Bonn,Germany Industrial partners Contact [email protected] | www.lifeandbrain.com • Hamilton Robotics • ALS Automated Lab Solutions GmbH • Evotec AG • DASGIP Information and Process Technology GmbH Your expert for stem cell automation and automated differentiation Due to increased worldwide market demand we are continously expanding our hardware and life science product business partner network. If you are interested in becoming a life&brain CellSolutions business partner please do not hesitate to contact us. Bonn, Germany Publications 1. McLaren, D., et al., Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells. J Biomol Screen (accepted). 2. Falk, A., et al., Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One 2012, 7, (1), e29597. 3. Haupt, S., et al., Automated selection and harvesting of pluripotent stem cell colonies. Biotechnology and Applied Biochemistry 2012, doi: 10.1002/bab.1014. 4. Koch, P., et al., Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature 2011, 480, (7378), 543-6. 5. Terstegge, S., et al., Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures. Stem Cell Rev 2010, 6, (2), 260-9. 6. Haupt, S., et al. Automated selection and collection of pluripotent stem cell colonies using the CellCelector™. Application Note, Nature Methods 6 2009, doi:10.1038/nmeth.f.252 7. Terstegge, S., et al., Laser-assisted selection and passaging of human pluripotent stem cell colonies. J Biotechnol 2009, 143, (3), 224-30. 8. Koch, P., et al., A rosette-type, self-renewing human ES cellderived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci U S A 2009, 106, (9), 3225-30. 9. Terstegge, S., et al., Automated maintenance of embryonic stem cell cultures. Biotechnol Bioeng 2007, 96, (1), 195-201. 10. Koch, P., et al. Automated generation of human stem cell clones by Image-Activated Cell Selection (IACS™). Application Note, Nature Methods 2 2005, doi:10.1038/nmeth809 11. Terstegge, S., et al., Hamilton's new cellhost system for full automation of embryonic stem cell cultures. Application Note, Nature Methods 1 2004, doi:10.1038/nmeth1204-271 life&brain GmbH CellSolutions Sigmund-Freud-Str. 25 D-53127 Bonn / Germany Tel +49 (0)228 6885-470 Fax +49 (0)228 6885-471 [email protected] www.lifeandbrain.com Profit from our unique expertise in stem cell biology and process automation to turn your ideas into success. Our Expertise → Your Benefit Project planning phase We qualify and revise your workflows to be fit for automation and compile the perfect hardware solution for your specific project. Your Application Project realization phase We guide, consult and support you during your way to efficiently set up a reliable automated system with highly reproducible applications to standardize your workflows. Project Organization Automated System Provider Post implementation phase We provide strong application support to streamline your process and research in the long-term. To find out more about our services visit us at: www.lifeandbrain.com > Automation, standardization and parallelization of all required cell culture steps for pluripotent stem cell handling and differentiation, including a comprehensive quality management system is becoming more and more essential to close the technology gap in the rapid development of the stem cell market. Thorough adaptation to individual cell types is required to harness individual hardware solutions for this highly competitive field. We lead and manage projects to set up stem cell-based applications on automated systems and provide independent consulting specifically tailored to your individual requirements. life&brain CellSolutions has a long history of codevelopments with leading labautomation manufacturers, including more than 10 years of experience in automation of proliferating human pluripotent stem cells and their controlled differentiation into specialized and functional cells of the nervous system (s. References). The excellent combination of unique expertise in stem cell research and automation turns life&brain CellSolutions into a highly valuable partner for both research or life science customers and provider of automated laboratory systems. Clustered know-how, independent consulting and personal assistance are the key benefits to realize your ideas for stem cell-based automation with life&brain CellSolutions. > life&brain CellSolutions addresses the unmet need of cell culture automation to fully exploit the market potential of human pluripotent stem cells and their derivatives. The advent of human embryonic stem cells and induced pluripotent stem cells (iPS cells) introduces a new dimension to the field of drug development and regenerative medicine. Our Services → Your Success Your Automated Solution
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