Resume

BIODATA
Professor Dr. Ibrahim Jantan
Address:
Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala
Lumpur, Malaysia.
Contact:
Tel: 603 92897315
Fax: 603 26983271
E mail: [email protected]
[email protected]
Present Appointments:
Senior Professor A at UKM (VK 5 – June 2013; VK 6 - June 2010; )
Professor in Medicinal and Natural Products Chemistry at UKM (April 2002 – VK 7)
Dean , Faculty of Pharmacy, UKM (since July 2008)
Head, Bioactive Natural Products Research Cluster, UKM (since 2008)
Head, Drug Discovery Cluster, NKEA, Agriculture: Herbal subsector, Ministry of Agriculture (20132014).
Chairman, Faculty of Pharmacy Deans Council, Public Institutions of Higher Learning (IPTA),
Ministry of Education, Malaysia (2013 – date)
Board member of Asian Association School of Pharmacy (AASP)
Malaysian Focal Point for Medicinal Plants Malaysia for Indian Ocean Rim Association (IORA)
RCSTT.
Previous Appointments:
Head, Department of Pharmacy, UKM (1998 – 2006)
Deputy Dean, Faculty of Allied Health Sciences, UKM (2007-2008)
Research Officer at the Forest Research Institute Malaysia (1986-1996)
Education:
BPharm(Hons)
MSc
PhD
Pharmacy
Medicinal Chemistry
Natural Products Chemistry
University of Mansoura, Egypt
University of Minnesota, USA
University of Malaya
1981
1985
1993
Professional affiliations:
President of the Malaysian Natural Products Society (2010-date)
Registered Pharmacist in Malaysia (No. 785)
Registered Chemist in Malaysia (No. A2012/90)
Associate Member of the Malaysian Institute of Chemistry
Member of the Malaysian Pharmacy Board (2010-date)
Member of the American Chemical Society (No. 30266756) (2012 – date)
Member of International Pharmacy Federation (2011 – date)
Asian Association of School of Pharmacy
Reviewer for manuscripts in Journals
Phytotherapy Research, Phytomedicine, Molecules, Pharmaceutical Biology, Fitoterapia, Journal of
Essential Oil Research, Flavour and Fragrance Journal, Natural Products Research, Journal of
Pharmacy and Pharmacology, Journal of Natural Medicines, Holzforschung, Biochemical Systematics
and Ecology, Journal of Tropical Forest Products, Sains Malaysiana, Journal of Biosciences, Malaysian
Oil Science and Technology, Malaysian Applied Biology, Buletin Kimia, Pertanika, Journal of Science
and Technology, Malaysian Journal of Science, Malaysian Journal of Pharmaceutical Sciences.
Evaluation panel member
• Evaluation panel member for ’Bengkel Pemantauan Geran Penyelidikan Universiti
Penyelidikan Apex 2009 - 2010’ Universiti Sains Malaysia.
• Evaluation panel member for Research University Grant USM (2012).
• Chairman for Technical Advisory Panel, Medicinal Plant Division, Forest Research Institute
Malaysia (FRIM) (2010).
• Technical evaluation panel member for Brain Gain Program Malaysia application (BGM),
MOSTI (2010).
• Evaluation panel member for the National Science Fellowship application, MOSTI Scholarship
(1998, 1999, 2000, 2007)
• Evaluation Panel member for HCD Program (STI), MOSTI (2007).
• Evaluation Panel member for Postgraduate Research Scheme (PDF), MOSTI (2007-2008).
• Evaluation IRPA panel member for Science and Engineering Sector of the 7th & 8 th Malaysia
Plan, MOSTI.
• Evaluation Panel member for MOSTI’s SKIM Feloship Penyelidikan Termaju Luar Negara
(ATTH) 2008.
• Evaluation Panel member for Bidang Tujahan Penyelidikan: Sains Kesihatan & Bioteknologi,
MOSTI (2007– date).
• Evaluation Panel member for R & D Herb DMO, Ministry of Agriculture and Agro-based
Industry Malaysia (2011- date).
Research Experiences:
Twenty-eight (28) years of research experiences in medicinal and natural products chemistry with
Forest Research Institute Malaysia (FRIM) (1986-1996) and Universiti Kebangsaan Malaysai (UKM)
(since 1996) and 18 years of teaching in Pharmacy at UKM.
Research Interests: Identification of chemical leads from natural products for specific therapeutic
efficacy (cardiovascular protective, immunomodulatory, anti-inflammatory, PAF antagonist &
antimicrobial activities) leading to the development of new drug candidates against complex and
challenging drug targets prior to clinical trials.
Postgraduate supervision
• Supervision: graduated- 8 PhD and 19 MSc projects; in progress-10 PhD and 5 MSc projects.
