Curriculum Vitae
John Pierce Wise, Sr.
Mailing Address:
Wise Laboratory of Environmental and Genetic Toxicology
Maine Center for Toxicology and Environmental Health
University of Southern Maine
478 Science Building
96 Falmouth Street
Portland, Maine 04104-9300
Office Location:
476B Science Building
(207) 228-8050
E-Mail:
[email protected]
Website:
http://www.usm.maine.edu/toxicology
Laboratory:
Rooms 182, 183, 189, 473, 477, 481, 482, 486, 489, 493 Science Building
(207) 228-8049
Education
1994-1996 Post-Doctoral Fellowship in Molecular Epidemiology, The National Cancer
Institute, Bethesda, MD.
1990-1994 Ph.D. in Pharmacology, The George Washington University, Washington D.C.
1986-1990 B.S. in Biology with High Distinction and with Recognition, George Mason
University, Fairfax, VA.
Current Appointments
Director, Maine Center for Toxicology and Environmental Health, University of Southern Maine
Professor of Toxicology and Molecular Epidemiology, University of Southern Maine
Adjunct Professor of Biology, University of Southern Maine
Associate Faculty Member, Muskie School of Public Service, University of Southern Maine
Cooperating Professor of Marine Sciences, University of Maine
Member, Graduate Faculty, University of Maine
Adjunct Professor of Pharmacology, University of New England
Research Fellow, Edgerton Research Laboratory, New England Aquarium
Adjunct Researcher, Mystic Aquarium and Sea Foundation
Guest Professor, Lanzhou University, China
Board Member, Friends of Casco Bay
Vice President, Metals Specialty Section, Society of Toxicology
Secretary/Treasurer, Carcinogenesis Specialty Section, Society of Toxicology
1
Editor-in-Chief, Journal of Environmental & Analytical Toxicology
Editorial Board Member, Journal of Carcinogenesis & Mutagenesis
Editorial Board Member, Journal of Ecosystem & Ecography
Editorial Board Member, Toxics
Member, Medical Advisory Committee for Maine Board of Pesticide Control
Member, Maine Economy Innovation Advisory Board
Member, Gulf of Maine Council’s Ecosystem Indicator Partnership-Contaminants Group
Member, State of Maine Environmental Risk Advisory Committee
Member, Maine Biological and Medical Sciences Symposium
Professional Experience
2006-Present
Professor of Toxicology and Molecular Epidemiology, University of Southern
Maine
2002-Present
Director, Maine Center for Toxicology and Environmental Health, University of
Southern Maine
2004-2006
Associate Professor of Toxicology and Molecular Epidemiology with tenure,
University of Southern Maine
2002-2006
Senior Scientist, Bioscience Research Institute, University of Southern Maine
2002-2004
Associate Professor of Biosciences, University of Southern Maine
1999-2002
Director Molecular Epidemiology Shared Resource, Yale Cancer Center
1999-2002
Assistant Professor of Epidemiology, Yale University
1999-2002
Assistant Professor of Internal Medicine, Yale University
1998-2002
Instructor of Internal Medicine, Yale University
1998-1999
Instructor of Epidemiology, Yale University
1997-1998
Lecturer in Internal Medicine, Yale University School of Medicine
1996-1998
Senior Toxicologist, Jonathan Borak and Company
1996-1998
Lecturer in Epidemiology, Yale University School of Medicine
1994-1996
IRTA Fellow, Laboratory of Human Carcinogenesis, National Cancer Institute,
National Institutes of Health
1990-1994
Research Assistant, Laboratory of Steven R. Patierno, Department of
Pharmacology, George Washington University
2
1988-1990
Undergraduate Internship, Laboratories of Dr. Steven R. Patierno, Department
of Pharmacology, George Washington University and Dr. Jay C. Leonard,
Wilson Genetics Center, George Washington University
Professional Appointments
Current
2013-Present
Guest Professor, Lanzhou University, Lanzhou, China
2013-Present
Cooperating Professor of Marine Sciences, School of Marine Sciences,
University of Maine
2013-Present
Advisory Board Member, Global Cancer Summit
2013-Present
Contributing Author and Task Force Member, The Halifax Project: Assessing
the carcinogenic effects of low dose exposures to chemical mixtures in the
environment
2013-Present
Vice President, Metals Specialty Section, Society of Toxicology
2013-Present
Editorial Board Member, Toxics
2012-Present
Secretary/Treasurer, Carcinogenesis Specialty Section, Society of Toxicology
2012-Present
Editor-in-Chief, Journal of Environmental & Analytical Toxicology
2012- Present
Member, Faculty of 1000 (F1000)
2011-Present
Associate Faculty Member, Muskie School of Public Service, University of
Southern Maine
2011-Present
Editorial Board Member, Journal of Environmental & Analytical Toxicology
2010-Present
Editorial Board Member, Journal of Ecosystem & Ecography
2010-Present
Board Member, Friends of Casco Bay
2008-Present
Adjunct Professor of Pharmacology, University of New England
2008-Present
Member, State of Maine’s Medical Advisory Committee for The Maine Board
of Pesticides Control
2007-Present
Adjunct Professor of Biology, University of Southern Maine
2007-Present
Member, Maine Innovation Economy Advisory Board
2007-Present
Member, Gulf of Maine Council’s Ecosystem Indicator Partnership (ESIP) contaminants group
2005-Present
Research Fellow Edgerton Research Laboratory, New England Aquarium
3
2005-Present
Member, State of Maine Environmental Risk Advisory Committee
2005-Present
Member, Maine Biological and Medical Sciences Symposium
2002-Present
Member, Graduate Faculty, University of Maine
2001-Present
Adjunct Researcher, Mystic Aquarium and Sea Foundation
Completed
2008-2014
Editorial Board Member, The Open Toxicology Journal
2012-2013
Vice President-Elect, Metals Specialty Section, Society of Toxicology
2007-2013
Director of Toxicology, Ocean Alliance
2010
Expert Panelist, U.S. Environmental Protection Agency’s (EPA’s) “Workshop
to Discuss Policy-Relevant Science to Inform EPA’s Integrated Plan for Review
of the National Ambient Air Quality Standards (NAAQS) for Lead (Pb)”
2009-2010
Panel Member, United States Army Research and Material Command
(USAMRMC), Congressionally Directed Medical Research Programs
(CDMRP), Peer Reviewed Cancer Research Program (PRCRP)
2009-2011
Secretary/Treasurer, Metals Specialty Section, Society of Toxicology
2008-2010
Consultant, Community Outreach and Education Core of the MDIBL Center for
Comparative Toxicogenomics (CCT)
2006-2013
Associate Editor, Life Sciences
2006
Member, Program Committee, Environmental Mutagen Society
2006-2007
Member, Maine Governor’s Task Force for Safer Chemicals in Consumer
Products
2005-2007
Member, Maine State Science and Technology Advisory Board
2005-2009
Member, Research Advisory Group, American Lung Association of Maine
2004
Guest Editor, Mutation Research Issue: ‘Chromium and Human Health”
2003-2011
Member, Maine State Department of Environmental Protection’s Surface Water
Ambient Toxics monitoring program
2002-2007
Adjunct Associate Professor of Pharmacology, University of New England
2002-2009
Member, Steering Committee Maine Indoor Air Quality Research Forum
4
2002-2010
Member, Center for Membrane Toxicity Studies, Mount Desert Island
Biological Laboratory
2002 - 2010
Mentor, BRIN grant program, Mount Desert Island Biological Laboratory
2002- 2004
Web Editor, Molecular Epidemiology Group, American Association for Cancer
Research (AACR)
2002-2003
Past President Northeast Society of Toxicology
2001
Participant, Workshop to Assess Contaminant Impacts on Steller Sea Lions in
Alaska
2001-2002
President Northeast Society of Toxicology
2000-2001
President-elect Northeast Society of Toxicology
2000-2010
Principle Investigator, Mount Desert Island Biological Laboratory
2000
Liaison to Committee for Public Communication, Society of Toxicology
1999-2005
Member, K-12 education subcommittee, Society of Toxicology
1997-2002
Toxicologist, State of Connecticut, Persian Gulf War Commission
1998-2002
Visiting Fellow, John B. Pierce Foundation, New Haven, Connecticut
Teaching
Full Courses:
2011-Present
Graduate/undergraduate course "Marine Mammal Biology and Toxicology"
(Course AMS 494/594), University of Southern Maine. Taught as a blended
online & classroom course.
2008-Present
Graduate level course “Metal Toxicology” (Course AMS 696), University of
Southern Maine
2006-Present
Graduate level course “Genetic Toxicology” (Course AMS 694), University of
Southern Maine. Taught either online or in the classroom.
2005-Present
Graduate level course “Chemical Carcinogenesis” (Course AMS 695),
University of Southern Maine
2004-2007
Graduate level course "Introduction to Toxicology II" (Course AMS 591),
University of Southern Maine
2003-Present
Graduate level course “Advanced Seminars in Biomedical Sciences” (Course
AMS 691), University of Southern Maine
2003-Present
Graduate level course "Advanced Biomedical Research Readings" (Course
AMS 692), University of Southern Maine
5
2003-Present
Graduate level course "Advanced Research Techniques in Biomedical
Sciences" (Course AMS 693), University of Southern Maine
2003-2006
Graduate level course "Introduction to Toxicology I" (Course AMS 590),
University of Southern Maine
2003-2005
Principal Investigator for undergraduate research internship, Department of
Sports Medicine, University of Southern Maine
2001-2002
Graduate level course "Introduction to Toxicology" (Course EHS 503b), Yale
School of Medicine, Yale University
2000- 2002
Undergraduate course “Research in Environmental Health” (Course MCDB
475a), Yale College, Yale University
2000- 2002
Undergraduate course “Toxicology in Environmental Health” (Course MCDB
470a), Yale College, Yale University
2000- 2002
Graduate level course “Advanced Laboratory Techniques in Environmental
Health” (Course EHS 579a/b), School of Medicine, Yale University
2000- 2002
Graduate level course “Advanced Research Laboratories” (Course EHS
611a/b), School of Medicine, Yale University
2000- 2002
Director and principal lecturer for graduate level course “Introduction to
Laboratory Techniques in Molecular Epidemiology” (Course EHS 577a/b),
School of Medicine, Yale University
1996-2002
Graduate level course “Environmental Toxicology” (Course EHS 509a), School
of Medicine, Yale University
1996
Co-taught graduate level course “Environmental Chemistry” (Course EHS
514a), School of Medicine, Yale University
Individual Lectures:
2001-2002
Lecture on “Biomarkers” for graduate level course "Environmental
Epidemiology" (Course EHS 507a), School of Medicine, Yale University
2001-2002
Lecture on “Chemical Carcinogenesis” for graduate level course "Environmental
Epidemiology" (Course EHS 507a), School of Medicine, Yale University
2001-2002
Lecture on “Biomarkers of Exposure” for graduate level course "Assessing
Exposure to Environmental Stressors" (Course EHS 508a), School of Medicine,
Yale University
2001-2002
Lecture on “Exposure Assessment in Toxicology” for graduate level course
"Assessing Exposure to Environmental Stressors" (Course EHS 508a), School of
Medicine, Yale University
6
1999-2002
Lecture on “Carcinogenesis” for graduate level course "Epidemiology of Cancer"
(Course CDE 532b), School of Medicine, Yale University
1997-2002
Lectures on "Toxicology of Metals” for graduate level course "Introduction to
Occupational and Environmental Medicine" (Course EHS 575), School of
Medicine, Yale University
Seminars/Presentations
2014
Invited Speaker: “Prolonged Exposure to Particulate Chromate Induces a Switch from
Homologous Recombination Repair to Non-Homologous End Joining Repair in Human
Lung Cells” To be Presented in Metals and DNA Repair Symposium at the Annual
Meeting of the Society of Toxicology (SOT) March, 2014.
2013
Invited Speaker: “Insights into the Mechanism of Chromium Carcinogenesis:
Leveraging Lessons Learned into a Project to Study the Carcinogenic Interaction of
Particulate Nickel and Cobalt in Human Lung Cells”. Presented at Lanzhou University,
Lanzhou, China.
2013
Stanback Distinguished Lecturer: "Of Whales and Men: Elucidating a Comprehensive
Carcinogenic Mechanism for Chromium, a Global Environmental Pollutant" Presented at
the Duke Nicholas School of the Environment and the Duke Cancer Institute.
2013
Keynote Speaker: “Particulate Chromate Alters the Localization of Proteins that Protect
Cells against Chromosome Instability”. Presented at the Toxicology 2013 Annual
Meeting.
2012
Invited Speaker: “The Gulf of Mexico Offshore Toxicology Study”, in The
Toxicological Impact of the Gulf of Mexico Oil Spill on Human and Wildlife Health
Symposium, Annual Meeting of the American Association for the Advancement of
Science (AAAS), Boston, Massachusetts. Talk recommended to AAAS by the Society of
Toxicology to represent the quality of science at Society of Toxicology.
2013
Invited Speaker: “Mechanisms of Particulate Chromate-Induced
Instability”, University of Kentucky, Lexington, Kentucky.
2012
Invited Speaker: “The Gulf of Mexico Offshore Toxicology Study”, in The
Toxicological Impact of the Gulf of Mexico Oil Spill on Human and Wildlife Health
Symposium, Annual Meeting of the Society of Toxicology, San Francisco, Maryland.
2011
Invited Speaker: "Voyage 2 of the Odyssey: the Impact of the Oil Crisis on Health Using
Whales as an Indicator Species", Annual meeting of the Environmental Mutagen
Society, Quebec, Canada. Presentation finally given by my colleague Dr. Holmes as I
was unable to attend at the last minute.
2011
Invited Speaker: "Lessons about Global Pollution and Human Health Learned from
Whales: The Gulf of Mexico Oil Crisis", University of Maine, Farmington, Farmington,
Maine.
7
Chromosome
2011
Invited Presenter, "Water Quality/Oil Spill", presented in "Protecting You and Your Pet
through the Science of Toxicology: Paracelsus Goes to Washington". Marion E.
Koshland Science Museum of the National Academy of Science, Washington, D.C.
2010
Invited Speaker: "DNA Damage in Marine Species", Annual meeting of the
Environmental Mutagen Society, Fort Worth, Texas. Presentation finally given by my
colleague Dr. Xie as I was caught out at sea and unable to reach port.
2010
Invited Speaker: "A Voyage to Save Our Oceans, Gulf of Mexico Voyage 2010",
University of Southern Mississippi, Ocean Springs, Mississippi.
2010
Invited Speaker: "Mechanism of Hexavalent Chromate-Induced Chromosome Instability
and Centrosome Amplification", Triennial meeting of the EMBO Workshop:
Chromosome Segregation and Aneuploidy, Edinburgh, Scotland.
2010
Invited Speaker: “Mechanisms of Particulate Chromate-Induced Chromosome
Instability”, Maine Institute for Human Genetics and Health, Bangor, Maine.
2009
Invited Speaker: “Whales as Sentinels for Human Health: A Global Assessment of
Chromium Pollution”, Annual Meeting of the Society of Toxicology, Baltimore,
Maryland.
2008
Invited Speaker: “Mechanisms of Hexavalent Chromium Induced Chromosome
Instability”, Department of Chemistry, University of Alabama.
2008
Invited Speaker: “STEM Education in the Wise Laboratory”, First Annual Conference
on Science, Technology, Engineering and Math (STEM) Education in Maine, Augusta,
Maine.
2007
Invited Speaker: “The Toxicology of Chromium in Great Whales: Is Chromium the Next
Global Pollutant?”, Department of Biology, University of Southern Maine.
2006
Invited Speaker: “Metal Toxicity and Carcinogenesis”, Fourth Conference on Molecular
Mechanisms of Metal Toxicity and Carcinogenesis, National Institute for Occupational
Safety and Health (NIOSH), Morgantown, West Virginia.
2006
Invited Speaker: “Sperm Whales: Are They Exposed to Dangerous Levels of Metals and
Are They Sentinels for Human Health? A Case Study of the Toxic Effects of
Chromium”, Voyage of the Odyssey Science Symposium II, Pacific Life Foundation,
Newport Beach, California.
2006
Invited Speaker: “Sperm Whales: Are They Exposed to Dangerous Levels of Metals and
Are They Sentinels for Human Health? A Case Study of the Toxic Effects of
Chromium”, Consultative Group on Biological Diversity’s Annual Marine Working
Group, San Pedro, Ambergris Caye, Belize.
2005
Invited Speaker: “Sperm Whales: Are They Exposed to Dangerous Levels of Metals and
Are They Sentinels for Human Health? A Case Study of the Toxic Effects of
Chromium”, Voyage of the Odyssey Science Symposium, University of Southern Maine,
Portland, Maine.
8
2005
Invited Speaker: “Chronic Exposure to Lead Chromate Causes Centrosome
Abnormalities and Aneuploidy in Human Lung Cells”, Workshop on Chromium and
Human Health, University of Southern Maine, Portland, Maine.
2005
Invited Speaker: “The Toxicology of Hexavalent Chromium in Humans and Marine
Mammals”, University of Texas at El Paso, Texas.
2005
Keynote Speaker: Seminar: “The Maine Center for Toxicology and Environmental
Health”, Meeting of the Corporate Partners of the University of Southern Maine,
Portland, Maine.
2005
Invited Speaker: “The Toxic Effects of Environmental Contaminants on Steller Sea Lion
Cells”, Mystic Aquarium & Institute for Exploration, Mystic, Connecticut.
2005
Invited Speaker: “Developing Right Whale Cell Lines to Study the Consequences of
Exposure to Environmental Contaminants”, New England Aquarium, Boston,
Massachusetts.
2005
Invited Speaker: “The Physico-Chemical Mechanisms of Particulate Cr(VI)-Induced
Chromosome Damage”, University of New England, Biddeford, Maine.
2004
Invited Speaker: “The Physico-Chemical Mechanisms of Particulate Cr(VI)-Induced
Genotoxicity”, University of Vermont, Burlington, Vermont.
2004
Invited Speaker: “Mechanisms of Arsenic-Induced Human Lung and Bladder Cancer”,
Maine Cancer Foundation, Portland, Maine.
2004
Invited Speaker: “Mechanisms of Particulate Chromate-Induced Genotoxicity ", Third
Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National
Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia.
2004
Invited Speaker: “The Future of Environmental Research”, Osher Lifelong Learning
Institute (OLLI), Portland, Maine.
2004
Invited speaker: “Toxicology of Hexavalent Chromium in Human Lung Cells”, Maine
Medical Center, Portland, Maine.
2004
Keynote Speaker: Seminar: “Developing a Nationally Recognized Program in
Environmental Toxicology”, Annual Meeting of the Alumni Association of the
University of Southern Maine, Portland, Maine.
2003
Invited Speaker: “Comparative Chemical Carcinogenesis of Environmental
Contaminants in Balaenidae Whales (Balaena mysticetus and Eubalaena glacialis) and
Humans: Bowhead Whales Are Resistant to Hexavalent Chromium”, Aquatic Animal
Models of Human Disease Conference, Reston, Virginia.
2003
Keynote Speaker: Seminar: “Application of Cell Culture Studies in Environmental
Toxicology and the Development of the Center for Integrated and Applied Environmental
9
Toxicology at the University of Southern Maine”, 30th Anniversary of the Maine
Biological and Biomedical Sciences Society, Bar Harbor, Maine.
2002
Invited Speaker: “Establishing a Center for Integrated and Applied Environmental
Toxicology at the University of Southern Maine”, Annual Meeting of the Biotechnology
Association of Maine, Portland, Maine.
2002
Invited Speaker: “Establishing A New Human Lung Cell Culture Model for Studying
Carcinogenic Metals", Second Conference on Molecular Mechanisms of Metal Toxicity
and Carcinogenesis, National Institute for Occupational Safety and Health (NIOSH),
Morgantown, West Virginia.
2002
Invited Speaker: “A Human Lung Cell Culture Model for Studying Carcinogenic
Metals", Department of Pathobiology, University of Connecticut, Storrs, Connecticut.
2002
Invited Speaker: “A New Human Lung Cell Culture Model for Studying Particulate
Metal Compounds", Department of Chemical Engineering, Yale University, New Haven,
Connecticut.
2001
Invited Speaker: “Establishing a New Human Lung Cell Culture Model to Study
Chromium-Induced Genotoxicity”, University of Southern Maine, Portland Maine.
2001
Invited Speaker: “Toxicology of Chromium in Marine Animals”, Mount Desert Island
Biological Laboratory, Salisbury Cove, Maine.
2001
Invited Speaker: “Establishing a New Cell Culture Model of Human Bronchial Cells”,
Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia.
2001
Invited Speaker: “Using Telomerase to Immortalize Cells”, Yale Cancer Center, Yale
University, New Haven, Connecticut.
2000
Invited Speaker: “Chromium and Cancer in Humans and Marine Animals”, Southern
California Chapter of the Society of Toxicology, San Diego, California.
2000
Invited Speaker: “Comparative Toxicology of Metals in Humans and Marine Animals”,
Mount Desert Island Biological Laboratory, Salisbury Cove, Maine.
1999
Invited Speaker: “Chromium-induced Carcinogenesis”, University of Connecticut at
Farmington, Farmington, Connecticut.
Advising and Mentoring
Research Faculty
2011-2014
Amie Holmes, Assistant Research Professor, University of Southern Maine
2007-Present
Hong Xie, Assistant Research Professor, University of Southern Maine
Visiting Faculty
2014-Present
Mohamed Salah Moawad, Ph.D., Visiting Research Scholar, Cairo University,
Egypt
2012-2013
Vedat Şekeroğlu, Ph.D., Visiting Research Scholar, Ordu University, Turkey
2012-2013
Zülal Şekeroğlu, Ph.D., Visiting Research Scholar, Ordu University, Turkey
10
2012
2011
2007-2010
2007
2006-2012
2004
Louis Hall, Ph.D., Mississippi Valley State College
Michael J. Carvan, Ph.D., The University of Wisconsin, Milwaukee
John Lechner, Ph.D., Visiting Libra Scholar, University of Southern Maine
Tolga Cavas, Ph.D., Visiting Research Scholar, Mersin University, Turkey
Nancy Gordon, Ph.D., Emerita Professor, University of Southern Maine
Peter Milligan, Ph.D., University of Maine, Augusta, Maine
Postdoctoral Fellows
2005-2007
Aldona Karaczyn
2004-2006
Celine Godard
2004-2006
Eliza Duzevik
2002-2004
Caroline Goertz
2001-2002
Hong Xie
2000
Shijie Li
1999
Hong Xie
Ph.D. Students
2013-Present
2012-Present
2011-Present
2010-Present
2009-2012
2009-2010
2007-Present
2007-Present
2007-2013
2007-2013
2007-2011
2006-2012
2006-2010
2006-2009
2005-2011
2005-2013
2002-2007
2001-2006
2001-2002
1999-2002
Rachel Speer, University of Southern Maine, Accepted fall 2014 in lab now
Kelsey Thompson, University of Southern Maine, Dissertation in Progress
Cynthia Browning, University of Southern Maine, Dissertation in Progress
Carolyne LaCerte, University of Southern Maine, Dissertation in Progress
Kellie Joyce, University of Southern Maine
Seungbum Choi, University of Maine (Committee Member)
Julieta Martino, University of Southern Maine, Dissertation in Progress
Daniel Swett, University of Southern Maine (Committee Member)
Sandra Wise, University of Southern Maine
Qin Qin, University of Southern Maine
Jamie Young, University of Southern Maine
Tania Li Chen, University of Southern Maine
Emily Notch, University of Maine (Committee Member)
Oana Popa, Romania, (Committee Member)
Amie Holmes, University of Southern Maine
Laura Savery, University of Southern Maine
Hong Xie, University of Southern Maine
Jason Rohan, University of Wisconsin
Catherine Mendenhall, Yale University
Jennifer Rusiecki, Yale University
Doctoral Dissertations
2013
Laura Savery, "Global Assessment of Ocean Pollution Using Sperm Whales as an
Indicator Species".
2013
Qin Qin, "Characterizing the Impact of Prolonged Exposure to Particulate Hexavalent
Chromium on DNA Double Strand Break Repair".
2012
Sandra Wise, "Characterizing the Role of Chromosome Instability in Particulate
Hexavalent Chromium-Induced Carcinogenesis".
2012
Tania Li Chen, "Chromium is a Potential Health Concern for the North Atlantic Right
Whale and Sperm Whale".
11
2011
Amie Holmes, "Elucidating a Mechanism of Particulate Hexavalent Chromium-Induced
Carcinogenesis".
2007
Hong Xie, “Misrepair of Particulate Chromium(VI)-Induced DNA Double Strand
Breaks Leads to Neoplastic Transformation”.
Masters Students
2012-Present
Jason Stewart, University of Southern Maine, (Committee Member)
2012-Present
Melissa Sassman, University of Southern Maine, Thesis in Progress
2011-Present
Sean Raph, University of Southern Maine, Thesis in Progress
2011-2013
Erin Lawson, University of Southern Maine
2011-2013
Leah Smith, University of Southern Maine
2009-2012
Naga Priya Karri, University of Southern Maine
2008-2010
Gregory Ballard, University of Maine (Committee Member)
2007-2009
Fariba Shaffiey, University of Southern Maine
2007-2009
Carolyne LaCerte, University of Southern Maine
2007-2008
Joseph Keierleber, University of Southern Maine
2007
Allison Gurney, University of Southern Maine
2005-2007
Shouping Huang, University of Southern Maine
2005-2006
Marijke Grau, University Bremen, Bremen, Germany
2004-2006
Tania Li Chen, University of Lisbon, Lisbon, Portugal
2004-2007
Eric Camyre, University of Southern Maine
2005-2007
Danielle Miniutti, University of Maine (Committee Member)
2004-2005
Alison Farrington, University of Southern Maine (Committee Member)
2003-2004
Kimberly Brothers, University of Southern Maine (Committee Member)
2001-2002
Annie O'Neill, Yale University (Committee Member)
2001-2002
Alex Poljak, Yale University(Committee Member)
2001-2003
Yawei Zhang, Yale University
2000-2002
Aurelian Bidulescu, Yale University
2000-2002
Melissa Slotnick, Yale University
2000-2002
Zimra Gordon, Yale University (Committee Member)
2000-2002
Sarah Vogel, Yale University (Committee Member)
1998-2000
Benjamin Piper, Yale University
1998-2000
Jason Kim, Yale University
1999-2001
Alfred May, Jr., Yale University
1999-2000
Kathleen McCarty, Yale University
1999-2001
Molini Patel, Yale University (Committee Member)
Master’s Theses
2013
Erin Lawson, Master’s Thesis “Comparative Cytotoxicity and Genotoxicity of Nickel
Compounds in Sperm Whale and Human Skin Fibroblasts”.
2013
Leah J. Smith, Master’s Thesis “Cobalt-Induced Human Lung Cell Toxicity”.
2012
Naga Priya Karri, Master’s Thesis “The Role of Cdc20 in Particulate Hexavalent
Chromium-Induced Spindle Assembly Checkpoint Bypass”.
12
2009
Carolyne LaCerte, Master’s Thesis “Human Bronchial Epithelial Cells That Are
Morphologically and Phenotypically Altered by Depleted Uranium Exhibit Chromosome
Instability”.
2008
Joseph Keierleber, Master’s Thesis “Cytotoxic and Genotoxic effects of Zinc Chromate
on Human Lung Cells and the Role of Mre11 in the Repair of Chromium-Induced DNA
Double Strand Breaks”.
2007
Eric Camyre, Master’s Thesis “Ku80 Deficiency Does Not Affect Particulate ChromateInduced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells”.
2005
Marijke Grau, Master’s Thesis “Interindividual differences in the effects of hexavalent
chromium on the North Atlantic right whale (Eubalaena glacialis)”.
2005
Tania Li Chen, Master’s Thesis “Cytotoxicity and Genotoxicity of Mercury in the
North Atlantic Right Whale (Eubalaena glacialis)”.
2003
Alfred May, Master's Thesis with Honors “Differential Effects of Particulate and Soluble
Hexavalent Chromium on the Cell Cycle”.
2003
Yawei Zhang, Master's Thesis with Honors “Cigarette Smoking, Alcohol Consumption,
Glutathione S-Transferase P1 Genetic Polymorphism and Breast Cancer Risk”.
2002
Melissa Slotnick, Master's Thesis with Honors “Impact of Soil Lead on Blood Lead
Levels of Chicago Children”.
2002
Aurelian Bidulescu, Master's Thesis “A Comparison of Chromium (VI) Toxicity in
Three Cell Culture Models: Current Cell Culture Models Are Inadequate”.
2000
Jason Kim, Master's Thesis with Honors “Lead Poisoning and Lead Abatement
Procedure for New York City Children”.
2000
Benjamin Piper, Master's Thesis “Estimating Arsenic Contamination of Groundwater in
Bangladesh”.
