Yun Wang, M.D., Ph.D.

Yun Wang, M.D., Ph.D.
Center for Neuropsychiatric Research, National Health Research Institutes
35, Keyan Road, Zhunan Town, Miaoli, 35053, Taiwan
Phone No.: 037-246166 ext 36700
Fax No.: 037-586453
E-mail: [email protected]
1972 - 1979
1981 - 1986
M.D., Medicine, National Defense Medical Center, Taipei, Taiwan
Ph.D., Pharmacology, University of Colorado, Denver, CO. U.S.A.
Research and Professional Positions Held in Chronological Sequence
1997 - 2013 Senior Investigator and Section Chief, Neural Protection and Regeneration
Section, National Institute on Drug Abuse, National Institute of Health,
Baltimore, MD, U.S.A.
2013Distinguished Investigator, Center for Neuropsychiatric Research, National
Health Research Institutes
Research Interests
Yun Wang heads a program that studies trophic factors, small molecules, and genes with
potential neuroprotective or neuroregenerative properties in various neurodegeneration disorders.
For example, he has recently reported a delayed treatment strategy with a p53 inhibitor to
enhance recovery in stroke brain. Using trophic factors and a bridge transplantation technique, he
has demonstrated the re-establishment of nigrostriatal dopaminergic pathway in
hemiparkinsonian rats. His ongoing experiments involve small molecules with antioxidant
properties or the capacity to activate neuroprotective genes in models of stroke, Parkinson’s
disease, and methamphetamine intoxication. These compounds include diadenosine
tetraphosphate, inosine, retinoic acid, vitamin D3, astaxanthin, and PFT-a.
For gene function
studies, regulation of protective or regenerative genes, such as GDNF, MANF, BMP7, were
examined in animal model of stroke. The goal of research conducted in his laboratory is to lead
to the development of therapies aimed at preventing neurodegeneration and promoting
neuroregeneration in stroke animals.
Major Honors and Awards
Michael J Fox Foundation, Repositioning Drug for PD program project grant
Collaborative research award, NIDA IRP, NIH
Tenured senior scientist, National Institute of Health
Outstanding Pharmacologist award (from Pharmacological Society in Taiwan)