The Institute of Human Genetics, University Medical Center Göttingen, currently offers a PhD student position Mitochondrial dysfunction in aging phenotypes part time 65 % | salary according to TV-L Über uns Die Universitätsmedizin Göttingen (UMG) umfasst die Medizinische Fakultät und das Universitätsklinikum. Mit über 7.400 Mitarbeiterinnen und Mitarbeitern ist die UMG der größte Arbeitgeber in der Region. Mehr als 65 Kliniken, Institute und Abteilungen stehen für eine qualitativ hochwertige Patientenversorgung, exzellente Forschung und moderne Lehre. Göttingen als Stadt der Wissenschaft liegt im Zentrum Deutschlands und die Universitätsmedizin ist vor Ort eingebunden in ein attraktives Netzwerk universitärer und außeruniversitärer Wissenschaftseinrichtungen. Mitochondrial dysfunction has been linked to physiological aging processes. However, the mechanisms by which mitochondria contribute to the aging process are not well understood. In our project, we combine human genetic approaches with high-end biochemical analysis and advanced super-resolution microscopy and image analysis technologies to define novel and general mechanisms of mitochondrial dysfunction and to link these to tissue-specific agingassociated diseases. The PhD student will be involved in using exome/genome sequencing to identify novel disease associated genes and mutations associated with inherited forms of accelerated aging phenotypes; generating induced pluripotent stem cells (iPSCs) and differentiating them into tissues of interest; analyzing mitochondrial function in cellular disease models and assessing mitochondrial organization and protein distribution; using super-resolution imaging and assessing the nanoscale distribution of proteins in disease-derived in vivo and in vitro models to classify potential changes in mitochondrial architecture The candidate will be enrolled in the GAUSS PhD program of the Georg August University Göttingen and close interactions with the Department of Cellular Biochemistry (Prof. Dr. P. Rehling) and the Max Planck Institute for Biophysical Chemistry (Prof. Dr. S. Jakobs) are part of this study. We are looking for a highly motivated candidate with a strong background in cell culture techniques and standard methods used in molecular biology. Applicants should have fluent English communication skills and enjoy working in an excellent and innovative research environment and a highly motivated, international team ofscientists. Please apply by e-mail and send a single pdf file including CV, certificates, description of your lab experience and contact details of two references. Ihre Bewerbung richten Sie bitte bis zum 15.08.2016 an: Universitätsmedizin Göttingen Prof. Dr. med. Bernd Wollnik Institute of Human Genetics 37099 Göttingen Tel.: 0551/39-7589 Fax: 0551/39-9303 E-Mail: [email protected] Web: http://www.humangenetik.gwdg.de Ansprechpartner/in: Prof. Dr. med. Bernd Wollnik Travel and application fees cannot be refunded or transferred. Men are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment. Powered by TCPDF (www.tcpdf.org)