Currently Open Paediatric Haematology/Oncology Trials Protocol Number ACCT003 Protocol Name Phase 1/11 study of valproate and interferon for relapsed, recurrent or progressive neuroblastoma Age Range ≤ 21 years at diagnosis Criteria Relapsed, recurrent or progressive neuroblastoma Centre(s) Starship Children's Hospital ACCT007 Phase I Study of Vinorelbine, Cyclophosphamide and Rapamycin for Recurrent Malignancies in Children < 22 years Solid tumour incl some CNS Must meet organ function and performance criteria Starship Children's Hospital/ Christchurch Hospital ASSG-AYAPK Pharmacokinetics and pharmacodynamics of Doxorubicin 1 year - 40 years Newly diagnosed osteosarcoma, Ewing family of tumours or Hodgkin Lymphoma Starship Children's Hospital COG AALL0434 Intensified MTX, Nelarabine and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell ALL or T-cell NHL > 1 year - < 31 years Starship Children's Hospital/ Christchurch Hospital COG AALL08B1 Classification of newly diagnosed ALL < 31 years COG AALL0932 Treatment of Patients with Newly Diagnosed Standard B-ALL: >365 days <10 years Risk B-Lymphoblastic Leukemia (B-ALL) or Localized B- B-LLy: >365 days < 31 years lineage Lymphoblastic Lymphoma (B-LLy) Newly diagnosed T-ALL or T-NHL (Stage II-IV) No prior cytotoxic chemotherapy with the exception of steroids and/or IT cytarabine No Down’s Syndrome Newly diagnosed acute leukaemia (suspect lymphoblastic) B-ALL: NCI Standard Risk; WCC <50000 B-Lly: Murphy Stage I-II Tissue submission COG AALL1131 A Phase III Randomised Trial for Newly Diagnosed High > 365 days - < 31years Risk B-precursor ALL testing Clofarabine in the Very High Risk Stratum COG AAML1031 A Phase III Randomised Trial for Patients with de novo AML using Bortezomib and Sorafenib for Patients with High Allelic Ratio FLT3/ITD COG ABTR01B1 Collecting and Banking Paediatric Research Specimens ≤ 30 years including Rare Paediatric Tumours Specimen submission per protocol Starship Children's Hospital COG ACNS02B3 CNS Banking Study No age restrictions Specimen submission per protocol Starship Children's Hospital COG ACNS0331 Limited Target Volume Boost Irradiation and Reduced Dose Cranio-spinal Rtx and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma Only ages 3-7 years Histologically confirmed intracranial medulloblastoma minimal volume non-metastatic Starship Children's Hospital/ Christchurch Hospital COG ACNS0821 Medulloblastoma/CNS PNET Recurrent/Refractory 1 - 21 years Relapsed, recurrent or refractory medulloblastoma/CNS Starship Children's Hospital/ Christchurch Hospital PNET; histological confirmation at diagnosis or recurrence; measurable disease. COG ACNS0822 A Randomized Phase II/III Study of Vorinostat (IND# ≥ 3 - < 22 years 71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab and Local Irradiation Followed by Maintenance Bevacizumab (IND # 7921) and Temozolomide in Newly Diagnosed High Grade Glioma Must meet disease, timing and organ function criteria Tissue submission required Starship Children's Hospital COG ACNS0831 Ependymoma Newly Diagnosed 1year - 21 years Starship Children's Hospital COG ACNS1022 A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytoma and Optic Pathway Gliomas < 22 years Histologically confirmed intracranial ependymoma nonmetastatic Must have measurable disease Must meet performance and organ function criteria Strict mandatory contraception advice processes < 30 years Starship Children's Hospital/ Christchurch Hospital Starship Children's Hospital/ Christchurch Hospital Age: >365 days - < 10 years: WCC ≥ 50000 Age: ≥ Starship Children's Hospital/ Christchurch Hospital 10 years - < 31years: Any WCC Any age: Any WCC + Testicular involvement, CNS 3 or steroid pretreatment per protocol De novo AML Starship Children's Hospital/ Christchurch Hospital This list is current at the time of posting and will be upated in May and November each year Starship Children's Hospital/ Christchurch Hospital Currently Open Paediatric Haematology/Oncology Trials COG ACNS1123 