8032750_187006_A Flook CV 2014

Adam Michael Flook
301 Central Ave NE #104  Albuquerque, NM 87102  720-289-8075  [email protected]
Education
Doctorate of Philosophy –University of New Mexico, Albuquerque, NM
Graduated May 9, 2014 (with Distinction)
Biomedical Sciences
Cumulative GPA – 3.96
Mentor: Yubin Miao, Ph.D. – Assistant Professor
Bachelor of Science – University of Redlands, Redlands, CA
Graduated cum laude May, 2009
Major – Biology
Cumulative GPA – 3.575
Biology GPA – 3.72
Mentor: Lisa Olson, Ph.D.- Associate Professor
Research Experience
Post-Doctoral Fellow, June, 2014 – present
University of New Mexico, Albuquerque, NM
Novel α-MSH Peptide Analogs for Melanoma Targeting and Therapeutic Efficacy
This project is being conducted under the supervision of Dr. Yubin Miao in the College of Pharmacy. I
am currently developing and characterizing novel radiolabeled α-MSH peptide analogs that target the
melanocortin-1 receptor overexpressed on human and murine melanoma cells to be used as targeted
radiation therapy radiopharmaceuticals against melanocytic lesions in a mouse model.
Doctoral Thesis, June, 2010 – May 2014
University of New Mexico, Albuquerque, NM
Novel α-MSH Peptide Analogs for Melanoma Targeting
This project is being conducted under the supervision of Dr. Yubin Miao in the College of Pharmacy.
Due to the high mortality rate of melanoma it is imperative to develop novel diagnostic and therapeutic
targeting molecules to aid in patient survival. I developed and characterized novel radiolabeled α-MSH
peptide analogs that target the melanocortin-1 receptor overexpressed on human and murine melanoma
cells to be used as imaging probes for non-invasive SPECT imaging of melanocytic lesions in a mouse
model. I successfully defended my dissertation project on March 17, 2014 and graduated as a Ph.D. (with
distinction) in Biomedical Sciences.
Undergraduate Student Research Assistant, May, 2008 – May, 2009
University of Redlands, Redlands, CA
This work was conducted under the supervision of Dr. Lisa E. Olson at the University of Redlands in
which I researched and successfully defended my honors thesis entitled “Enhanced Doxorubicin
Chemotherapy Efficacy in a Carbonyl Reductase 1 Knockout (Cbr1+/-) Mouse Model.”
Research Intern, May, 2008 – September, 2008
University of Redlands, Redlands, CA
This was a summer research internship for Dr. Lisa E. Olson in the at the University of Redlands in
which I cared for an entire mouse colony and learned techniques and skills necessary for researching both
the pharmacogenomic effect of Doxorubicin treatment on transgenic mice with metastatic breast cancer
possessing a null allele of the Cbr1 gene and determining the relationship between Down Syndrome and
tumor suppression in transgenic mice.
Publications
Yang, J., Flook, A.M., Feng, C. and Miao, Y. (2014) Linker modification reduced the renal uptake of
technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide.
Bioorganic & Medicinal Chemistry Letters, 24, 195-198.
Flook, A.M., Yang, J., and Miao, Y. (2013) Effects of Amino Acids on Melanoma Targeting and Clearance
Properties of Tc-99m-Labeled Arg-X-Asp-Conjugated α‑Melanocyte Stimulating Hormone Peptides. Journal
of Medicinal Chemistry, 56, 8793-8802.
Flook, A.M., Yang, J., and Miao, Y. (2013) Evaluation of New Tc-99m-Labeled Arg-X-Asp-Conjugated
α‑Melanocyte Stimulating Hormone Peptides for Melanoma Imaging. Molecular Pharmaceutics, 10, 34173424.
Jie Lu, Adam M. Flook, Haixun Guo, Jianquan Yang, and Yubin Miao. (2013) Radiolabeled lactam bridgecyclized alpha-MSH peptides for SPECT imaging of melanoma. Small-Animal SPECT Imaging, M. Kupinski
and L. Furenlid (Eds.), Springer Science + Business Media, New York, NY, in press.
Freeland, M. M., Angulo, J., Davis, A. L., Flook, A. M., Garcia, B. L., King, N. A., Mangibin, S. K., Paul, K.