Undergraduate Students
2013-Present
Alex Dalton (University of Southern Maine)
2013-Present
Christopher Poulin (University of New England)
2013
Stella Keck (Rice University)
2013-Present
Juliani Rodriguez (University of Puerto Rico, Rio Piedras)
2012-Present
Nicole Nutter (University of Southern Maine)
2012-2013
MacKenzie Sullivan (University of Southern Maine)
2012-Present
Alexandra Smith (University of Southern Maine)
2012-Present
Amanda Smith (University of Southern Maine)
2012
Jayson Richter (University of Southern Maine)
2012
Kevin O'Conner (Alfred University)
2012
Ben Garelick (University of Southern Maine)
2012
Amanda Pasquali (Texas State University)
2012
Jaimyal Lindsey (Mississippi Valley State College)
13
2012-2013
2011
2011
2011
2011
2011
2011
2011
2011-2012
2010-2011
2010
2010
2010-2012
2010
2010-2011
2010
2010-2012
2010-2011
2009-2011
2009-2010
2009-2010
2009-2013
2009-Present
2009
2009-2010
2009
2009
2009
2009
2009-2010
2008-2010
2008-Present
2008-2010
2008-2012
2007-2013
2007-2013
2008
2008
2007
2007-2008
2007-2008
2007-2008
2007
2006-2007
2005-2007
2005-2006
2005-2006
2005-2006
2005
2005
Madison Blackwell (Louisiana State University)
Ariel Kaplan (University of Southern Maine)
Rikki Kuech (University of Southern Maine)
Brady Kuech (University of Southern Maine)
Nick Tobat (University of Virginia)
Shanelle Dugan (University of Southern Maine)
Nora Daley (Middlebury College)
Nathan Polhemus (University of Southern Maine)
Melanie Hebert (Carleton University)
Jennifer Ditano (University of Southern Maine)
Allison Sample (Susquehanna University)
Alex Doering (Bowdoin College)
Sara Martin (Wellsley College)
Hillevi Jagerman (Tufts University)
Nicole Merrill (University of Southern Maine)
Emily Tupper (University of Maine)
Jana Sacco (University of Southern Maine)
Taylor Burgdorff (St. Mary’s College of Maryland)
David Kreps (University of Southern Maine)
Greg Lake (University of Southern Maine)
Greer Chapman (Bates College)
Jenny Huang (University of Pittsburgh)
Catherine Wise (University of Southern Maine)
Kate McPherson (University of Maine)
Adam Perez (University of Bridgeport)
Melissa Perez (University of Bridgeport)
Devon Dass (University of Bridgeport)
Marina Konta (University of Bridgeport)
Hiroyuki Nakahigashi (University of Bridgeport)
Jill Davenport (University of Southern Maine)
Rob Leighton (Merrimack University)
Matthew Braun (University of Southern Maine)
Jane McKay (University of Southern Maine)
Ryan Duffy (University of Southern Maine)
James Wise (University of Southern Maine)
John Pierce Wise, Jr. (University of Southern Maine)
Dennis Buehler (Cornell University)
Hamida Suja (University of Southern Maine)
Kamil Suja (Southern Maine Community College)
Mark Okeny (University of Southern Maine)
Sri Dhyana (University of Southern Maine)
Kellie Joyce (Drew University)
Kaitlynne Levine (Middlebury College)
Ruta Grebliunaite (University of Southern Maine)
Alex Bresler (University of Southern Maine)
Fariba Shaffiey (Bowdoin College)
Kevin Bui (University of Southern Maine)
Ian Slaymaker (University of Southern Maine)
Danielle Grondin (University of Southern Maine)
Erik Martin (University of Southern Maine)
14
2005
2005
2005
2005
2004-2007
2004-2005
2004
2004
2004
2004
2003-2005
2003-2004
2003
2003
2003
2003
2003
2002
2002
2002
2001-2002
2001-2002
2001-2002
1999-2002
2000-2001
Dalin Chan (Connecticut College)
Daniel Cooper (McGill University)
Imhoitseme Dako (University of Bridgeport)
Yuliana Bermudez (University of Southern Maine)
Megan Stackpole (University of Southern Maine)
Heather Throckmorton (University of Southern Maine)
Natalie Patzlaff (McGill University)
Jeff Chason (University of Southern Maine)
Annette Bodoky (University of Bridgeport)
Lindsay Brin (Swarthmore College)
Sarah Sandwick (University of Southern Maine)
Sonia Teufack (University of Bridgeport)
Jean-Francois Dufour (University of Southern Maine)
Molly Thompson (Wheaton College)
Nishad Jayasundra (College of the Atlantic)
Benjamin Smith (University of Southern Maine)
Darryl Whitney (University of Southern Maine)
Elena Fomchenko (University of Bridgeport)
Sunhee Mudgett (University of Bridgeport)
Julie Schuler (University of Bridgeport)
Amber Pincavage (Yale University)
Jason Sell (Yale University)
Elizabeth Tang (Yale University)
Peter Antonucci (Southern Connecticut State University)
Ellen Morrow (Yale University)
High School Teachers
2007-Present
Marni Bickford (Windham High School)
2012-Present
Mukhaye Muchimuti (Hyde School)
High School Students
2012
J. Conor Kennedy (Deerfield Academy)
2011-2013
Ashley Aube (Windham High School)
2011-2103
Cassandra Bickford (Windham High School)
2011-2013
Haley Plante (Windham High School)
2011-2012
Lauren Thurlow (Windham High School)
2011
Lydia Berman (Cape Elizabeth High School)
2011
Camille Braun (Cape Elizabeth High School)
2010-2011
Abigail Page (Greely High School)
2010
Thomas Moutinho (Gorham High School)
2010
Sarah Abromson (Falmouth High School)
2010
Malinka Jankowski (Portland High School)
2010
Sam Walker (Falmouth High School)
2010
Lizzie Canarie (South Portland High School)
2010
Er-Li Peng (South Portland High School)
2010
Dalton Burke (Bonny Eagle High School)
2010-2011
Stephen Adams (Windham High School)
2010
Maggie Kilgallon (Windham High School)
2010
Amber Verrill (Windham High School)
2010-2012
Talia McKay (Windham High School)
15
2009
2009
2009
2009
2009
2009-2010
2009-2010
2009-2010
2009-20111
2009-2011
2009-2011
2008-2010
2008-2010
2008-2010
2006-2009
2006-2009
2009
2009
2008-2009
2008
2008
2008
2007-2008
2007
2006-2007
2006-2007
2005
2004-2007
2004-2005
2003
2003
2002
2002-2003
2000-2001
Student Clubs
2009-Present
2009-Present
Field Work
2013
Ryan Gao (Falmouth High School)
Andrew Nelligan (Bonny Eagle High School)
Nathanial Chasse (Noble High School)
Chadwick Prichard (Falmouth High School)
Christine Agneta (Windham High School)
Sara Martin (Gorham High School)
Megan Stevenson (Windham High School)
Nicole Merrill (Windham High School)
Ben Richardson (Windham High School)
Beth Shively (Windham High School)
Emma Krieg (Windham High School)
Alex Doering (Windham High School)
Dan McGovern (Windham High School)
Allison Sample (Windham High School)
Jenny Huang (Portland High School)
Catherine Wise (Cheverus High School)
Greer Chapman (Portland High School)
Leah Fischer (Cape Elizabeth High School)
Joe Servadio (Scarborough High School)
Emily MacDuffie (Cape Elizabeth High School)
Robert Leighton (Deering High School)
Shannon Doherty (Cheverus High School)
Patrick Martin (Windham High School)
Nicholas Link (South Portland High School)
Mark Okeny (Cheverus High School)
James Wise (Cape Elizabeth High School)
Julien Demassey (Bonny Eagle High School)
John Pierce Wise, Jr. (Cheverus High School)
Raymond Monroe (Cheverus High School)
Thu Danh (Portland High School)
Tharjiath Ruot (Portland High School)
Matt Lankowski (Portland High School)
Kyle Schumm (Charter Oaks High School)
Bronwyn Bryant (Orono High School)
Faculty Sponsor (i.e. faculty advisor), New England Student Chapter of the
Society of Marine Mammalogy
Faculty Advisor, University of Southern Maine’s Toxicology and
Environmental Health student club
Sea turtle and fish research in Vieques, Puerto Rico
2013
Conducted scientific ballooning experiment in Lewiston-Auburn/Waterboro,
Maine.
2013
Conducted Alligator sampling expedition in South Carolina.
2013
Continued development of Vieques marine field research laboratory in Puerto Rico
16
2013
Conducted 2 day Alligator sampling expedition at Kennedy Space Center, Florida.
2012
Conducted scientific ballooning experiment in Sanford/New Gloucester, Maine.
2012
Conducted sample collecting in the Gulf of Maine during the fall season. Biopsies
were taken from fin, humpback and minke whales.
2012
Conducted three month voyage in deepwater in the Gulf of Mexico. Samples were
collected from marine life and the marine environment with a particular focus on
Bryde's, pilot and sperm whales. Voyage occurred from May through July.
2012
Conducted scientific ballooning experiment in Bethel/Chester, Maine.
2012
Began development of marine field research laboratory in Vieques, Puerto Rico
2011
Conducted sample collecting in the Gulf of Maine during the fall season. Biopsies
were taken from fin whale and humpback whales.
2011
Conducted three month voyage in deepwater in the Gulf of Mexico. Samples were
collected from marine life and the marine environment with a particular focus on
Bryde's and sperm whales. Voyage occurred from June through August.
2011
Conducted scientific ballooning experiment in Pittsfield, Maine.
2010
Conducted four-month voyage from Maine, in deepwater, in along the eastern
seaboard of the United States and through the Gulf of Mexico. Samples were
collected from marine life and the marine environment with a particular focus on
Bryde's and sperm whales. First voyage to successfully culture whale cells at sea.
Voyage occurred from July through November.
2008-2009
Conducted altered gravity research at Johnson Space Center, Houston, Texas.
Students flew experiments in microgravity in summer.
2005
Conducted sample collection from and observations of southern right whales in
Península Valdés, Argentina in fall.
2003-2006
Conducted sample collection and preparation from bowhead whales. A team of
staff and students worked on site with local Alaskan officials and natives to collect
tissue samples from subsistence hunted bowhead whales in fall months.
2000-2002
Conducted marine and marine-based biomedical research in summer months at
Mount Desert Island Biological Laboratory, Salisbury Cove Maine.
Public Lectures
2013
Public Presentation on Wise Laboratory Marine Research in Vieques. Vieques
Conservation and Historical Trust, Vieques, Puerto Rico.
2012
Panelist, Discussion on Silent Spring Revisited: 50 Years Later, Portland Public Library,
Portland, Maine.
17
2012
Public Presentation on Oil Toxicology in Whales, Curtis Library, Brunswick, Maine.
2012
Public Presentation on Wise Laboratory Marine Research in Vieques. Vieques
Conservation and Historical Trust, Vieques, Puerto Rico.
2010
Public Presentation on Metal Toxicology in Bowhead Whales, Nantucket Historical
Association, Nantucket, Massachusetts.
2000
Public Presentation on Metal Toxicology in Whales, Mount Desert Island Biological
Laboratory, Salisbury Cove, Maine.
Conferences
2013
Organizing Committee, Toxicology-2013, Las Vegas, California
2013
Judge, Student and New Investigator Poster Awards, Annual Meeting of the
Environmental Mutagenesis and Genomics Society.
2013
Chair, Poster Session titled “Metals II”, Annual Meeting of the Society of Toxicology.
2013
Symposium Chair, “The Toxicological Impact of Metals, Crude Oil, and Chemical
Dispersants from the Gulf of Mexico Oil Crisis on Human and Wildlife Health”, Annual
Meeting of American Association for the Advancement of Science (AAAS).
2012
Organizing Committee, 7th Conference on Metal Toxicity and Carcinogenesis,
University of New Mexico.
2012
Symposium Chair, “The Toxicological Impact of Metals, Crude Oil, and Chemical
Dispersants from the Gulf of Mexico Oil Crisis on Human and Wildlife Health”, Annual
Meeting of the Society of Toxicology. San Francisco, California.
2011
Chair, Poster Session titled “Toxicology of the Gulf Oil Spill”, Annual Meeting of the
Society of Toxicology.
2010
Organizing Committee, 6th Conference on Metal Toxicity and Carcinogenesis,
Lexington, Kentucky.
2010
Session Chair, "Applications of Aneuploidy Research", Triennial meeting of the EMBO
Workshop: Chromosome Segregation and Aneuploidy. Edinburgh, Scotland.
2009
Symposium Chair, “Aquatic Species as Sentinels for Human Health: Comparative
Toxicology of Metals, Nanoparticles and PCB's”, Annual Meeting of the Society of
Toxicology.
2006
Session Chair, “Aquatic Toxicology”, Annual Meeting of the Society of Environmental
Toxicology and Chemistry.
2006
Session Chair, 4th Conference on Molecular Mechanisms of Metal Toxicity and
Carcinogenesis.
18
2006
Session Chair, “Innovative Approaches in Environmental Toxicology”, Annual Meeting
of the North Atlantic Chapter of the Society of Environmental Toxicology and
Chemistry.
2005
Host and Co-organizer, Symposium, “Voyage of the Odyssey, Science Symposium”,
University of Southern Maine.
2005
Host and Co-organizer, Workshop, “Chromium and Human Health”, University of
Southern Maine.
2004
Host and Co-organizer, Annual Meeting, Northeast Chapter, Society of Toxicology,
University of Southern Maine.
2004
Co-organizer, Workshop, “Creating the Northeast Consortium of Aquatic Toxicology”,
University of Connecticut.
2004
Host and Co-organizer, Workshop/Conference,
Consortium”, University of Southern Maine.
2004
Co-organizer, Workshop/Conference, “Indoor Health and Environmental Tracking
Indicators: Focus on Schools”, University of New England.
2004
Session Chair, Workshop/Conference, “Exploring Potential Collaborative Research
in Human Health and Ecotoxicology Risks Using Medaka as a Model Organism”,
University of Georgia.
2003
Session Chair, Conference, “Annual Meeting Maine Biological and Biomedical Sciences
Symposium”, Mount Desert Island Biological Laboratory.
2002
Chair, Poster Session titled “Metal Toxicity”, 40th Annual Meeting of the Society of
Toxicology.
2001
Conference Director Workshop/Conference, "Generation of New Marine Cell Lines and
Transgenic Species", Mount Desert Island Biological Laboratory.
“Maine
Environmental
Health
Honors, Awards and Professional Activities:
Awards
2013
First Stanback Distinguished Lecturer, Duke Cancer Institute and the Duke
Nicholas School of the Environment, Duke University
2013
Keynote Speaker, Toxicology 2013 Annual Meeting
2013
Certificate of Appreciation, United States Environmental Protection Agency Gulf
Guardian Award Program
2012
Faculty Scholarship Award, School of School of Environmental, Health, and Life
Sciences, University of Southern Maine
2011
Candidate, 2012 Rolex award for the Environment
2010
Candidate, 2011 ENI award for the Environment
2009
Editor's Choice article for volume 50 issue 5 of Environmental and Molecular
Mutagenesis
2005
Faculty Scholarship Award, School of Applied Science, Engineering and
Technology, University of Southern Maine
19
2003
2000
1990-1993
1989
1988
1983
1982
Public Service Award, State of Connecticut
Host - Colgate-Palmolive Visiting Scientist Award
Presidential Merit Scholarship, George Washington University
Beta Beta Beta (national honor society in biology)
Alpha Chi and Golden Key (national honor society in academics)
Frank Preti Award (highest academic ranking for an athlete (13th in class)
Henry Wadsworth Longfellow Honor Society (national academic honor society)
Awards Received by Students
2013
Maine Space Grant Academic Year Internship (Catherine Wise)
2013
Maine Space Grant Academic Year Internship (Nicole Nutter)
2013
Best poster award of the 1st International Cell Death Research Congress (Zulal
Şekeroğlu).
2013
Outstanding student leader for the University of Southern Maine (John Pierce
Wise, Jr.), University of Southern Maine
2013
Outstanding graduate student of the year for the Maine Center for Toxicology and
Environmental Health (Leah Smith), University of Southern Maine
2012
Outstanding doctoral student of the year in Applied Medical Sciences (Tania Li
Chen), University of Southern Maine
2012
Outstanding graduate student of the year for the Maine Center for Toxicology and
Environmental Health (Tania Li Chen), University of Southern Maine
2012
Outstanding undergraduate student of the year for the Maine Center for Toxicology
and Environmental Health (James Wise), University of Southern Maine
2011
Greater Research Opportunities (GRO) fellowship from USEPA (Catherine Wise)
2011
Student Travel Award (Julieta Martino), Biennial Meeting of the Society of Marine
Mammalogy
2011
Student Travel Award (John Wise, Jr.), Biennial Meeting of the Society of Marine
Mammalogy
2011
Student Travel Award (John Wise, Jr.), Annual Meeting of the American Society
of Gravitational and Space Biology
2011
Outstanding doctoral student of the year in Applied Medical Sciences award
(Sandra Wise), University of Southern Maine
2011
Outstanding graduate student of the year for the Maine Center for Toxicology and
Environmental Health (Amie Holmes), University of Southern Maine
2011
Outstanding undergraduate student of the year for the Maine Center for Toxicology
and Environmental Health (Catherine Wise), University of Southern Maine
2011
Student Award for the PRIMO16 conference (John Wise, Jr.)
2011
Student Award for the PRIMO16 conference (Sandra Wise)
2011
Student Award for the PRIMO16 conference (James Wise)
2011
Student Award for the PRIMO16 conference (Catherine Wise)
2011
Maine Space Grant Academic Year Internship (John Wise, Jr.)
2010
Maine Space Grant Academic Year Internship (Catherine Wise)
2010
Maine Space Grant Academic Year Internship (Matthew Braun)
2010
Maine Space Grant Academic Year Internship (David Kreps)
2010
Maine Space Grant Academic Year Internship (John Wise, Jr.)
2010
Summer Undergraduate Research Fellowship, EAST fellowship (Greg Lake),
University of Southern Maine
2010
Summer Undergraduate Research Fellowship, EAST fellowship (Ryan Duffy),
University of Southern Maine
20
2010
2010
2010
2009
2009
2009
2009
2009
2009
2009
2009
2009
2009
2009
2009
2009
2009
2009
2008
2008
2008
2008
2008
2008-2009
2008
2008
2008
2008
2008
2007-2008
2007
2007
Outstanding doctoral student of the year in Applied Medical Sciences award (Amie
Holmes), University of Southern Maine
Outstanding graduate student of the year for the Maine Center for Toxicology and
Environmental Health (Sandra Wise), University of Southern Maine
Outstanding undergraduate student of the year for the Maine Center for Toxicology
and Environmental Health (John Wise, Jr.), University of Southern Maine
Society of Toxicology Undergraduate Travel Award (Ryan Duffy)
American Society for Gravitational and Space Biology Travel Award (John Wise,
Jr.)
Maine Space Grant Academic Year Internship (Catherine Wise)
Maine Space Grant Academic Year Internship (Ryan Duffy)
Maine Space Grant Academic Year Internship (James Wise)
Maine Space Grant Academic Year Internship (Jane McKay)
Maine Space Grant Academic Year Internship (John Wise, Jr.)
Summer Undergraduate Research Fellowship, EAST fellowship (Nathanial
Chasse), University of Southern Maine
MERITS award (Chadwick Prichard), Maine Space Grant Consortium
MERITS award (Christine Agneta), Maine Space Grant Consortium
Summer Undergraduate Research Fellowship, (John Wise, Jr.), University of
Southern Maine
Summer Undergraduate Research Fellowship, EAST fellowship (Ryan Duffy),
University of Southern Maine
Outstanding graduate student in Applied Medical Sciences award (Carolyne
LaCerte), University of Southern Maine
Poster Award (Ryan Duffy), Northeast Undergraduate Research and Development
Symposium
Research grant “Developing a Cytogenetic Biomarker for Chromate-Induced Lung
Cancer” awarded by the Maine Chapter of the American Lung Association (Sandra
Wise)
Student Travel Award (Julieta Martino), North Atlantic Chapter of the Society of
Environmental Toxicology and Chemistry
Student Travel Award (Tania Li Chen), North Atlantic Chapter of the Society of
Environmental Toxicology and Chemistry
MERITS award (Emily MacDuffie), Maine Space Grant Consortium
Undergraduate student travel award (Jane McKay), Society of Toxicology
Alternate for Undergraduate student travel award (James Wise), Society of
Toxicology
Microgravity University Grant (John Wise, Jr.), National Aeronautics and Space
Administration (NASA)
Maine Space Grant Academic Year Internship (Jane McKay)
Maine Space Grant Academic Year Internship (John Wise, Jr.)
Greater Research Opportunities (GRO) fellowship from USEPA (Jamie Young)
Poster Award, (Amie Holmes), Society of Toxicology awarded by the Northeast
Chapter
Delta Kappa Gamma International (Julieta Martino), World Fellowship. Delta
Kappa Gamma Society International.
Microgravity University Grant (John Wise, Jr.), National Aeronautics and Space
Administration (NASA)
Maine Space Grant Academic Year Internship (John Wise, Jr.)
Maine Space Grant Summer Internship (John Wise, Jr.)
21
2007
2007
2007
2007
2007
2006
2006
2005
2005
2005
2004
2004
2004
2004
Grant Review
2013-Present
2013-Present
2012-Present
2012-Present
2011
2011
2010
2010
2009
2008
2007
2006-2010
2006
2005-Present
2005-2010
2005-2010
Student Award, (Amie Holmes), 7th International Chromosome Segregation and
Aneuploidy Workshop
Greater Research Opportunities (GRO) fellowship from USEPA (Amie Holmes)
Poster Award, Second Place, (Hong Xie), Society of Toxicology awarded by the
Northeast Chapter
Poster Award, Third Place, (Megan Stackpole), Society of Toxicology awarded by
the Northeast Chapter
Fulbright Fellowship (Julieta Martino)
Maine Space Grant Academic Year Internship (Sarah Sandwick)
Maine Space Grant Academic Year Internship (Heather Throckmorton)
STAR fellowship from USEPA (Laura Savery)
Student Travel Award (Amie Holmes), Annual Meeting of the North Atlantic
Chapter of Society of Environmental Toxicology and Chemistry
Poster Award, Second Place, (Hong Xie), Annual Meeting of Society of
Toxicology
Poster Award, Second Place, (Sarah Sandwick), Annual Meeting of the Northeast
Chapter of the Society of Toxicology
Student Travel Award (Carrie Goertz), Annual Meeting of the International
Association of aquatic Animal Medicine
Poster Award, First Place, (Jon Moreland), Annual Meeting of the Northeast
Chapter of the Society of Toxicology
Summer Undergraduate Research Fellowship, (Sarah Sandwick), University of
Southern Maine
Grant Reviewer for National Institutes of Health (NIH), Systemic Injury by
Environmental Exposure Panel
Grant Reviewer, Nazarbayev University, Republic of Kazakhstan
Grant Reviewer, Pennsylvania Department of Health Commonwealth Universal
Research Enhancement Programs
Grant Reviewer, Italian Ministry of Health
Member, Connecticut Sea Grant Omnibus Independent Technical Review Panel
Grant Reviewer, New York University Environmental Health Sciences Center
Pilot Project Research Program
Grant Reviewer for RFA, ES09-011 Engineered Nanomaterials: Linking
Physical and Chemical Properties to Biology (U19), National Institute of
Environmental Health Sciences
Grant Reviewer for the Department of Defense, Army Research Office
Grant Reviewer for National Institutes of Health (NIH), National Institute of
General Medical Sciences (NIGMS), Minority Biomedical Research (MBRS)
program
Grant Reviewer for the National Aeronautics and Space Administration
(NASA)
Grant Reviewer for the Department of Defense (DOD)
Grant Reviewer for the Exxon Valdez Oil Spill Trustee Council (EVOS)
Grant Reviewer for INDO-US Science and Technology Forum, Smithsonian
Institution
Grant Reviewer for National Institutes of Health (NIH), Superfund program
Grant Reviewer for California Oiled Wildlife Care Network (OWCN)
Grant Reviewer for National Fish and Wildlife Foundation (NFWF)
22
2005-2010
2004-2010
2004
2004
2003
Grant Reviewer for National Oceanic and Atmospheric Administration (NOAA)
Grant Reviewer, Harvard University School of Public Health Pilot Project
Research Program
Grant Reviewer, The Wellcome Trust, United Kingdom
Grant Reviewer, Uniformed Services University Exploratory Research Program
Grant Reviewer, Science Center Program, United States Department of State
Manuscript Review
2013-Present
Peer Reviewer for the Journal of Hazardous Materials
2013-Present
Peer Reviewer for the Journal of Reproductive Medicine
2013-Present
Peer Reviewer for the Journal Environmental Toxicology and Pharmacology
2013-Present
Peer Reviewer for the Journal of Toxicology and Environmental Health
Sciences
2012-Present
Peer Reviewer for the Journal Molecular Carcinogenesis
2012-Present
Peer Reviewer for the Journal Critical Reviews in Toxicology
2012-Present
Peer Reviewer for the Journal Bulletin of Marine Science
2012-Present
Peer Reviewer for the Journal Cytotechnology
2012-Present
Peer Reviewer for the Journal of Environmental & Analytical Toxicology
2012-Present
Peer Reviewer for the Journal Indian Journal of Medical Research
2012-Present
Peer Reviewer for the Journal Nanotechnology, Science and Applications
2012-Present
Peer Reviewer for the Journal Science of the Total Environment
2011-Present
Peer Reviewer for the Journal Environmental Science & Pollution Research
2011-Present
Peer Reviewer for the Journal of Nanobiotechnology
2011-Present
Peer Reviewer for the Journal DNA Repair
2011-Present
Peer Reviewer for the Journal of Zhejiang University Science B: Biomedicine &
Biotechnology
2011-Present
Peer Reviewer for the Journal Nano Letters
2011-Present
Peer Reviewer for the Journal of Environmental Monitoring
2011-Present
Peer Reviewer for the Journal Environmental Health Perspectives
2010-Present
Peer Reviewer for the Journal International Journal of Nanomedicine
2010-Present
Peer Reviewer for the Journal BMC Public Health
2010-Present
Peer Reviewer for the Journal Toxicological Mechanisms and Methods
2010-Present
Peer Reviewer for the Journal Toxicological and Environmental Chemistry
2010-Present
Peer Reviewer for the Journal PLoS ONE
2010-Present
Peer Reviewer for the Journal Aquatic Mammals
2009-Present
Peer Reviewer for the Journal Cell Biology and Toxicology
2009-Present
Peer Reviewer for the Journal Aquatic Toxicology
2009-Present
Peer Reviewer for the Journal Environmental Toxicology
2009-Present
Peer Reviewer for the Journal Cancer Biomarkers
2008-2009
Peer Reviewer for the National Institute for Occupational Safety and Health
(NIOSH), Centers for Disease Control and Prevention document: “NIOSH
Criteria Document Update: Occupational Exposure to Hexavalent Chromium”
2008
Peer Reviewer for the Agency for Toxic Substances and Disease Registry
(ATSDR) document: “Toxicological Profile for Chromium”
2008-Present
Peer Reviewer for the Journal Toxicology and Applied Pharmacology
2008-Present
Peer Reviewer for the Journal Toxicology Letters
2008-Present
Peer Reviewer for the Journal Human & Experimental Toxicology
2008-Present
Peer Reviewer for the Journal Radiation and Environmental Biophysics
2008-Present
Peer Reviewer for the Journal Nanotoxicology
2008-Present
Peer Reviewer for the Journal Ecotoxicology and Environmental Safety
23
2007-Present
2007-Present
2007-Present
2006-Present
2006-Present
2006-Present
2005-Present
2005-Present
2005-Present
2005-Present
2004
2003-Present
2003-Present
2003-Present
2002-Present
2001-Present
2001-Present
1999-Present
1994-Present
1994-Present
Peer Reviewer for the Journal Organic Letters
Peer Reviewer for the Journal Environmental Toxicology and Chemistry
Peer Reviewer for the Journal Chemico-Biological Interactions
Peer Reviewer for the Journal Developmental Biology
Peer Reviewer for the Journal of Toxicology and Environmental Health
Peer Reviewer for the Journal Comparative Biochemistry & Physiology
Peer Reviewer for the Journal Chemosphere
Peer Reviewer for the Journal Environmental and Molecular Mutagenesis
Peer Reviewer for the Journal Thermochemica Acta
Peer Reviewer for the Journal Biochemical Pharmacology
Peer Reviewer for book “Sea Lions of the World”
Peer Reviewer for the Journal Fertility and Sterility
Peer Reviewer for Journal of Pharmacology & Experimental Therapeutics
Peer Reviewer for the Journal Chemical Research in Toxicology
Peer Reviewer for the Journal Toxicological Sciences
Peer Reviewer for the Journal of Biological Inorganic Chemistry
Peer Reviewer for the Journal Molecular and Cellular Biochemistry
Peer Reviewer for the Journal Mutation Research
Peer Reviewer for the Journal Carcinogenesis
Peer Reviewer for the Journal American Journal of Respiratory Cell and
Molecular Biology
Professional Memberships & Societies:
American Association for the Advancement of Science (AAAS)
American Association for Cancer Research (AACR)
American College of Toxicology (ACT)
American Society for Gravitational and Space Research (ASGSR)
American Thoracic Society (ATS)
Association of Marine Laboratories of the Caribbean (AMLC)
Environmental Mutagenesis and Genomics Society (EMGS)
Genetic Toxicology Association (GTA)
International Association for Aquatic Animal Medicine (IAAAM)
International Society for Stem Cell Research (ISSCR)
Society for Marine Mammalogy (SMM)
Society of Environmental Toxicology and Chemistry (SETAC)
Society for In Vitro Biology (SIVB)
Society of Toxicology (SOT)
Academic Committees:
University of Southern Maine
Active
2010-Present
Member, Senior Research Advisory Group
2009-Present
Faculty Advisor, University of
Environmental Health Student Club
2007-Present
Member, Steering Committee, University of Maine’s Graduate School of
Biomedical Sciences, for the University of Southern Maine
2003-Present
Member, Radiation Safety Committee
24
Southern
Maine’s
Toxicology
and
Service Completed
2010-2012
Provost's Consultant Selection Committee for OSP External Review
2010-2011
Member, Strategic Planning Committee #1 Implementation Task Force:
"Serving the needs and aspirations of 21st-century Maine"
2008-2010
Member, University of Southern Maine’s Budgetary Advisory Council
2008-2011
Member, School of Applied Science Engineering and Technology’s
Administrative Council
2008-2011
Member, School of Applied Science Engineering and Technology’s Executive
Advisory Council
2007-2008
Member, Admissions Committee, University of Maine’s Graduate School of
Biomedical Sciences, for the University of Southern Maine
2007-2008
Chair, Bioscience Resource Council, University of Southern Maine
2005-2007
Co-Chair Public Health Planning Committee for the Provost, University of
Southern Maine
2004-2007
USM Faculty Representative to University of Maine’s Graduate School of
Biomedical Sciences, University of Southern Maine
2004-2008
Member, Curriculum Committee, University of Maine’s Graduate School of
Biomedical Sciences, University of Southern Maine
2005-2006
Member, Interim Research Council for the Provost, University of Southern
Maine
2005
Member, Internal Advisory Panel for the Provost’s Assessment of Research,
Creative and Scholarly Activity of the University of Southern Maine
2002- 2005
Chair, Biosafety Committee, University of Southern Maine
2002-2003
Led successful effort to obtain a use of radioactive materials license (license
#05807) and to implement a radiation safety, use and control program at the
University of Southern Maine
2002-2003
Led successful effort to obtain a controlled substances license from the United
States Drug Enforcement Agency for materials used in toxicology studies at the
University of Southern Maine
2002- 2003
Member, Academic Program Review Committee
2002-2003
Member, Faculty Search Committee Biology/BRISM
25
Maine
Active
2008-Present
Member, State of Maine’s Medical Advisory Committee for The Maine Board
of Pesticides Control
2008-Present
Track leader (toxicology), Graduate School of Biomedical Sciences, University
of Maine
2007-Present
Member, Maine Innovation Economy Advisory Board
2007-Present
Member, Gulf of Maine Council’s Ecosystem Indicator Partnership (ESIP) contaminants group
2005-Present
Member, Maine Department of Agriculture’s Environmental Risk Advisory
Committee
Service Completed
2008
Member, Associate Professor of Pharmaceutics Faculty Search Committee,
Department of Pharmacy, School of Pharmacy, University of New England.
