Yun Wang, M.D., Ph.D. Center for Neuropsychiatric Research, National Health Research Institutes 35, Keyan Road, Zhunan Town, Miaoli, 35053, Taiwan Phone No.: 037-246166 ext 36700 Fax No.: 037-586453 E-mail: [email protected] Web: http://www.nhri.org.tw/NHRI_WEB/nhriw1001Action.do?emp_cd=020120 Education 1972 - 1979 1981 - 1986 M.D., Medicine, National Defense Medical Center, Taipei, Taiwan Ph.D., Pharmacology, University of Colorado, Denver, CO. U.S.A. Research and Professional Positions Held in Chronological Sequence 1997 - 2013 Senior Investigator and Section Chief, Neural Protection and Regeneration Section, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD, U.S.A. 2013Distinguished Investigator, Center for Neuropsychiatric Research, National Health Research Institutes Research Interests Yun Wang heads a program that studies trophic factors, small molecules, and genes with potential neuroprotective or neuroregenerative properties in various neurodegeneration disorders. For example, he has recently reported a delayed treatment strategy with a p53 inhibitor to enhance recovery in stroke brain. Using trophic factors and a bridge transplantation technique, he has demonstrated the re-establishment of nigrostriatal dopaminergic pathway in hemiparkinsonian rats. His ongoing experiments involve small molecules with antioxidant properties or the capacity to activate neuroprotective genes in models of stroke, Parkinson’s disease, and methamphetamine intoxication. These compounds include diadenosine tetraphosphate, inosine, retinoic acid, vitamin D3, astaxanthin, and PFT-a. For gene function studies, regulation of protective or regenerative genes, such as GDNF, MANF, BMP7, were examined in animal model of stroke. The goal of research conducted in his laboratory is to lead to the development of therapies aimed at preventing neurodegeneration and promoting neuroregeneration in stroke animals. Major Honors and Awards 2011-2013 Michael J Fox Foundation, Repositioning Drug for PD program project grant 2010 Collaborative research award, NIDA IRP, NIH 2006 Tenured senior scientist, National Institute of Health 1997 Outstanding Pharmacologist award (from Pharmacological Society in Taiwan)