• Published 140 papers in indexed journals; 73 papers in proceedings; 2 books; 3 chapters in
books.
• MSc and PhD Examiner: University of Gadja Mada, Indonesia (1PhD), Andhra University, India
(1 PhD), Annamalai Universitry, India (2 PhD), Pune University, India (1 PhD), Mahidol University (!
MSc), Universiti Sains Malaysia (9 PhD, 12 MSc), Universiti Malaya (4 PhD, 2 MSc), Universiti
Putra Malaysia (2 PhD, 5 MSc), Universiti Teknologi Malaysia (1 PhD, 2 MSc), Islamic International
University Malaysia (3 PhD)
Awards and Honors:
Japanese International Cooperation Agency Award, 1989; United Nation Development Grant (UNDP),
1989;
Chevening scholarship British Council, 1991; Overseas Development Agency Grant, 1993;
Korean Scientific & Technological Foundation Grant, 1996; The Marquis Who’s Who in Science and
Engineering (since 2003). Medicine Srinakharinwirot University (MEDSWU) Honorable Award 2010,
Thailand.
Research grants (the past three years) (Project leader)
• Inhibitory effects of xanthones from selected Garcinia species on low-density lipoprotein
peroxidation and platelet-mediated thrombosis (MOSTI eScience fund, RM250,000.00) (20062009).
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Immunomodulatory effects of the extracts and isolates of Eurycoma longifolia, Lamisia pumila,
Orthosiphon stamineus and Phyllantus nirurii
(Geran Universiti Penyelidikan (GUP),
RM290,000.00)(2007-2009).
Cardioprotective effect of the extracts and essential oils of Cymbopogon citrus, Piper nigrum
and Polygonum minus (eScience, Ministry of Agriculture (MOA), RM263,000.00) (20092011).
Effects of isolates and their derivatives from Curcuma xanthorrhiza and Curcuma mangga on
polymorphonuclear neutrophils respiratory bust, T-cell proliferation and cytokine production from
mononuclear cells (FRGS, RM95,000.00) (2010-2012).
Palm Oil Tocotrienol Isomers effects on Glucose-Stimulated Insulin Secretion Pathway in
Pancreatic Isolated Islets (FRGS, RM85,000) (2010-2012).
Discovery and mechanistic studies of Dukung Anak in regulating the immune activity (NRGS,
Ministry of Agriculture (MOA), RM345,000.00) (2011-2013).
Development of nutraceutical from herbal formulation of Kacip Fatimah, Ginger and Tumeric
to prevent cardiovascular disease (NRGS, Ministry of Agriculture (MOA), RM500,000.00)
(2011-2013).
In vivo modulatory effects of standardized extracts of Phyllanthus amarus and Tinospora
crispa on innate immune responses (MOSTI eScience fund, RM301,000.00) (2013-2015).
Recent Publications: (*corresponding author)
2012
1. Noraziah Nordin, Juriyati Jalil, Ibrahim Jantan, Shahnaz Murad. 2012. PAF receptor binding
activity of the roots of Enicosanthellum pulchrum. Pharmaceutical Biology. 50(3), 284-290.
2. Ibrahim Jantan*, Syed Nasir A. Bukhari, Nordin Lajis, Faridah Abas, Lam Kok Wai, Malina
Jasamai. 2012. Effects of diarylpentanoid analogues of curcumin on chemiluminescence and
chemotactic activities of phagocytes. Journal of Pharmacy and Pharmacology 64, 404-412.
3. Bushra A Moharam, Ibrahim Jantan*, Juriyati Jalil, Fasihuddin Ahmad. 2012. Inhibitory
effects of compounds from Goniothalamus tapis and Goniothalamus uvaroides on platelet
activating factor binding. Phytotherapy Research 26, 687-691.
4. Adlin Afzan, Noor Rain Abdullah, Siti Zaleha Halim, Badrul Amini Rashid, Raja Hazlini Raja
Semail, Noordini Abdullah, Ibrahim Jantan, Hussin Muhammad and Zakiah Ismail. 2012.
Repeated Dose 28-days Oral Toxicity Study of Carica papaya L. leaf Extract in Sprague
Dawley Rats. Molecules 17, 4326-4342.
5. Sakina Saadawi, Juriyati Jalil, Malina Jasamai & Ibrahim Jantan. 2012. Inhibitory Effects of
Acetylmelodorinol, Chrysin and Polycarpol from Mitrelia kentil on Prostaglandin E2 and
Thromboxane B2 Production and Platelet Activating Factor Receptor Binding. Molecules 17,
4824-4835.
6. Ibrahim Jantan* & Fadlina C. Saputri. 2012. Benzophenones and xanthones from Garcinia
cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein
oxidation and platelet aggregation. Phytochemistry, 80, 58-63.