2008
Member, Associate Professor of Medicinal Chemistry Faculty Search
Committee, Department of Pharmacy, School of Pharmacy, University of New
England.
2006-2007
Member, Maine Governor’s Task Force for Safer Chemicals in Consumer
Products
2005-2007
Member, Committee to Develop Portland as a Marine City
2005-2008
Member, Maine Department of Economic and Community Development’s
Maine Science and Technology Advisory Board
2005-2010
Member, Research Advisory Group, Maine Chapter, American Lung
Association
2003-2011
Member, Maine State Department of Environmental Protection’s Surface Water
Ambient Toxics monitoring program
2003- 2004
Member, Steering committee for Indoor Air Quality Research Forum, Maine
Chapter, American Lung Association
Yale
2001-2002
2001-2002
Chair, Division Environmental Health Science Curriculum Committee,
Department of Epidemiology and Public Health, Yale University School of
Medicine.
Member, Admissions Committee, Department of Epidemiology and Public
Health, Yale University School of Medicine
26
2001-2002
Member, Faculty Search Committee, Division of Emerging Microbial Diseases,
Department of Epidemiology and Public Health, Yale University School of
Medicine.
2000-2002
Member, Disciplinary Committee, Department of Epidemiology and Public
Health, Yale University School of Medicine
2000-2002
Member, Safety and Security Committee, Department of Epidemiology and
Public Health, Yale University School of Medicine
1999-2000
Member, Doctoral Committee, Department of Epidemiology and Public Health,
Yale University School of Medicine
1999-2000
Chairman of Faculty Search Committee, Division of Environmental Health
Sciences, Department of Epidemiology and Public Health, Yale University
School of Medicine.
1998-1999
Member, Distance Learning Committee, Department of Epidemiology and
Public Health, Yale University School of Medicine.
MDIBL
2001-2002
2000
Member, Search Committee, Mount Desert Island Biological Laboratory.
Co-Chair of Steering Committee, Workshop/Conference "Generation of New
Marine Cell Lines and Transgenic Species", Mount Desert Island Biological
Laboratory.
Continuing Education Coursework
2013
Oil Spill Preparedness Workshop
2011
Development of Standardized Procedures for Cetacean Dart Biopsy Sampling Workshop
2010
Comparative Biology of the Lung
2009
Toxicology Excellence for Risk Assessment’s (TERA’s) Dose Response Assessment
Boot Camp
2009
Evaluation of Toxicity to Male and Female Reproductive Systems: Biology, Study
Design and Data Interpretation
2005
Fundamentals of Nanotechnology
2005
Developmental Toxicology
2004
Neurotoxicology
2003
Genomic and Proteomic Array Formats on the Cutting Edge
2001
Molecular Epidemiology
2000
Genomics and Proteomics: A Practical “How To” For Toxicologists
1997
Use of Benchmark Dose in Risk Assessment
1997
Toxicology of Agents: Metals
1995
DNA Binding Proteins
1995
Methods in High Pressure Liquid Chromatography
Meetings Attended (current year and previous 5 years)
2009 Keystone Symposium on Genome Instability and Repair
Annual Meeting of the Society of Toxicology (SOT)
Thinking Matters, USM’s student research day
27
2010
2011
2012
2013
Biennial Meeting of the Society for Marine Mammalogy (SMM)
2nd USAF ASC/AFRL ESOH Nanomaterials Workshop
Annual Meeting of the American Society for Gravitational and Space Biology (ASGSB)
Annual Meeting of the Society of Toxicology (SOT)
Thinking Matters, USM’s student research day
Annual Meeting of the American Association for Cancer Research (AACR)
8th International Chromosome Segregation and Aneuploidy Workshop
Strategic Environmental Research and Development Program (SERDP) and
Environmental Security Technology Certification Program's (ESTCP) 6th Annual Partners
in Environmental Technology Technical Symposium & Workshop
11th National Conference on Science, Policy and the Environment "Our Changing
Oceans". National Council for Science and the Environment
Keystone Symposium on Genomic Instability and Repair
Annual Meeting of the Society of Toxicology (SOT)
Thinking Matters, USM’s student research day
16th International Symposium on Pollutant Responses in Marine Organisms (PRIMO)
35th Scientific Conference of the Association of Marine Laboratories of the Caribbean
(AMLC)
Annual Meeting of the American Society for Gravitational and Space Biology (ASGSB)
Biennial Meeting of the Society for Marine Mammalogy (SMM)
Annual Meeting of the Society of Toxicology (SOT)
Thinking Matters, USM’s student research day
Annual Meeting of the American Association for Cancer Research (AACR)
Annual Meeting of the International Association of Aquatic Animal Medicine (IAAAM)
Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC)
Annual Meeting of the American Association for the Advancement of Science (AAAS)
Keystone Symposium on Genomic Instability and Repair
Annual Meeting of the Society of Toxicology (SOT)
Annual Meeting of the International Association of Aquatic Animal Medicine (IAAAM)
6th Aquatic Animal Models for Human Disease
Annual Meeting of the Environmental Mutagen and Genomics Society (EMGS)
2nd International Summit on Toxicology
Publications
Journals and Book Chapters
1. Wise, J.P., Leonard, J.C. and Patierno, S.R. Clastogenicity of Lead Chromate Particles in
Hamster and Human Cells. Mutation Research, 278: 69-79, 1992.
2. Xu, J., Wise, J.P. and Patierno, S.R. DNA Damage Induced by Carcinogenic Lead Chromate
Particles in Cultured Mammalian Cells. Mutation Research, 280: 129-136, 1992.
3. Wise, J.P., Orenstein, J.M. and Patierno, S.R. Inhibition of Lead Chromate Clastogenesis by
Ascorbate: Relationship to Particle Dissolution and Uptake. Carcinogenesis, 14: 429-434, 1993.
4. Clawson, G. A., Norbeck, L.L., Wise, J.P. and Patierno, S.R. An Inhibitor of Nuclear
Scaffold Protease Blocks Chemically Induced Transformation of Embryonic Fibroblasts. Cell
Growth and Differentiation, 4: 589-594, 1993.
28
5. Wise, Sr., J.P., Stearns, D.M., Wetterhahn, K.E. and Patierno, S.R. Cell-Enhanced
Dissolution of Carcinogenic Lead Chromate Particles: The Role of Individual Dissolution
Products in Clastogenesis. Carcinogenesis, 15: 2249-2254, 1994.
6. Manning, F.C.R., Blankenship, L., Wise, J.P., Xu, J., Bridgewater, L.C. and Patierno, S.R.
Induction of Internucleosomal Fragmentation by Carcinogenic Chromate: Relationship to
Genotoxicity, Cell Cycle Delay and Inhibition of Macromolecular Synthesis. Environmental
Health Perspectives, 102: 159-167, 1994.
7. Patierno, S.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C. and Manning, F.C.R.
Genotoxin-Induced Apoptosis: Implications for Carcinogenesis. In: Hu, V.W. (Ed), The Cell
Cycle: Regulators, Targets and Clinical Applications. Plenum Press, pp. 331-340, 1994.
8. Stearns, D.M., Wise, Sr., J.P., Patierno, S.R. and Wetterhahn, K.E. Chromium (III) Picolinate
Produces Chromosome Damage in Chinese Hamster Ovary Cells. The FASEB Journal, 9: 16431648, 1995.
9. Blankenship, J.J., Carlisle, D., Wise, Sr., J.P., Orenstein, J.M., Dye, L.E. and Patierno, S.R.
Induction of Apoptotic Cell Death by Particulate Lead Chromate: Differential Effects of Vitamins
C and E on Genotoxicity and Survival. Toxicology and Applied Pharmacology, 146: 270-280,
1997.
10. Wise, Sr., J.P. and Stearns, D.M. Chromium carcinogenicity: The Roles of Valence State and
Solubility. The Occupational and Environmental Medicine Report (The OEM Report), 11(11):
100-103, 1997.
11. Borak J. and Wise, J.P. DNA-Protein Crosslinks as Biomarkers of Formaldehyde Exposure.
International Journal of Occupational and Environmental Health, 3(4): 307, 1997.
12. Borak J. and Wise, Sr., J.P. Does Aluminum Exposure of Pregnant Animals Lead to
Accumulation in Mothers or Their Offspring? Teratology, 57: 127-139, 1998.
13. Wise, J. and Lechner, J.F. Normal Human Bronchial Epithelial Cell Culture. Chapter 8 in
Freshney, R.I. and Freshney, M.G. (eds.) Culture of Epithelial Cells: A Manual of Technique.
Wiley Inc, New York, NY. 2001.
14. Wise, Sr., J.P., Winn, R.N. and Renfro, J.L. Generating New Marine Cell Lines and
Transgenic Species. Journal of Experimental Zoology, 292: 271-220, 2002.
15. Wise, Sr., J.P., Wise, S.S. and Little, J.E. The Cytotoxicity and Genotoxicity of Particulate
and Soluble Hexavalent Chromium in Human Lung Cells. Mutation Research, 517: 221-229,
2002.
16. Rabinowitz, P.M., Wise, Sr., J.P., Mobo, B.H., Antonucci, P.G., Powell, C. and Slade, M.
Antioxidant status and hearing function in noise-exposed workers. Hearing Research,173: 164171, 2002.
17. Zheng, T., Holford, T.R., Zahm, S.H., Owens, P.H., Boyle, P., Zhang, Y., Wise, Sr., J.P.,
Stephenson, L.P. and Ali-Osman, F. Cigarette Smoking, Glutathione S-Transferase M1 and T1
Genetic Polymorphisms and Breast Cancer Risk (United States). Cancer Causes Control, 13: 637645, 2002.
29
18. Zheng, T., Holford, T.R., Zahm, S.H., Owens, P.H., Boyle, P., Zhang, Y., Wise, Sr., J.P. and
Ali-Osman, F. Glutathione S-transferase M1 and T1 Genetic Polymorphisms, Alcohol
Consumption and Breast Cancer Risk. British Journal of Cancer, 88: 58-62, 2003.
19. Zheng, T., Boyle, P., Zhang, B., Zhang, Y., Owens, P.H., Lan, Q. and Wise, J. Tobacco Use and
Risk of Oral Cancer . In: Boyle P, ed. Tobacco: The public health disaster of the 20th century. Oxford
University Press, Oxford, UK., 2003.
20. Wise, S.S., Elmore, L.W., Holt, S.E., Little, J.E., Antonucci, P.G., Bryant, B.H. and Wise, Sr.,
J.P. Telomerase-Mediated Lifespan Extension of Human Bronchial Cells Does Not Affect
Hexavalent Chromium-Induced Cytotoxicity or Genotoxicity. Molecular and Cellular
Biochemistry, 255: 103-111, 2004.
21. Wise, S.S., Schuler, J.H.C., Katsifis, S.P. and Wise, Sr., J.P. Barium Chromate Is Cytotoxic
and Genotoxic to Human Lung Cells. Environmental and Molecular Mutagenesis, 42: 274-278,
2004.
22. Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P.,
Thompson, W.D. and Wise, Sr., J.P. Chromium Is the Proximate Clastogenic Species for Lead
Chromate-Induced Clastogenicity in Human Bronchial Cells. Mutation Research, 560: 79-89,
2004.
23. Wise, S.S., Schuler, J.H.C., Holmes, A.L., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J.,
Zheng T. and Wise, Sr., J.P. A Comparison of Two Carcinogenic Particulate Hexavalent
Chromium Compounds: Barium Chromate Is More Genotoxic than Lead Chromate in Human
Lung Cells. Environmental and Molecular Mutagenesis, 44: 156-162, 2004.
24. Zhang, Y, Wise, Sr., J.P., Holford, T.R., Xie, H., Boyle, P., Zahm, S.H., Zou, K.Y., Zhang B.,
Owens, P.H., Zheng, T. Serum Polychlorinated Biphenyls, Cytochrome P4501A1 Polymorphisms
and Risk of Breast Cancer in Connecticut Women. American Journal of Epidemiology, 160(12):
1177-1183, 2004.
25. Xie, H., Holmes, A.L., Wise, S.S., Gordon, N. and Wise, Sr., J.P. Lead Chromate-Induced
Chromosome Damage Requires Extracellular Dissolution to Liberate Chromium Ions but Does
Not Require Particle Internalization or Intracellular Dissolution. Chemical Research in
Toxicology, 17(10): 1362-1367, 2004.
26. Holmes, A.L., Wise, S.S., Xie, H., Gordon, N., Thompson W.D. and Wise, Sr., J.P. Lead Ions
Do Not Cause Human Lung Cells to Escape Chromate-Induced Cytotoxicity. Toxicology and
Applied Pharmacology, 203: 167-176, 2005.
27. Xie, H., Wise, S.S., Holmes, A.L., Xu, B., Wakeman, T., Pelsue, S.C., Singh, N.P. and Wise,
Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks in Human Lung
Cells. Mutation Research, 586(2): 160-172, 2005.
28. Wise, S.S., Holmes, A.L., Moreland, J.A., Xie, H., Sandwick, S.J., Stackpole, M.M.,
Fomchenko, E., Teufack, S., May, Jr., A.J., Katsifis, S.P. and Wise, Sr., J.P. Human Lung Cell
Growth Is Not Stimulated by Lead Ions after Lead Chromate-Induced Genotoxicity. Molecular
and Cellular Biochemistry, 279(1-2): 75-84, 2005.
30
29. Grlickova-Duzevik E., Wise, S.S., Munroe, R.C., Thompson, W.D. and Wise, J.P., Sr.
XRCC1 Protects against Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in
Chinese Hamster Ovary Cells. Toxicological Sciences, 92(1): 96-102, 2006.
30. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., Thompson W.D. and
Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and
Aneuploidy in Human Lung Cells. Cancer Research, 66(8): 4041-4048, 2006.
31. Wise, Sr., J.P., Goertz, C.E.C., Wise, S.S., Morin, A.T., Dunn, J.L., Gulland, F.M.D., Bozza,
M., Atkinson, S. and Thompson, W.D. Chromium Cytotoxicity in Steller Sea Lion Lung, Skin
and Testes Cells. In Trites, A.W., Atkinson, S.K., DeMaster, D.P., Fritz, L.W., Gelatt, T.S., Rea,
L.D. and Wynne, K.M. (Eds.), Sea Lions of the World Conservation and Research in the 21st
Century. Alaska Sea Grant College Program, pp. 57-68, 2006.
32. Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and
Wise, Sr., J.P. Benzo[a]pyrene Cytotoxicity in Right Whale (Eubalaena glacialis) Skin, Testis
and Lung Cell Lines. Marine Environmental Research, 62: S20-S24, 2006.
33. Duzevik, E.G., Wise, S.S., Munroe, R.C., Thompson, W.D. and Wise, Sr., J.P. XRCC1
Protects against Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in Chinese
Hamster Ovary Cells. Toxicological Sciences, 92(2): 409-415, 2006.
34. Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. Particulate and Soluble Hexavalent Chromium
Are Cytotoxic and Genotoxic to Human Lung Epithelial Cells. Mutation Research, 610(1-2): 2-7,
2006.
35. Holmes, A.L., Wise, S.S., Sandwick, S.J. and Wise, Sr., J.P. The Clastogenic Effects of
Chronic Exposure to Particulate and Soluble Cr(VI) in Human Lung Cells. Mutation Research,
610(1-2): 8-13, 2006.
36. Grlickova-Duzevik, E., Wise, S.S., Munroe, R.C., Thompson, W.D. and Wise, Sr., J.P.
XRCC1 Protects Cells from Chromate-Induced Chromosome Damage, but Does Not Affect
Cytotoxicity. Mutation Research, 610(1-2): 31-37, 2006.
37. Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D. and Wise, Sr., J.P. Chronic Exposure to
Particulate Chromate Induces Spindle Assembly Checkpoint Bypass in Human Lung Cells.
Chemical Research in Toxicology, 19(11):1492-1498, 2006.
38. Wise, Sr., J.P. Genotoxic and Carcinogenic Effects of Lead. In, U.S. EPA. Air Quality
Criteria for Lead (Final). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R05/144aF-bF, 5-125 – 5-147, 2006.
39. Savery, L.C., Grlickova-Duzevik, E., Wise, S.S., Thompson, W.D., Hinz, J.M., Thompson,
L.H. and Wise, Sr., J.P. Role of the Fancg Gene in Protecting Cells from Particulate ChromateInduced Chromosome Instability. Mutation Research, 626(1-2): 120-127, 2007.
40. Camrye, E., Wise, S.S., Milligan, P., Gordon, N., Goodale, B., Stackpole, M., Patzlaff, N.,
Aboueissa, A. and Wise, Sr., J.P. Ku80 Deficiency Does Not Affect Particulate Chromate-
31
Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells. Toxicological
Sciences, 97(2): 348-54, 2007.
41. Wise, S.S., Thompson, W.D., Aboueissa, A., Mason, M.D. and Wise, Sr., J.P. Particulate
Depleted Uranium Is Cytotoxic and Clastogenic to Human Lung Cells. Chemical Research in
Toxicology, 20(5): 815-820, 2007.
42. Zhang, Y., Holford, T.R., Leaderer, B., Boyle, P., Zhu, Y., Wang, R., Zou, K., Zhang, B.,
Wise, Sr., J.P., Qin, Q., Kilfoy, B., Han, J. and Zheng, T. Ultraviolet Radiation Exposure and
Risk of Non-Hodgkin’s Lymphoma. American Journal of Epidemiology, 165(11): 1255-64, 2007.
43. Stackpole, M.M., Wise, S.S., Goodale, B.C. Duzevik, E.G., Munroe, R.C., Thompson, W.D.,
Thacker, J., Thompson, L.H., Hinz, J.M. and Wise, Sr., J.P. Homologous Recombination
Protects Against Particulate Chromate-Induced Genomic Instability in Chinese Hamster Cells,
Mutation Research, 625: 145-154, 2007.
44. Xie, H., Holmes, A.L., Wise, S.S., Huang, S., Peng, C. and Wise, Sr., J.P. Neoplastic
Transformation of Human Bronchial Cells by Lead Chromate Particles, American Journal of
Respiratory Cell and Molecular Biology, 37(5): 544-552, 2007.
45. Xie, H., Wise, S.S. and Wise, Sr., J.P. Deficient Repair of Particulate Chromate-Induced
DNA Double Strand Breaks Leads To Neoplastic Transformation. Mutation Research, 649: 230238, 2008.
46. Wise, Sr., J.P., Wise, S.S, Kraus, S. Shaffiey, F., Grau, M., Li Chen, T., Perkins, C.,
Thompson, W.D., Zheng, T., Zhang, Y., Romano, T. and O’Hara, T. Hexavalent Chromium Is
Cytotoxic and Genotoxic to the North Atlantic Right Whale (Eubalaena glacialis) Lung and
Testes Fibroblasts. Mutation Research, 650: 30–38, 2008. (PMID: 18006369)
47. Goodale, B.C., Walter, R., Pelsue, S.R., Thompson, W.D., Wise, S.S., Winn, R.N., Mitani, H.
and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium in Medaka
(Oryzias latipes) Cells. Aquatic Toxicology, 87: 60–67, 2008.
48. Brooks, B., O’Brien, T.J., Ceryak, S., Wise, Sr., J.P., Wise, S.S., Wise, Jr., J.P., DeFabo, E.
and Patierno, S.R. Excision Repair is Required for Genotoxin-Induced Mutagenesis in
Mammalian Cells. Carcinogenesis, 29(5): 1064–1069, 2008.
49. Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. Hexavalent chromium-induced DNA damage
and repair mechanisms. Reviews on Environmental Health, 23(1): 39-57, 2008.
50. Holmes, A.L., Wise, S.S., Goertz, C.E.C., Dunn, J.L., Gulland, F.M.D., Gelatt, T., Beckmen,
K.B., Burek, K., Atkinson, S., Bozza, M., Taylor, R., Zheng, T., Zhang, Y., Aboueissa , A. and
Wise, Sr., J.P. Metal Tissue Levels in Steller Sea Lion (Eumetopias jubatus) Pups. Marine
Pollution Bulletin, 56(8): 1416-1421, 2008.
51. Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Carcinogenicity of hexavalent chromium. Indian
Journal of Medical Research, 128: 353-372, 2008.
52. Wise, Sr., J.P., Wise, S.S., Goodale, B.C., Shaffiey, F., Kraus, S. and Walter, R.B. Medaka
(Oryzias latipes) as a Sentinel Species for Aquatic Animals: Medaka Cells Exhibit a Similar
32
Genotoxic Response as North Atlantic Right Whale Cells. Comparative Biochemistry and
Physiology, Part C, 149: 210–214, 2009.
53. Xie, H., Holmes, A.L., Young, J.L., Qin, Q., Joyce, K, Pelsue, S.C., Peng, C., Wise, S.S.,
Jeevarajan, A., Wallace, W.T., Hammond, D. and Wise, Sr., J.P. Zinc Chromate Induces
Chromosome Instability and DNA Double Strand Breaks in Human Lung Cells. Toxicology and
Applied Pharmacology, 234: 293–299, 2009.
54. Ierardia, J.L., Manciab, A., McMillan, J., Lundqvist, M.L., Romano, T.A., Wise, Sr., J.P.,
Plant, A. and Warr, G.W. Sampling the Skin Transcriptome of the North Atlantic Right Whale.
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 4: 154–158, 2009.
55. Wise, J.P. Hexavalent Chromium Compounds. In: Schwab M. (Ed.). Encyclopedia of Cancer,
2nd ed. pp. 1374-1387. Springer, Berlin Heidelberg New York. 2009.
56. Wise, S.S., Shaffiey, F, LaCerte, C., Goertz, C,E.C., Dunn, J.L., Gulland, F.M.D., Aboueissa,
A., Zheng, T. and Wise, Sr., J.P. Particulate and Soluble Hexavalent Chromium Are Cytotoxic
and Genotoxic to Steller Sea Lion Lung Cells. Aquatic Toxicology, 91(4): 329-335, 2009.
57. Wise, Sr., J.P., Payne, R., Wise, S.S., LaCerte, C., Wise, J., Gianios, Jr., C., Thompson,
W.D., Perkins, C., Zheng, T., Zhu, C., Benedict, L. and Kerr, I. A Global Assessment of
Chromium Pollution using Sperm Whales (Physeter macrocephalus) as an Indicator Species.
Chemosphere, 75: 1461–1467, 2009.
58. Li Chen, T., Wise, S.S., Kraus, S., Shaffiey, F., Grau, M., Thompson, W.D., Zheng, T.,
Zhang, Y., Romano, T., O’Hara, T. and Wise, Sr., J.P. Particulate Hexavalent Chromium Is
Cytotoxic and Genotoxic to the North Atlantic Right Whale (Eubalaena glacialis) Lung and Skin
Fibroblasts. Environmental and Molecular Mutagenesis, 50: 387-393, 2009. (PMID: 19230002)
59. Alley, D. F., Gordon, N. R., Langley-Turnbaugh, S., Wise, Sr., J.P., Van Epps, G. and
Jalbert, A. The Effect of PM10 on Human Lung Fibroblasts. Toxicology and Industrial Health,
25: 111–120, 2009.
60. Li Chen, T., Wise, S.S., Holmes, A., Shaffiey, F., Wise, Jr., J.P., Thompson, W.D., Kraus, S.
and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Hexavalent Chromium in Human and North
Atlantic Right Whale (Eubalaena glacialis) Lung Cells. Comparative Biochemistry and
Physiology - Part C: Toxicology & Pharmacology, 150(4): 487-494, 2009. (PMID: 19632355)
61. Jones, B.A., Christensen, A., Wise, Sr., J.P. and Yu, H. Glutathione S-transferase
polymorphisms and survival in African-American and White colorectal cancer patients. Cancer
Epidemiology, 33(3-4): 249-256, 2009.
62. Wise, S.S., Holmes, A.L., Qin, Q., Xie, H., Katsifis, S., Thompson, W.D. and Wise, Sr., J.P.
Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in
Human Bronchial Cells. Chemical Research in Toxicology, 23(2): 365-372, 2010 (PMID:
20000473).
63. Xie, H., LaCerte, C., Thompson, W.D. and Wise, Sr., J.P. Depleted Uranium Induces
Neoplastic Transformation in Human Lung Epithelial Cells. Chemical Research in Toxicology,
23(2): 373-378, 2010. (PMID: 20000475)
33
64. Holmes, A.L., Wise, S.S., Pelsue, S.C., Aboueissa, A., Lingle, W., Salisbury, S., Gallaher, J.
and Wise, Sr., J.P. Chronic Exposure to Zinc Chromate Induces Centrosome Amplification and
Spindle Assembly Checkpoint Bypass in Human Lung Fibroblasts. Chemical Research in
Toxicology, 23(2): 386-395, 2010 (PMID: 20030412).
65. LaCerte, C., Xie, H., Aboueissa, A. and Wise, Sr., J.P. Particulate Depleted Uranium Is
Cytotoxic and Clastogenic to Human Lung Epithelial Cells. Mutation Research, 697: 33–37,
2010. (PMID: 20172046)
66. Wise, Sr., J.P., Goodale, B.C., Wise, S.S., Craig, G., Pongan A.F., Walter, R.B., Thompson,
W.D., Ng, A.K., Aboueissa, A.M., Mitani, H., Spalding, M.J. and Mason, M.D. Silver
Nanospheres Are Cytotoxic and Genotoxic to Fish Cells. Aquatic Toxicology, 97: 34–41, 2010.