Phase II Trial of Response-based Radiation Therapy for ≥ 3 years - ≤ 21 years Patients with Localised CNS Germ Cell Tumours Newly diagnosed, localised disease Starship Children's Hospital/ Christchurch Hospital COG AEPI10N5 Genetic Epidemiology of Ewing Sarcoma Any COG AEWS07B1 Ewing Tumour Biology and Banking Study No age restrictions Must have at least one biological parent willing to participate Requires submission of saliva and Specimen submission per protocol Starship Children's Hospital COG AEWS1031 A Phase III Randomized Trial of Adding VincristineTopotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue ≤ 50 years Histologically confirmed Ewing’s of bone or soft tissue No previous chemotherapy No abnormal cardiac or renal function < 31years COG ANBL00B1 Neuroblastoma biology studies No age restrictions Diagnosis of HR neuroblastoma Starship Children's Hospital/ Christchurch Hospital Completed therapy including intensive induction followed by ASCT and RT No more than 9 months from 1st induction chemotherapy after diagnosis to ASCT Specimen submission per protocol Starship Children's Hospital/ Christchurch Hospital COG ANBL1221 Phase II Trial of Irinotecan/Temozolamide with Temsirolimus or Ch 14.18 in Children with Relapsed, Refractory or Progressive Neuroblastoma No age restrictions COG ANBL12P1 Pilot Study Using Myeloablative Busulfan/Melphalan ≤ 30 years (BuMel) Consolidation Following Induction Chemotherapy for Patients with Newly Diagnosed HighRisk Neuroblastoma COG AOST06B1 Collecting and Banking Osteosarcoma Specimens COG AREN03B2 COG ANBL0032 Starship Children's Hospital/ Christchurch Hospital Starship Children's Hospital/ Christchurch Hospital Starship Children's Hospital Specimen submission per protocol Starship Children's Hospital Renal Tumour Classification, Banking and Biology Study < 30 years Specimen submission per protocol Starship Children's Hospital/ Christchurch Hospital COG AREN0534 Bilateral Wilms tumours Wilms tumour bilateral or bilaterally pre-disposed Starship Children's Hospital/ Christchurch Hospital COG ASCT1221 A Randomized Phase II Study Comparing Two Different ≥ 3 months - ≤ 18 years Conditioning Regimens Prior to Allogeneic Hematopoietic Cell Transplantation (HCT) for Children with Juvenile Myelomonocytic Leukemia (JMML) Must meet disease and function criteria Starship Children's Hospital COG D9902 Soft Tissue Sarcoma Biology and Banking ≤ 50 years Specimen submission per protocol Starship Children's Hospital/ Christchurch Hospital CPT-SIOP-2009 Treatment Optimisation for Choroid Plexus Tumours No age restrictions Choroid Plexus Tumour newly diagnosed or recurrent Starship Children's Hospital/ Christchurch Hospital Interfant-06 Infant ALL Up to 365 days Newly diagnosed ALL / biphenotypic leukaemia Starship Children's Hospital/ Christchurch Hospital R3ACT Therapeutic infusion of most closely HLA-matched third Any party donor-derived virus-specific cytotoxic Tlymphocytes in patients with active viral reactivation postallogeneic stem cell transplantation Randomised Phase III trial of the Efficacy of Sodium > 1mth - ≤ 18yrs Thiosulphate in reducing ototoxicity in patients receiving Cisplatin chemotherapy for Standard Risk Hepatoblastoma Must meet disease, organ function and pre-treatment criteria Starship Children's Hospital Histologically confirmed newly diagnosed hepatoblastoma Standard risk hepatoblastoma Centre willing and able to organise audiometry No abnormal renal function Starship Children's Hospital/ Christchurch Hospital SIOPEL 6 No age restrictions Histological diagnosis of neuroblastoma or ganglioneuroblastoma at diagnosis or recurrence; measurable disease; first episode of recurrence or progression Must meet disease, organ function, performance and timing criteria Must enrol on NBL biology study ANBL00B1 Starship Children's Hospital/ Christchurch Hospital < 30 years This list is current at the time of posting and will be upated in May and November each year
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