AUTO ISLET CELL TRANSPLANTATION: WHAT IS

AUTO ISLET CELL TRANSPLANTATION: WHAT IS HAPPENING TO WEIGHT AND FAT SOLUBLE VITAMIN
STATUS?
Maria Nestleroad, MS, RD, CNSC, LD; Kelley Martin, MPH, RD, LD; Elizabeth Shuford, RN, CGRN; Stefanie
Owczarski, PA-C, MPAS, Katherine Morgan, MD, David Adams, MD
Medical University of South Carolina Department of Gastrointestinal and Laparoscopic Surgery
Limited data has been reported about chronic pancreatitis and nutritional compromise after Total
pancreatectomy and islet auto-transplantation (TP-IAT). This study aims to distinguish nutritional status
of TP-IAT patients pre- and post-surgery. Nutrition parameters (BMI, vitamins D3, A, and E) were
obtained from an IRB-approved prospective data base collected for TPI-AT patients at a single
institution. Two-tailed paired T-test and two-tailed student T-test for unequal variances were used for
data analysis. Weight loss was observed from pre-op to 6 month post-op (n=111) from mean BMI
(26.1kg/m2±6.6 to 23.0kg/m2±4.9, p<0.0001). There was little change in weight from 6 months to 1 year
post-op. BMI at 2 and 3 years post-op were also unchanged. Average vitamin D3 levels dropped
significantly pre to 6 months post-op (27.8ng/ml±10.5 to 24.4ng/ml±10.3, p=0.02). Levels also dropped
from 6 months post-op to 1 year post-op (24.4ng/ml±10.3 to 22.5ng/ml±11.8), indicating moderate
deficiency after TP-IAT. Despite having fewer data at 2 and 3 years post-op, mean vitamin D levels
indicated prolonged Vitamin D deficiency (20.3ng/ml±11.8, 21.6 ml±15.8). Mean levels of a
subpopulation (n=55) for vitamins A and E were normal (0.34mg/L±0.15 and 7.4mg/L±3.1) at time points
ranging from 6 months to 3 years post-op. Vitamins A and E deficiencies were observed in 45% and 29%
of subjects. Nutritional compromise is a notable problem in patients after TP/IAT. Although nutritional
risk may improve over time, these patients require long-term nutrition follow-up.

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