(PMID: 20060603)
67. Wise Jr., J.P., Wise, S.S., Wise, J., McKay, J., Browne, M., Joyce, K., Braun, M., Wise, C.F.,
Duffy, R., Estell, E., Brown, J., Gianios Jr., C., Mason, M., Shehata, T., Hammond, D.,
Thompson, W.D. and Wise, Sr., J.P. Altered Gravity Exacerbates Chromate-Induced
Genotoxicity. Gravitational and Space Biology, 23(2): 83-84, 2010.
68. Wise, Sr., J.P., Wise, S.S., Holmes, A.L., LaCerte, C., Shaffiey, F, and Aboueissa, A. The
Cytotoxicity and Genotoxicity of Hexavalent Chromium in Steller Sea Lion Lung Fibroblasts
Compared to Human Lung Fibroblasts. Comparative Biochemistry and Physiology - Part C:
Toxicology & Pharmacology, 152(1): 91-98, 2010. (PMID:20211760)
69. Holmes, A.L. and Wise, Sr., J.P. Mechanisms of Metal-Induced Centrosome Amplification.
Biochemical Society Transactions, 38(6): 1687-1690, 2010. (PMID: 21118148)
70. Wise, S.S. and Wise, Sr., J.P. Aneuploidy as an Early Mechanistic Event in Metal
Carcinogenesis. Biochemical Society Transactions, 38(6): 1650-1654, 2010. (PMID: 21118142)
71. Wise, Sr., J.P., Wise, S.S., LaCerte, C. and Aboueissa, A. The Genotoxicity of Particulate
and Soluble Chromate in Sperm Whale (Physeter macrocephalus) Skin Fibroblasts.
Environmental and Molecular Mutagenesis, 52: 43-49, 2011. (PMID: 20839228)
72. Markowski, V.P., Currie, D., Reeve, E.A., Thompson, W.D. and Wise, Sr., J.P. TissueSpecific and Dose-Related Accumulation of Arsenic in Mouse Offspring Following Maternal
Consumption of Arsenic-Contaminated Water. Basic & Clinical Pharmacology & Toxicology,
108: 326-332, 2011. (PMID: 21205216)
73. Ali, A., Ma, Y., Reynolds, J., Wise, Sr., J.P., Inzucchi, S.E. and Katz, D.L. Chromium Effects
on Glucose Tolerance, Insulin Sensitivity and Vascular Function in People at Risk for Diabetes.
Endocrine Practice, 17(1):16-25, 2011. (PMID:20634174)
74. Wise, S.S. and Wise, Sr., J.P. Letter to the Editor. Toxicology, 285: 81–82, 2011.
75. Wise, Sr., J.P., Thompson, W.D., Wise, S.S., LaCerte, C., Wise, J., Gianios, Jr., C., Perkins,
C., Zheng, T., Benedict, L., Mason, M., Payne, R. and Kerr, I. A Global Assessment of Gold,
Titanium, Strontium and Barium Pollution using Sperm Whales (Physeter macrocephalus) as an
34
Indicator Species. Journal of Ecosystem and Ecography, 1(1):1-9, 2011. doi:10.4172/21577625.1000101.
76. Xie, H., Mason, M.M. and Wise, Sr., J.P. Genotoxicity of Metal Nanoparticles. Reviews on
Environmental Health, 26(4): 251-268, 2011. (PMID: 22435324)
77. Wise, J. and Wise, Sr., J.P. A Review of the Toxicity of Chemical Dispersants. Reviews on
Environmental Health, 26(4): 281-300, 2011. (PMID: 22435326)
78. Li Chen, T., Wise, S.S., LaCerte, C., Martino, J., Wise, Jr., J.P., Thompson, W.D. and Wise,
Sr., J.P. The Comparative Genotoxicity of Particulate and Soluble Chromate in Sperm Whale
(Physeter macrocephalus) and Human Skin Fibroblasts. Comparative Biochemistry and
Physiology - Part C: Toxicology & Pharmacology, 155: 143–150, 2012. (PMID: 21466859)
79. LaCerte, C. and Wise, Sr., J.P. The Potential Threat of Genotoxic Metals to Marine Mammal
Health: A Case Study of Chromium Toxicity in Toothed and Baleen Whales in Aquatic Animals,
Biology, Habitats, and Threats. Chapter 3, pp 77-97, in Eder D.L. (ed.) Aquatic Animals:
Biology, Habitats and Threats. Nova Science Publishers Inc., Hauppauge, NY. 2012.
80. Wise, J.P. Hexavalent Chromium Compounds. In: Schwab M. (Ed.). Encyclopedia of Cancer,
3rd ed. Springer, Berlin Heidelberg New York. 2012.
81. Wise, S.S. and Wise, Sr., J.P. Chromium and Genomic Instability. Mutation Research, 733:
78– 82, 2012. (PMID: 22192535)
82. Kost, G.C., Patierno, S.R., , Wise, S.S., Holmes, A.L., Wise, Sr., J.P. and Ceryak, S.
PTP inhibition enhances chromosomal stability after genotoxic stress: Decreased CIN at the
expense of enhanced GIN? Mutation Research, 735: 51– 55, 2012. (PMID: 22583656)
83. Holmes, A.L. and Wise, Sr., J.P. Aneuploidy: Mechanisms, Cancer and the Role of
Environmental Pollutants. Chapter 1, pp. 1-33 in de Rossi, S. and Bianchi, F. (eds.) Aneuploidy:
Etiology, Disorders and Risk Factors. Nova Science Publishers Inc., Hauppauge, NY. 2012.
84. Wise, C.F., Wise, Jr., J.P., Wise, S.S. and Wise, Sr., J.P. Skin Biopsy Applications in Free
Ranging Marine Mammals: A Case Study of Whale Skin Biopsies as a Valuable and Essential
Tool for Studying Marine Mammal Toxicology and Conservation. Chapter 5, pp. 109-122 in
Romero, A. and Keith, E.O. (eds.) New Approaches to the Study of Marine Mammals. InTech,
Rijeka, Croatia. 2012.
85. Savery, L.C., Evers, D., Wise, S.S., Falank, C., Wise, J., Gianios, Jr., C., Kerr, I., Payne, R.
Thompson, W.D., Perkins, C., Zheng, T., Zhu, C., Benedict, L. and Wise, Sr., J.P. Global
Mercury and Selenium Concentrations in Skin from Free-Ranging Sperm Whales (Physeter
macrocephalus). Science of the Total Environment, 450–451: 59–71, 2013.
86. Pabuwal, V., Boswell, M., Pasquali, A., Wise, S.S., Kumar, S., Shen, Y., Garcia, T., LaCerte,
C., Wise, Jr., J.P., Wise, Sr., J.P., Warren, W. and Walter, R.B. Transcriptomic Analysis of
Cultured Whale Skin Cells Exposed to Hexavalent Chromium [Cr(VI)]. Aquatic Toxicology, 134135: 74-81, 2013.
35
87. Savery, L.C., Wise, S.S., Falank, C., Wise, J., Gianios, Jr., C., Thompson, W.D., Perkins, C.,
Mason, M.D., Payne, R. Kerr, I. and Wise, Sr., J.P. A Global Assessment of Silver Pollution
using Sperm Whales (Physeter macrocephalus) as an Indicator Species. Journal of Environmental
and Analytical Toxicology, 3 (2):169-177, 2013. http://dx.doi.org/10.4172/2161-0525.1000169.
88. Karri, N.P., Xie, H. and Wise, Sr., J.P. Chronic Exposure to Particulate Hexavalent
Chromium Alters Cdc20 Protein Localization, Interactions and Expression. Journal of
Carcinogenesis & Mutagenesis, 4(2): 140-147, 2013.
http://dx.doi.org/10.4172/2157-2518.1000140.
89. Wise, Sr., J.P. and Qin, Q. Hexavalent Chromium and DNA, Biological Implications of
Interaction. In: Kretsinger, R.H., Uversky, V.N. and Permyakov, E.A. (Eds.). Encyclopedia of
Metalloproteins. 1st ed. Springer, New York. 2013. DOI 10.1007/978-1-4614-1533-6. ISBN 9781-4614-1532-9
90. Holmes, A.L., The, T., Thompson, K., Mason, M., Kandpal, S., Zheng, T., and Wise, Sr., J.P.
Chronic Exposure to Particulate Nickel Induces Neoplastic Transformation in Human Lung
Epithelial Cells. Toxics, 1(1): 46-59, 2013. doi:10.3390/toxics1010046
91. Martino, J. Wise, S.S., Perkins, C., Sironi, M. and Wise, Sr., J.P. Metal Levels in Southern
Right Whales (Eubalaena australis) from Península Valdés, Argentina. Journal of Environmental
and Analytical Toxicology, 3(6): 190-195, 2013. doi: 10.4172/2161-0525.1000190
92. Xie, H., Huang, S. Martin, S. and Wise, Sr., J.P. Arsenic is Cytotoxic and Genotoxic to
Primary Human Lung Cells. Mutation Research, 760: 33-41, 2014.
93. Savery, L.C., Wise, S.S., Falank, C., Wise, J., Gianios, Jr., C., Thompson, W.D., Perkins, C.,
Zheng, T., Zhu, C., and Wise, Sr., J.P. Global Assessment of Oceanic Lead Pollution using
Sperm Whales (Physeter macrocephalus) as an Indicator Species. Marine Pollution Bulletin,
79(1-2): 236–244, 2014.
94. Savery, L.C., Wise, J.T.F., Wise, S.S., Falank, C., Gianios, Jr., C., Thompson, W.D., Perkins,
C., Zheng, T., Zhu, C., and Wise, Sr., J.P. Global Assessment of Arsenic Pollution Using Sperm
Whales (Physeter macrocephalus) as an Emerging Aquatic Model Organism. Comparative
Biochemistry and Physiology - Part C: Toxicology & Pharmacology. In Press.
95. Wise, Jr., J.P., Wise, J., Wise, C.F., Wise, S.S., Gianios, Jr. ,C., Xie, H., Thompson, W.D.,
Perkins, C. Falank, C. and Wise, Sr., J.P. Concentrations of the Genotoxic Metals, Chromium
and Nickel, in Whales, Tarballs, Oil Slicks and Released Oil from the Gulf of Mexico in the
Immediate Aftermath of the Deepwater Horizon Oil Crisis: Is Genotoxic Metal Exposure Part of
the Deepwater Horizon Legacy? Environmental Science and Technology. In Press.
96. Holmes, A.L., Joyce, K., Falank, C., Xie, H. Hinz, J. and Wise, Sr., J.P. The Impact of
Homologous Recombination Repair Deficiency on Depleted Uranium Clastogenicity in Chinese
Hamster Ovary Cells: XRCC3 Protects Cells from Chromosome Aberrations, but Increases
Chromosome Fragmentation. In Press.
97. Wise, C.F., Wise, J.T.F., Wise, S.S., Thompson, W.D., Wise, Jr., J.P. Wise, Sr., J.P.
Chemical Dispersants used in the Gulf of Mexico Oil Crisis Are Cytotoxic and Genotoxic to
Sperm Whale Skin Cells. Submitted.
36
98. Qin, Q., Xie, H., Wise, S.S., Browning, C.L., Thompson, K.N., Holmes, A.L., and Wise, Sr.,
J.P. Homologous Recombination Repair Signaling in Chemical Carcinogenesis: Prolonged
Particulate Hexavalent Chromium Exposure Suppresses the Rad51 Response in Human Lung
Cells. Submitted.
99. Carnero, A., Blanco-Aparicio, C., Kondoh, H., Lleonart, M., Martinez-Leal, J.F., Mondello,
C., Scovassi, A.I., Wise, Sr., J.P., Wise, S.S., and Yasaey, H. Assessing the Carcinogenic
Potential of Low Dose Exposures to Chemical Mixtures in the Environment: Replicative
immortality. Submitted.
100. Smith, L.J., Holmes, A., Mason, M., Zheng, T., and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Soluble and Particulate Cobalt in Human Lung Fibroblast Cells. Submitted.
101. Wise, S.S., Xie, H., Fukuda, T., and Wise, Sr., J.P. Particulate and Soluble Hexavalent
Chromium Are Genotoxic to Hawksbill (Eretmochelys imbricata) Sea Turtle Cells. In
Preparation.
102. Wise, S.S., Holmes, A.L., Hebert, M., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity
of Hexavalent Chromium in Human Bladder Urothelial Cells. In Preparation.
103. Browning, C., Mason, M., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of
Titanium Dioxide Nanoparticle in Human Skin Cells. In Preparation.
104. Wise, C.F., Wise, J., Wise, S.S., and Wise, Sr., J.P. Toxicity of Alaskan Oil and Chemically
Dispersed Alaskan Oil in Sperm Whale (Physeter macrocephalus) Skin Cells. In Preparation.
105. Wise, Jr., J.P., Xie, H., Mason, M., Jeevarajan, A., Wallace, W., Hammond. D., Shehata, T.
and Wise, Sr., J.P. Comparative Toxicity of Earth Dust and Simulated Lunar and Martian Dusts
in Human Lung Fibroblast Cells. In Preparation.
106. Wise, S.S., Wise, C.F., Xie, H., Wise, Jr., J.P., Guillette, Jr., L.J., and Wise, Sr., J.P.
Particulate and Soluble Hexavalent Chromium Are Genotoxic to American Alligator (Alligator
Mississippiensis) Scute Cells. In Preparation.
107. Wise, C.F., Wise, S.S., and Wise, Sr., J.P. Fin Whale Cells Show a High Tolerance for
Particulate and Soluble Hexavalent Chromium Genotoxicity. In Preparation.
109. Şekeroğlu, Z.A., Holmes, A.L. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of
Cobalt-Chromium Nanoparticles in Human Bladder Epithelial Cells. In Preparation.
109. Falank, C., and Wise, Sr., J.P. Chronic Exposure to Particulate Hexavalent Chromium
Disrupts Shugoshin1 (Sgo1) Localization in Human Lung Cells Resulting a Chromosome
Cohesion Defect. In Preparation.
110. Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D. and Wise, Sr., J.P. Repeated Particulate
Chromate Exposure Induces Chromosome Instability, a DNA Double Strand Break RepairDeficient Phenotype, and Neoplastic Transformation in Human Lung Cells. In Preparation.
37
111. Martino, J., Holmes, A.L., Xie, H., Nigg, E. and Wise, Sr., J.P. Particulate Hexavalent
Chromium Causes Centrosome Separation by Activating the Kinase Nek2A. In Preparation.
112. Browning, C.L., Xie, H., Qin, Q., Masson, J.Y., and Wise, Sr., J.P. Prolonged Exposure to
Particulate Chromate Inhibits Homologous Recombination Repair Proteins. In Preparation.
114. Thompson, K.N., Qin, Q., Browning, C., Wise, S.S., Xie, H., Holmes, A.L., and Wise, Sr.,
J.P. Prolonged Exposure to Particulate Chromate Induces a Switch from Homologous
Recombination Repair to Non-Homologous End Joining Repair in Human Lung Cells. In
Preparation.
114. Stewart J., Nutter N., Wise, Sr., J.P. and Xie H. Additive Effect of Arsenic on Hexavalent
Chromium Cytotoxicity and Genotoxicity in Human Lung Cells. In Preparation.
115. Raph, S., Browning, C.L., Xie, H., Qin, Q., Masson, J.Y., and Wise, Sr., J.P. The impact of
DNA Double Strand Break Repair Deficiency on Cobalt Clastogenicity. In Preparation.
116. Sassman, M., Wise, S.S. and Wise, Sr., J.P. Particulate Nickel Is Cytotoxic and Genotoxic
to Sperm Whale (Physeter Macrocephalus) cells. In Preparation.
117. Bank, M.S., Crocker, J., Wachtl, J., Kleeman, P., Currens, C., Fellers, G., May, J., Hothem,
R., Madej, M.A. and Wise, Sr., J.P. Mercury Speciation and Exposure in Giant Salamanders
from Lotic Ecosystems in the Pacific Northwestern United States. In Preparation.
118. Martino, J., Xie, H., Mason, M., Jeevarajan, A., Wallace, W., Hammond. D., Shehata, T. and
Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Simulated Lunar Dusts and Models of Its
Component Particles in Human Lung Fibroblast Cells. In Preparation.
Reports
1. O’Hara, T., Hoekstra, P., Rosa, C., Dehn, L., Muir, D., Woshner, V., Wise, J.P, Sr., Ylitalo,
G., Wetzel, D. and Bratton, G. Bowhead whale contaminants: A review of current state of
knowledge and possible future research directions. SC/56/E1 at the International Whaling
Commission Scientific Committee, 2004.
2. Wise, Sr., J.P. Lobster Shell Disease Workshop. Environmental contaminants: A potential
confounding factor to lobster shell disease in the American lobster (Homarus americanus)
Aquatic Forum Series 05-1. Tlusty, M.F., Halvorson, H.O., Smolowitz, R. and Sharma, U. (eds.)
New England Aquarium, Boston, Massachusetts, 2005.
3. Wise, Sr., J.P., Kerr, I.A. and Payne, R. The Voyage of the Odyssey: A Journey of Discovery,
2009.
4. Wise, Jr., J.P. and Wise, Sr., J.P. Education Outreach Program - Effects of Altered Gravity on
Cellular Function in NASA/TM-2010-216132, C-9 and Other Microgravity Simulations Summary
Report, prepared by Space Life Sciences Directorate, Human Adaptation and Countermeasures
Division, NASA Johnson Space Center, Houston, September, 2010.
38
5. Martino, J. Wise, S.S., Perkins, C., Kerr, I., Rowntree, V.J., Sironi, M. and Wise, Sr., J.P.
Metal levels in southern right whale (Eubalaena australis) skin biopsies from Península Valdés,
Argentina. SC/64/BRG7 at the International Whaling Commission Scientific Committee, 2012.
Abstracts
1. Patierno, S.R., Dirscherl, L. and Wise, J.P. Mitogenesis and Clastogenesis of Particulate
Metal Carcinogens in Respiratory Epithelial Cells. The FASEB Journal, Abstracts, 5: 7156, 1991.
2. Wise, J.P., Leonard, J.C. and Patierno, S.R. Clastogenesis of Lead Chromate (PbCrO4)
Particles in Hamster and Human Cells. Proceedings of the American Association for Cancer
Research, 32: 635, 1991.
3. Wise, J.P., Xu, J. and Patierno, S.R. Relationship of Chromate-Induced DNA Damage to
Chromosomal Aberrations. The Toxicologist, 12: 1201, 1992.
4. Manning, FC.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C. and Patierno, S.R.
Induction of Apoptosis by Carcinogenic Chromate: Relationship to Genotoxicity, Cell Cycle
Delay and Inhibition of Macromolecular Synthesis. Proceedings, Second International Meeting on
Molecular Mechanisms of Metal Toxicity and Carcinogenicity, 1993.
5. Wise, J.P., Orenstein, J.M. and Patierno, S.R. Inhibition of Lead Chromate Clastogenesis by
Ascorbate: Relationship to Particle Dissolution and Uptake. Proceedings of the American
Association for Cancer Research, 34: 3316, 1993.
6. Stearns, D.M., Wise, J.P. Sr., Patierno, S.R. and Wetterhahn, K.E. The Dietary Supplement
Chromium Picolinate Induces Chromosome Damage in Chinese Hamster Ovary Cells. The
FASEB Journal Abstracts, 9(3): A451, 1995.
7. Blankenship, L.J., Wise, J.P., Orenstein, J.M. and Patierno, S.R. Vitamin Pretreatment
Protects Cells from Chromium-Induced Apoptosis without Decreasing Chromium-Induced DNA
Adducts. Proceedings of the American Association for Cancer Research, 36: 68, 1995.
8. Wise, Sr., J.P., Caporasso, N.E., Trivers, G.E., Tucker, M.A., Trump, B.F., Harris, C.C. and
Shields, P.G. Glutathione-S-Transferase Theta (GST-T) and Lung Cancer Risk. Proceedings of
the American Association for Cancer Research Conference on Cancer Susceptibility Genes and
Molecular Carcinogenesis Meeting, February 1996.
9. Wise, Sr., J.P., Caporasso, N.E., Trivers, G.E., Tucker, M.A., Trump, B.F., Harris, C.C. and
Shields, P.G. The relationship of Glutathione-S-Transferase Theta (GST-T) Polymorphism to
Lung Cancer Risk. Proceedings of the American Association for Cancer Research, 37: 1784,
1996.
10. Hussain, S.P., Amstad, P., Ambs, S., Bennett, W.P., Wise, Sr., J.P., Harrington, A., Shields,
P.G. and Harris, C.C. P53 Mutation Load Is Increased in Ulcerative Colitis, a Cancer-Prone
Disease. Proceedings of the American Association for Cancer Research, 37: 963, 1996.
11. May, Jr., A.J., Wise, S.S., Stearns, D.M., Ketterer, M.E. and Wise, Sr., J.P. Particulate
Hexavalent Chromium and Human Health in The Arctic. Proceedings of the American
Association for the Advancement of Science Meeting, September 1999.
39
12. May, Jr., A.J., Wise, S.S., Stearns, D.M., Ketterer, M.E. and Wise, Sr., J.P. Differential
Effects of Particulate and Soluble Hexavalent Chromium on the Cell Cycle. Proceedings of the
American Association for Cancer Research Conference on the Genetic and Functional
Consequences of Cell Cycle Alteration in Cancer, October 1999.
13. Rabinowitz, P.M., Wise, Sr., J.P., Antonucci, P.G. and Mobo, B.H. Glutathione-STransferase M1 (GSTM1) and T1(GSTT1) as Predictors of Susceptibility to High Frequency
Hearing Changes in Noise-Exposed Workers. Proceedings of the Environmental Carcinogenesis
Population Risk and Genetic Susceptibility Meeting, October, 2000.
14. Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H. and Wise, Sr., J. P. A
Human Bronchial Cell Model for Lung Carcinogens. Proceedings of the Northeast Society of
Toxicology Meeting, October 2000.
15. Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H. and Wise, Sr., J. P.
Establishing a Human Bronchial Cell Culture Model for Lung Carcinogens. Proceedings of the
American College of Toxicology Annual Meeting, November 2000.
16. Wise, S.S., Ketterer, M.E., Antonucci, P. G. and Wise, Sr., J.P. Genotoxic Effects of
Particulate and Soluble Cr(VI) in a Human Bronchial Cell Culture Model. Environ Mol Mutagen,
37: 80, 2001.
17. Wise, Sr., J.P., Wise, S.S., Elmore, L.W., Antonucci, P.G. and Holt, S.E. Establishing
Continuous Human Cell Lines with hTERT. Proceedings of the Mount Desert Island Biological
Laboratory Meeting on Marine Models, May 2001.
18. Wise, Sr., J.P., Wise, S.S. and St. Aubin, D.J. Establishing Continuous Cell Lines in Three
Marine Species Delphinus delphius, Tursiops truncatus and Delphinapterus leucas. Proceedings
of the Mount Desert Island Biological Laboratory Meeting on Marine Models, May 2001.
19. Wise, Sr., J.P., Wise, S.S. and St. Aubin, D.J. Establishing Cultures of Bronchial Cells from
the Common Dolphin (Delphinus delphis). Society of Environmental Toxicology and Chemistry
(SETAC) Abstracts, p. 158, 2001.
20. Bidulescu, A, Wise, S.S., May, A., Tang, E.R., Bryant, B.H., Schumm, K.R. and Wise, Sr.,
J.P. A Comparison of Chromium Toxicity in Three Cell Culture Models. Proceedings of the
Northeast Society of Toxicology (NESOT) Annual Meeting, November 2001.
21. Wise, S.S. and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Particulate and Soluble
Hexavalent Chromium in Human Bronchial Cells. Proceedings of the Northeast Society of
Toxicology (NESOT) Annual Meeting, November 2001.
22. Wise, Sr., J.P., Antonucci, P.G. and Bryant, B.H. Toxicology of Hexavalent Chromium in
Five Marine Animals: Bowhead Whale, (Balaena mysticetus), Beluga Whale (Delphinapterus
leucas), Little Skate (Raja erinacea), Spiny Dogfish (Squalus acanthias) and the Killifish
(Fundulus heteroclitus). The Bulletin, Mount Desert Island Biological Laboratory, 40: 29-30,
2001.
40
23. Bidulescu, A., Wise, S.S., May, A., Tang, E.R., Bryant, B.H., Schumm, K.R. and Wise, Sr.,
J.P. Hexavalent Chromium Toxicity in Human Lung Cells, Chinese Hamster Ovary Cells and
A549 Cells: Current Cell Culture Models Are Inadequate. Toxicological Sciences, 66(S): 32
(150), 2002.
24. Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H. and Wise, Sr., J. P. A
New Human Bronchial Cell Culture Model for Investigating Metal-Induced Lung Carcinogenesis.
Toxicological Sciences, 66(S): 32 (151), 2002.
25. Antonucci, P.G., Wise, S.S., Pincavage, A., Singh, N.P. and Wise, Sr., J.P. Cytotoxicity and
Genotoxicity of Cr(VI) in Human Bronchial Cells. Toxicological Sciences 66(S): 32 (152), 2002.
26. Little, J.E., Wise, S.S. and Wise, Sr., J.P. The Genotoxicity of Particulate and Soluble
Hexavalent Chromium in Human Bronchial Cells. Toxicological Sciences, 66(S): 32 (LB16),
2002.
27. Barnes, D.W., Forrest Jr., J.N., Wise, Sr., J.P. and Winn, R.N. Derivation of Continuous
Marine Cell Lines for Model Systems in Toxicology and Cell Biology The Bulletin, Mount
Desert Island Biological Laboratory, 41: 45-47, 2002.
28. Wise, Sr., J.P., Antonucci, P.G., Holt, S.E., Elmore, L.W., Forrest Jr., J.N., Boyer, J. and
Bryant, B.H. Establishing Cell Lines In Four Marine Species: Bowhead Whale, (Balaena
mysticetus), Beluga Whale (Delphinapterus leucas), Little Skate (Raja erinacea) and Spiny
Dogfish (Squalus acanthias). The Bulletin, Mount Desert Island Biological Laboratory, 41: 4849, 2002.
29. Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Little, J.E., Bryant, B.H. and Wise,
Sr., J. P. Establishing a New Lung Cell Culture Model for Studying Carcinogenic Metals.
Proceedings of the 2nd Conference on Molecular Mechanisms of Metal Toxicity and
Carcinogenesis, September, 2002.
30. Holmes, A.L., Wise, S.S., Ketterer, M.E., Xie, H., Hartsock, W.J., Shuler, J.H.C., Katsifis,
S.P. and Wise, Sr., J.P. Barium Chromate Is More Potent Than Lead Chromate in Human
Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting,
November 2002.
31. Shuler, J.H.C., Wise, S.S., Katsifis, S.P. and Wise, Sr., J.P. The Cytotoxicity and
Clastogenicity of Barium Chromate in Human Bronchial Cells. Proceedings of the Northeast
Society of Toxicology (NESOT) Annual Meeting, November 2002.
32. Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A.,
Fomchenko, E., Katsifis, S.P. and Wise, Sr., J.P. Lead Chromate-Induced Cell Cycle Arrest
Progresses From G1 to S-Phase Arrest With Increasing Concentrations. Proceedings of the
Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.
33. Lynch, J.P., Little, J.E., Wise, S.S., Slotnick, M.J and Wise, Sr., J.P. Comparative
Genotoxicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Proceedings of the
Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.
41
34. Xie, H., Wise, S.S., Holmes, A.L, Ketterer, M.E., Hartsock, W.J. and Wise, Sr., J.P. Particle
Dissolution Is Necessary For Lead Chromate-Induced Genotoxicity in Human Bronchial Cells.
Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.
35. Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P. and
Wise, Sr., J.P. Lead Chromate-Induced Genotoxicity Is Mediated by Chromium and Not Lead in
Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual
Meeting, November 2002.
36. Wise, S.S., Elmore, L.W., Holt, S.E., Little, J.E., Bryant, B.H. and Wise, Sr., J. P. Ectopic
Expression of hTERT in Human Bronchial Cells Extends Cellular Lifespan without Affecting
Hexavalent Chromium-Induced Cytotoxicity or Genotoxicity. Proceedings of the American
Association for Cancer Research Conference on the Role of Telomeres and Telomerase in Cancer,
December, 2002
37. Wise, Sr., J.P., Holmes, A. L., Wise, S.S., Little, J.A., Xie, H., Bozza, M., Moreland, St.
Aubin, D.J., J.A., Dunn, J.L., Atkinson, S., Gulland, F. and Bursian, S. Hexavalent Chromium
Cytotoxicity Is Organ and Species Specific for Steller Sea Lion and Mink Cells. Proceedings of
the EVOS-GEMS/GLOBE /NMFS Steller Sea Lion Research Symposium, January 2003.
