。レセプターやリガンドの変更，記載の無い測定項目につき ましても，お気軽にご相談下さい。 ＜試験費用算出について＞ レセプター調製費 弊社指定の測定系で実施する場合，レセプター調製費は測定単価に含まれ無償となります。 なお，指定以外のレセプターで測定する場合，別途レセプター調製費が必要となります。 トレーサー費用 弊社指定の測定系で実施する場合，トレーサー費用は，測定単価に含まれ無償となります。 但し，備考欄に「注」の記載がある測定系については，トレーサーが「125Iリガンド」のため， トレーサー代を実費で加算させて頂きます。 測定費用 化合物数，濃度数，例数（測定本数）および回数に測定単価を掛けて算出させて頂きます。 なお，Ki値を算出するためのスキャッチャード解析に関しましては，１レセプターあたり100,000円を加算させて頂きます。 報告書作成費 スクリーニングあるいは申請用試験など用途により費用が変わりますので，随時お問い合わせ下さい。 * 測定項目については特許の関係で予告なく変更することがありますので、ご了承下さいます様お願い致します。 薬物動態研究所 〒319-1182 茨城県那珂郡東海村村松2117 TEL : 029(282)0234, FAX : 029(287)2030 E-mail : [email protected] URL ： ｈｔｔｐ：//ｗｗｗ.sekisuimedical.jp RRA-60 200903
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