The 55th Annual Meeting of the Japanese Respiratory Society 第55回日本呼吸器学会学術講演会ランチョンセミナー27 Luncheon Seminar 27 日時会場 4月19日（日）11：50∼12：50 2015年東京国際フォーラム第7会場（ホールD5） D棟5階〒100-0005 東京都千代田区丸の内3-5-1 日本語通訳 Heart lung interaction in heart failure during quiet wakefulness,sleep and exercise: new knowledge for a common problem. 座長陳和夫先生京都大学大学院医学研究科呼吸管理睡眠制御学講座教授演者 Matthew T．Naughton,ＭＤＦＲＡＣＰ Head,General Respiratory and Sleep Medicine Service Department of Allergy, Immunology &Respiratory Medicine Alfred Hospital & Monash University ●本セミナーは整理券制ではありません。共催：第55回日本呼吸器学会学術講演会フクダ電子株式会社／フクダライフテック株式会社／レスメド株式会社 The 55th Annual Meeting of the Japanese Respiratory Society Luncheon Seminar27 第55回日本呼吸器学会学術講演会ランチョンセミナー27 日本語通訳 Heart lung interaction in heart failure during quiet wakefulness,sleep and exercise: new knowledge for a common problem. 演者抄録 Matthew T． Naughton,ＭＤＦＲＡＣＰ Head,General Respiratory and Sleep Medicine Service Department of Allergy, Immunology &Respiratory Medicine Alfred Hospital & Monash University ABSTRACT: Dyspnoea in heart failure commonly occurs during sleep and exercise. The mechanisms of heart failure related dyspnoea during sleep can be explained by a combination of factors (low cardiac output, high ventilatory response and impaired pulmonary gas exchange) which result in hyperventilation and periodic breathing (also known as central sleep apnea with Cheyne Stokes respiration). In contrast to central apnoea with Cheyne Stokes respiration which is caused by heart failure, obstructive sleep apnoea is a cause of heart failure. The pathophysiology of exercise induced dyspnoea can be explained by cardiac and skeletal myopathy in addition to pulmonary vascular and airway changes. Positive airway pressure is a non-pharmacological therapy for acute and chronic heart failure the mechanism of which can relate to pneumatic splinting of the upper airway, chest and heart. In contrast supplemental oxygen therapy may be detrimental to normoxic patients with heart failure.