hla class ii restricted minor histocompatibility antigens identification

HLA CLASS II RESTRICTED MINOR HISTOCOMPATIBILITY
ANTIGENS
–
IDENTIFICATION, PROCESSING AND BIOLOGY
ANITA KREMER
Cover Page
The handle http://hdl.handle.net/1887/29604 holds various files of this Leiden University
dissertation
Author: Kremer, Anita
Title: HLA class II restricted minor histocompatibility antigens : identification,
processing and biology
Issue Date: 2014-11-06
HLA class II restricted minor histocompatibility antigens - identification, processing
and biology
© Anita N. Kremer, Erlangen, Germany, 2014
COVER:
Anita N. Kremer
AndreaMosaic)
(Academiegebouw,
LAYOUT:
Anita N. Kremer
PRINTING:
Ipskamp Drukkers, Enschede
Leiden;
modified
with
ISBN: 978-94-6259-375-6
FINANCIAL SUPPORT:
The research described in this thesis was financially supported by the Dutch Cancer
Society (UL2008-4111), the European Union (6th Framework Program Allostem), the
Deutsche Forschungsgemeinschaft (STU540/1-1) and the ELAN Fond of the FAU
Erlangen-Nürnberg (12-04-05-1-Kremer).
Printing of this thesis was supported by the Dutch Cancer Society.
HLA CLASS II RESTRICTED MINOR HISTOCOMPATIBILITY
ANTIGENS
–
IDENTIFICATION, PROCESSING AND BIOLOGY
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 6 november 2014
klokke 16:15 uur
door
ANITA NATALIE KREMER
geboren te München (Duitsland)
in 1980
PROMOTIECOMMISSIE
PROMOTOR:
PROF. DR. J.H.F. FALKENBURG
CO-PROMOTOR:
DR. M. GRIFFIOEN
OVERIGE LEDEN:
PROF. DR. C. VAN KOOTEN
PROF. DR. J.J.C. NEEFJES, NETHERLANDS CANCER INSTITUTE
PROF. DR. W. HERR, UNIVERSITY OF REGENSBURG
TABLE OF CONTENTS
CHAPTER 1: INTRODUCTION
7
CHAPTER 2: IDENTIFICATION
27
OF 4 NEW HLA-DR-RESTRICTED MINOR
HISTOCOMPATIBILITY ANTIGENS AS HEMATOPOIETIC TARGETS
IN ANTITUMOR IMMUNITY
BLOOD, 2009
CHAPTER 3: ENDOGENOUS
HLA
CLASS II EPITOPES THAT ARE
IMMUNOGENIC IN VIVO SHOW DISTINCT BEHAVIOR TOWARD
HLA-DM AND ITS NATURAL INHIBITOR HLA-DO
57
BLOOD 2012
CHAPTER 4: HLA-DO REGULATES SURFACE PRESENTATION
CLASS-II ANTIGENS ON B-CELL MALIGNANCIES
OF
HLA-
89
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014
CHAPTER 5: DEVELOPMENT OF A COORDINATED ALLO T-CELL AND AUTO
B-CELL RESPONSE AGAINST AUTOSOMAL PTK2B AFTER
107
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
HAEMATOLOGICA, 2013
CHAPTER 6: INTERCELLULAR
TRANSFER OF NATURAL HLA CLASS II
LIGANDS IS MEDIATED BY FULL LENGTH PROTEINS THAT ARE
SEQUESTERED AND SECRETED INTO MICROVESICLES
125
CHAPTER 7: SUMMARY AND GENERAL DISCUSSION
153
CHAPTER 8: NEDERLANDSE SAMENVATTING
177
ACKNOWLEDGEMENTS
185
CURRICULUM VITAE
187
LIST OF PUBLICATIONS
189

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