Cover Page The handle http://hdl.handle.net/1887/29822 holds various files of this Leiden University dissertation. Author: Timmers, Petra Jeanette Title: Early ovarian cancer Issue Date: 2014-10-16 EARLY OVARIAN CANCER Petra Timmers The research described in this thesis was performed at the European Organisation for Research and Treatment of Cancer in Brussels, Belgium. www.fsc.org MIX Paper from responsible sources FSC® C002434 ISBN/EAN: Author: Cover design: Printed by: 978-94-91955-03-7 Petra Timmers Els Kruit Pasmans, Den Haag © Petra J. Timmers, 2014 All rights reserved. No part of this thesis may be reproduced or transmitted, in any form or by any means, without prior permission of the author. EARLY OVARIAN CANCER Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op donderdag 16 oktober 2014 klokke 15.00 uur door Petra Jeanette Timmers geboren te Katwijk in 1966 P RO M O TIE COMMISSIE Promotores Prof. dr. J.B.M.Z. Trimbos Prof. dr. I. Vergote Overige leden Prof. dr. G.J. Fleuren Prof. dr. ir. J.J.M. van der Hoeven Prof. dr. G.G. Kenter Prof. dr. A.A.W. Peters Prof. dr. A.H. Zwinderman In liefdevolle herinnering aan mijn vader Voor mijn moeder Contents C H A P TE R 19 General Introduction C H A P TE R 2 27 Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: European Organisation for Research and Treatment of Cancer– Adjuvant ChemoTherapy in Ovarian Neoplasm trial J Natl Cancer Inst 2003; 95(2): 113–125 C H A P TE R 3 Chemotherapy for early ovarian cancer 53 Curr Opin Obstet Gynecol 2004; 16(1): 43-48 C H A P TE R 4 65 Clear cell carcinoma compared to serous adenocarcinoma in early ovarian cancer: same prognosis in a large randomized trial Int J Gynecol Cancer 2009; 19(1): 89-93 C H A P TE R 5 81 Understanding the problem of inadequately staging early ovarian cancer Eur J Cancer 2010; 46(5): 880-884 C H A P TE R 6 93 Lymph node sampling and taking of blind biopsies are important elements of the surgical staging of early ovarian cancer Int J Gynecol Cancer 2010; 20(7): 1142-1147 C H A P TE R 7 105 Prognostic value of Ic substages in invasive epithelial ovarian carcinoma Submitted C H A P TE R 8 117 Surgical staging and treatment of early ovarian cancer: long-term analysis from a randomized trial J Natl Cancer Instit 2010; 102(13): 982-987 C H A P TE R 9 131 General Discussion C H A P TE R 1 0 143 Summary C H A P TE R 1 1 149 Nederlandse Samenvatting Abbreviations159 Curriculum Vitae 161 Publications163 Authors and affiliations 165 Alphabetic order references 167
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