第 527 回難研セミナー第 100 回難治疾患共同研究拠点セミナー下記により難研セミナーを開催しますので、多数御来聴下さい。記日時：平成 26 年 12 月 17 日（水）17:20 場所： M&D タワー9 階大学院講義室 4 演者： Professor David E. Fisher ～ 18:20 Professor and Chairman, Department of Dermatology Director, Melanoma Program MGH Cancer Center Director, Cutaneous Biology Research Center Massachusetts General Hospital, Harvard Medical School 演題：Skin Pigmentation Pathways and Melanoma Risk 要旨：Melanoma risk is well known to be strongly linked to UV exposure. Yet despite this important linkage, melanoma incidence increases relentlessly, at one of the steepest rates of all human cancers. Prevention approaches that include education, sunscreen, avoidance of tanning beds, and sun-safe behavior messages are excellent in principal, but have not as yet produced sufficient decreases in melanoma incidence. Here we present studies which explore cutaneous responses to ultraviolet radiation exposure. These results indicate the presence of multiple cutaneous responses and pathways that are triggered by UV and which modulate not only skin signaling, but also systemic effects of this cutaneous UV exposure. These pathways include pigmentation or tanning. Other studies will describe a murine “redhair/lightskin” melanoma model of melanoma which identifies roles for pigmentation intermediates in melanoma formation. Finally, the MITF transcription factor plays central roles in both melanocyte and melanoma growth, survival, and differentiation. Studies will be described which characterize several MITF transcriptional targets, some of which may represent novel therapeutic opportunities. 連絡先：幹細胞医学分野・西村栄美（内線:4651）共催：分子細胞遺伝分野・稲澤譲治（内線：5820）