Ph.D. Course in Materials Science and Nanotechnology University of Milano-Bicocca, Department of Materials Science, via Cozzi 55, 20125 Milano November 3, 2014 – 3.00 p.m. Sala Lauree - Department of Materials Science U5 Alberto Bianco CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d’Immunopathologie et Chimie Thérapeutique, Strasbourg, France Carbon-based nanomedicines and challenges ahead Carbon-based nanomaterials (carbon nanotubes, graphene, adamantane, etc.) are considered unique materials and molecules for many applications in different fields including biomedicine and nanomedicine. All these types of carbon forms are offering the possibility of original chemical functionalization and design of complex systems that allow further their exploitation in therapy, imaging and diagnosis. In this presentation, I will describe the chemical approaches to functionalize the different carbon nanomaterials with appropriate functional groups and therapeutic molecules in view of future biomedical applications. I will also present few example of their use in therapy (i.e. cancer and brain diseases) and imaging (i.e. ultrasonography and MRI). In addition, the intense research activity on applications of carbon nanomaterials imperatively needs to be associated to the assessment of their safety profile. We have evidenced a correlation between the structure and the chemical nature of the different carbon forms and their potential toxicity. I will show how appropriate chemical approaches help in alleviating undesired pathogenic effects. PhD students and all interested in the seminar are kindly invited to participate. The PhD Coordinator Prof. Gianpaolo Brivio
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