Acknowledgement It is an utmost pleasure to transcribe my deep sense of indebtedness and sincere appreciation to my respected mentor, Dr. Shital S. Panchal, Assistant Professor, Department of Pharmacology, Institute of Pharmacy, Nirma University for initiating and suggesting the theme of the work, her valuable guidance, supervision, creative suggestions and meticulous attention, sustained interest and everlasting support throughout the course of this work. I express my profound gratitude to Prof. Gaurang B. Shah (Principal, K.B. Institute of Pharmaceutical Education and Research, Gandhinagar) and Dr. Shrikalp S. Deshpande (Professor and Head, Department of Pharmacology, K.B. Institute of Pharmaceutical Education and Research, Gandhinagar) as a panel of review committee set up at university for the regular assessment of the progress of my research work. I express my sincere thanks to Prof. Manjunath D. Ghate, Director, Institute of Pharmacy, Nirma University, for providing the facilities required to complete the work and for his support, encouragement and precious words of wisdom. I sincerely express my gratitude to my teachers Dr. Anuradha K. Gajjar, Ex. Professor, Department of Pharmaceutical Chemistry, Institute of Pharmacy, Dr. Vimal Kumar, Professor and Head, Department of Pharmacognosy, Institute of Pharmacy, Dr. Priti J. Mehta, Professor and Head, Department of Pharmaceutical Analysis, Institute of Pharmacy, Dr. Tejal A. Mehta, Professor and Head, Department of Pharmaceutics and Pharmaceutical technology, and Dr. Murali B, Associate Professor and Head, Department of Pharmacology, for their relentless support and encouragement throughout the course of my research work. I am equally thankful to all other faculty members of the Institute of Pharmacy for their timely assistance and cooperation. I express my sincere gratitude to Dr. Lalitha Poluru, Mr. Sandeep Patel, and Mr. Virendra Goswami for helping me in the maximum utilization of the library. I wish to acknowledge the strong support, and sincere cooperation of all the non-teaching staffs of the Institute of Pharmacy, Nirma University, for their help as and when required. I am extremely thankful to Torrent Research Centre, Ahmedabad, India and Biochem Pharmaceutical Industries, India for providing me with the timely gift samples of Glibenclamide and 5-FU respectively. iii I owe my deepgratitudeto the SophisticatedAnalytical Instrumentation Facility (SAIF) at PanjabUniversity,Chandigarh,for carryingout the NMR and Massspecirometricanalysi5, stLrdies, Prime Path Solutions,Ahmedabadfor render;nghelp during the histopathological Dr. Vipul. P. Patel, Asst. Professorand Head, Deparment of Biotechnology,ShreeS.K. PatelCollegeof Phafmaceutical Education& Research,GanpatUn;versityfor the t vtlro cytotoxic;tystudies,and Mr. Alok Pandya, ResearchScholar,Departmentof Chemistry, CujaratUniversitylor the particlesizeanalysisofmy formulalions. (INSPIRE Fellowship: JRF/SRF I ackflo,'{ledgewith gratitude the financial ass;stance Prolessional)and contingencygrant from the Department ol Scienceand Technology (DST), Govt. of lndia for carryingout this entirework. I also gratefullyacknowledgetheir supportfor providing me with the International Travel Grant for presentinga research paperat The International Conference& Exhibition on Cancer Science& Therapy, held in Las Veges,USA. I am especiallygratefulto Mr. Neeraj K. Sharma,not only for his pricelessfriendshipand invaluablemoral supporl,but also for extend;ngimmensetechnicalhelp in performingthe formulationexperiments.I am than-kfulto Mr, Omkar D. Sherikar and Mr. Kuldip Barot analyt;calwork with precisionand accwacy. for helpingme carry out someindispensable my skilledcolleagues in the field ofPharmacolog: Nihar, Rajiv, I alsowarmly acknowledge Vinit, Surender,Ravi, Ujjval, Samir, Sameer,Vishal, and Devrasfor alwaysbe;ngready to helDandbeins accessible for technicalassistance. love and suppon.Not Sneha,my soulmate,has beenan immensesourceof relentless forgettingMa andmy dearest sisterTitli, the othertwo mostimportantpeoplein my life, whosepatience,understanding, even in the most unfailingsupportand encouragement desperate circumstances inspired mein everystepoflhe way, Finally,I would like to thank everybodywho has beeninstrumental to the successful reaiization of this thesis,eitherdirectlyor indirectly,andwhosenanesI haveunknowingly nissedout in makingthisprojecta worthyendeavor. 4,o rut.,o 3[o+ft3 AYt'1.'- Soms-uvrfB- charak