38. Holmes, A.L., Wise, S.S., Ketterer, M.E., Xie, H., Hartsock, W., Shuler, J., Katsifis, S. and
Wise, Sr., J.P. Comparative Genotoxicity of Two Particulate Hexavalent Chromium Compounds
in Human Bronchial Cells. Toxicological Sciences, 72(S): 218, 2003.
39. Wise, S.S., Holmes, A, Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S. and Wise,
Sr., J.P. Chromium Is the Proximate Genotoxic Species in Lead Chromate-Induced
Clastogenicity in Human Bronchial Cells. Toxicological Sciences, 72(S): 217, 2003.
40. Shuler, J.H.C., Wise, S.S., Katsifis, S. and Wise, Sr., J.P. Barium Chromate is Cytotoxic and
Clastogenic to Human Bronchial Cells. Toxicological Sciences, 72(S): 218, 2003.
41. Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A.,
Fomchenko, E., Katsifis, S.P. and Wise, Sr., J.P. The Phase of Lead Chromate Induced Cell
Cycle Arrest Is Concentration Dependent. Toxicological Sciences, 72(S): 218, 2003.
42. Little, J.E., Wise, S.S., Slotnick, M.J and Wise, Sr., J.P. Cytotoxicity and Clastogenicity of
Arsenic, Cadmium and Chromium in Human Bronchial Cells. Toxicological Sciences, 72(S): 219,
2003.
43. Xie, H, Wise, S.S., Holmes, A, Ketterer, M.E., Hartsock, W.J. and Wise, Sr., J.P. Lead
Chromate Genotoxicity Is Mediated by Particle Dissolution and Not Particle Internalization.
Toxicological Sciences, 72(S): 217, 2003.
44. Goertz, C.E.C., Wise, S.S., Dunn, J.L. and Wise, Sr., J.P. Cell Culture, Toxicology and
Stranded Marine Mammals Proceedings of the Maine Biotechnology Association Annual
Meeting, April, 2003.
45. Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A.,
Fomchenko, E., Katsifis, S.P. and Wise, Sr., J.P. The Phase of Lead Chromate Induced Cell
42
Cycle Arrest Is Concentration Dependent. Proceedings of the Maine Biotechnology Association
Annual Meeting, April, 2003.
46. Goertz, C.E.C., Wise, S.S., Dunn, J.L. and Wise, Sr., J.P. Cell Culture, Toxicology and
Stranded Marine Mammals. Proceedings of the Northeast Region Stranding Network, April,
2003.
47. Lynch, J.P., Little, J.E., Wise, S.S., Slotnick, M.J. and Wise, Sr., J.P. Comparative
Genotoxicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Proceedings of the
Maine Biological and Medical Sciences Annual Symposium, April, 2003.
48. Xie, H., Wise, S.S., Holmes, A.L, Ketterer, M.E., Hartsock, W.J. and Wise, Sr., J.P. Particle
Dissolution Is Necessary for Lead Chromate-Induced Genotoxicity in Human Bronchial Cells.
Proceedings of the Maine Biological and Medical Sciences Annual Symposium, April, 2003.
49. Holmes, A.L., Goertz, C.E.C., Wise, S.S., Little, J.E., Moreland, J.A., Bozza, M., St. Aubin,
D.K., Dunn, J.L., Atkinson, S., Gulland, F. and Wise, Sr., J.P. Cell Culture and Toxicology of
Marine Mammals. Proceedings of the Maine Biological and Medical Sciences Annual
Symposium, April, 2003.
50. Wise, S.S., Goertz, C.E.C., Little, J.E., Bozza, M., St. Aubin, D.K., Dunn, J.L., Atkinson, S.,
Gulland, F and Wise, Sr., J.P. Metal Toxicity in Cultured Steller Sea Lion Fibroblasts.
Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine,
35: 140, 2003.
51. Wise, Sr., J.P., Wise, S.S., Goertz, C.E.C., Thompson, M., Smith, B., O’Hara, T., St. Aubin,
D.K. and Dunn, J.L. Comparative Chemical Carcinogenesis of Environmental Contaminants in
Balaenidae Whales (Balaena mysticetus and Eubalaena glacialis) and Humans: Bowhead Whales
Are Resistant to Hexavalent Chromium. Proceedings of the Aquatic Animal Models of Human
Disease Conference, September 30, 2003.
52. Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F., Jayasundara, N., Bozza, M,
Atkinson, S. and Wise, Sr., J.P. Comparative Cytotoxicity of Hexavalent Chromium in Humans
and Steller Sea Lions. Proceedings of the Northeast Society of Toxicology (NESOT) Annual
Meeting, November 2003.
53. Diaz, W.C., Wise, S.S. and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Depleted
Uranium in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology
(NESOT) Annual Meeting, November 2003.
54. Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F., Morin, A.T., Jayasundara, N., Bozza, M.,
Atkinson, S. and Wise, Sr., J.P. Sodium Chromate and Cadmium Chloride Toxicity in Steller Sea
Lion Dermal, Renal, Bronchial and Testicular Cells. Proceedings of the Northeast Society of
Toxicology (NESOT) Annual Meeting, November 2003.
55. Moreland, J.A., Teufack, S., Sandwick, S., Dufour, J-F., Wise, S.S., Holmes, A.L., Ketterer,
M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P. and Wise, Sr., J.P. Particulate Hexavalent
Chromium-Induced Cell Cycle Arrest Is Mediated by Cr Ions. Proceedings of the Northeast
Society of Toxicology (NESOT) Annual Meeting, November 2003.
43
56. Wise, S.S., Holmes, A.L., Thompson, M., Smith, B.E., O’Hara, T. and Wise, Sr., J.P.
Cytotoxicity of Particulate and Soluble Hexavalent Chromium in Bowhead Whale and Human
Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting,
November 2003.
57. Xie, H., Holmes, A.L., Wise, S.S., Gordon, N. and Wise, Sr., J.P. Lead Chromate Releases
Extracellular Cr Ions That Produce Its Clastogenic Effects. Proceedings of the Northeast Society
of Toxicology (NESOT) Annual Meeting, November 2003.
58. Wise, Sr., J.P., Wise, S.S., Goertz, C.E.C., Bozza, M., St. Aubin, D.K., Dunn, J.L.,
Atkinson, S. and Gulland, F. Toxicity of Heavy Metals in Cultured Steller Sea Lion Cells.
Proceedings of the Society of Environmental Toxicology and Chemistry, November, 2003.
59. Goertz, C.E.C., Wise, S.S., Jayasundara, N., St. Aubin, D.K., Dunn, J.L., Bozza, M.,
Atkinson, S., Gulland, F. and Wise, Sr., J.P. Metal Toxicity in Cultured Steller Sea Lion
Fibroblasts. Proceedings of the Annual Meeting of the Society of Marine Mammalogy, December
2003.
60. Wise, S.S., Goertz, C.E.C., Thompson, M., Smith, B., O’Hara, T., St. Aubin, D.K. and Dunn,
J.L. and Wise, Sr., J.P. The Effects of Environmental Contaminants on Balaenidae Whales
(Balaena mysticetus and Eubalaena glacialis): Metal Toxicity in Bowhead Whales. Proceedings
of the Annual Meeting of the Society of Marine Mammalogy, December 2003.
61. Diaz, W.C., Wise, S.S. and Wise, Sr., J.P. The Cytotoxicity of Depleted Uranium in Human
Bronchial Cells. Proceedings of the Annual Meeting of the New England Chapter of New
England Pharmacologists, February, 2004.
62. Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Jayasundara, N., Bozza, M.,
Atkinson, S. and Wise, Sr., J.P. Comparative Cytotoxicity of Hexavalent Chromium Compounds
in Humans and Steller Sea Lions. Proceedings of the Annual Meeting of the New England
Chapter of New England Pharmacologists, February, 2004.
63. Holmes, A.L., Gordon, N. and Wise, Sr., J.P. Chromium Ions Are the Proximate Clastogenic
Species for Particulate Hexavalent Chromium in Human Lung Cells. Proceedings of the Annual
Meeting of the New England Chapter of New England Pharmacologists, February, 2004.
64. Xie, H, Wise, S.S., Holmes, A, Ketterer, M.E., Hartsock, W.J. and Wise, Sr., J.P. Particle
Dissolution Is Necessary for Lead Chromate-Induced Genotoxicity in Human Bronchial Cells.
Proceedings of the Annual Meeting of the New England Chapter of New England
Pharmacologists, February, 2004.
65. Wise, S.S., Holmes, A.L., Xie, H. and Wise, Sr., J.P. The Physico-Chemical Mechanisms of
Particulate Chromium (VI)-Induced Clastogenesis. Proceedings of the AACR Special Conference
in Radiation Biology and Cancer, February 2004.
66. Holmes, A.L., Gordon, N. and Wise, Sr., J.P. Lead Chromate-Induced Cytotoxicity in
Human Bronchial Cells is Mediated by Extracellular Chromium. Toxicological Sciences 67(S):
760, 2004.
44
67. Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Jayasundara, N., Bozza, M.,
Atkinson, S. and Wise, Sr., J.P. Sodium Chromate Toxicity in Bronchus and Dermis of Steller
Sea Lions and Humans. Toxicological Sciences, 67(S): 757, 2004.
68. Diaz, W.C., Wise, S.S. and Wise, Sr., J.P. Uranium is Cytotoxic and Genotoxic to Human
Lung Cells. Toxicological Sciences, 67(S): 272, 2004.
69. Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Morin, A., Jayasundara, N., Bozza, M.,
Atkinson, S. and Wise, Sr., J.P. Cytotoxicity of Two Heavy Metals in Steller Sea Lion Dermal,
Renal, Bronchial and Testicular Cells. Toxicological Sciences, 67(S): 756, 2004.
70. Moreland, J.A., Teufack, S., Sandwick, S., Dufour, J-F., Wise, S.S., Holmes, A.L., Ketterer,
M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P. and Wise, Sr., J.P. Lead Chromate (LC)
Induces Cell Cycle Arrest in WTHBF-6 Cells, However Lead Alone Is Mitogenic. Toxicological
Sciences, 67(S): 270, 2004.
71. Wise, S.S., Holmes, A.L., Thompson, M., Smith, B.E., O’Hara, T. and Wise, Sr., J.P.
Comparative Chromium Toxicity in Cultured Bowhead Whale and Human Lung Cells.
Toxicological Sciences, 67(S): 759, 2004.
72. Xie, H., Holmes, A.L., Wise, S.S., Gordon, N. and Wise, Sr., J.P. Particulate Hexavalent
Chromium-Induced Clastogenesis is Mediated by Extracellular Dissolution that Does Not Require
Particle Cell Contact. Toxicological Sciences, 67(S): 281, 2004.
73. Jalbert, A., Gordon, N., Langley-Turnbaugh, S. and Wise, Sr., J.P. The Effect of Urban
Particulate Matter on Human Lung Cells Toxicological Sciences, 67(S): 1039, 2004.
74. Zhang, Y, Wise, Sr., J.P., Holford, T.R., Xie, H., Boyle, P., Zahm, S.H., Zhang B., Zou,
K.Y., Owens, P.H. and Zheng, T. Polychlorinated Biphenyls, Cytochrome P4501A1
Polymorphism and Risk of Breast Cancer in Connecticut Women. Proceedings of the American
Association for Cancer Research, 45: 3729, 2004.
75. Wise, S.S., Holmes, A.L., Xie, H., Gordon, N., Thompson W.D. and Wise, Sr., J.P. Lead
Chromate-Induced Cytotoxicity In Human Bronchial Cells Is Mediated By Extracellular
Chromium and Does Not Require Functional p53 or Rb. Proceedings of the American Association
for Cancer Research, 45: LB-180, 2004.
76. Xie, H., Moreland, J.A., Wise, S.S. and Wise, Sr., J.P. Particulate Hexavalent Chromium
Induces DNA Double Strand Breaks in Human Bronchial Cells. Proceedings of the American
Association for Cancer Research, 45: LB-168, 2004.
77. Goertz, C.E.C., Wise, S.S., Dunn, J.L., Bozza, M., Atkinson, S., Gulland, F.M.D., Taylor,
R.J. and Wise, Sr., J.P. In Vitro Metal Toxicity in Steller Sea Lion (Eumetopias jubatus)
Fibroblasts with an Emphasis on Hexavalent Chromium. Proceedings of the Annual Meeting of
the International Association of Aquatic Animal Medicine, 35: 74-75 2004.
78. Wise, S.S., Holmes, A.L., Xie, H., Gordon, N., Moreland, J.A., Sandwick, S.J., Stackpole,
M.M., Fomchenko, E., Teufack, S., May, Jr., A.J., Katsifis, S.P., Thompson, W.D. and Wise, Sr.,
J.P. Mechanisms of Particulate Chromate-Induced Genotoxicity. Proceedings of the 3rd
Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, September, 2004.
45
79. Xie, H., Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces
Double-Strand Breaks in Human Lung Cells. Proceedings of the 3rd Conference on Molecular
Mechanisms of Metal Toxicity and Carcinogenesis, September, 2004.
80. Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F.M.D., Morin, A., Jayasundra, N., Bozza,
M., Atkinson, S. and Wise, Sr., J.P. Sodium Chromate Toxicity and Uptake in Steller Sea Lion
Cells. Proceedings of the 22nd Wakefield Fisheries Symposium: Sea Lions of the World
Conservation and Research in the 21st Century, September, 2004.
81. Lynch, J.P., Wise, S.S. and Wise, Sr., J.P. Arsenic Induces Centromeric Abnormalities and
Endoreduplication in Chromosomes of Human Lung Cells. Proceedings of the Annual Meeting of
the Northeast Chapter of the Society of Toxicology, October 2004.
82. Chason, J., Bodoky, A., Xie, H., Wise, S.S., Holmes, A.L., Teufack, S., Katsifis, S. and
Wise, Sr., J.P. The Functional Role of NBS1 in the Repair of Cr(VI)-Induced DNA Damage.
Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology,
October 2004.
83. Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe, R.C., Thompson, L.H. and Wise, Sr.,
J.P. Particulate Chromate-Induced Genomic Instability Is Prevented by Homologous
Recombination. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of
Toxicology, October 2004.
84. Duzevik, E.G., Munroe, R.C., Wise, S.S. and Wise, Sr., J.P. XRCC1 Is Involved in Repair
of Lead Chromate-Induced Chromosome Damage. Proceedings of the Annual Meeting of the
Northeast Chapter of the Society of Toxicology, October 2004.
85. Sandwick, S.J., Holmes, A.L., Wise, S.S., Gordon, N. and Wise, Sr., J.P. Lead Ions Disrupt
Normal Mitotic Progression in Human Lung Cells after More Chronic Exposures to Lead
Chromate. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of
Toxicology, October 2004.
86. Xie, H., Wise, S.S. and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces DNA DoubleStrand Breaks in Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter
of the Society of Toxicology, October 2004.
87. Van Epps, G., Jalbert, A., Alley, D., Langley-Turnbaugh, S., Gordon, N.R. and Wise, J.P.
Metal Composition of Maine Particulate Matter (PM) and Effects of These Metals on Human
Lung Fibroblasts. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of
Toxicology, October 2004.
88. Kelly, R., Wise, S.S., Kraus, S., O’Hara, T., Romano, T. and Wise, Sr., J.P. Development of
Right Whale and Bowhead Whale Cell Lines. Proceedings of the Annual Meeting of the North
Atlantic Right Whale Consortium, November 2004.
89. Wise, S.S., Kelly, R., Kraus, S., O’Hara, T., Romano, T. and Wise, Sr., J.P. The Effect of
Environmental Contaminants on Northern Atlantic Right Whale and Bowhead Whale Cell
Cultures. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium,
November 2004.
46
90. Bank, M.S., Driscoll, C., Fernandez, I., Wise, J., Amirbahman, A. and Foster, D. Effects of
Disturbance Regimes on Mercury Bioaccumulation in Two-Lined Salamanders from Stream
Ecosystems in the Northeastern United States. Proceedings of the Annual Meeting of the
Northeast Resource Council, November 2004.
91. Wise, S.S., Stackpole, M.M., Duzevik, E.G., Munroe, R.C., Thompson, L.H. and Wise, Sr.,
J.P. Homologous Recombination Protects against Particulate Chromate-Induced Genomic
Instability in Chinese Hamster Cells. Proceedings of the ASM Special Conference: DNA Repair
and Mutagenesis: from Molecular Structure to Biological Consequences, November, 2004.
92. Van Epps, G., Langley-Turnbaugh, S., Gordon, N.R. and Wise, J.P. The Relationship
between Maine Soil and PM10. Proceedings of the International Soil Science Meeting, December
2004.
93. Duzevik, E.G., Wise, S.S., Munroe, R.C. and Wise, Sr., J.P. Repair of Chromate-Induced
Chromosome Damage Is Mediated by XRCC1. Toxicological Sciences, 84(S-1): 1135, 2005.
94. Xie, H., Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces
DNA Double-Strand Breaks and Activates ATM Kinase in Human Lung Cells. Toxicological
Sciences, 84(S-1): 1134, 2005.
95. Holmes, A.L., Sandwick, S.J., Wise, S.S., Gordon, N., Thompson W.D. and Wise, Sr., J.P.
Chronic Exposure to Lead Ions from Lead Chromate Interferes with Normal Mitotic Progression.
Toxicological Sciences, 84(S-1): 1145, 2005.
96. Wise, S.S., Moreland, J.A., Wise, Sr., J. P. Depleted Uranium is Genotoxic and Cytotoxic to
Human Lung Cells. Toxicological Sciences, 84(S-1): 160, 2005.
97. Lynch, J.P., Wise, S.S. and Wise, Sr., J.P. Arsenic Induces Chromosomal and Centromeric
Abnormalities in Human Lung Cells. Toxicological Sciences, 84(S-1): 145, 2005.
98. Xie, H., Wise, S.S. and Wise, Sr., J.P. ATM Mediated Repair of Lead Chromate Induced
DNA Double-Strand Breaks Prevents Genomic Instability in Human Lung Cells. Proceedings of
the Keystone Symposia on DNA Repair, 243, 2005.
99. Wise, S.S., Holmes, A.L., Sandwick, S.J., Gordon, N., Thompson W.D. and Wise, Sr., J.P.
Lead Ions Interfere with Repair of Particulate Chromate-induced Chromosome Aberrations
Resulting in Prolonged Chromosome Instability in Human Lung Cells. Proceedings of the
American Association for Cancer Research, 46:3043, 2005.
100. Xie, H., Wise, S.S. and Wise, Sr., J.P. MRE11 Mediated Repair of Lead Chromate Induced
DNA Double-Strand Breaks. Proceedings of the American Association for Cancer Research,
46:3064, 2005.
101. Wise, S.S., Holmes, A.L., Sandwick, S.J. and Wise, Sr., J.P. Chronic Exposure to Lead
Chromate Induces Premature Anaphase and Inhibits Repair of Chromosome Damage in Human
Lung Cells. Proceeding of the American Thoracic Society, 2: A744, 2005.
47
102. Holmes, A.L., Wise, S.S., Morin, A.T., Goertz, C.E.C, Atkinson, S., Dunn, J.L., Gulland,
F.M.D. and Wise, Sr., J.P. Sodium Chromate Toxicity in Steller Sea Lion Cells. Proceedings of
the Annual Meeting of the North Atlantic Chapter of the Society for Environmental Toxicology
and Chemistry, June, 2005.
103. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and Aneuploidy in
Human Lung Cells. Proceedings of the Biennial Meeting of the Chromium and Human Health
Workshop, August, 2005.
104. Wise, S.S., Holmes, A.L., Sandwick, S.J. and Wise, Sr., J.P. Lead Chromate-Induced
Centromeric Abnormalities in Human Lung Cells. Proceedings of the Biennial Meeting of the
Chromium and Human Health Workshop, August, 2005.
105. Xie, H, Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. Mechanisms of Repair of Particulate
Cr(VI)-Induced DNA Double Strand Breaks. Proceedings of the Biennial Meeting of the
Chromium and Human Health Workshop, August, 2005.
106. Duzevik, E.G., Wise, S.S., Munroe, R.C. and Wise, Sr., J.P. Repair of Chromate-Induced
Chromosome Damage Is Mediated by XRCC1. Proceedings of the Biennial Meeting of the
Chromium and Human Health Workshop, August, 2005.
107. Kelly, R., Holmes, A.L., Wise, S.S., Morin, A.T., Goertz, C.E.C., Atkinson, S., Dunn, J.L.,
Gulland, F.M.D. and Wise, Sr., J.P. Sodium Chromate Toxicity in Steller Sea Lion Cells.
Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August,
2005.
108. Savery, L.C., Wise, S.S. and Wise, Sr., J.P. Particulate Chromate-Induced DNA-DNA
Crosslinks Do Not Lead to Chromosome Damage. Proceedings of the Biennial Meeting of the
Chromium and Human Health Workshop, August, 2005.
109. Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and
Wise, Sr., J.P. Benzo[a]pyrene Cytotoxicity in Right Whale (Eubalaena Glacialis) Skin, Testis
and Lung Cell Lines. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in
Marine Organisms), June, 2005.
110. Wise, S.S., Morin, A.T., Goertz, C.E.C., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson,
S. and Wise, Sr., J.P. Metal Toxicity of Sodium Chromate in Steller Sea Lion Bronchus and
Dermis Compared To Humans. Proceedings of the Biennial Meeting of PRIMO (Pollution
Research in Marine Organisms), June, 2005.
111. Wise, S.S., Stackpole, M.M., Camrye, E., Duzevik, E.G. and Wise, Sr., J.P. NonHomologous End Joining and Homologous Recombination Repair Protect Against Particulate
Chromate-Induced Chromosome Instability. Proceedings of the International Conference on
Environmental Mutagens and the Annual Meeting of the Environmental Mutagenesis Society,
Mutation Research, 577 (1-2): 413, 2005.
112. Kelly, R.S., Wise, S.S., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P.
Establishment and Immortalization of Whale Cell Lines. Proceedings of the North Atlantic Right
Whale Consortium, November, 2005.
48
113. Wise, S.S., Kelly, R.S., Kraus, S., O’Hara, T., Romano, T. and Wise, Sr., J.P. Tributyltin
and Hexavalent Chromium Are Cytotoxic and Genotoxic to the North Atlantic Right Whale
(Eubalaena glacialis). Proceedings of the North Atlantic Right Whale Consortium, November,
2005.
114. Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and
Wise, Sr., J.P. The Cytotoxicity of Benzo[a]pyrene in Reproductive and Somatic Cells from the
Northern Right Whale (Eubalaena glacialis). Proceedings of the Annual Meeting of the North
Atlantic Right Whale Consortium, November, 2005.
115. Wise, S.S., Kelly, R.S., Kirstein, D.P., Romano, T. and Wise, Sr., J.P. The National Marine
Cell Line Library Repository. Proceedings of the International Environmental Specimen Bank
Symposium, November, 2005.
116. Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and
Wise, Sr., J.P. Clonogenic Toxicity of Benzo[a]pyrene Is Higher in Reproductive Tissue than in
Somatic Tissues of the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the 16th
Biennial Conference of the Biology of Marine Mammals, p. 107, 2005.
117. Hu, C., Wise, S., Trites, A., Wise, J. and Kitts, D.D. Vitamin E Protects Steller Sea Lion
Cells from Reactive Oxygen Radical Induced Damage. Proceedings of the 16th Biennial
Conference of the Biology of Marine Mammals, p. 132, 2005.
118. Wise, S.S., Kelly, R.S., Kraus, S., O’Hara, T., Romano, T. and Wise, Sr., J.P. The Effect of
Environmental Contaminants; Chromium, Mercury and Tributyltin, on Bowhead and Northern
Atlantic Right Whale Cells. Proceedings of the 16th Biennial Conference of the Biology of
Marine Mammals, p. 306, 2005.
119. Wise, S.S., Pfefferle, L., Goodale, B., Bresler, A., Ng, A. and Wise, Sr., J.P. The
Genotoxicity of Carbon Single-Walled Nanotubes in Human Bronchial Cells. Proceedings of the
international symposium: Nanotoxicology Biomedical Aspects, January, 2006.
120. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Chronic Exposure to Lead Chromate Causes Centrosome Amplification and Aneuploidy in
Human Lung Cells. Toxicological Sciences, 90: 519, 2006.
121. Xie, H, Dako, S., Wise, S.S., Katsifis, S. and Wise, Sr., J.P. ATM and MRE11 Are
Involved in the Repair of Particulate Chromium (VI)-Induced DNA Double Strand Breaks.
Toxicological Sciences, 90: 544, 2006.
122. Savery, L.C., Wise, S.S. and Wise, Sr., J.P. Particulate Chromium Induced DNA-DNA
Crosslinks Lead to Chromosome Damage. Toxicological Sciences, 90: 545, 2006.
123. Wise, Sr., J.P. Sperm Whales: Are They Exposed to Dangerous Levels of Metals and Are
They Sentinels for Human Health? A Case Study of the Toxic Effects of Chromium. Proceedings
of the Consultative Group on Biological Diversity’s Annual Marine Working Group, March,
2006.
49
124. Wise, S.S., Kirstein, D., Romano, T. and Wise, Sr., J.P. The National Marine Cell Line
Library. Proceedings of the annual meeting of the Northeast Regional Stranding Network, March,
2006.
125. Wise, S.S., Holmes, A., Xie, H., Mason, M.D., Chada, V.G.R., Goodale, B., Shaffiey, F.,
LaCerte, C., Qin, Q., Ng., A.K. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Gold
Nanospheres in Human Lung Cells. Presented at the workshop: Overcoming Obstacles to
Effective Research Design in Nanotoxicology, April, 2006.
126. Wise, S.S., Pfefferle, L., Goodale, B., Bresler, A., Ng, A. and Wise, Sr., J.P. The
Genotoxicity of Carbon Single-Walled Nanotubes in Human Bronchial Cells. Presented at the
workshop: Overcoming Obstacles to Effective Research Design in Nanotoxicology, April, 2006.
127. Knight, T., Wise, S.S., Wise, Sr., J.P. and Ng, A.K. Immunological and Toxic Effects of
Gold Nanoparticles. Presented at the workshop: Overcoming Obstacles to Effective Research
Design in Nanotoxicology, April, 2006.
128. Duzevik, E.G., Wise, S.S., Munroe, R.C. and Wise, Sr., J.P. XRCC1 Is Involved in Repair
of Lead Chromate-Induced Chromosome Damage. Proceedings of the American Association for
Cancer Research, 47: 1072, 2006.
129. Karaczyn, A.A., Xie, H. and Wise, Sr., J.P. Depleted Uranium-Induced Malignant
Transformation in Human Lung Epithelial Cells. Proceedings of the American Association for
Cancer Research, 47: 5215, 2006.
130. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Lead Chromate-Induced Chromosome Instability is Caused by Centrosome Amplification in
Human Lung Cells. Proceedings of the American Association for Cancer Research, 47: 1088,
2006.
131. Xie, H, Wise, S.S., Dako, S., Katsifis, S. and Wise, Sr., J.P. Functional Role of MRE11 in
the Repair of Particulate Chromium (VI)-Induced DNA Double Strand Breaks. Proceedings of the
American Association for Cancer Research, 47: 1086, 2006.
132. Savery, L.C., Wise, S.S. and Wise, Sr., J.P. Lead Chromate Induces DNA-DNA Crosslinks
Leading to Chromosome Damage. Proceedings of the American Association for Cancer Research,
47: 1084, 2006.
133. Wise, S.S., Stackpole, M.M., Camrye, E., Duzevik, E.G. and Wise, Sr., J.P. Particulate
Chromate-Induced Chromosome Instability Is Attenuated by Non-Homologous End Joining and
Homologous Recombination Repair. Proceedings of the American Association for Cancer
Research, 47: 1087, 2006.
134. Wise, S.S., Kelly, R.S., Throckmorton, H., Kraus, S., O’Hara, T., Romano, T. and Wise,
Sr., J.P. The Effect of Environmental Contaminants: Chromium, Mercury and Tributyltin, on
Northern Atlantic Right Whale Cells. Proceedings of the Annual Meeting of the International
Association of Aquatic Animal Medicine, 37: 110, 2006.
50
135. Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Hexavalent Chromium and Hypoxia in Medaka Cells. Proceedings of the North
Atlantic Chapter of the Society or Environmental Toxicology and Chemistry, June, 2006.
136. Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena
glacialis). Proceedings of the North Atlantic Chapter of the Society or Environmental Toxicology
and Chemistry, June, 2006.