7. Fadlina C. Saputri, Ibrahim Jantan*. 2012. Inhibitory activities of compounds from the twigs
of Garcinia hombroniana on human LDL odidation and platelet aggregation. Phytotherapy
Research 26: 1845-1850 (2012).
8. brahim Jantan*, Fadlina C. Saputri, Qaisar, M.N., Fhataheya Buang. Correlation between
chemical composition of Curcuma domestica and C. xanthorrhiza and their antioxidant effect
on human LDL oxidation. Evidence-Based Complementary and Alternative Medicine, vol.
2012, 10 pages. Doi:10.1155/2012/438356.
9. Bukhari SN, Jasamai M, Ibrahim Jantan. 2012. Synthesis and biological evaluation of
chalcone derivatives (mini review). Mini Rev Med Chem. 2012 Nov 1;12(13):1394-1403.
10. Jalil J, Ibrahim Jantan, Ghani AA, Murad S.Platelet-activating factor (PAF) antagonistic
activity of a new biflavonoid from Garcinia nervosa var. pubescens King. Molecules. 2012.
10;17(9):10893-901.
11. Bukhari SN, Ibrahim Jantan, Jasamai M. Anti-inflammatory trends of 1, 3-Diphenyl-2propen-1-one derivatives. 2012. Mini Rev Med Chem. 13, 87-94.
12. Santana RL, Yu KX, Rohani A, Ibrahim Jantan. 2012. Rapid method for scanning electron
microscopy of the larvae of Aedes aegypti and Aedes albopictus (Diptera: Culicidae). Annals
of Microscopy, 12, 39-42.
2013
1. Bukhari SN, Jasamai, M, Ibrahim Jantan. 2013. Review of methods and various catalysts
used for chalcone synthesis. Mini-Reviews in Organic Chemistry, 10, 73-83..
2.
Yuandani, Menaga Ilangkovan, Ibrahim Jantan*, Hazni Falina, Mohamad, Khairana Husain,
Amirul Faiz A. Razak Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and
Phyllanthus urinaria and their Marker Compounds on Phagocytic Activity of Human
Neutrophils. Evidence-Based Complementary and Alternative Medicine Vol. 2013, Article ID
603634 pages, Doi./10.1155/2013/603634.
3.
Bukhari SN, Ibrahim Jantan, Jasamai M. 2013. An-inflammatory trends of 1,3-diphenyl-2propen-1-one derivatives. Mini-Reviews in Medicinal Chemistry, 13(1), 87-94.
4.
Bukhari SN, Ibrahim Jantan, Malina Jasamai, Waqas Ahmad, Amjad MW. 2013. Synthesis
and biological evaluation of curcumin analogues. Journal of Medical Sciences, 13(7), 501513.
5.
Shukranul Mawa, Khairana Husain, and Ibrahim Jantan. 2013. Ficus carica L. (Moraceae):
Phytochemistry, Traditional Uses and Biological Activities. Evidence-Based Complementary
and Alternative Medicine Volume 2013 (2013), Article ID 974256, 8 pages
doi.org/10.1155/2013/974256
6.
Bukhari SN, Franzblau SG, Ibrahim Jantan, Jasamai, M. 2013. Current prospects of
synthetic curcumin analogues and chalcone derivatives against Mycobacterium tuberculosis.
Medicinal Chemistry 9(7); 897-903.
7. Vongsak B, Gritsanapan W, Wongkrajang Y and Ibrahim Jantan. 2013. In vitro inhibitory
effects of Moringa oleifera leaf extract and its major components on chemotactic activity of
phagocytes. Natural Product Communications 8(11); 1559-1561.
8. Bukhari SN, Ibrahim Jantan*, Wai LK, Lajis NH, Abas F, Jasamai M. 2013. Synthesis and
Effects of Pyrazolines and Isoxazoles on the Phagocytic Chemotaxis and Release of
Reactive Oxygen Species by Zymosan Stimulated Human Neutrophils. Medicinal Chemistry
vol. 9 (8) : 1091-1098.
2014
1. Waqas A, Endang K, Ibrahim Jantan*, Bukhari SN, Malina J. 2014. Effects of novel
diarylpentanoid amnalogues of curcumin on secretory phospholipase A2, cyclooxygenases,
lipooxygenase and microsomal prostaglandin E synthase-1. Chemical Biology and Drug
Design 83: 670-681.
2. Bukhari SN, Yasmin T, Vannessa JB, Lam KW, Ibrahim Jantan, Jalil J, Jasamai M. 2014.
Synthesis and evaluation of chalcone derivatives as inhibitors of neurtrophils’ chemotaxis,
phagocytosis and production of reactive oxygen species. Chemical Biology and Drug Design
83: 198-206.
