"Leading edge nanomaterials for human health” Judith Sendra Cuadal Directora Científica www.endornanotech.com The company Endor is a nanotechnology company developing innovative products for human health using metallic nanoparticles Nanomaterials Designing advanced metallic nanosystems Metallic Nanoparticles Advanced Metallic Nanoparticles Nanotechnology Platform Physical & Chemical Characterization -ICP-Ms -RMN -Elemental Analysis -HPLC-Ms -TGA -HR-TEM -SEM -AFM -Rhaman -FTIR -ESCA -DLS-zPot… BioMed In vitro and in vivo non-regulatory pre-clinical studies • Efficacy (POC) • Toxicology Medical Programs Oncology Conjugated metallic nanoparticles to develop targeted antitumoral therapies Dermatology A novel nanomaterial to effectively regenerate damaged skin Products Cosmetics The beauty of life www.yen-effect.com Textile A new approach to beauty: premium fibers with antiaging properties http://www.nylstar.com Nanosafety Nanosafety Gold nanoparticles aerosol emissions monitoring Instituto de Diagnóstico Ambiental y Estudios del Agua Indoor emissions monitoring and characterization of worker exposure during different laboratory processes that deal with gold nanomaterials Au NP synthesis Liophilization process NPs manipulation Particulate matter (PM) in the size range of 5 nm to 20 µm NP collected on grids Monitored during ~49h SMPS TSI (5 nm to 162.5 nm) DiscMini, portable “Diffusion Size Classifier“(10 - 700 nm) Grimm Model 1.108 (0.3 to 20 µm) NAS Model 3089 4. INDOOR VS. OUTDOOR WH: Working Hours NWH: Non-Working Hours WH NWH ENDOR (In vs. Out) - Number WH WH NWH 1,0E+05 Parts. cm-3 OUT IN 1,0E+04 Source: Suspension of polyurethane (PUR) foams 1,0E+03 4/28/2014 11:11 4/28/2014 23:11 4/29/2014 11:11 4/29/2014 23:11 4/30/2014 11:11  Comparison between working hours and non-working hours  Indoor concentration were highly affected by the outdoor sources in terms of particle number concentration during all sampling  Outdoor concentrations were always higher than indoor excepting one event (PUR foams) N, [Parts. cm-3] 3,0E+04 Liophilization IN Au NP manipulation 3,5E+04 OUT Cooling 4,0E+04 Au NP Synthesis 4,5E+04 2,5E+04 2,0E+04 Liophilization room: influenced by outdoor sources 1,5E+04 1,0E+04 Liophilization process influenced by outdoor sources 5,0E+03 0,0E+00 4/28/2014 11:46 4/28/2014 12:00 4/28/2014 12:14 4/28/2014 12:29 4/28/2014 12:43 4/28/2014 12:58  Indoor particle diameter was higher than particles found in outdoor (40 vs. 29 nm) Gracias! Judith Sendra Cuadal Directora Científica Endor Nanotechnologies [email protected] +34 93 402 04 68