Drug Discovery Anno 2014: from target identification to personalized medicine 27-28 May 2014, KU Leuven - Campus Gasthuisberg, O&N2 27 May 2014 - AM Target identification 8h30-9h00 Welcome coffee 9h00-9h10 Introduction 9h10-10h10 Stefan OFFERMANNS Max-Planck-Institute for Heart and Lung Research, Germany GPCRs as drug targets - new candidates for metabolic disorders and cancer metastasis 10h10-11h10 Nabil SEIDAH Clinical Research Institute of Montreal, Canada PCSK9: from discovery to clinical applications 11h10-11h30 Coffee break 11h30-12h30 Roderick BEIJERSBERGEN Netherlands Cancer Institute, Netherlands Functional Genomics, Genomics and Therapy: “Putting one and one together” 12h30-13h30 Meet-the-expert Lunch 27 May 2014 - PM Preclinical pharmacological models 13h30-14h30 Serge MUYLDERMANS VIB - Vrije Universiteit Brussel, Belgium Nanobody technology for (pre)clinical applications 14h30-15h30 Jacky VAN GOMPEL Janssen R&D, Belgium Efficacy and Safety evaluation with tissue models 15h30-15h50 Coffee break 15h50-16h50 Greet TEUNS Janssen R&D, Belgium From zebrafish to non-human primates: role of animal models in drug development 28 May 2014 - AM Basic aspects related to clinical drug development 8h30-9h00 Welcome coffee 9h00-10h00 Jan DE HOON KU Leuven, Belgium Phase I up to Phase IV: what’s in a name 10h00-10h40 Thierry VANDENDRIESSCHE Vrije Universiteit Brussel - KU Leuven, Belgium Advance Therapeutic Medicinal Products 10h40-11h00 Coffee break 11h00-12h00 Philippe BEUTELS University of Antwerp, Belgium Factors determining the value of a drug: basic insights in pharmaco-economics 12h00-13h00 Meet-the-expert Lunch 28 May 2014 - PM Personalized medicine 13h00-14h00 Katelijne DE NYS KU Leuven, Belgium The European & Belgian legislation related to clinical research. Current situation and upcoming changes 14h00-14h45 Ron VAN SCHAIK Erasmus MC Rotterdam, Netherlands Pharmacogenetics 14h45-15h30 Isabel SPRIET KU Leuven, Belgium Clinical pharmacokinetics and therapeutic drug monitoring 15h30-15h50 Coffee break 15h50-16h35 Reinier VAN HEST Academic Medical Center, Netherlands Population pharmacokinetics as a tool to personalize drug therapy: what is it and when to use? 16h35-17h00 Fabienne DOBBELS KU Leuven, Belgium Medication nonadherence: the Achilles heel of modern healthcare