Green BioPharma: Innovative Medicines from Sustainable Labs Kristi Budzinski, PhD Monday, May 19, 2014 ©2012, Genentech Genentech Introduction Green BioPharma Program Green Lab Assessments Findings Greening the Culture ©2012, Genentech Genentech Background Founder of biotechnology industry Mission: Our goal is to use the power of genetic engineering and advanced technologies to make medicines that address unmet medical needs, and help millions of people worldwide. Our commitment to sustainable development respects the needs of the individual, the society, and the environment. South San Francisco Headquarters • 15,000 employees support entire value chain • Additional manufacturing sites in Vacaville and Oceanside, CA Member of Roche Group since 2009 • Robust GNE/Roche clinical development pipeline • 37 marketed products • 45 NMEs in clinical trials • Increased emphasis on corporate environmental sustainability ©2012, Genentech 3 Corporate Sustainability Goals 4 SSF Site goals by 2014 11% 10% 50% 20 % energy, water, and waste reductions in just 2 years ©2012, Genentech Governance Structure ©2012, Genentech 5 Employee Engagement Grass roots: 2500 members and growing, formed 2002. Mission Statement: • To increase our colleagues’ knowledge and awareness of sustainability • To provide a forum to generate, exchange, and evaluate sustainability ideas to improve the environmental performance of Genentech's operations, our communities, and our homes • And to have fun while leading by example in our industry. More green genes members means more environmentally-conscious scientists! ©2012, Genentech 6 Environmental Impact of Labs Square foot allocation by area Energy usage by area Life Science Chemistry Office space HVAC-related 46% 60% 3% Space/water heating 20% 20% 74% Equipment/ small power 25% 15% 12% Lighting 10% 5% 11% Category HEEPI July 2011 Detailed results from S-Lab audits ©2012, Genentech 7 Total -20/ULT Freezers Lower campus 321 FRC I & II 482 B27 Freezer farm 170 South campus 482 Sustainability: From the Office to the Lab Creation of Green BioPharma Program ‒ Inspired by Green Chemistry ‒ Focuses on our core competencies ‒ Develop tools and metrics to influence behavior and decisionmaking Foundations ‒ Scientifically defensible and data driven ‒ Sustainable business process ‒ Engage employees ‒ Encourage innovation Cross-functional governance structure ‒ Enable leaders to do what’s best for the company and sustainability ‒ Use metrics to drive implementation and build leadership support ©2012, Genentech 8 Definition and Vision Definition Green BioPharma is the design, development, and implementation of biological and chemical products and processes that reduce or eliminate the use and generation of substances hazardous to human health and the environment. Vision • Customers, business partners, and the community regard Genentech as a leader in efforts that reduce its ecological footprint resulting from its core competencies. • Employees continuously innovate, evaluate, and implement ways to reduce the environmental impact of their decisions and operations. • Wherever possible, the result of green innovations are quantified. Green BioPharma forges the bridge between patients, people and the environment. ©2012, Genentech 9 Green BioPharma @ GNE: a short timeline ~2009 • Roche Technical Working Group on Green Chemistry established • 1-2 GNE process chemists involved • Sponsors lectures and annual process chemistry contest • Limited exposure to rest of company Fall 2011 • Green Genes lunch and learn talks by Green Chemistry scientists at UCB • Great response from employees • Created a Green Genes subteam • Launched the Green BioPharma Program • Hired a Green BioPharma Project Manager • Established Green BioPharma Steering Committee, as part of Sustainability Council 2012 • Steering Committee endorsed 2012 goals and projects • Green Genes Subteam ~130 volunteers 2013 • Published a video on this effort ©2012, Genentech 10 Green BioPharma Steering Committee Objectives: 1. Recommend SSF Green BioPharma projects 2. Provide project guidance and prioritization 3. Promote employee innovation in lab and manufacturing areas 4. Develop and report performance metrics to stakeholders 11 ©2012, Genentech 11 Strategic Focus Areas 12 Engage Leadership and Employees • Behaviors, decisionmaking Develop and Deploy Tools/ Metrics • Educate stakeholders • Drive performance Collaborate with Vendors Institutionalize Programs Manage Supply Chain and End-ofLife • Streamline procurement and waste decisions ©2012, Genentech • Promote innovation • Drive higher value services • Greener products Green Genes Sub-team 13 Socialize initiatives within labs Green Chemistry lecture series Green Product Lunch and Learns Test greener products, share data Green Chemistry Task force 13 ©2012, Genentech Raising Impact Awareness ©2012, Genentech Green Lab Assessments Purpose: 1. Collect baseline data on the environmental footprint of different types of laboratories at Genentech i. Examples: chemistry, molecular biology, quality control, DNA sequencing 2. Engage employees to effect personal or behavioral change through data collection and sharing. Method: 1. Identify candidate