137. Throckmorton, H., Wise, S.S., Kelly, R., Kraus, S., O’Hara, T., Romano, T. and Wise, Sr.,
J.P. Cytotoxicity and Genotoxicity of Mercury in Bowhead Whale (Balaena mysticetus) and
Human Lung Cells. Proceedings of the North Atlantic Chapter of the Society of Environmental
Toxicology and Chemistry, June, 2006.
138. LaCerte, C., Wise, S.S., Wise, Jr., J.P., Kerr, I.A.R., Payne, R., Evers, D. and Wise, Sr., J.P.
Chromium Exposure and Its Toxicity in the Sperm Whale. Proceedings of the North Atlantic
Chapter of the Society of Environmental Toxicology and Chemistry, June, 2006.
139. Bank, M.S., Crocker, J.B., Wachtl, J.L., Kleeman, P., Currens, C., Fellers, G., May, J.,
Hothem, R., Wise, J.P. and Madej, M.A. Mercury Bioaccumulation in Pacific Giant Salamander
Larvae from Lotic Ecosystems in the Pacific Northwestern United States. Presented at the
Conference on Mercury as a Global Pollutant (Mercury 2006), Madison, Wisconsin, August,
2006.
140. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Lead Chromate Induces Chromosome Instability via Centrosome Amplification and Spindle
Assembly Checkpoint Bypass in Human Lung Cells. Proceedings of the Fourth Conference on
Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute for Occupational
Safety and Health (NIOSH), Morgantown, West Virginia, September, 2006.
141. Xie, H., Wise, S.S., Dako, S., Katsifis, S. and Wise, Sr., J.P. Impaired Repair of Lead
Chromate-Induced DNA Double Stand Break Leads To Neoplastic Transformation. Fourth
Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute
for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, September, 2006.
142. Savery, L.C., Grlickova-Duzevik, E., Wise, S.S., Thompson, W.D., Hinz, J.M., Thompson,
L.H. and Wise, Sr., J.P. Fancg Gene Protects Cells from Particulate Chromate-Induced
Chromosome Instability. Proceedings of the EPA Graduate Fellowship Conference, September,
2006.
143. Karaczyn, A.A., Xie, H, Cheng, R.Y.S. and Wise, Sr., J.P. In Vitro Toxicity and Neoplastic
Transformation of Depleted Uranium: Effects on Human Bronchial Epithelial Cells. Proceedings
of the Northeast Society of Toxicology (NESOT) Annual Meeting, October, 2006.
144. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Lead Chromate-Induced Chromosome Instability and Centrosome Amplification Is Not Mediated
by Lead. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October,
2006.
51
145. Uygur, B., Wise, S.S., Mason, M.D., Ng, A.K. and Wise, Sr., J.P. Cytotoxicity and
Genotoxicity of Silver Nanoparticles. Proceedings of the Northeast Society of Toxicology
(NESOT) Annual Meeting, October, 2006.
146. Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z., Winn, R.N. and Wise, Sr., J.P. The
Cytotoxicity and Genotoxicity of Hexavalent Chromium in Medaka Cells and Interactions with
Hypoxia. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting,
October, 2006.
147. Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena
glacialis). Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting,
October, 2006.
148. Xie, H., Wise, S.S. and Wise, Sr., J.P. Functional Role of MRE11 in the Repair of
Particulate Cr(VI)-induced DNA Double Strand Breaks. Proceedings of the Northeast Society of
Toxicology (NESOT) Annual Meeting, October, 2006.
149. Savery, L.C., Xie, H., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Particulate Hexavalent
Chromium Causes Chromosome Instability through Decreased Expression of Spindle Assembly
Checkpoint Proteins. Proceedings of the Northeast Society of Toxicology (NESOT) Annual
Meeting, October, 2006.
150. Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe R.C., Thompson, L.H., Thacker, J. and
Wise, Sr., J.P. Homologous Recombination Repair Protects Against Chromate-induced
Chromosome Instability in Chinese Hamster Cells. Proceedings of the Northeast Society of
Toxicology (NESOT) Annual Meeting, October, 2006.
151. Qin, Q., Wise, S.S., Oberdorster, G., Mason, M.D., Xie, H. and Wise, Sr., J.P. The
Cytotoxicity of Copper Nanoparticles in Human Lung Cells. Proceedings of the Northeast Society
of Toxicology (NESOT) Annual Meeting, October, 2006.
152. Wise, S.S., Mason, M.D., Chada, V.G.R, LaCerte, C, Ng, A.K. and Wise, Sr., J.P. The
Cytotoxicity of Gold Nanospheres in Human Lung Cells. Proceedings of the Northeast Society of
Toxicology (NESOT) Annual Meeting, October, 2006.
153. Huang, S., Xie, H., Peng, C., Gupta, B.C. and Wise, Sr., J.P. Particulate Chromate-Induced
Gene Changes in Microarrays. Proceedings of the Northeast Society of Toxicology (NESOT)
Annual Meeting, October, 2006.
154. Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T. and Wise, Sr., J.P. Cytotoxicity and
Genotoxicity of Mercury and TBT in the Northern Atlantic Right Whale. Proceedings of the
Northeast Society of Toxicology (NESOT) Annual Meeting, October, 2006.
155. Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Hexavalent Chromium and Hypoxia in Medaka Cells. Society of Environmental
Toxicology and Chemistry (SETAC) Abstracts, p. 114, 2006.
52
156. Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena
glacialis). Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 316, 2006.
157. Wise, S.S., LaCerte, C., Wise, Jr., J.P., Kerr, I.A.R., Payne, R., Evers, D. and Wise, Sr., J.P.
Chromium Exposure and Its Toxicity in the Sperm Whale. Society of Environmental Toxicology
and Chemistry (SETAC) Abstracts, p. 316, 2006.
158. Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T. and Wise, Sr., J.P. Cytotoxicity and
Genotoxicity of Mercury and TBT in the Northern Atlantic Right Whale. Society of
Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 316, 2006.
159. Wise, S.S., Goertz, C.E.C, Morin, A.T., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson,
S., Thompson, W.D. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Chromium in
Steller Sea Lion Lung, Skin and Testes Cells. Society of Environmental Toxicology and
Chemistry (SETAC) Abstracts, p. 316, 2006.
160. Bank, M.S., Crocker, J.B. Wachtl, J. Kleeman, P., Currens, C., Fellers, G., May, J., Hothem,
R., Wise, J. and Madej, M.A. Spatial Variation in Mercury Bioaccumulation, Energy Flow and
Trophic Complexity in Giant Salamanders from the Pacific Northwestern United States. Society
of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 345, 2006.
161. Wise, S.S., Throckmorton, H., Li Chen, T., Kraus, S., O’Hara, T. and Wise, Sr., J.P.
Cytotoxicity and Genotoxicity of Chromium and Mercury in Bowhead and North Atlantic Right
Whale Cells. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium,
November, 2006.
162. Bank, M. S., Crocker, J.B., Wachtl, J., Kleeman, P., Currens, C., Fellers, G., May, J.,
Hothem, R., Madej, M.A. and Wise, J. Mercury in giant stream salamanders from west coast
national parks. Presented at the National Park Service Natural Resource Education Symposium,
Marin Headlands Institute, Golden Gate National Recreation Area, Sausalito, California,
February, 2007.
163. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Centrosome Amplification is a Mechanism for Genomic Instability Induced by Environmental
Carcinogens in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic
Instability and Repair, 161, 2007.
164. Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D. and Wise, Sr., J.P. Chemical
Carcinogens Target the Centromere to Induce Chromosome Instability in Human Lung Cells.
Proceedings of the Keystone Symposia on Genomic Instability and Repair, 344, 2007.
165. Xie, H., Wise, S.S. and Wise, Sr., J.P. MRE11 Protects Cells from DNA Double Strand
Break-Induced Neoplastic Transformation. Proceedings of the Keystone Symposia on Genomic
Instability and Repair, 346, 2007.
166. Savery, L.C., Xie, H., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Particulate Hexavalent
Chromium Induces Chromosome Instability and Decreased Expression of Spindle Assembly
Checkpoint Proteins. Toxicological Sciences, 96: 635, 2007.
53
167. Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe R.C., Thompson, L.H., Thacker, J. and
Wise, Sr., J.P. Rad51D, XRCC3 and Rad51C Play a Role in Repairing Chromate-Induced
Chromosome Instability in Mammalian Cells by Homologous Recombination. Toxicological
Sciences, 96: 1082, 2007.
168. Huang, S., Xie, H., Peng, C., Gupta, B.C. and Wise, Sr., J.P. Microarray Analysis of
Particulate Chromate-Induced Gene Changes in Human Lung Cells. Toxicological Sciences, 96:
1083, 2007.
169. Xie, H., Wise, S.S. and Wise, Sr., J.P. Impaired Repair of Particulate Cr(VI)-induced DNA
Double Strand Breaks Leading to Neoplastic Transformation. Toxicological Sciences, 96: 1084,
2007.
170. Wise, S.S., Shaffiey, F., LaCerte, C., Payne, R., Kerr, I.A.R., Kraus, S. and Wise, Sr., J.P.
The Effects of Chromium on Human, Sperm Whale and North Atlantic Right Whale Cells.
Proceedings of the 14th International Pollution Responses in Marine Organisms (PRIMO)
Symposium, p. 107, 2007.
171. Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T., Kerr, I.A.R., Payne, R. and Wise, Sr., J.P.
Genotoxicity of Mercury in the North Atlantic Right Whale (Eubalaena glacialis) and in the
Sperm Whale (Physeter macrocephalus). Proceedings of the 14th International Pollution
Responses in Marine Organisms (PRIMO) Symposium, p. 105, 2007.
172. Wise, S.S., Mason, M.D., Shaffiey, F., Li Chen, T., Goodale, B., Craig, G., Walter, R.,
Payne, R., Kerr, I.A.R., Winn, R. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Silver
Nanoparticles in Target Species. Proceedings of the 14th International Pollution Responses in
Marine Organisms (PRIMO) Symposium, p. 101, 2007.
173. Wise, S.S., LaCerte, C., Wise, Jr., J.P., Kerr, I.A.R., Payne, R., Evers, D. and Wise, Sr., J.P.
The Effects of Chromium Exposure and Its Toxicity in the Sperm Whale. Proceedings of the 14th
International Pollution Responses in Marine Organisms (PRIMO) Symposium, p. 102, 2007.
174. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Environmental Carcinogens Induce Chromosome Instability through Centrosome Amplification
in Human Lung Cells. Proceedings of the 7th International Chromosome Segregation and
Aneuploidy Workshop, T36, 2007.
175. Savery, L.C., Holmes, A.L., Sandwick, S.J., Xie, H., Wise, S.S. and Wise, Sr., J.P. Lead
Chromate Induced Chromosome Instability and Decreased Expression of Key Spindle Assembly
Checkpoint Proteins. Proceedings of the 7th International Chromosome Segregation and
Aneuploidy Workshop, T33, 2007.
176. Wise, S.S., Mason M.D., Holmes, A.L., Savery, L., Li Chen, T., Goodale, B., Shaffiey, F.,
Wise, Jr., J.P., Craig, G., Walter, R., Payne, R., Kerr, I., Spaulding, M. and Wise, Sr., J.P.
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human and Marine Cell Lines.
Environmental and Molecular Mutagenesis, 48(7): 606, 2007.
177. Wise, Sr., J.P., Wise, S.S., Kraus, S., Shaffiey, F., Grau, M., Li Chen, T., Perkins, C.,
Thompson, W.D., Zheng, T., Zhang, Y., Romano, T. and O’Hara, T. The Cytotoxic and
Genotoxic of Hexavalent Chromium in North Atlantic Right Whale (Eubalaena glacialis) Cells.
54
Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November,
2007.
178. Wise, S.S., Wise, Jr., J.P., Xie, H., Mason M.D., Craig, G., Payne, R., Kerr, I.A.R. and
Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Silver Nanoparticles in Sperm Whale Cells.
Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 295, 2007.
179. Goodale, B.C., Walter, R., Pelsue, S.R., Thompson, W.D., Wise, S.S., Winn, R.N., Mitani,
H., Wise, Sr., J.P. Medaka Cell Lines as Tools for Mechanistic Toxicity Studies. Proceedings of
the Aquatic Models of Human Disease Conference, pp. 63-64, January, 2008.
180. Holmes, A.L., Qin, Q., Young, J.L., Joyce, K., Xie, H., Cavas, T. and Wise, Sr., J.P.
Chronic Exposure to Zinc Chromate Induces Chromosome Instability in Human Lung Cells.
Toxicological Sciences, 102: 2093, 2008.
181. Xie, H., Holmes, A.L., Joyce, K. Pelsue, S.R., Cavas, T., Young, J.L., Qin, Q. and Wise, Sr.,
J.P. Zinc Chromate Induces Chromosome Instability and DNA Double Strand Breaks in Human
Lung Cells. Proceedings of the American Association for Cancer Research, 49: 4731, 2008.
182. Holmes, A.L., Wise, S.S., Qin, Q., Young, J.L., Keierleber, J., Xie, H., Cavas, T., Schuler,
J.H.C., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Thompson, W.D. and Wise, Sr., J.P.
Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in
Human Bronchial Cells. Proceedings of the American Association for Cancer Research, 49: 4730,
2008.
183. Young, J.L., Holmes, A.L., Qin, Q., Xie, H. and Wise, Sr., J.P. Zinc Chromate Induces
Spindle Assembly Checkpoint Bypass and Chromosome Instability in Human Lung Cells.
Proceedings of the American Association for Cancer Research, 49: 4729, 2008.
184. Wise, S.S., Holmes, A.L., Xie, H., Pelsue, S.R., Thompson, W.D. and Wise, Sr., J.P.
Repeated exposure to particulate chromate induces a DNA double strand break repair-deficient
phenotype and chromosome instability in human lung cells. Proceedings of the American
Association for Cancer Research, 49: 1873, 2008.
185. Xie, H., Holmes, A.L., Joyce, K., Pelsue, S.R., Cavas, T., Young, J.L., Qin Q. and Wise, Sr.,
J.P. Particulate Chromium Induces Chromosome Damage and DNA Double Strand Breaks in
Human Lung Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children
Conference, March, 2008.
186. Keierleber, J., Xie, H. and Wise, Sr., J.P. Cytotoxic and Genotoxic Effects of Zinc
Chromate on Human Lung Cells. Presented at Making the Connection III: Toxics and
Tomorrow’s Children Conference, March, 2008.
187. LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Neoplastic
Transformation in Human Lung Epithelial Cells. Presented at Making the Connection III: Toxics
and Tomorrow’s Children Conference, March, 2008.
188. Martino, J., Li Chen, T., Wise, S., LaCerte, C., Keierleber, J., Kraus, S. and Wise, Sr., J.P.
Zinc Chromate Cytotoxicity on Human and Right Whale Cells. Presented at Making the
Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.
55
189. Young, J.L., Holmes, A.L., Qin, Q., Xie, H. and Wise, Sr., J.P. Zinc Chromate Induces
Spindle Assembly Checkpoint Bypass and Chromosome Instability in Human Lung Cells.
Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March,
2008.
190. Qin Q., Wise, S.S, Michael D. Mason, D.M, Xie, H. and Wise, Sr., J.P. The Cytotoxicity
and Genotoxicity of Gold Nanoparticles in Human Lung Cells. Presented at Making the
Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.
191. Li Chen, T., Martino, J., Wise, S.S., Holmes, A., Shaffiey, F., Popa, O., Goertz, C.E.C.,
Kraus, S., Dunn, J.L., Gulland, F.M., Thompson, W.D., Zheng, T. and Wise, Sr., J.P. ChromiumContaminated Environments Are a Health Concern for Humans and Wildlife. Presented at
Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.
192. Holmes, A.L., Wise, S.S., Qin, Q., Young, J.L., Keierleber, J., Xie, H., Cavas, T., Schuler,
J.H.C., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Thompson, W.D. and Wise, Sr., J.P.
Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human
bronchial cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children
Conference, March, 2008.
193. Wise S.S., Holmes A.L., Xie H., Pelsue S., Thompson W.D. and Wise, Sr., J.P. Repeated
exposure to particulate chromate induces a repair-deficient phenotype and chromosome instability
in human lung cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children
Conference, March, 2008.
194. Wise, J., LaCerte, C., Xie, H., Huang, J., Okeny, M. and Wise, Sr., J.P. Are Cellulose
Nanoparticles Toxic to Humans? Presented at Making the Connection III: Toxics and
Tomorrow’s Children Conference, March, 2008.
195. Goodale, B.C., Walter, R., Pelsue, S.R., Thompson, W.D., Wise, S.S., Winn, R.N., Mitani,
H. and Wise, Sr., J.P. Medaka Cell Lines as Tools for Mechanistic Toxicity Studies. Presented at
Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.
196. Shaffiey, F., Wise, S.S., Goertz, C.E.C., LaCerte, C., Dunn, J.L., Gulland,
F.M.D.,Thompson, W.D., Zheng T. and Wise, Sr., J.P. Cytotoxicity and Clastogenicity of
Hexavalent Chromium in Steller Sea Lion Lung Cells. Presented at Making the Connection III:
Toxics and Tomorrow’s Children Conference, March, 2008.
197. Wise, Jr., J.P., Xie, H., Wallace, W. Hammond, D., Jeevarajan, A. and Wise, Sr., J.P.
Colonizing the Moon: A Study of the Toxic Effects of Lunar Dust on Human Lung Cells.
Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March,
2008.
198. Wise, Sr., J.P., Wise, S.S, Kraus, S., Shaffiey, F., Grau, M., Li Chen, T., Perkins, C.,
Thompson, W.D., Zheng, T., Zhang, Y., Romano, T. and O’Hara, T. Hexavalent Chromium May
Threaten the Heath of the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the
Annual Meeting of the International Association of Aquatic Animal Medicine, 39: 2, 2008.
56
199. Wise, S.S., Payne, R., LaCerte, C., Wise, J., Gianios, Jr., C., Perkins, C., Zheng, T., Zhu, C.,
Kerr, I. and Wise, Sr., J.P. Chromium in Sperm Whales: A Global Assessment. Proceedings of
the Annual Meeting of the International Association of Aquatic Animal Medicine, 39: 3, 2008.
200. Wise, J., Wise, Jr. J.P., Xie, H., LaCerte, C., Yong, J., Mason, M., Jeevarajan, A., Wallace,
W., Hammond, D. and Wise, Sr., J.P. Toxic Effects of Lunar Dust in Human Lung Fibroblast
Cells. Presented at the Maine Space Grant Consortium Annual Meeting. April 2008.
201. Martino, J., Li Chen, T., Wise, S.S., Shaffiey, F., Popa, O., Goertz, C.E.C., Kraus, S., Dunn,
J.L., Gulland, F.M.D., Thompson, W.D., Zheng, T. and Wise, Sr., J.P. Cytotoxic and Genotoxic
Effects of Chromium on Marine Mammal Lung Cells. Proceedings of the Annual Meeting of the
North Atlantic Chapter of the Society for Environmental Toxicology and Chemistry, June, 2008.
202. Li Chen, T., Wise, S.S, Kraus, S., Shaffiey, F., Grau, M., Perkins, C., Thompson, W.D.,
Zheng, T., Zhang, Y., Romano, T. and O’Hara, T. and Wise, Sr., J.P. Hexavalent Chromium May
Be a Risk Factor for the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the
Annual Meeting of the North Atlantic Chapter of the Society for Environmental Toxicology and
Chemistry, June, 2008.
203. Xie, H., LaCerte, C. and Wise, Sr., J.P. Carcinogenicity of Depleted Uranium in Human
Lung Epithelial Cells. Proceedings of the Fifth Conference on Molecular Mechanisms of Metal
Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health (NIOSH),
Morgantown, West Virginia, September, 2008.
204. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Particulate Hexavalent Chromium Induces Centrosome Amplification Resulting in Chromosome
Instability in Human Lung Cells. Proceedings of the Fifth Conference on Molecular Mechanisms
of Metal Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health
(NIOSH), Morgantown, West Virginia, September, 2008.
205. Wise S.S., Mason M.D., Shaffiey F., Li Chen, T., Goodale, B., LaCerte, C., Craig, G.,
Walter, R., Payne, R., Kerr, I., Kraus, S. and Wise, Sr., J.P. Comparative Toxicity of Silver
Nanoparticles in Human, Marine Mammal and Fish Cells. Proceedings of the Annual Meeting of
the Northeast Chapter of the Society of Toxicology, p. 27, October, 2008.
206. Holmes, A.L., Buehler, D., Young, J., Wise, S.S., Jeevarajan, A., Wallace, W., Hammond,
D. and Wise, Sr., J.P. Arsenic Potentiates Particulate Chromate-Induced Chromosome Instability.
Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 14,
October, 2008.
207. Martino, J., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T.
and Wise, Sr., J.P. Aluminum Is More Cytotoxic than Lunar Dust in Human Skin and Lung
Fibroblasts. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of
Toxicology, p. 18, October, 2008.
208. Young, J.L., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T.
and Wise, Sr., J.P. Lunar Dust and its Components are Cytotoxic to Human Lung Cells.
Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology,
October, p. 30, 2008.
57
209. Qin, Q., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P.
Particulate Chromate Induced DNA Double Strand Breaks Are Associated with XPF Gene
Activity in Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of
the Society of Toxicology, p. 23, October, 2008.
210. Wise, J.T., LaCerte, C., Xie, H., Huang, J., McKay, J., Bickford, M., Okeny, M., Bousfield,
D., Mason, M. and Wise, Sr., J.P. Are Cellulose Nanoparticles Toxic to Humans and Fish?
Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 25,
October, 2008.
211. Wise, Jr., J.P., Wise, S.S., Wise, J., McKay, J., Courtemanche, A., Freedman, B., Browne,
M., Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity
Exacerbates Chromate-Induced Genotoxicity. Proceedings of the Annual Meeting of the
Northeast Chapter of the Society of Toxicology, p. 26, October, 2008.
212. Li Chen, T., Wise, S.S., Shaffiey, F., Xie, H., Holmes, A.L., Kraus, S.D. and Wise, Sr., J.P.
Hexavalent Chromium Is More Clastogenic to Northern Right Whale Cells than Human Cells.
Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 6,
October, 2008.
213. LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Transformation in
Human Bronchial Epithelial Cells. Proceedings of the Annual Meeting of the Northeast Chapter
of the Society of Toxicology, p. 17, October, 2008.
214. Xie, H., LaCerte, C. and Wise, Sr., J.P. Depleted Uranium Has Genotoxic and Epigenetic
Effects in Human Lung Epithelial Cells. Proceedings of the Annual Meeting of the Northeast
Chapter of the Society of Toxicology, p. 28, October, 2008.
215. Xie, H., LaCerte, C. and Wise, Sr., J.P. A Potential Mechanism for Depleted Uraniuminduced Carcinogenesis in Human Lung Epithelial Cells. Proceedings of the Keystone Symposia
on Genomic Instability and Repair, 104, 2009.
216. Wise, S.S., Holmes, A.L., Xie, H., Pelsue, S., Thompson, W.D. and Wise, Sr., J.P.
Repetitive treatment of particulate chromate induces chromosome instability and a repairdeficient phenotype in human lung cells. Proceedings of the Keystone Symposia on Genomic
Instability and Repair, 103, 2009.
217. Wise, Sr., J.P, Holmes, A.L., Young, J.L., Savery, L.C., Wise, S.S., Sandwick, S.J., Lingle,
W.L., Negron, V.C. and Xie, H. Hexavalent Chromium Induces Chromosome Instability by
Disrupting Mitosis and Inducing Centrosome Amplification in Human Lung Cells. Proceedings of
the Keystone Symposia on Genomic Instability and Repair, 103, 2009.
218. Wise, Sr., J.P., Kraus, S., Payne, R., Wise, S.S., Kerr, I., LaCerte, C., Wise, J., Gianios, Jr.,
C., Shaffiey, F., Grau, M., Li Chen, T., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Zhu,
C. and O’Hara, T. Whales as Sentinels for Human Health: A Global Assessment of Chromium
Pollution. Toxicological Sciences, 108: 1221, 2009.
219. LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Transformation in
Human Bronchial Epithelial Cells. Toxicological Sciences, 108: 731, 2009.
58
220. Li Chen, T., Wise, S.S., Shaffiey F., Xie H., Holmes A.L., Kraus S.D. and Wise, Sr., J.P.
Hexavalent Chromium Is More Clastogenic to Northern Right Whale Cells than Human Cells.
Toxicological Sciences, 108: 1783, 2009.
221. Holmes, A.L., Buehler, D., Young, J., Wise, S.S., Jeevarajan, A., Wallace, W., Hammond,
D. and Wise, Sr., J.P. Arsenic Synergistically Increases Zinc Chromate-Induced Aneuploidy and
Spindle Assembly Checkpoint Bypass in Human Lung Cells. Toxicological Sciences, 108: 1773,
2009.
222. Wise, Jr. J.P., Wise, S.S., Wise, J., McKay, J., Courtemanche, A., Freedman, B., Browne,
M., Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity
Exacerbates Chromate-Induced Genotoxicity. Toxicological Sciences, 108: 1793, 2009.
223. Wise S.S., Mason M.D., Shaffiey F., Li Chen, T., Goodale, B., LaCerte, C., Craig, G.,
Walter, R., Payne, R., Kerr, I., Kraus, S. and Wise, Sr., J.P. Comparative Toxicity of Silver
Nanoparticles in Human, Marine Mammal and Fish Cells. Toxicological Sciences, 108:1223,
2009.
224. Wise, J.T., LaCerte, C., Xie, H., Huang, J., McKay, J., Bickford, M., Okeny, M., Bousfield,
D., Mason, M. and Wise, Sr., J.P. Are Cellulose Nanoparticles Toxic to Humans and Fish?
Toxicological Sciences, 108: 876, 2009.
225. Young, J.L., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T.
and Wise, Sr., J.P. Lunar Dust and its Components are Cytotoxic to Human Lung Cells.
Toxicological Sciences, 108: 1778, 2009.
226. Martino, J., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T.
and Wise, Sr., J.P. Aluminum Is More Cytotoxic than Lunar Dust in Human Skin and Lung
Fibroblasts. Toxicological Sciences, 108: 1787, 2009.
227. Xie, H., LaCerte, C. and Wise, Sr., J.P. Mechanism of Carcinogenicity of Depleted Uranium
in Human Lung Epithelial Cells. Toxicological Sciences, 108: 734, 2009.
228. Qin, Q., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P.
Particulate Chromate Induced DNA Double Strand Breaks Are Associated with XPF Gene
Activity in Human Lung Cells. Toxicological Sciences, 108: 735, 2009.
229. Wise, S.S., Li Chen, T., LaCerte, C., Martino, J., Doering, A., Martin, P., McGovern, D.,
Sample, A., Bickford, M., Goodwin, T.J., O’Hara, T. and Wise, Sr., J.P. Hexavalent Chromium
Is More Clastogenic to Human Cells than Bowhead Whale (Balaena mysticetus) Cells.
Toxicological Sciences, 108: 1785, 2009.
230. Duffy, R., Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W.,
Hammond, D., Shehata, T. and Wise, Sr., J.P. Cytotoxicity of Lunar Dust to Human Skin
Fibroblast Cells. Toxicological Sciences, 108: 2305, 2009.
231. Wise, Sr., J.P. and De Guise, S. Aquatic Species as Sentinels for Human Health:
Comparative Toxicology of Metals, Nanoparticles and PCBs. Toxicological Sciences, 108: 1220,
2009.
59
232. Duffy, R., Wise, J., LaCerte, C., Xie, H., Huang, J., Mckay, J., Bickford, M., Okeny, M.,
Bousfield, D., Mason, M. and Wise, Sr., J.P. Are Cellulose Nanoparticles Toxic to Humans and
Fish? Proceedings of the 1st Annual Northeast Undergraduate Research Development
Symposium, March, 2009.
233. McKay, J., Wise, Jr., J.P. and Wise, Sr., J.P. Effects of Hypergravity on Chromate-Induced
Toxicity in Bowhead Whale Lung Cells. Proceedings of the 1st Annual Northeast Undergraduate
Research Development Symposium, March, 2009.
234. Wise, J., Wise S.S. and Wise, Sr., J.P. Development of Amphibian Cell Lines for
Toxicological Studies. Proceedings of the 1st Annual Northeast Undergraduate Research
Development Symposium, March, 2009.
235. Wise, Jr. J.P., Wise, S.S., Wise, J., Wise, C.F., McKay, J., Braun, M., Courtemanche, A.,
Freedman, B., Browne, M., Hamilton, I., Brown, J., Gianios, Jr. C., Mason, M. and Wise, Sr.,
J.P. Dirigo, Maine’s First Student Team Aboard the Weightless Wonder: Effects of Altered
Gravity on Cellular Function. Proceedings of the 1st Annual Northeast Undergraduate Research
Development Symposium, March, 2009.
