氏名服部喜之所属医療薬剤学教室職位准教授学位

Hoshi University
氏
名
服部
所
属
医療薬剤学教室
学
位
博士（薬学）
最終学歴
教育活動
（担当授業科目）
喜之
職
位
准教授
京都大学大学院薬学研究科博士課程修了
バイオ医薬品とゲノム情報 (第 3 学年前期・専任)
生体分子の立体構造と相互作用
DDS
(第 3 学年後期・分担)
(第 4 学年前期・分担)
機能分子薬学特論 II (大学院・分担・隔年)
製剤学実習 (第 3 学年後期・分担 )
研究活動
（研究テーマ）
所属学会
がん治療のための非ウイルス性遺伝子ベクターの開発
日本薬学会、日本 DDS 学会、日本薬剤学会、日本癌学会、
遺伝子デリバリー研究会
学内活動
機器センター委員、CBT 実施委員、動物センター委員
（役職・委員等）
学外活動
（委員会委員等）
Editorial Board Member of Journal of Pharmaceutics
研究業績等
（受賞歴）
平成 11 年米国甲状腺学会 Travel Grant 受賞,
平成 13 年日本内分泌学会若手研究奨励賞受賞
平成 21 年星薬科大学大谷記念研究助成金受賞, 平成 21 年日本薬学会関東支部奨励賞受賞
（主な論文）
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HATTORI, Y. AND MAITANI, Y.: Folate-linked nanoparticle-mediated suicide gene therapy in human
prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase . Cancer Gene Ther.,
12, 796-809 (2005)
HATTORI, Y., KUBO, H., HIGASHIYAMA, K. AND MAITANI, Y.: Folate-linked nanoparticles formed
with DNA complexes in sodium chloride solution enhance transfection efficiency, J. Biomed. Nanotechnol.,
1, 176-184 (2005) (IF =7.578)
HATTORI, Y. AND MAITANI, Y.: Folate-linked lipid-based nanoparticle for targeted gene delivery,
Current Drug Delivery, 2, 243-252 (2005)
HATTORI, Y., SAKAGUCHI, M. AND MAITANI, Y.: Folate-linked lipid-based nanoparticles deliver a
NFB decoy into activated murine macrophage-like RAW264.7 cells, Biol. Pharm. Bull., 29, 1516-1520
(2006)
HATTORI, Y. AND MAITANI, Y.: Two-step transcriptional amplification-lipid-based nanoparticles using
PSMA or midkine promoter for suicide gene therapy in prostate cancer, Cancer Science, 97, 787-798
(2006)
HATTORI, Y., DING, W. AND MAITANI, Y.: Highly efficient cationic hydroxyethylated cholesterol -based
nanoparticle-mediated gene transfer in vivo and in vitro in prostate carcinoma PC-3 cells, J Control.
Release, 120, 122-130 (2007) (IF =7.261)
HATTORI, Y., FUKUSHIMA, M. AND MAITANI, Y.: Non-viral delivery of connexin 43 gene with histone
deacetylase inhibitor to human nasopharyngeal tumor cells enhances gene expression and inhibits in vivo
tumor growth, Int. J. Oncology, 30, 1427- 1439 (2007)
HATTORI, Y., HAGIWARA, A., DING, W. AND MAITANI, Y.:, NaCl improves siRNA delivery mediated
by nanoparticles of hydroxyethylated cationic cholesterol with amido -linker, Bioorganic & Medicinal
Chemistry letters, 18, 5228-5232 (2008)
HATTORI, Y., YOSHIZAWA, T., KOGA, K., AND MAITANI, Y.: NaCl induced high cationic
hydroxyethylated cholesterol-based nanoparticle-mediated synthetic siRNA transfer into prostate
carcinoma PC-3 cells, Biol. Pharm. Bull., 31, 2294-2301 (2008)
HATTORI, Y., SHI, L., DING, W., KOGA, K., KAWANO, K., HAKOSHIMA, M., AND MAITANI, Y.:
Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors, J.
Control. Release, 136, 30-37 (2009) (IF =7.261)
HATTORI, Y., HAKOSHIMA, M. KOGA K. AND MAITANI, Y.: Increase of therapeutic effect by treating
nasopharyngeal tumor with combination of HER-2 siRNA and paclitaxel, Int. J. Oncology, 36, 1039-1046
(2010)
HATTORI, Y., KANAMOTO, N., KAWANO, K., IWAKURA, H., SONE, M., MIURA, M., YASODA, A.,
TAMURA, N., ARAI, H., AKAMIZU, T., NAKAO, K. AND MAITANI, Y.: Molecular characterization of
tumors from a transgenic mice adrenal tumor model: Comparison with human pheochromocytoma, Int. J.
Oncology, 37, 695-705 (2010)
HATTORI, Y., UBUKATA, H., KAWANO, K. AND MAITANI, Y.: Angiotensin II-induced hypertension
enhanced therapeutic efficacy of liposomal doxorubicin in tumor-bearing mice, Int. J. Pharm., 403,
178-184 (2011)
HATTORI, Y., NAKAMURA, T., OHNO, H., FUJII, N.,AND MAITANI, Y.: siRNA delivery for tumor by
lipid-based nanoparticle composed with hydroxyethylated cholesteryl triamine , Int. J. Pharm.,443:221-229
(2013).
HATTORI, Y., YAMASAKU, H. AND MAITANI, Y.: Anionic polymer-coated lipoplex for safe gene
delivery into tumor by systemic injection, J. Drug Target., 21(7): 639-647 (2013)
HATTORI, Y., ARAI, S., OKAMOTO, R., HAMADA, M., KAWANO, K. AND YONEMOCHI, E.:
Sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA could effectively
deliver siRNA to the liver, Int J Pharm., 476: 289-298 (2014)
(分担著書)
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HATTORI, Y., AND MAITANI, Y.: Folate-linked lipid-based nanoparticles for tumor-targeted gene
therapy, Nanotechnologies for the Life Science, Biofunctionalization of nanomaterials, edited by Challa.
Kumar, Wiley-VCH, 1, 270-298 (2005)
HATTORI, Y., AND MAITANI, Y.: Tumor-targeting non-viral gene therapy for the treatment of oral cancer,
Oral Cancer Research Advances, edited by Alexios P. Nikolakakos, Nova Science Publishers, Inc. , 95-124
(2007)
HATTORI, Y., AND MAITANI, Y.: Folate-linked lipid-based nanoparticle gene delivery to the tumor,
Encyclopedia of Nanoscience and Nanotechnology, edited by H. S. Nalwa, American Scientific Publishers,
14, 263-277 (2011)
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