the invitation

Invitation to Seminar Talk
Fibrosis and transdifferentiation of cardiomyocytes
during zebrafish heart regeneration
Hector Sanchez
CNIC
Host: Carl-Philipp Heisenberg
Zebrafish have the capacity to efficiently regenerate their heart upon injury. During the process of
regeneration, a transient fibrosis appears at the site of injury, and I will show the contribution of
different populations of cells to the fibrosis. However, in contrast with mammals, there is a fibrosis
regression. We hypothesized that this can occur via two mechanisms: cell death or cell inactivation.
Using new genetic tools to label fibroblasts, we obtained results that show that cell inactivation is
the main mechanism, while cell death doesn’t contribute significantly.
It has been described that new cardiomyocytes during regeneration originate from preexisting
cardiomyocytes. However, we have found out that there is an unexpected heterogeneity in the
cardiomyocytes of the zebrafish heart, and that different types of them can transdifferentiate during
the process of rebuilding an adult zebrafish heart.
Monday, December 19, 2016, 03:00pm
Experimental Biology Room, Bertalanffy Foundation Building, 2nd floor
This invitation is valid as a ticket for the IST Shuttle from and to Heiligenstadt Station. Please find a schedule
of the IST Shuttle on our webpage (note that the IST Shuttle times are highlighted in dark green):
http://ist.ac.at/fileadmin/user_upload/pdfs/IST_shuttle_bus.pdf
The IST Shuttle bus is marked IST Shuttle (#242) and has the Institute Logo printed on the side.
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