236. Martino, J., Wise, Jr., J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T.
and Wise, Sr., J.P. Aluminum Is More Cytotoxic than Lunar Dust in Human Skin and Lung
Fibroblasts. Proceedings of the 36th Maine Biological and Medical Sciences Symposium, April,
2009.
237. LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Transformation in
Human Lung Epithelial Cells. Proceedings of the 36th Maine Biological and Medical Sciences
Symposium, April, 2009.
238. Wise, Jr. J.P., Wise, S.S., Wise, J., McKay, J., Courtemanche, A., Freedman, B., Browne,
M., Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity
Exacerbates Chromate-Induced Genotoxicity. Proceedings of the 36th Maine Biological and
Medical Sciences Symposium, April, 2009.
239. Young, J.L., Holmes, A.L., Qin, Q., Xie, H. and Wise, Sr., J.P. Zinc Chromate Induced
Spindle Assembly Checkpoint Bypass and Chromosome Instability in Human Lung Cells.
Proceedings of the 36th Annual Biological and Medical Science Symposium, April, 2009.
240. McKay, J., Wise, Jr., J.P. and Wise, Sr., J.P. Effects of Hypergravity on Chromate-Induced
Toxicity in Bowhead Whale Lung Cells. Proceedings of the 36th Annual Biological and Medical
Science Symposium, April, 2009.
241. Holmes, A.L., Buehler, D., Young, J., Wise, S.S., Jeevarajan, A., Wallace, W., Hammond,
D. and Wise, Sr., J.P. Arsenic Synergistically Increases Zinc Chromate-Induced Aneuploidy and
Spindle Assembly Checkpoint Bypass in Human Lung Cells. Proceedings of the 36th Annual
Biological and Medical Science Symposium, April, 2009.
242. Chun, G., Wise, S.S., Wise Sr., J.P. Holmes, A.L., Patierno, S.R. and Ceryak, S.M. Protein
tyrosine phosphatase inhibition enhances survival and chromosomal stability after genotoxin
exposure at the expense of increased mutagenesis. Proceedings of the American Association for
Cancer Research, 50: 464, 2009.
60
243. Atkinson, J., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R., Kerr, I.,
Thompson, W.D. and Wise, Sr., J.P. Arsenic Levels in Sperm Whale (Physeter macrocephalus)
Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings
of the 18th Biennial Conference of the Biology of Marine Mammals, p. 20, 2009.
244. Knowlton, C., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R., Kerr, I.,
Thompson, W.D. and Wise, Sr., J.P. Barium Levels in Sperm Whale (Physeter macrocephalus)
Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings
of the 18th Biennial Conference of the Biology of Marine Mammals, p. 130 , 2009.
245. Marshall, K., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R. Kerr, I.,
Thompson, W.D. and Wise, Sr., J.P. Cadmium Levels in Sperm Whale (Physeter
macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the
Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p.
153, 2009.
246. Hayes, M., Wise, S.S., LaCerte, C., Gianios, Jr., C. Wise, J., Payne, R., Kerr, I., Thompson,
W.D. and Wise, Sr., J.P. Copper Levels in Sperm Whale (Physeter macrocephalus) Skin
Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the
18th Biennial Conference of the Biology of Marine Mammals, p. 109, 2009.
247. Wise, J., LaCerte, C., Wise, S.S., Gianios, Jr., C., Payne, R., Kerr, I., Thompson, W.D. and
Wise, Sr., J.P. Lead Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected
from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial
Conference of the Biology of Marine Mammals, p. 278, 2009.
248. Kerr, I., LaCerte, C. Wise, S.S., Gianios, Jr., C., Wise, J., Evers, D., Payne, R., Thompson,
W.D. and Wise, Sr., J.P. Mercury Levels in Sperm Whale (Physeter macrocephalus) Skin
Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the
18th Biennial Conference of the Biology of Marine Mammals, p. 128, 2009.
249. LaCerte, C., Wise, S.S., Shaffiey, F., Li Chen, T., Payne, R., Kerr, I., Thompson, W.D. and
Wise, Sr., J.P. Comparison of Chromium Toxicity in Cells from Sperm Whales (Physeter
macrocephalus) and Steller Sea Lions (Eumetopias jubatus). Proceedings of the 18th Biennial
Conference of the Biology of Marine Mammals, p. 136, 2009.
250. Wise, C.F., Wise, S.S., Li Chen, T., Mate, B.R., Kraus, S., Thompson, W.D. and Wise, Sr.,
J.P. A Tale of Two Whales: Toxic Effects of Hexavalent Chromium in Right Whale (Eubalaena
glacialis) and Blue Whale (Balaenoptera musculus) Cells. Proceedings of the 18th Biennial
Conference of the Biology of Marine Mammals, p. 278, 2009.
251. Gianios, Jr., C., LaCerte, C., Wise, S.S., Wise, J., Payne, R., Kerr, I., Thompson, W.D. and
Wise, Sr., J.P. Marine Mammal Sightings in the Pacific Ocean Observed During the Voyage of
the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p.
90, 2009.
252. Wise, Sr., J.P., Wise, S.S., LaCerte, C., Li Chen, T., Wise, J., Gianios, Jr., C., Payne, R.,
Kerr, I. and Thompson, W.D. Genotoxicity and Global Distribution of Chromium in Sperm
61
Whale (Physeter macrocephalus) Skin Cells and Tissues. Proceedings of the 18th Biennial
Conference of the Biology of Marine Mammals, p. 279, 2009.
253. Wise, Jr., J.P., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R., Kerr, I.,
Thompson, W.D., Mason, M.D. and Wise, Sr., J.P. Gold and Titanium Levels in Sperm Whale
(Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of
the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p.
278, 2009.
254. Martino, J., Wise, S.S., Holmes, A.L., Thompson, W.D. and Wise, Sr., J.P. Hexavalent
Chromium Is More Cytotoxic but Less Genotoxic to Bowhead Whale Lung Fibroblasts than
Human Lung Fibroblasts. Proceedings of the 18th Biennial Conference of the Biology of Marine
Mammals, p. 155, 2009.
255. Cain, S., LaCerte, C., Wise, S.S. Gianios, Jr., C., Wise, J., Payne, R., Kerr, I., Thompson,
W.D. and Wise, Sr., J.P. Marine Mammal Sightings in the Indian Ocean Observed During the
Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine
Mammals, p. 46, 2009.
256. McNamara, L., Wise, S.S., LaCerte, C., Gianios, Jr., Wise, J., Payne, R., Kerr, I., Thompson,
W.D. and Wise, Sr., J.P. Nickel Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies
Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th
Biennial Conference of the Biology of Marine Mammals, p. 162, 2009.
257. Wise, S.S., Mason, M.D., LaCerte, C., Li Chen, T., Craig, G., Walter, R., Payne, R., Kerr, I.,
Gianios, Jr., C., Wise, J., Thompson, W.D. and Wise, Sr., J.P. Silver nanoparticle toxicity in
sperm whale (Physeter macrocephalus) cells and global distribution of silver levels in sperm
whale skin tissue. Proceedings of the 18th Biennial Conference of the Biology of Marine
Mammals, p. 278, 2009.
258. Li Chen, T., LaCerte, C., Shaffiey, F., Wise, S.S., Payne, R., Kerr, I,. Thompson, W.D. and
Wise, Sr., J.P. Sperm Whale Skin Fibroblasts Are More Resistant to Hexavalent Chromium
Toxicity than Human Skin Fibroblasts. Proceedings of the 18th Biennial Conference of the
Biology of Marine Mammals, p. 143, 2009.
259. Payne, R., LaCerte, C., Wise, S.S., Gianios, Jr., C, Wise, J., Kerr, I., Thompson, W.D. and
Wise, Sr., J.P. Tin Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected
from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial
Conference of the Biology of Marine Mammals, p.196, 2009.
260. Alexander, A.M., Payne, R., Kerr, I., Wise, Sr., J.P., Steel, D., Baker, C.S. Circumequatorial survey of mtDNA diversity in the sperm whale (Physeter macrocephalus): Voyage of
the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals,
p.11, 2009.
261. Wise, Jr., J.P., Wise, S.S., Mason, M.D., Li Chen, T., LaCerte C., Craig, G., Walter, R.,
Payne, R., Kerr, I., Kraus, S. and Wise, Sr., J.P. Toxicity of Silver Nanoparticles in Human,
Marine Mammal and Fish Cells. Proceedings of the 2nd USAF ASC/AFRL ESOH Nanomaterial
Workshop, 2009.
62
262. Wise, Jr. J.P., Wise, S.S., Wise, J., McKay, J., Browne, M., Joyce, K., Braun, M., Wise, C.F.,
Duffy, R., Estell, E., Brown, J., Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D. and Wise,
Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity. Gravitational and Space
Biology, 23(1): 32, 2009.
263. Xie, H., LaCerte, C. and Wise, Sr., J.P. Study on Mechanism for Depleted Uranium-induced
Transformation in Human Lung Epithelial Cells. Toxicological Sciences, 114: 2170, 2010.
264. Wise, J., Duffy, R., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W.,
Hammond. D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Lunar, Martian and Earth
Dusts in Human Skin Fibroblast Cells. Toxicological Sciences, 114: 375, 2010.
265. Wise, Jr., J.P., Wise, S.S., Wise, J., Mckay, J., Browne, M., Joyce, K., Braun, M., Wise,
C.F., Duffy, R., Estell, E., Brown, J., Gianios Jr., C., Mason, M., Shehata, T., Hammond, D. and
Wise, Sr., J.P. Simulated Spaceflight Increases Chromate-Induced Genotoxicity. Toxicological
Sciences, 114: 1125, 2010.
266. Duffy, R. Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond.
D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Short-Term and Chronic Exposure to
Lunar Dust and Its Component Particles in Human Skin Fibroblast Cells. Toxicological Sciences,
114: 292, 2010.
267. Wise, S.S, Xie, H., Holmes, A.L., Wise, C.F., Doering, A., McGovern, D., Sample, A.,
Stevenson, M., Merrill, N., Chen, T.L., Martino, J., Bickford, M., Goodwin, T.J., O’Hara, T. and
Wise, Sr., J.P. Bowhead (Balaena mysticetus) Lung Cells are Resistant to Chromium-Induced
Damage. Toxicological Sciences, 114: 1128, 2010.
268. Wise, S.S., Holmes, A.L., Xie, H., Pelsue, S., Thompson, W.D. and Wise, Sr., J.P. Repeated
Particulate Chromate Exposure Induces Chromosome Instability and a DNA Double Strand Break
Repair-Deficient Phenotype in Human Lung Cells. Proceedings of the American Association for
Cancer Research, 51: 3467, 2010.
269. Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J., Gallagher, J. and Wise, Sr.,
J.P. Prolonged Exposure to Zinc Chromate Induces Numerical Chromosome Instability via
Centrosome Amplification in Human Lung Cells. Proceedings of the American Association for
Cancer Research, 51: 3473, 2010.
270. Xie, H., LaCerte, C. and Wise, Sr., J.P. Epigenetic Mechanism Is Involved in Depleted
Uranium-induced Transformation in Human Lung Epithelial Cells. Proceedings of the American
Association for Cancer Research, 51: 3464, 2010.
271. Savery, L.C., O’Brien, T.J., Holmes, A.L., Wise, Sr., J.P. and Patierno, S.R. Nucleotide
Excision Repair Contributes to Hexavalent Chromium-Induced Double Strand Breaks and
Chromosomal Damage. Proceedings of the American Association for Cancer Research, 51: 2978,
2010.
272. Braun, M., Leighton, R., Xie, H., Bickford, M., Lake, G., Mason, M., Jeevarajan, A.,
Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Cytotoxicity and
Genotoxicity of Mars, Earth, and Moon Dusts in Human Skin Epithelial Cells. Presented at 2nd
63
Annual Northeast Undergraduate Research Development Symposium, University of New
England, April, 2010.
273. Duffy, R., Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W.,
Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Short-Term and Chronic
Exposure to Lunar Dust and Its Component Particles in Human Skin Fibroblast Cells. Presented
at 2nd Annual Northeast Undergraduate Research Development Symposium, University of New
England, April, 2010.
274. Lake, G., Xie, H., LaCerte, C., Martino, J., Leighton, R., Mason, M., Jeevarajan, A.,
Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Toxicity of Lunar Dust Simulant on
Human Brain Cells. Presented at 2nd Annual Northeast Undergraduate Research Development
Symposium, University of New England, April, 2010.
275. Wise, J., Duffy, R., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W. and Wise,
Sr., J.P. Comparative Toxicity of Lunar, Martian and Earth Dusts in Human Skin Fibroblast
Cells. Presented at 2nd Annual Northeast Undergraduate Research Development Symposium,
University of New England, April, 2010.
276. Wise, Jr. J.P., Wise, S., Wise, J., Wise, C.F., McKay, J., Braun, M., Courtemanche, A.,
Joyce, K., Freedman, B., Browne, M., Estell, E., Brown, J., Gianios, Jr. C., Mason, M. and Wise,
Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Chromosome Damage in Human Lung
Cells. Presented at 2nd Annual Northeast Undergraduate Research Development Symposium,
University of New England, April, 2010.
277. Wise, Sr., J.P., Holmes, A.L, Wise, S.S., Lingle, W. and Salisbury, J. Mechanism of
Hexavalent Chromium-Induced Chromosome Instability and Centrosome Amplification.
Proceedings of the 8th International Chromosome Segregation and Aneuploidy Workshop, 11,
2010.
278. Wise, S.S., Holmes, A.L, Xie, H., Pelsue, S., Thompson, W.D. and Wise, Sr., J.P. Repeated
Acute Exposure to Particulate Chromate Disrupts Mitosis to Induce Numerical and Structural
Chromosome Instability in Human Lung Cells. Proceedings of the 8th International Chromosome
Segregation and Aneuploidy Workshop, 38, 2010.
279. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W., Salisbury, J. and Wise, Sr., J.P.
Mechanism of Hexavalent Chromium-Induced Chromosome Instability and Centrosome
Amplification. Proceedings of the 8th International Chromosome Segregation and Aneuploidy
Workshop, 54, 2010.
280. Ather, A., Ma, Y., Reynolds, J., Wise, Sr., J.P., Inzucchi, S. and Katz, D. L. Chromium
Effects on Glucose Tolerance, Insulin Sensitivity and Vascular Function in People at Risk for
Diabetes. Presented at the 70th Scientific Sessions of the American Diabetes Association, June,
2010.
281. Eagle, S.D., Stapleton, H.M., Kerr, I. and Wise, Sr., J.P. Geographic Variation in the
Concentrations of Polybrominated Diphenyl Ethers (PBDEs) and Methoyxlated PBDEs in Sperm
Whale (Physeter macrocephalus) Blubber. Presented at the 30th International Symposium on
Halogenated Persistent Organic Pollutants (Dioxin 2010), September, 2010.
64
282. Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J. and Wise, Sr., J.P. Zinc
Chromate Induces Chromosome Instability and Centrosome Amplification in Human Lung Cells.
Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, 2,
October, 2010.
283. Xie, H., McGovern, D., Sample, A., Abramson, S., Perez, A., Mason, M.D., Craig, G. and
Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Lung Cells.
Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, 13,
October, 2010.
284. Wise, J., Wise, S.S., Xie, H. and Wise, Sr., J.P. Chemical Dispersants in the Gulf of Mexico
Are Cytotoxic and Genotoxic to Human Skin Fibroblasts. Proceedings of the Annual Meeting of
the Northeast Chapter of the Society of Toxicology, 16, October, 2010.
285. Wise, Sr., J.P., Wise, S.S.,, Holmes, A.L., LaCerte, C., Li Chen, T., Martino, J. and Wise
Jr., JP. DNA Damage in Marine species. Environmental and Molecular Mutagenesis, 51(7): 702,
2010.
286. Wise, Sr., J.P., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Wise, S.S., Gianios, Jr., C.,
Braun, M., Martino, J., Chen, T., LaCerte, C., Duffy, R. and Joyce, K. The Impact of the Gulf Oil
Crisis on Cetaceans: Establishing a Baseline of Toxicology Data for Sperm Whales and Bryde's
Whales in the Gulf of Mexico. Presented at the Collaborative Scientific Research in Relation to
the Gulf Oil Spill, November, 2010.
287. Wise, Sr., J.P., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Wise, S.S., Gianios, Jr., C.,
Braun, M., Davenport, J., Chapman, G., Duffy, R., Leighton, R., Martino, J., Chen, T., LaCerte,
C., Joyce, K. And Wray, G. The Impact of the Gulf Oil Crisis on Whales: Establishing a Baseline
of Toxicology Data in the Gulf. Society of Environmental Toxicology and Chemistry (SETAC)
Abstracts, p. 381, 2010.
288. Wise, Jr., J.P., Braun, M., Wise, C.F., Wise, J., Wise, S.S., Gianios, Jr., C., LaCerte, C.,
Chen, T., Huang, S., Martino, J., Holmes, A.L., McKay, J., Joyce, K. and Wise, Sr., J.P. Voyage
II of the Odyssey: An expedition to study whales in the Gulf of Mexico in response to the Gulf oil
crisis. Presented at the 2nd Annual Civic Matters Conference, November, 2010.
289. Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J. and Wise, Sr., J.P.
Mechanism of Particulate Chromate-Induced Chromosome Instability in Human Lung Cells.
Presented at the 6th Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis,
November, 2010.
290. Xie, H., LaCerte, C. and Wise, Sr., J.P. Mechanism of Depleted Uranium-induced
Neoplastic Transformation in Human Lung Epithelial Cells. Presented at the 6th Conference on
Molecular Mechanisms of Metal Toxicity and Carcinogenesis, November, 2010.
291. Wise, S.S., Holmes, A.L., Xie, H., Martin, S., Pelsue, S.C., Thompson, W.D. and Wise Sr.,
J.P. Repeated Particulate Chromate Exposure Induces Chromosome Instability and a Subsequent
DNA Double Strand Break Repair Deficient Phenotype and Neoplastic Transformation. Presented
at the 6th Conference on Molecular Mechanism of Metal Toxicity and Carcinogenesis, Lexington,
KY, November 2010.
65
292. Savery, L.C., Eagle, S., Stapleton, H.M., Kerr, I., Thompson, W.D. and Wise, Sr., J.P.
Global Assessment of Polybrominated Diphenyl Ethers in Sperm Whale (Physeter
Macrocephalus) Skin. Program of the National Council for Science and the Environment's
(NCSE) 11th National Conference on Science, Policy, and the Environment, p. 50, 2011.
293. Wise Sr., J.P., Wise, S.S., LaCerte, C., Li Chen, T., Wise, J., Gianios Jr., C., Payne, R., Kerr,
I. and Thompson, W. D. Chromium Is a Global Concern for Sperm Whales (Physeter
macrocephalus). Program of the National Council for Science and the Environment's (NCSE)
11th National Conference on Science, Policy, and the Environment, p. 49, 2011.
294. Wise, S.S., Wise, Jr., J.P., Braun, M., Wise, C.F., Wise, J., Gianios Jr., C., Huang, S.,
Wallace, B., Glass, I., Walker, R., LaCerte, C., McKay, J., Kerr, I., Payne, R. and Wise Sr., J.P.
Assessing the Impact of the Deepwater Horizon Oil Spill on Whales. Program of the National
Council for Science and the Environment's (NCSE) 11th National Conference on Science, Policy,
and the Environment, p.49, 2011.
295. Wise, S.S., Holmes, A.L., Xie, H., Martin, S., Pelsue, S.C., Thompson, W.D. and Wise Sr.,
J.P. Hexavalent chromium induces chromosome instability resulting in a DNA double strand
break repair deficient phenotype and neoplastic transformation. Proceedings of the Keystone
Symposia on Genomic Instability and Repair, p.125, 2011.
296. Qin Q., Holmes, A.L., Xie, H., Wise, S.S. and Wise, Sr., J.P. Particulate Chromate Induces
Chromosome Instability by Disrupting Normal DNA Double Strand Break Repair and Cell Cycle
Regulation in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability
and Repair, p. 109, 2011.
297. Xie, H., LaCerte, C., Joyce, K. and Wise, Sr., J.P. Depleted Uranium Induces Chromosome
Instability and Epigenetic Modification in Human Lung Epithelial Cells. Proceedings of the
Keystone Symposia on Genomic Instability and Repair, p. 126, 2011.
298. Braun, M., Qin, Q., Xie, H., Leighton, R., Mason, M., Jeevarajan, A., Wallace, W.,
Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Cytotoxicity of Simulated Moon and
Mars Dusts, Earth Dust and Selected Lunar Dust Components in Human Lung Epithelial Cells.
Toxicological Sciences, 120: 65, 2011.
299. LaCerte, C., Chen, T., Holmes, A., Wise, S., Kraus, S., Gulland, F.M.D. and Wise, Sr., J.P.
Comparison of Chromium Toxicity on Human, Steller Sea Lion, Sperm Whale and Northern
Right Whale Skin Cells. Toxicological Sciences, 120: 517, 2011.
300. Wise, C.F., Braun, M., Wise, Jr., J.P., Wise, J., Wise, S.S., Kerr, I., Xie, H. and Wise, Sr.,
J.P. Developing a Whale Cell Line at Sea to Evaluate the Cytotoxicity and Genotoxicity of
Chemical Dispersants Used in the Gulf Of Mexico Oil Crisis. Toxicological Sciences, 120: 503,
2011.
301. Duffy, R., Wise, J., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and
Wise, Sr., J.P. Lunar Dust Simulant is Cytotoxic but Not Genotoxic to Human Skin Fibroblast
Cells. Toxicological Sciences, 120: 64, 2011.
66
302. Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J. and Wise, Sr., J.P. Chronic
Exposure to Particulate Chromate Induces Numerical Chromosome Instability and Centrosome
Amplification in Human Lung Cells. Toxicological Sciences, 120: 59, 2011.
303. Xie, H., McGovern, D., Sample, A., Abramson, S., Perez, A., Falank, L., Mason, M.D.,
Graig, G. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Acute and Chronic Exposure to
Silver Nanoparticles in Human Lung Cells. Toxicological Sciences, 120: 464, 2011.
304. Wise, J., Wise, S., Xie, H. and Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of
Mexico Are Cytotoxic and Genotoxic to Human Skin Fibroblasts. Toxicological Sciences, 120:
503, 2011.
305. Wise, Jr., J.P., Wheeler, C. and Wise, Sr., J.P. The Impact of Altered Gravity on Chromate
Genotoxicity: Using a Bioreactor to Simulate Microgravity in Cell Culture. Toxicological
Sciences, 120: 60, 2011.
306. Joyce, K., LaCerte, C. and Wise, Sr., J.P. Particulate Depleted Uranium Induces Selective
X-Chromosome Fragmentation Dependent on XRCC3 in Chinese Hamster Ovary Cells.
Toxicological Sciences, 120: 60, 2011.
307. Kerr, I. and Wise, Sr., J.P. The Voyages of the Odyssey: A Unique Platform for
Toxicological Research and Education. Toxicological Sciences, 120: 400, 2011.
308. Martino, J., Wise, S.S., Holmes, A.L., Xie, H. and Wise, Sr., J.P. Bowhead Whale Lung
Cells Are Resistant to Cr(IV)-Induced Genotoxicity. Toxicological Sciences, 120: 59, 2011.
309. Wise, S.S., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Gianios, Jr., C., Braun, M., Wallace,
B., Glass, I., Walker, R., LaCerte, C., McKay, J., Chen, T., Martino, J., Chapman, G., Duffy, R.,
Leighton, R., Joyce, K. and Wise, Sr., J.P. The Gulf Oil Crisis: Impact on Whales. Toxicological
Sciences, 120: 514, 2011.
310. Chen, T., Martino, J., Wise, S.S., LaCerte, C., Shaffiey, F., Xie, H., Holmes, A.L.,
McPhearson, K., Kerr, I., Payne, R., Kraus, S.D. and Wise, Sr., J.P. The Toxic Effects of
Chromium Compounds in North Atlantic Right Whale and Sperm Whale Cells. Toxicological
Sciences, 120: 516, 2011.
311. Savery, L.C., Eagle, S., Stapleton, H.M., Kerr, I., Thompson, W.D. and Wise, Sr., J.P.
Global Assessment of Polybrominated Diphenyl Ethers in Sperm Whale (Physeter
Macrocephalus) Skin. Toxicological Sciences, 120: 403, 2011.
312. Wise, C.F., Wise, S.S. and Wise, Sr. J.P. Chemical Dispersants Used in the Gulf of Mexico
Are Cytotoxic and Genotoxic to Sperm Whale Skin Fibroblasts. Presented at the 16th
International Symposium on Pollutant Responses in Marine Organisms (PRIMO), May 2011.
313. Wise, J., McKay, J.M., Lacerte, C., Walter, R.B. and Wise Sr., J.P. The Cytotoxicity and
Genotoxicity of Hexavalent Chromium in Medaka Cells. Presented at the 16th International
Symposium on Pollutant Responses in Marine Organisms (PRIMO), May 2011.
67
314. Wise, Jr. J.P., Wise, S.S. and Wise, Sr., J.P. The Use of Sperm Whale Karyotype to Assess
the Potential Impacts of the Gulf of Mexico Oil Spill. Presented at the 16th International
Symposium on Pollutant Responses in Marine Organisms (PRIMO), May 2011.
315. Wise, S.S., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Gianios Jr., C., Braun, M., Wallace,
B., Walker, R., LaCerte, C., McKay, J.M. and Wise, Sr., J.P. The Impact of the Gulf Oil Crisis
on Whales. Presented at the 16th International Symposium on Pollutant Responses in Marine
Organisms (PRIMO), May 2011.
316. Wise, Sr., J.P., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, S.S., Wise, J., Gianios Jr., C.,
Wallace, B., Glass, I., Walker, R., LaCerte, C. and Holmes, A.L. Voyage 2 of the Odyssey: the
Impact of the Oil Crisis on Health Using Whales as an Indicator Species. Environmental and
Molecular Mutagenesis 52: S29, 2011.
317. Wise, Jr., J.P., Xie, H., Wallace, W., Jeevarajan, A., Jenniskens, P., Shaddad, M.H. and
Wise, Sr., J.P. Toxicity of Simulated Martian and Lunar Dusts, Earth and Asteroidal Dust in
Human Lung Cells. Proceedings of the annual meeting of the American Society for Gravitational
and Space Biology, p 80, 2011
318. Wise, Jr., J.P., Wise, S.S., Kerr, I. and Wise, Sr., J.P. Assessing the Potential Effects of the Gulf
of Mexico Oil Disaster using Sperm Whale Karyotypes. Proceedings of the 19th Biennial
Conference of the Biology of Marine Mammals, p. 315, 2011.
319. Savery, L., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Global Assessment of
Mercury and Selenium Levels in Sperm Whale (Physeter Macrocephalus) Skin. Proceedings of
the 19th Biennial Conference of the Biology of Marine Mammals, p.264, 2011.
320. Martino, J., Li Chen, T. and Wise Sr., J.P. Cytotoxicity and Genotoxicity of Chromium and
Lead Compounds in Harbor Porpoise Lung Cells. Proceedings of the 19th Biennial Conference of
the Biology of Marine Mammals, p.192, 2011.
321. Wise Sr., J.P., Wise, S.S., Kerr, I. and Thompson, W.D. The Gulf of Mexico Offshore
Toxicology Study: Chromium and Nickel Levels in Sperm Whale (Physeter macrocephalus) and
Bryde’s Whale (Brydei edeni) Skin Tissues. Proceedings of the 19th Biennial Conference of the
Biology of Marine Mammals, p.315, 2011.
322. Gianios, Jr., C., Wise, Jr., J.P., Wise, C.F., Wise, S.S., Wallace, R., Glass, I., Walker, R.,
LaCerte, C., McKay, J., Braun, M., Wise, J., Kerr, I. and Wise, Sr., J.P. The Gulf of Mexico
Offshore Toxicology Study: Marine Mammal and Other Sightings in the Two Summers
Immediately Following the 2010 Gulf of Mexico Oil Crisis. Proceedings of the 19th Biennial
Conference of the Biology of Marine Mammals, p.108, 2011.
323. Kerr, I., Payne, R. and Wise, Sr., J.P. The Research Vessel Odyssey: A Unique Platform for
Marine Mammal Toxicological Research and Education. Proceedings of the 19th Biennial
Conference of the Biology of Marine Mammals, p.156, 2011.
324. Payne, R., Savery, L.C., Eagle, S., Stapleton, H.M., Kerr, I., Thompson, W.D. and Wise, Sr.,
J.P. Polybrominated Diphenyl Ethers Levels in Free Ranging Sperm Whale (Physeter
Macrocephalus) Skin Samples from Around the Globe. Proceedings of the 19th Biennial
Conference of the Biology of Marine Mammals, p.232, 2011.
68
325. Wise, Sr., J.P. and Griffit, J. The Toxicological Impact of Metals, Crude Oil, and Chemical
Dispersants from the Gulf of Mexico Oil Crisis on Human and Wildlife Health. Toxicological
Sciences, 126: 379, 2012.
