Sex-specific aspects of venous thrombosis

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The handle http://hdl.handle.net/1887/23449 holds various files of this Leiden University
dissertation.
Author: Roach, Rachel Elizabeth Jo
Title: Sex-specific aspects of venous thrombosis
Issue Date: 2014-02-06
Sex-specific aspects of venous thrombosis
Rachel E.J. Roach
Sex-specific aspects of venous thrombosis
PhD Thesis, Leiden University Medical Center
Cover: False-colour SEM of a human blood clot
Printed by: Mostert en Van Onderen, Leiden
ISBN/EAN: 978-90-9027909-1
Copyright © R.E.J. Roach, 2014
All rights reserved. No part of this book may be reproduced, stored in a retrieval
system, or transmitted in any form or by any means, electronically, mechanically,
by photocopy, by recording, or otherwise, without prior written permission of the
author.
Sex-specific aspects of venous thrombosis
Proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 6 februari 2014
klokke 15.00 uur
door
Rachel Elizabeth Jo Roach
geboren te Den Haag
in 1988
Promotiecommissie
Promotor
Prof. dr. F.R. Rosendaal
Copromotores
Dr. W.M. Lijfering
Dr. S.C. Cannegieter
Overige leden
Prof. dr. F.M. Helmerhorst
Prof. dr. P.H. Reitsma
Prof. dr. J.B. Hansen (University of Tromsø, Norway)
The work described in this thesis was performed at the Department of Clinical
Epidemiology of the Leiden University Medical Center, the Netherlands. Part of
the research described in this thesis was supported by the Dutch Heart Foundation
(DHS 98.113), the Dutch Cancer Foundation (RUL 99/1992) and the Netherlands
Organization for Scientific Research (912-03-033| 2003).
Financial support by the Dutch Heart Foundation and the Federatie van
Nederlandse Trombosediensten for the publication of this thesis is gratefully
acknowledged. Additional financial support was kindly provided by Medical
Dynamics, ABN Amro, Boehringer Ingelheim, GlaxoSmithKline, LeoPharma BV
and Bayer HealthCare.
Table of contents
Chapter 1. General Introduction and Outline of this Thesis
7
Chapter 2. The risk of venous thrombosis in individuals with
superficial vein thrombosis and acquired venous
thrombotic risk factors 19
Chapter 3.
The risk of venous thrombosis in women over 50 years
old using oral contraception or postmenopausal hormone
therapy
37
Chapter 4.
Sex difference in risk of second but not of first venous
thrombosis: paradox explained 57
Chapter 5.
A detailed analysis of the sex difference in the risk of
venous thrombosis in four European cohorts
75
Chapter 6. Differential risks in men and women for first and recurrent
venous thrombosis: the role of genes and environment.
93
Chapter 7. Summary and General Discussion
113
Nederlandse samenvatting
127
Acknowledgements 133
List of publications
135
Curriculum Vitae
137
5

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