laboratories 2. Present process at group meeting i. Establish lab champion as single point-of-contact 3. Perform assessment and collect data 4. Report feedback with follow-up action items ©2012, Genentech 15 Lab Assessment: The Approach Impact categories • • • • Energy usage Cold storage Waste streams Purchasing 5/19/2014 ©2012, Genentech 16 Energy Results for Bench-top Equipment Centrifuges (9/lab) Cooled centrifuges (2/lab) Equipment Water bath @37C CO2 Incubator @ 37C Thermal cycler Ultracentrifuge (benchtop) Centrifuge Cooled centrifuge Heat block @ 42 Vortexers (5/lab) Average power (W) Typical usage (hrs/yr) 5 8760 42 2 130 120 109 10 30 10 8760 1500 8760 8760 8760 8760 1139 180 955 88 263 88 2 1 1 9 2 2 Pipet aides (1pp) 17 Energy # units per consumption per lab unit (kWh/yr) Shakers (2/lab) Est. total energy consumed by lab (kwH/yr) VS84 2278 180 955 788 526 175 $11.76 $23.52 $318.86 $25.20 $133.68 $110.38 $73.58 $24.53 $697.99 $637.73 $25.20 $133.68 $993.38 $147.17 $49.06 $2,009.73 Thermomixer or heat block (2/lab) Total ©2012, Genentech Estimated Cost Estimated Cost per unit per lab ($/yr) ($/yr) Bench-top Centrifuge Case study 18 Avg power consumption Week 1: 0.072 kWh/day Week 2: 0.062 kWh/day Yearly savings: 3.65 kWh or 5.7 lbs CO2 per unit! Standby energy difference is 0.0024 kWh 0.0026 kWh 0.00014 kWh ©2012, Genentech Cold Storage Metrics for GNE Labs 1455+ total freezers on campus Unplugging freezers <10% full would be equivalent to taking 74 cars off the road. Raising all freezers to -70 would save the CO2 emissions equivalent to 39 homes. ©2012, Genentech 19 state Current Future state Freezer Footprint Reduction Campaign New freezers are energy efficient Stirling freezers >70% 50% have havean an online online or inventory written inventory systemsystem for for contents contents ©2012, Genentech 20 35% Lab conduct a periodic freezer Cleanouts clean-out include a freezer clean-out >>40% 50% of plan labs to purchase share freezer new freezers space within 3 years Non-hazardous Lab Waste Metrics B5 waste forensics data Recyclable lab plastics/PPE 26% 21 Current collection systems Bottles/cans 5% Mixed paper 9% Cardboard 3% Compostable 37% Actual landfill 22% 1 trash can per person 0.5 recycling bin per person Avg 45-50 pairs/ week (400-450 g) ©2012, Genentech Lab Purchasing Habits Cataloging lab supply stocks guides greener product recommendations ©2012, Genentech 22 Using Data to Change Behavior ©2012, Genentech Create a Sharing Economy: Surplus Chem Recycling 1. Lower the activation energy for participation! 2. Create system that mimics current business process as closely as possible. 3. Advertise, advertise, advertise. 1 Lab Clean-outs Donate excess chemicals global Roche award! Inspire Sustainable Behavior Award Inventory and >$10,000 storage saved! 24 ©2012, Genentech 330 containers purchased 415 items in stock 24 Greener Products: Replacing Ethidium Bromide SyberSafe GNE Testing ©2012, Genentech 25 Green Chemistry Committee: Better Solvent Selection 26 Resulted in 2014 Dept Goal: Reduce use of dichloromethane (DCM) by 25%. ©2012, Genentech Reducing Laboratory Landfill Waste Make it easy, available, and applicable Add additional streams as necessary ©2012, Genentech 27 Encouraging Greener Lab Supply Choices Reuse before buying new! Reuse, less packaging, and safer products where appropriate! ©2012, Genentech 28 Greener Instrumentation Initiatives 29 Center for Advanced Light Microscopy (CALM) core microscopy resource for Genentech Research LEDs Eliminate: • > $7000/year in bulb costs • Disposal cost and time • Surprise bulb failures CALM has found LED systems to be bright, stable and reliable - Equivalent or lower exposure times - Intensity stable over time In partnership with: - Reduced energy usage Commitment to replace all Hg-based light sources by 2016 ©2012, Genentech Roadmap for Successful Organizational Change Steering Committee sets goals that align with program mission Program Manager researches and identifies potential initiatives and early adopters Prospective initiatives are tested within scientific communities Steering Committee helps achieve senior management support for initiative Necessary groups, depts., etc. connected to provide resources --products, staff, publicity, etc -- for initiative Track initiative progress, collect data, and communicate results “Successful” initiative turned over to stakeholders and becomes embedded in program, process, procedure ©2012, Genentech 30 Effecting Individual Change Use early adopters to gain institutionally relevant data Mimic current business processes Recognize efforts ©2012, Genentech 31 Empower labs to make better choices Provide data to support recommendations Gain leadership support Acknowledgements Participating Labs 32 Site Services Jane Grogan Green BioPharma Steering Committee Jacob Corn Tina Larson, PTDU Sustainability Erin Deuber Tse-Sung Wu, EHS Clean Harbors Media Prep B6, B10, B48 Stefan Koenig, SMPC Facilities Jacob Corn, EDB Cool Ops Ira Mellman Labs Ekta Mahajan, PD Eng Vishva Dixit Debbie O’Conner, CCPP Kathy Kozak Joe Jerkins, IMP QS Pamela Chan Bonnie Shum, MSAT ©2012, Genentech EHS
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