acute and chronic pain after cardiac surgery

Cover Page
The handle http://hdl.handle.net/1887/28397 holds various files of this Leiden University
dissertation.
Author: Gulik, Laura van
Title: Acute and chronic pain after cardiac surgery
Issue Date: 2014-09-02
ACUTE AND
CHRONIC PAIN
AFTER CARDIAC
SURGERY
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen
op dinsdag 2 september 2014
klokke 15:00 uur
door
Laura van Gulik
Geboren te Schiedam in 1977
Promotiecommissie
Promotores:Prof. dr. C.A.J. Knibbe
Leiden Academic Centre for Drug Research, LACDR
Prof. dr. D. Tibboel
Erasmus Medisch Centrum, Sophia kinderziekenhuis,
Rotterdam
Co-promotor:Dr. P. Bruins
St. Antonius Ziekenhuis, Nieuwegein
Overige leden:Prof. Dr. P.H. van der Graaf
Leiden Academic Centre for Drug Research, LACDR
Prof. Dr. T. Hankemeier
Leiden Academic Centre for Drug Research, LACDR
Prof. Dr. M. Danhof
Leiden Academic Centre for Drug Research, LACDR
Prof. Dr. L.P.H.J. Aarts
Leids Universitair Medisch Centrum, LUMC
Prof. Dr. F.J.P.M. Huygen
Erasmus Medisch Centrum, Rotterdam
Colofon
Copyright © 2014 L. van Gulik
All rights reserved. No part of this thesis may be reproduced, stored or
transmitted in any form by any means, without prior permission of the author.
Lay-out: Proefschrift-aio.nl
Cover: Proefschrift-aio.nl
ISBN: 978-90-9028431-6
CONTENTS
Section I: General Introduction
Chapter 1 General Introduction
7
Chapter 2 Scope and intent of the investigations
23
Section II: Acute pain in the Intensive Care
Chapter 3 Improved analgesia after the realisation of a pain management
programme in ICU patients after cardiac surgery
33
L. van Gulik, S.J.G.M. Ahlers, Z. Brkić, S.V. Belitser, W.J. van Boven, E.P.A. van Dongen, C.A.J.
Knibbe, P. Bruins. Eur J Anaesthesiol. 2010 Oct;27(10):900-5
Chapter 4 Efficacy of an intravenous bolus of morphine 2.5 versus
morphine 7.5 mg for procedural pain relief in postoperative cardiothoracic
patients in the intensive care unit: a randomised double-blind controlled
trial
47
S.J.G.M. Ahlers , L. van Gulik, E.P.A. van Dongen, P. Bruins, E.M.W. van de Garde, W.J. van
Boven, D. Tibboel, C.A.J. Knibbe. Anaesth Intensive Care. 2012 May;40(3):417-26
Chapter 5 Procedural pain does not raise plasma levels of cortisol or
catecholamines in adult intensive care patients after cardiac surgery
63
L. van Gulik, S.J.G.M. Ahlers, M. van Dijk, P. Bruins, M.E. Meima, Y.B. de Rijke, H.S. BiemondMoeniralam, D. Tibboel, C.A.J. Knibbe. Submitted for publication
Chapter 6 Adherence to all steps of a pain management protocol in
intensive care patients after cardiac surgery is hard to achieve
75
L. van Gulik, S.J.G.M. Ahlers, P. Bruins, D. Tibboel, C.A.J. Knibbe, M. van Dijk. Submitted for
publication
Section III: Chronic pain one year after surgery
Chapter 7 Risk factors for chronic thoracic pain after cardiac surgery via
sternotomy
89
L. van Gulik, L.I. Janssen,S.J.G.M. Ahlers, P. Bruins, A.H. Driessen, W.J. van Boven, E.P.A.van
Dongen, C.A.J. Knibbe. Eur J Cardiothorac Surg. 40 (2011) 1309—1313
Chapter 8 Remifentanil during cardiac surgery is associated with chronic
thoracic pain one year after sternotomy
103
L. van Gulik, S.J.G.M. Ahlers, E.M.W. van de Garde, P. Bruins, W.J. van Boven, D. Tibboel, E.P.A.
van Dongen, C.A.J. Knibbe . Br. J. Anaesth. 2012 Oct; (109 (4):616-22
Section IV: Summary, conclusions and perspectives
Chapter 9 Conclusions and perspectives
Samenvatting (Synopsis in Dutch)
Nawoord (Epilogue in Dutch)
Curriculum Vitae
List of Publications
119
137
144
145
146

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