3. Khaleghi F, Ibrahim Jantan*, Laily D, Yaacob WA, Khalilzadeh MA, Bukhari SN. 2014.
Immunomodulatory effects of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone
from Petasites hybridus and its synthesized benzoxazepine derivatives. Journal of Natural
Medicines. 68: 351-357.
4. Emil S, Endang K, Ibrahim Jantan. 2014. Inhibitory effect of selected medicinal plants on
the release of pro-inflammatory cytokines in LPS-stimulated human peripheral blood
mononuclear cells. Journal of Natural Medicines 68(3), 647-653.
5. Waqas A, Endang K, Ibrahim Jantan, Malina Jasamai, Emil S. 2014. Modulatory effect of
phytoestrogens and curcumin on induction of annexin 1 in human peripheral blood
mononuclear cells and their inhibitory effect on secretory phospholipase A2. Tropical Journal
of Pharmaceutical Research 13: 171-177.
6. Endang K, Emil S, Ibrahim Jantan, Waqas A. 2014. Kinetics of intercellular, extracellular
and production of pro-inflammatory cytokines in LPS-stimulated human peripheral blood
mononuclear cells. Tropical Journal of Pharmaceutical Research 13: 536-543.
7. Rani S, Faizah O, Ibrahim Jantan, Thent ZC, Srijit D. 2014. Effect of subacute dose of
Mitragyna speciosa Korth crude extract in female Srague Dawley rats. Journal of Medical
and Bioengineering, 3: 98-101.
8. Bukhari SN, Gianluigui L, Ibrahim Jantan*, Guiseppe, Amjab MW. 2014. Pharmacological
Evaluation and Docking Studies of α, β-Unsaturated Carbonyl Based Synthetic Compounds
as Inhibitors of Secretory Phospholipase A2, Cyclooxygenases, Lipoxygenase and
Proinflammatory Cytokines. Bioorganic and Medicinal Chemistry. 22, 4151-4161.
9. Bukhari SN, Ibrahim Jantan*, Oya UT, Sher M, Naeem-ul- Hassan M, Qin HL. 2014.
Biological activity and molecular docking studies of curcumin-related α,β-unsaturated
carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase
inhibitors. Agricultural and Food Chemistry 62(24), 5538-5547.
10. Rani S, Faizah O, Ibrahim Jantan, Zar CT, Srijit D. 2014. An insight into the effect of
Mitragyna speciosa Korth extract on various systems of the body. Global Journal of
Pharmacology 8(3):340-346.
11. Ibrahim Jantan*, Bukhari SN, Adekoya OA, Sylte I. 2014. Studies of synthetic chalcone
derivatives as potential inhibitors of se4cretory phospholipase A2, cyclooxygenases,
lipoxygenase and pro-inflammatory cytokines. Drug Design, Development and Therapy, 8,
1405-1418.
12. Seyed MA, Ibrahim Jantan and Bukhari SN. 2014. Emerging anticancer potentials of
goniothalamin and its molecular mechanism. Biomed Research International article ID
536508, 10 pages http://dx.doi.org/10.1155/2014/536508.
13. Kamal Rullah, Mohd Aluwi MF, Yamin B, Abdul Bahari MZ, Wei LS, Ahmad S, Abas F, Ismail
NH, Ibrahim Jantan, Wai KW. 2014. Inhibition of prostaglandin E2 production by synthetic
minor prenylated chalcones and flavonoids: Synthesis, biochemical activity, crystal structure
and in silico evaluation. Bioorganic and Medicinal Chemistry Letters 24(16), 3826-3834.
14. Fhataheya Buang, Ibrahim Jantan, Zawani A, Arbain D. 2014. Optimization of zinger
(Zingiber offinale) oil yield from Malaysia in different hydrodistillation physical parameters via
central composite design of response surface methodology (RSM). Research Journal of
Applied Sciences, Engineering and Technology. 5098-5105.
15. Ke Xin Yu, Ibrahim Jantan*, Rohani Ahmad and Ching-Lee Wong. 2014. The major bioactive
components of seaweeds and their mosquitocidal potential. Parasitology Research. 113(9),
3121-3141.
16. Nasir SN, Ibrahim Jantan*, Masand VH, Mahajan DT, Sher M, ul-Hassan N, Amjad MW.
2014. Synthesis of α,β-unsaturated carbonyl based compounds as acetylcholinesterase and
butyrylcholinesterase inhibitors: Chracaterization, molecular modeling, QSAR studies and
effect against amyloid β-induced cytotoxicity. European Journal of Medicinal Chemistry. 83,
355-365.
17. Tuekaew J, Siriwatanametanon N, Wongkrajang Y, Temsiririrkkul R, Ibrahim Jantan*.
2014. Evaluation of the antioxidant activities of Ya-hom Intajak, a Thai herbal formulation,
and its component plants. Tropical Journal of Pharmaceutical Research 13(9), 1319-1326.

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