15:00-18:30 Wednesday February 4, 2015 Venue: Suzuki Hall

Top-collaboration Support Project
トップランナーとの協働教育機会拡大支援事業
Promote innovative therapy on Immune disease
免疫疾患に対する先進的治療を可能にするための米国国立衛生研究所とのコラボ活動
Date:
Venue:
Chair
Co-chair
Advisor
15:00-18:30 Wednesday February 4, 2015
Suzuki Hall
Frontier Research in Applied Sciences Building,
School of Engineering, Hokkaido University
鈴木章ホール
北海道大学工学部フロンティア応用科学研究棟
Masayuki Noguchi (Cancer Biology, Hokkaido University)
北海道大学遺伝子病制御研究所癌生物学分野教授教授野口昌幸
Tatsuya Atsumi (Rheumatology, Hokkaido University)
北海道大学大学院医学研究科免疫・代謝内科学分野教授渥美達也
Yoshimasa Watanabe (School of Engineering, Hokkaido University)
北海道大学工学部名誉教授渡辺義公
Secretariat
Division of Rheumatology, Endocrinology and Nephrology
Hokkaido University Graduate School of Medicine
事務局
北海道大学大学院医学研究科内科学講座免疫・代謝内科学分野
(内線 5913)
Date:
Venue:
15:00-18:30 Wednesday February 4, 2015
Suzuki Hall, Frontier Research in Applied Sciences Building,
School of Engineering, Hokkaido University
北海道大学工学部フロンティア応用科学研究棟鈴木章ホール
Session 1 Basic and Clinical research on Sjögren‘s syndrome and related diseases
シェーグレン症候群と関連疾患の基礎的、臨床的研究
Chairperson: Tatsuya Atsumi (Rheumatology, Hokkaido University)
座長北海道大学大学院医学研究科免疫・代謝内科学分野教授渥美達也先生
15:00-15:20
Genetic background of Sjögren’s syndrome
シェーグレン症候群の遺伝的背景
Tetsuya Horita (Rheumatology, Hokkaido University)
北海道大学大学院医学研究科免疫・代謝内科学分野講師堀田哲也先生
15:20-15:40
Primary Immunodeficiency as a model of autoimmune diseases
自己免疫疾患のモデルとしての原発性免疫不全症
Ichiro Kobayashi (Pediatrics, Hokkaido University)
北海道大学大学院医学研究科小児科学分野講師小林一郎先生
15:40-16:00
Sjögren’s Syndrome & IgG4-related Dacryoadenitis and Sialadenitis,
so called ‘Mikulicz’s Disease’
シェーグレン症候群と IgG4 関連涙腺・唾液腺炎、いわゆるミクリッツ病
Motohisa Yamamoto (Rheumatology, Sapporo Medical University)
札幌医科大学医学部消化器・免疫・リウマチ内科助教山本元久先生
16:00-16:40
A crucial role of Th1, Th17 and Treg cells in mouse model for Sjögren's
syndrome
シェーグレン症候群のマウスモデルにおける Th1、Th17、Treg 細胞の役割
Mana Iizuka (Rheumatology, Tsukuba University)
筑波大学医学医療系内科膠原病・リウマチ・アレルギー助教飯塚麻菜先生
16:40-17:20
The activation of the inflammation amplification loop in non-immune cells
during autoimmune disease development
自己免疫疾患発症過程における非免疫担当細胞での炎症増幅ループの活性化
Masaaki Murakami (Molecular Neuroimmunology, Hokkaido University)
北海道大学遺伝子病制御研究所分子神経免疫学分野教授村上正晃先生
Session 2 Special lecture
特別講演
Chairperson: Masayuki Noguchi (Cancer Biology, Hokkaido University)
座長北海道大学遺伝子病制御研究所癌生物学分野教授野口昌幸先生
17:30-18:30
Microarray Based Transcriptome Analysis as a Tool for
Investigating Sjögren’s Syndrome
John A. Chiorini, Ph.D.
Chief, Adeno-Associated Virus Biology Section
National Institutes of Health, USA
.
Special lecture
John A. Chiorini, Ph.D.
Chief
Adeno-Associated Virus Biology Section
National Institutes of Health (NIH)/
National Institutes of Dental and
Craniofacial Research (NIDCR)
Microarray Based Transcriptome Analysis as a Tool for
Investigating Sjögren’s Syndrome
Major problem facing medicine today is defining the mechanism associated with the
onset and symptoms of disease and developing treatment for them.
Analysis of the transcriptome can provide a global perspective of the physiologic state of
the cell and identify specific as well as broad changes within the cell. Our lab has utilized
this approach to investigate central questions related to Sjögren’s syndrome such as the
gene expression changes associated with the loss of gland activity and the role of viral
gene expression in initiating a Sjögren’s syndrome phenotype.
<Biography>
Dr. Chiorini received his Bachelor’s in biochemistry and molecular biology from the
University of California, Santa Cruz in 1986 and his Ph.D. in genetics from George
Washington University in 1993. Afterwards he completed post-doctoral training fellowships
at both the National Institutes of General Medical Science (Pharmacology Research and
Training Program) and in the National Heart, Lung, and Blood Institute. He joined the
NIDCR as a tenure track investigator in 1999 and was awarded tenure in 2006. He
currently serves as Chief of the AAV Biology Section in the Molecular Physiology and
Therapeutics Branch of the National Institute of Dental and Craniofacial Research
(NIDCR). His research has focused on the underlying biology associated with viral gene
transfer and the development of novel high activity gene transfer vectors. A major
application of the vectors is the treatment of xerostomia as it relates to Sjögren’s
syndrome and radiation induced damage to the gland.
<MEMO>

Download Report