March 2014! Master in Biology, option Genetics, Development and Evolution (GDE)! List of projects proposed at the Faculty of Sciences Department of Biochemistry Department of Cell Biology Department of Genetics and Evolution Department of Molecular Biology List of projects proposed at the Faculty of Medicine GONZALEZ-GAITAN laboratory Department of Biochemistry What are the physics principles! of the growth of an organ?! Sciences II, Contact: [email protected] ! MARTINOU laboratory (Audrey BELLIER) Department of Cell Biology Project:! Study the mechanisms of resistance to oxygen deprivation (=anoxia) in the nematode Caenorhabditis elegans! Sciences III, Contact Dr Audrey BELLIER, [email protected] ! Labo MILINKOVITCH Département de Génétique et Evolution 1. Bioinformatics: • Comparaisons in-silico de génomes complets pour l’analyse de l’évolution des génomes, des transcriptomes, et des interactomes; • Comparaisons d’heuristiques stochastiques pour l’inférence phylogénétique. 2. Génétique évolutive du développement (Evo-Devo): • Evolution des patterns de coloration chez les reptiles; • Evolution de la morphologie des membres chez les marsupiaux. http://www.lanevol.org! DUBOULE Laboratory" Department of Genetics and Evolution! Our laboratory is interested in the regulatory mechanisms underlying vertebrate pattern formation, in both developmental and evolutionary contexts. The projects focus on Hox genes, a family of transcription factors that display special paradigmatic values, regarding their regulatory strategies, their functional organization and their key roles in morphological evolution! Sciences III, ContactI: [email protected]! [email protected] RODRIGUEZ laboratory Department of Genetics and Evolution How mammals extract socially relevant information from the outside world?! How this information is translated into an adequate behavior?! we study the vomeronasal circuit, a neuronal system involved in pheromone recognition that plays a crucial role in peermediated neuroendrocine effects and instinctive behaviors.! Sciences III, Contact: [email protected] ! GALLIOT laboratory ! Department of Genetics and Evolution What signaling regulates injuryinduced apoptosis? STRESS! What is the stress-induced signaling that leads! to the regeneration of a 3D complex structure?! Contact Sciences III: [email protected] ! NAGOSHI laboratory Department of Genetics and Evolution How does the nervous system generate and modulate behaviors? What causes abnormal behaviors? The research in our lab is aiming at answering these questions at the molecular and neuronal levels. ! To this end, we have been pursuing two research foci related to locomtor behavior: 1) Molecular and neural basis of circadian locomotor behavior, and 2) Mechanisms of neurodegeneration in Parkinson’s disease.! Sciences III, Contact : [email protected] ! The Mammalian Circadian Timing System: How does the master clock in the suprachiasmatic nucleus (SCN) synchronize the countless oscillators present in virtually all peripheral cells? Group SCHIBLER, Department of Molecular Biology Monitoring circadian gene expression in real time in the liver of freely moving mice: An Adenoviral vector encoding a circadian Rev-erb!-luciferase reporter gene is transduced into the liver via injection into the tail vein. Luciferin, the substrate of luciferase, is delivered constantly via a microsomotic pump. The bioluminescence produced in the liver can be recorded via photomultiplier tube technology during days. bioluminescence locomotor activity hours SHORE lab. Department of Molecular Biology 1) Replication and capping of telomeres! 1I) Transcriptional networks controling cell growth! Sciences III, Contact: [email protected] ! Robbie Loewith lab Who we are: 2 Post Docs, ~6 PhDs, 2 techs, plus visiting interns What we do: We use chemical, genetic and biochemical approaches to interrogate the relatively simple eukaryote Saccharomyces cerevisiae (Bakers yeast) to understand how the conservedTarget Of Rapamycin (TOR) kinase regulates cell growth. Streptomyces! hygroscopicus! HALAZONETIS lab. Department of Molecular Biology Projects in Cancer Genetics and Development! Schema indicating driver and passenger mutations in colon adenomas! Sciences III, Contact : [email protected] ! Master in Biology, option Genetics, Development and Evolution (GDE) Laboratories offering GDE Master Projects at the Medical School (need to find a co-responsible PI at the Faculty of Sciences) Characterization of genes required for Asymmetric Cell Division Monica GOTTA lab CMU, Faculty of Medicine, [email protected] We study the process of asymmetric cell division which is fundamental for the generation of cell diversity during development and the self renewal of stem cells.! ! We use the embryo of the nematode C. elegans as a model system and combine genome-wide RNAi screening, biochemistry and in vivo imaging to study this process.! Asymmetric Cell Division! One-cell embryo! Two-cell embryo! C. elegans! NEF lab. Mammalian sex determination and testicular function Background: 50% of human disorders of sexual development remain unexplained. Our long-standing interest lies in the elucidation of the molecular mechanisms regulating gonadal differentiation and testicular function. Project: to be defined based on preferences and availability Team: 2 post-docs, 2 grad. students, 2 lab. techs, 1 undergrad student Techniques: - mouse genetics (transgenic animals, Cre/lox system, RNA seq) - human genetics (exome sequencing of sex-reversed patients) - in vitro cell culture and ex-vivo gonadal cultures Contact info: Serge Nef, PhD Dept of Genetic Medicine & Development CMU, University of Geneva Medical School Contact: mail: [email protected] tel: 022 379 5193