第 22 回バイオベースマテリアルセミナー日時：2015 年 5 月 11 日（月）13:30～15:30 場所：京都工芸繊維大学総合研究棟４F 多目的室 Kenneth J. Wynne 教授 Chemical and Life Science Engineering Virginia Commonwealth University Richmond, VA 23284 “Soft surface science and engineering: applications driven tailoring of nanostructure and mesostructure” 皆様の多数のご参加をお待ちしています。連絡先：バイオベースマテリアル学専攻櫻井伸一（内線：7864） Kenneth J. Wynne Chemical and Life Science Engineering Virginia Commonwealth University Richmond, VA 23284 E-mail: [email protected] Ph: 804-828-9303 Soft surface science and engineering: applications driven tailoring of nanostructure and mesostructure Progress in two areas will be described (1) minimizing adhesion of ice to polymer surfaces and (2) polycation surface modification for contact bacterial kill and cytocompatibility. Interest in fundamental understanding of the ice-polymer interface and the development of polymer coatings from which ice can be easily removed presented the challenge of developing a straightforward laboratory test for the force to remove ice. To address this need, a test with a TA Instruments RSA-3 was developed. The method involves removal of an ice cylinder from a polymer coating with a probe and the determination of peak removal force (Ps). Using this test, coatings based on poly(dimethylsiloxane) have been investigated. Contributions to ice adhesion based on thickness and the practical work of adhesion have been identified. Antimicrobial coatings that affect contact kill (no biocide or heavy metal release) offer promise in helping curb the spread of (CH 2)4N(CH 2)11CH3 infections.[1] Because polyurethanes are often (CH 2CH 2O)2CH3 Br used in biomaterials applications, ways for O O spontaneous surface concentration of polycations HO O O H such as C12-50 have been explored. Objectives 0.5 0.5 include establishing minimum modifier content C12-50 for antimicrobial effectiveness, minimizing protein adsorption, demonstrating stability in water at 40 ºC, and ensuring cytocompatibility. Progress toward achieving these goals will be summarized. * The author is grateful for support from the National Science Foundation. Reference [1] Wynne K. J.; Kurt P.; Brunson K.; Chakravorty A.; Gupta M; Zhang W.; Wood L. F.; and Ohman D. E. ACS Symp. Ser. 2013; 1135, Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications: 303-318, 316 pp.