M., Prosser, M. E., Sata, N., Bentley, J. L., and Olson, L. E. (2012) Sex differences in improved efficacy of
doxorubicin chemotherapy in Cbr1+/- mice. Anti-Cancer Drugs 23, 584-589.
Presentations and Abstracts
Flook, AM, Yang, J., Miao, Y. Introduction of Arg and β-Ala Linkers reduced the renal Uptake of 99mTcLabeled RAD-Conjugated α-MSH Peptides. University of New Mexico College of Pharmacy Research and
Scholarship Day, April 10, 2014. Poster.
Flook, AM, Miao, Y. Reducing the Renal Uptake of 99mTc-Labeled α-MSH Peptide Analogs using a β-Ala
Linker. University of New Mexico Biomedical Sciences Graduate Program Student Research Day, February
28, 2014. Poster.
Flook, AM, Miao, Y. Reducing the Renal Uptake of 99mTc-Labeled α-MSH Peptide Analogs using a β-Ala
Linker. University of New Mexico Biomedical Sciences Graduate Program Fall Retreat, September 29, 2013.
Poster.
Flook, AM, Miao, Y. Reducing the Renal Uptake of 99mTc-Labeled α-MSH Peptide Analogs using a β-Ala
Linker. University of New Mexico College of Pharmacy Research and Scholarship Day, April 11, 2013.
Poster.
Flook, AM, Miao, Y. Reducing the Renal Uptake of Melanoma-targeting 99mTc-labeled a-MSH Peptide
Analogs. University of New Mexico Biomedical Sciences Graduate Program Student Research Day, February
15, 2013. Presentation.
Flook, AM, Yang, J, Guo, H, Miao, Y. Novel Radiolabeled α-MSH Peptide Analogs for Melanoma Targeting.
University of New Mexico, College of Pharmacy Research and Scholarship Day, April 19, 2012. Poster.
Flook, AM, Yang, J, Guo, H, Miao, Y. Novel α-MSH Peptide Analogues for Melanoma Imaging. University of
New Mexico Biomedical Sciences Graduate Program Research Day, February 13, 2012. Presentation.
Flook, AM, Yang, J, Guo, H, Miao, Y. Development of Novel α-MSH Peptide Analogues for Diagnosis and
Treatment of Melanoma. University of New Mexico, College of Pharmacy, Pharmacy/ Toxicology Seminar,
October 24, 2011. Presentation.
Flook, AM, Davis, A, Rawlings, T, Olson LE. Using Mouse Models to Determine the Relationship between
Down Syndrome and Tumor Suppression. Southern California Conference for Undergraduate Research,
California Polytechnic Institute of Pomona, Pomona, CA. November, 2008. Poster.
Flook, AM, Davis, A, Rawlings, T, Olson, LE. Using Mouse Models to Determine the Relationship between
Down Syndrome and Tumor Suppression. University of Redlands Summer Research Symposium, Redlands,
CA. September, 2008. Poster.
Awards and Honors
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Under leadership of Dr. Yubin Miao, licensed α-MSH research to SolaranRx to begin clinical trials of
theranostic melanoma radiopharmaceuticals- September 2014
Awarded honor of graduating as Ph.D. (with Distinction) from the University of New Mexico- March 2014
1st Place Poster Award at University of New Mexico College of Pharmacy Research and Scholarship Day,
April 11, 2013.
Graduated cum laude with Department of Biology Honors from the University of Redlands- May 2009
Recipient of the Quincy Brown Memorial Endowed Scholarship- Fall 2008
Edmond C. Jaeger Award for exceptional scholarship in a male, junior biology student planning a career
in research- Spring 2008
Academic Achievement Award & Presidential Scholar- Fall 2005-Spring 2009
Positions Held
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Post-doctoral Fellow at the University of New Mexico, College of Pharmacy, Yubin Miao’s Lab,
Albuquerque, NM- June 2014-present
Research Assistant at the University of New Mexico, College of Pharmacy, Yubin Miao’s Lab,
Albuquerque, NM- June 2010-May 2014
Biomedical Sciences Graduate Student Society Social Committee Co-Chair- 2011-2012
Undergraduate Research Assistant at the University of Redlands, Dr. Lisa Olson’s Lab- Fall 2008-Spring
2009
Research Intern at the University of Redlands, Dr. Lisa Olson’s Lab, Redlands, CA - Summer 2008
Emergency Room volunteer at Loma Linda Hospital, Loma Linda, CA- May 2006

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