How do cells make decisions? The yeast glucose-galactose circuit as a model for cellular responses to complex environments ジュエワン（Jue Wang）システム生物学専攻・ハーバード大学医学部 Department of Systems Biology, Harvard Medical School ※開催日時に変更がありました。 3 月 5 日（木）16：00〜17：00 京都大学医学・生命科学総合研究棟（Ｇ棟）２階講義室セミナー室 A（Bldg. G, Rm. A） In order to survive in nature, cells must sense and respond to complex, time-‐varying mixtures of nutrient and stresses. Cells in animals must also respond correctly to outside signals or else jeopardize the health of the organism. This cellular "decision-‐making” is the combined result of many genes, proteins, and metabolites. Despite having a detailed understanding of individual molecular parts, we often still cannot explain how these parts contribute to the overall behavior of cells and populations. Our lab uses the S. cerevisiae glucose-‐galactose circuit as a model system to understand how genetic variation and molecular mechanisms shape cellular decision-‐making. We have demonstrated that this circuit can perform complex tasks such as predicting environmental changes and comparing the concentrations of different nutrients. In ongoing work, w e are uncovering the genetic mutations responsible for modulating t hese behaviors in natural yeast populations. Graduate School of Biostudies 連絡先細胞周期学分野石川冬木 (内線) 4195 He is invited to give a talk in ISS (International student seminar, Mar 3 and 4). We asked him to give a second and independent seminar here. We strongly advise you to attend ISS too.