IMIPRAMINE (Tofranil. Your brand is: ) What does it do? Imipramine is used to treat and prevent depression, and sometimes other conditions. How should you take it? Take imipramine regularly as directed with a glass of water, usually at night time. What if you miss a dose? Take the missed dose if you remember on the same day. If not, skip the dose and carry on as normal. Do not take two doses at the same time. Can you take other medicines? Some medicines available without a prescription may react with imipramine including:  some antihistamines (may be in anti-allergy, anti-nausea and cough/cold preparations)  cold and flu preparations containing phenylephrine (e.g. Sudafed PE) or dextromethorphan (e.g. Robitussin Dry Cough Forte)  anti-sickness preparations (e.g. Sea-legs)  anti-diarrhoea preparations (e.g. Diastop) Tell your pharmacist or doctor about all medicines or treatments that you may be taking including vitamins, herbal products (e.g. St John’s wort) or recreational drugs (e.g. ecstasy). What side effects might you notice? Side Effects Fast or irregular heartbeat, fainting Fever, sweating, tremor, confusion Anxiety, restlessness Drowsiness, dizziness, headache, trouble sleeping Dry mouth, changes in taste, changes in vision, trouble urinating Constipation, weight gain Involuntary movements Changes in sexual function Recommended action Tell your doctor immediately Tell your doctor Tell your doctor if troublesome If you notice any other effects, discuss them with your doctor or pharmacist. Other information:     Tell your doctor if you have liver, heart, thyroid, prostate or urinary problems. Tell your doctor if you have glaucoma, bipolar disorder, or if you have ever had a seizure. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Your doctor may need to do a heart test (ECG) before you start and while you are taking imipramine.  Imipramine may make you dizzy or sleepy and make it dangerous to drive, operate machinery or do activities that require you to be alert. Limit alcohol intake because it can increase these effects.  If your depression continues to get worse, see your doctor.  Do not stop taking imipramine without talking to your doctor. Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. Jan 2015