326. Wise, S.S., Holmes, A.L., Xie, H. Martin, S., Thompson, W.D. and Wise, Sr., J.P.
Hexavalent chromium induces chromosome instability resulting in a DNA double strand break
repair deficient phenotype and neoplastic transformation. Toxicological Sciences, 126: 540, 2012.
327. McKay, J.M., Holmes, A.L., Case, C.P. and Wise, Sr., J.P. Chronic Exposure to Hexavalent
Chromium Induces Chromosome Instability in Primary Human Urothelial Cells. Toxicological
Sciences, 126: 533, 2012.
328. LaCerte, C., Wise, S.S. and Wise, Sr., J.P. Particulate hexavalent chromate induces a
permanent phenotypic change in human lung fibroblast cells after chronic exposure.
Toxicological Sciences, 126s: 2800, 2012.
329. Kerr, I and Wise, Sr., J.P. The Deepwater Horizon Disaster. Toxicological Sciences, 126:
379, 2012.
330. Karri, N.P. and Wise, Sr., J.P. Role of a Spindle Assembly Checkpoint Protein, Cdc20, in
Chromate-Induced Spindle Assembly Checkpoint Bypass. Toxicological Sciences, 126: 539,
2012.
331. Wise, Jr., J.P. Huang, S., Wheeler C. and Wise, Sr., J.P. Effects of Altered Gravity on
Chromium-Induced Genotoxicity in Human Lung Cells. Toxicological Sciences, 126: 540, 2012.
332. Falank, L., Xie, H., McGovern, D., Sample, A. Abramson, S., Perez, A., Mason, M.D.,
Craig, G. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human
Lung Cells. Toxicological Sciences, 126: 277, 2012.
333. Xie, H., Martin, S., Huang, S. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Arsenic
in Primary Human Lung Cells. Toxicological Sciences, 126: 314, 2012.
334. Holmes, A.L. and Wise, Sr., J.P. Arsenic is Clastogenic and Aneugenic to Primary Human
Urothelial Cells. Toxicological Sciences, 126: 383, 2012.
335. Duffy, R., Holmes, A.L. and Wise, Sr., J.P. Elucidating the role of Nek2A in zinc chromateinduced centrosome amplification and aneuploidy in human lung fibroblasts. Toxicological
Sciences, 126: 533-534, 2012.
336. Wise, C.F., Wise, S.S. and Wise, Sr., J.P. Fin Whale Cells Are More Resistant to
Hexavalent Chromium than Human Cells. Toxicological Sciences, 126: 583, 2012.
337. Braun, M., McKay, J.M., Wheeler C. and Wise, Sr., J.P. Simulated Microgravity Decreases
Chromium (VI)-Induced Genotoxicity in Human Skin Fibroblast Cells. Toxicological Sciences,
126: 540, 2012.
69
338. Wise, J., Wise, S.S. Xie, H., Griffit, J. and Wise, Sr., J.P. Are Chemical Dispersants Used in
the Gulf of Mexico Cytotoxic and Genotoxic to Human Lung and Skin Fibroblasts? Toxicological
Sciences, 126: 580, 2012.
339. Wise, Sr., J.P., Kerr, I, Wise, Jr., J.P., Wise, C.F., Wise, S.S., Wise, J., Gianios, G., Wallace,
B., Huang, S., LaCerte, C. and Holmes, A.L. Voyage 2 of the Odyssey: The Impact of the Oil
Crisis on Health Using Whales As An Indicator Species. Toxicological Sciences, 126: 380, 2012.
340. Wise, S.S., Holmes, A.L., Xie, H. Martin, S., Thompson, W.D. and Wise, Sr., J.P.
Hexavalent chromium induces chromosome instability leading to DNA double strand break repair
deficiency and neoplastic transformation. Proceedings of the American Association for Cancer
Research, 52: 750-751, 2012.
341. Xie, H., Martin, S., Wise, Sr., J.P. and Huang, S. Genotoxicity of Arsenic in Primary Human
Bronchial Cells. Proceedings of the American Association for Cancer Research, 52: LB-393,
2012.
342. Qin, Q., Xie, H., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Particulate Chromate Induces
Persistent DNA Double Strand Breaks Resulting in Disruption of Homologous Recombination
Repair in Human Lung Cells. Proceedings of the American Association for Cancer Research, 52:
514, 2012.
343. Wise, C.F., Wise, S.S. and Wise, Sr., J.P. Chemical Dispersants Used in The Gulf of
Mexico Are Cytotoxic to Sperm Whale Skin Fibroblasts. Proceedings of the Annual Meeting of
the International Association of Aquatic Animal Medicine, 43: 152, 2012.
344. Wise, Jr., J.P., Wise, C.F., Keim, E. and Wise, Sr., J.P. Comparison of Observed Nickel
Levels and Nickel Toxicity in Whales. Proceedings of the Annual Meeting of the International
Association of Aquatic Animal Medicine, 43: 153, 2012.
345. Wise, J., Wise, S.S., Xie, H., Griffitt, J. and Wise, Sr., J.P. Chemical Dispersants Used in
the Gulf of Mexico Oil Crisis Response Are Cytotoxic to Human Skin Fibroblasts. Society of
Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 200, 2012.
346. Falank, Jr., L.F., Wise, C.F. and Wise, Sr., J.P. Chemical Dispersants Are Cytotoxic to
Humpback Whale and Sperm Whale Skin Cells. Society of Environmental Toxicology and
Chemistry (SETAC) Abstracts, p. 401, 2012.
347. Wise, Sr., J.P., Wise, Jr., J.P., Wise, J., Perkins, C., Thompson, W.D. Is Exposure to
Genotoxic Metals Part of the Toxic Legacy of the Deepwater Horizon Oil Crisis? Proceedings of
the Gulf of Mexico Oil Spill and Ecosystem Science Conference, p.30, 2013.
348. Wise, Sr., J.P. and Griffit, J. The Toxicological Impact of Metals, Crude Oil, and Chemical
Dispersants from the Gulf of Mexico Oil Crisis on Human and Wildlife Health. Proceedings of
the annual meeting of the American Association for the Advancement of Science (AAAS), p 72,
2013.
349. Kerr, I and Wise, Sr., J.P. The Deepwater Horizon Disaster. Proceedings of the annual
meeting of the American Association for the Advancement of Science (AAAS), p 73, 2013.
70
350. Wise, Sr., J.P., Kerr, I, Wise, Jr., J.P., Wise, C.F., Wise, S.S., Wise, J., Gianios, G., Wallace,
B., Huang, S., LaCerte, C. and Holmes, A.L. Voyage 2 of the Odyssey: The Impact of the Oil
Crisis on Health Using Whales As An Indicator Species. Proceedings of the annual meeting of the
American Association for the Advancement of Science (AAAS), p 73, 2013.
351. Qin, Q., Wise, S.S., Xie, H., Holmes, A.L. and Wise, Sr., J.P. Chronic Particulate Chromate
Exposure Induces Persistent DNA Double Strand Breaks and Suppresses Rad51 Response in
Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and DNA
Repair, p 201, 2013.
352. Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D. and Wise, Sr., J.P. Repeated Particulate
Chromate Exposure Induces a Permanent Phenotypic Change of Genomic Instability, DNA
Double Strand Break Repair Deficiency and Neoplastic Transformation in Human Lung Cells.
Proceedings of the Keystone Symposia on Genomic Instability and DNA Repair, p 201, 2013.
353. Braun, M., Sacco, J., Lechner, J. and Wise, Sr., J.P. E162 Protects Against Chromium (VI)Induced Cytotoxicity and Genotoxicity in Human Lung Fibroblast Cells. Toxicological Sciences,
132: 250, 2013.
354. Holmes, A.L., Hebert, M., Case, C.P. and Wise, Sr., J.P. Development of an Immortalized
Urothelial Cell Line to Study Metal-Induced Bladder Carcinogenesis. Toxicological Sciences,
132: 254, 2013.
355. Wise, J., Wise, S.S., Xie, H., Griffitt, J. and Wise, Sr., J.P. Chemical Dispersants Used in
the Gulf of Mexico Are Cytotoxic to Human Lung and Skin Fibroblasts. Toxicological Sciences,
132: 32, 2013.
356. Falank, C., and Wise, Sr., J.P. Chronic Exposure to Particulate Hexavalent Chromium
Disrupts Shugoshin1 Localization in Human Lung Cells. Toxicological Sciences, 132: 123, 2013.
357. Wise, Jr., J.P., Wise, J., Thompson, W.D., Perkins, C. and Wise, Sr., J.P. Is Genotoxic
Metal Exposure Part of the Toxic Legacy of the Deepwater Horizon Oil Crisis? Toxicological
Sciences, 132: 330, 2013.
358. Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D. and Wise, Sr., J.P. Repeated Particulate
Chromate Exposure Induces Chromosome Instability, a DNA Double Strand Break RepairDeficient Phenotype, and Neoplastic Transformation in Human Lung Cells. Toxicological
Sciences, 132: 250, 2013.
359. Wise, C.F., Wise, S.S., Holmes, A. and Wise, Sr., J.P. Fin Whale Cells Are More Resistant
to Particulate Chromate Cytotoxicity than Human Cells. Toxicological Sciences, 132: 251, 2013.
360. Qin, Q., Xie, H., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Chronic Exposure to
Particulate Chromate Induces Persistent DNA Double Strand Breaks in Human Lung Cells.
Toxicological Sciences, 132: 250, 2013.
361. Savery, L.C., Holmes, A.L., Braun M.C., Evers, D.C., Kerr I., Payne R., Thompson W.D.,
Perkins, C., Zheng, T., Zhu, C. and Wise, Sr., J.P. Selenium Protects Against the Toxic Effects of
Methylmercury in Sperm Whale (Physeter macrocephalus) Skin Cells. Toxicological Sciences,
132: 328, 2013.
71
362. Wise, C.F., Wise, S.S., Wise, Sr., J.P. Toxicity of chemical dispersants, oil and chemically
dispersed oil in sperm whale skin cells (Physeter macrocephalus). Proceedings of the Annual
Meeting of the International Association of Aquatic Animal Medicine, 44: 143, 2013.
363. Wise, Jr., J.P., Wise, J.T.F., Thompson, W.D., Perkins, C. and Wise, Sr., J.P. Is Genotoxic
Metal Exposure Part Of The Toxic Legacy Of The Deepwater Horizon Oil Crisis? Proceedings of
the Annual Meeting of the International Association of Aquatic Animal Medicine, 44: 147, 2013.
364. The, T., Holmes, A.L. and Wise, Sr., J.P. Chronic Exposure to Particulate Nickel Induces
Neoplastic Transformation in Human Lung Epithelial Cells. Environmental and Molecular
Mutagenesis 52: P41, 2013.
365. Hernandez-Ramon, E.E., Wise, Sr., J.P., Si, N., Wise, S.S., Wise, Jr., J.P. and Poirier, M.C.
Detection of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in epidermis from sperm
whales (Physeter macrocephalus) in the Gulf of Mexico. Environmental and Molecular
Mutagenesis 52: P87, 2013.
366. Wise, S.S., Holmes, A.L., Xie, H., Martino, J., Raph, S., Thompson, W.D. and Wise, Sr.,
J.P. Hexavalent Chromium Impairs DNA Repair Resulting in Mitotic Disruption and
Chromosome Instability. Environmental and Molecular Mutagenesis 52: P21, 2013.
367. Wise, Sr., J.P., Xie, H., Holmes, A.L., Falank, C., Karri, N.D. and Wise, S.S. Particulate
Chromate Alters the Localization of Proteins that Protect Cells against Chromosome Instability.
Journal of Clinical Toxicology 3: 35, 2013.
368. Wise, S.S., Holmes, A.L., Xie, H., Martino, J., Raph, S., Thompson, W.D. and Wise, Sr.,
J.P. Chromosome Instability Induced by Hexavalent Chromium is a Result of Impaired DNA
Repair and Mitotic Disruption. Journal of Clinical Toxicology 3: 36, 2013.
369. Şekeroğlu, Z.A., Holmes, A.L. and Wise, Sr., J.P. Exposure to Particulate Chromate Induces
Cytotoxicity and Chromosome Instability in Human Bladder Cells. Proceedings of the 1st
International Cell Death Research Congress, page 117.
370. Şekeroğlu, V., Xie, H., Holmes, A.L., and Wise, Sr., J.P. Depleted Uranium Induces DNA
Double Strand Breaks and Cell Death in Human Lung Epithelial Cells. Proceedings of the 1st
International Cell Death Research Congress, page 124.
371. Wise, C.F., Wise, J.T.F., Wise, S.S., Wise, Sr., J.P. The Cytotoxic and Genotoxic Impacts of
Chemical Dispersants, Oil and Chemically Dispersed Oil on Sperm Whale Skin Cells.
Proceedings of the Gulf of Mexico Oil Spill and Ecosystem Science Conference, p.50, 2014.
372. Wise, Sr., J.P., Qin, Q., Browning, C., Wise, S.S., Xie, H., and Holmes, A.L. Prolonged
Exposure to Particulate Chromate Induces a Switch from Homologous Recombination Repair to
Non-Homologous End Joining Repair in Human Lung Cells. To be presented at the Annual
Meeting of the Society of Toxicology (SOT) March, 2014.
373. Martino, J., Holmes, A.L., Xie, H., Nigg, E. and Wise, Sr., J.P. Particulate Hexavalent
Chromium Causes Centrosome Separation by Activating the Kinase Nek2A. To be presented at
the Annual Meeting of the Society of Toxicology (SOT), March, 2014.
72
374. Wise, C.F., Wise, J., Wise, S.S., and Wise, Sr., J.P. Toxicity of Chemical Dispersants, Oil
and Chemically Dispersed Oil in Sperm Whale Skin Cells. To be presented at the Annual Meeting
of the Society of Toxicology (SOT), March, 2014.
375. Holmes, A., Smith, L.J., Wise, S.S., Mason, M., Zheng, T., and Wise, Sr., J.P. The
Cytotoxicity and Genotoxicity of Soluble and Particulate Cobalt in Human Lung Fibroblasts. To
be presented at the Annual Meeting of the Society of Toxicology (SOT), March, 2014.
376. Browning, C.L., Xie, H., Qin, Q., Masson, J.Y., and Wise, Sr., J.P. Prolonged Exposure to
Particulate Chromate Inhibits Homologous Recombination Repair Proteins. To be presented at the
Annual Meeting of the Society of Toxicology (SOT), March, 2014.
377. Xie, H., Şekeroğlu V., Şekeroğlu Z., Falank C., Holmes A. L. and Wise, Sr., J.P. Depleted
Uranium Induces DNA Damage and Alteration of DNA Repair Proteins in Human Lung
Epithelial Cells. To be presented at the Annual Meeting of the Society of Toxicology (SOT),
March, 2014.
378. Stewart J., Nutter N., Wise, Sr., J.P. and Xie H. Synergistic Effect of Arsenic on Hexavalent
Chromium Cytotoxicity and Genotoxicity in Human Lung Cells. To be presented at the Annual
Meeting of the Society of Toxicology (SOT), March, 2014.
379. Wise, S.S., Xie, H., Wise, Jr., J.P., Wise, C.F., Guillette, Jr., L.J., and Wise, Sr., J.P.
Comparative Toxicity of Hexavalent Chromium (Cr(VI)) in Human and Alligator Cells. To be
presented at the Annual Meeting of the Society of Toxicology (SOT), March, 2014.
380. Savery, L.C., Wise, J.T.F., Wise, S.S., Falank, C., Gianios, Jr., C., Thompson, W.D.,
Perkins, C., Zheng, T., Zhu, C., and Wise, Sr., J.P. Global Assessment of Arsenic Pollution
Using Sperm Whales (Physeter macrocephalus) As an Indicator Species. To be presented at the
Annual Meeting of the Society of Toxicology (SOT), March, 2014.
381. Wise, S.S., Xie, H., Smith, A., Fukuda, T., and Wise, Sr., J.P. The Cytotoxic and Genotoxic
Effects of Hexavalent Chromium in Sea Turtle Cells. To be presented at the 34th Annual
Symposium on Sea Turtle Biology and Conservation, April 2014.
University of Southern Maine Student Research Day Presentations
1. Wise, S.S., Holmes, A., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S. and Wise,
Sr., J.P. Chromium Is the Proximate Genotoxic Species in Lead Chromate-Induced
Clastogenicity in Human Bronchial Cells. Presented at the University of Southern Maine’s
Annual Scholarship and Creativity Fair, May, 2003.
2. Holmes, A.L, Wise, S.S., Ketterer, ME, Xie, H, Hartsock, W, Shuler, J., Katsifis, S. and Wise,
Sr., J.P. Comparative Genotoxicity of Two Particulate Hexavalent Chromium Compounds in
Human Bronchial Cells. Presented at the University of Southern Maine’s Annual Scholarship and
Creativity Fair, May, 2003.
73
3. Whitney, D., Wise, S.S. and Wise, Sr., J.P. Cytotoxicity of Soluble Hexavalent Chromium in
Human Lung Cells under Hypoxic Conditions. Presented at the University of Southern Maine’s
Annual Scholarship and Creativity Fair, May, 2003.
4. Lynch, J.P., Little, J.E., Wise, S.S., Slotnick, M.J and Wise, Sr., J.P. Comparative
Genotoxicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells Presented at the
University of Southern Maine’s Annual Scholarship and Creativity Fair, May, 2003.
5. Goertz, C.E.C., Wise, S.S., Holmes, A.L., Little, J.E., Moreland, J.A., Bozza, M., St. Aubin,
D.K., Dunn, J.L., Atkinson, S., Gulland, F. and Wise, Sr., J.P. Cell Culture and Toxicology of
Marine Mammals. Presented at the University of Southern Maine’s Annual Scholarship and
Creativity Fair, May, 2003.
6. Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A.,
Fomchenko, E., Katsifis, S.P. and Wise, Sr., J.P. The Phase of Lead Chromate Induced Cell
Cycle Arrest Is Concentration Dependent. Presented at the University of Southern Maine’s
Annual Scholarship and Creativity Fair, May, 2003.
7. Xie, H., Wise, S.S., Holmes, A.L, Ketterer, M.E., Hartsock, W.J. and Wise, Sr., J.P. Particle
Dissolution Is Necessary for Lead Chromate-Induced Genotoxicity in Human Bronchial Cells.
Presented at the University of Southern Maine’s Annual Scholarship and Creativity Fair, May,
2003.
8. Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Morin, A., Jayasundara, N., Bozza, M.,
Atkinson, S. and Wise, Sr., J.P. Cytotoxicity of Two Heavy Metals in Steller Sea Lion Dermal,
Renal, Bronchial and Testicular Cells. Proceedings of University of Southern Maine’s 1st Annual
Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium, 17, 2004.
9. Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Jayasundara, N., Bozza, M.,
Atkinson, S. and Wise, Sr., J.P. Metal Toxicity of Sodium Chromate in Steller Sea Lion
Bronchus and Dermis Compared to Humans. Proceedings of University of Southern Maine’s 1st
Annual Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium,
17, 2004.
10. Sandwick, S., Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. The Effect of Exposure Time on
Lead Chromate-Induced Cytotoxicity in Human Lung Cells. Proceedings of University of
Southern Maine’s 1st Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 20, 2004.
11. Lynch, J.P. and Wise, Sr., J.P. Effects of Arsenic on Chromosomes with Time after
Exposure. Proceedings of University of Southern Maine’s 1st Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 23, 2004.
12. Holmes, A.L., Gordon, N. and Wise, Sr., J.P. Lead Chromate-induced Cytotoxicity in
Human Bronchial Cells is Mediated by Extracellular Chromium. Proceedings of University of
Southern Maine’s 1st Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 44, 2004.
13. Moreland, J.A., Teufack, S., Sandwick, S., Dufour, J-F., Wise, S.S., Holmes, A.L., Ketterer,
M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P. and Wise, Sr., J.P. Lead is Mitogenic to
74
WTHBF-6 cells, but Lead Chromate (LC) Induces Cell Cycle Arrest. Proceedings of University
of Southern Maine’s 1st Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 45, 2004.
14. Lynch, J.P. and Wise, Sr., J.P. Arsenic Induces Chromosomal and Centromeric
Abnormalities in Human Lung Cells. Proceedings of University of Southern Maine’s 2nd Annual
Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium, 1, 2005.
15. Goodale, B., Godard, C., Frechette, D. and Wise, Sr., J.P. Cloning of Cytochrome P4501A2
in Marine Mammals. Proceedings of University of Southern Maine’s 2nd Annual Thinking
Matters Conference: USM Research, Scholarship and Creativity Symposium, 9, 2005.
16. Sandwick, S., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Comparison of Human and
Bowhead Lung Cells through Cytotoxicity, Metal Ion Uptake and Clastogenicity. Proceedings of
University of Southern Maine’s 2nd Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 11, 2005.
17. Throckmorton, H., Wise, S.S. and Wise, Sr., J.P. Comparison of Mercury on Human and
Bowhead Whale Lung Cells. Proceedings of University of Southern Maine’s 2nd Annual Thinking
Matters Conference: USM Research, Scholarship and Creativity Symposium, 12, 2005.
18. Chen, T., Wise, S.S. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Mercury and TBT
in the Northern Atlantic Right Whale. Proceedings of University of Southern Maine’s 2nd Annual
Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium, 18, 2005.
19. Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe, R.C. and Wise, Sr., J.P. Homologous
Recombination Repair Protects against Chromate-Induced Chromosome Instability. Proceedings
of University of Southern Maine’s 2nd Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 44, 2005.
20. Grau, M., Wise, S.S. and Wise, Sr., J.P. Interindividual Differences in the Effects of
Chromium on the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of University
of Southern Maine’s 2nd Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 54, 2005.
21. Camrye, E.A., Wise, S.S. and Wise, Sr., J.P. Role of Ku in NHEJ Repair of Particulate and
Soluble-Induced Double Strand Breaks and Chromosome Damage. Proceedings of University of
Southern Maine’s 2nd Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 77, 2005.
22. Savery, L.C., Wise, S.S. and Wise, Sr., J.P. Role of the Fanc-g Genes in Repair of
Particulate Chromium Induced DNA-DNA Crosslinks and Chromosome Damage. Proceedings of
University of Southern Maine’s 2nd Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 78, 2005.
23. Bresler, A., Wise, S.S., Walter, R.B., Ju, Z. and Wise, Sr., J.P. Characterization and
Lifespan Extension of Elephant Seal (Mirounga anustirostris). Proceedings of University of
Southern Maine’s 3rd Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 16, 2006.
75
24. West, C., Holmes, A., Wise, Sr., J.P. and Gordon, N. Chromium Distribution and Speciation
of Urban Soils in the West End of Portland, Maine. Proceedings of University of Southern
Maine’s 3rd Annual Thinking Matters Conference: USM Research, Scholarship and Creativity
Symposium, 17, 2006.
25. Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Hexavalent Chromium and Hypoxia in Medaka Cells. Proceedings of University
of Southern Maine’s 3rd Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 29, 2006.
26. Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena
Glacialis). Proceedings of University of Southern Maine’s 3rd Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 90, 2006.
27. Throckmorton, H., Wise, S.S., Kelly, R., Kraus, S., O’Hara, T., Romano, T. and Wise, Sr.,
J.P. Cytotoxicity and Genotoxicity of Mercury in Bowhead Whale (Balaena Mysticetus) and
Human Lung Cells. Proceedings of University of Southern Maine’s 3rd Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 30, 2006.
28. Knight, T., Mason, M., Wise, S.S., Wise, Sr., J.P. and Ng, A.K. Cytotoxic and
Proinflammatory Effects of Gold Nanoparticles on Immune Cells and Lung Cells. Proceedings of
University of Southern Maine’s 3rd Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 27, 2006.
29. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Lead Chromate-Induced Chromosome Instability Is Caused by Centrosome Amplification in
Human Lung Cells. Proceedings of University of Southern Maine’s 3rd Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 65, 2006.
30. Slaymaker, I.M., Savery, L.C. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Chronic
Exposures to Zinc Chromate, Barium Chromate and Strontium Chromate. Proceedings of
University of Southern Maine’s 3rd Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 28, 2006.
31. Bui, K.S., Holmes, A.L. and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes an
Increase in Aberrant Mitosis in Human Lung Cells. Proceedings of University of Southern
Maine’s 3rd Annual Thinking Matters Conference: USM Research, Scholarship and Creativity
Symposium, 18, 2006.
32. Sandwick, S.J., Karaczyn, A.A. and Wise, Sr., J.P. In Vitro Toxicity and Neoplastic
Transformation of Depleted Uranium: Effects on Human Bronchial Epithelial Cells. Proceedings
of University of Southern Maine’s 3rd Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 58, 2006.
33. Huang, S., Xie, H., Peng, C., Gupta, B.C. and Wise, Sr., J.P. DNA Microarray and Its Data
Analysis. Proceedings of University of Southern Maine’s 3rd Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 37, 2006.
76
34. Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe, R.C. and Wise, Sr., J.P. Homologous
Recombination Repair Protects against Chromate-Induced Chromosome Instability. Proceedings
of University of Southern Maine’s 3rd Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 56, 2006.
35. Savery, L.C., Wise, S.S. and Wise, Sr., J.P. The Role of the Fancg Gene in Protecting Cells
from Particulate Chromate-Induced Chromosome Instability. Proceedings of University of
Southern Maine’s 3rd Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 85, 2006.
35. Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Wise, Sr., J.P.
Centrosome Amplification is a Mechanism for Genomic Instability Induced by Environmental
Carcinogens in Human Lung Cells. Proceedings of University of Southern Maine’s 4th Annual
Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium, 9, 2007.
36. Li Chen, T., Wise, S.S., Krauss, S. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of
Mercury and TBT in the North Atlantic Right Whale. Proceedings of University of Southern
Maine’s 4th Annual Thinking Matters Conference: USM Research, Scholarship and Creativity
Symposium, 21 , 2007.
37. Shaffiey, F., Wise, S.S., Kraus S., O’Hara T. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Cr(VI) in Lung and Testes Cells From The Northern Right Whale (Eubalaena
glacialis) Proceedings of University of Southern Maine’s 4th Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 19, 2007.
38. LaCerte, C., Kerr, I., Payne, R., Evers, D., Wise, S.S. and Wise, Sr., J.P. Chromium Exposure
and its Toxicology in the Sperm Whale. Proceedings of University of Southern Maine’s 4th
Annual Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium,
11, 2007.
39. Savery, L.C., Xie, H., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Lead Chromate Induces
Chromosome Instability and Decreased Expression of Spindle Assembly Checkpoint Proteins.
Proceedings of University of Southern Maine’s 4th Annual Thinking Matters Conference: USM
Research, Scholarship and Creativity Symposium, 68, 2007.
40. Goodale, B., Je, Z., Walter R., Winn, R., Wise, S.S. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Hexavalent Chromium in Medaka Cells and Interactions with Hypoxia.
Proceedings of University of Southern Maine’s 4th Annual Thinking Matters Conference: USM
Research, Scholarship and Creativity Symposium, 20, 2007.
41. Qin Qin, Wise S.S, Mason M., Hong Xie, Oberdorster G. and Wise, Sr., J.P. Cytotoxicity and
Genotoxicity of Copper Nanoparticles in Human Lung Cells. Proceedings of University of
Southern Maine’s 4th Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 18, 2007
42. Huang, S., Xie, H., Peng, C., Gupta, B. and Wise, Sr., J.P. Particulate Chromate-Induced
Gene Changes in Microarrays. Proceedings of University of Southern Maine’s 4th Annual
Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium, 84, 2007.
77
43. Bresler, A., Grebliunaite, R., Karaczyn, A. and Wise, Sr., J.P. In Vitro Toxicity of Depleted
Uranium in Human Bronchial Epithelial Cells. Proceedings of University of Southern Maine’s 4th
Annual Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium,
60, 2007.
44. Uygur, B., Wise, S.S., Mason, M., Ng, A.K. and Wise, Sr., J.P. Cytotoxicity and
Genotoxicity of Silver Nanoparticles. Proceedings of University of Southern Maine’s 4th Annual
Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium, 17, 2007.
45. Stackpole, M. Wise, S.S., Duzevik, E., Munroe, R. and Wise, Sr., J.P. Rad51, XRCC3 and
Rad51C Protect Cells from Particulate Chromate-induced Chromosome Instability in Mammalian
Cells. Proceedings of University of Southern Maine’s 4th Annual Thinking Matters Conference:
USM Research, Scholarship and Creativity Symposium, 95, 2007.
46. Gurney, A., Holmes, A., Savery, L., Wise, S.S. and Wise, Sr., J.P. Influence of Vitamin B2
and Vitamin E on DNA damage, Chromosome Instability and Cytotoxicity Induced by Lead
Chromate in Human Lung Fibroblast Cells (WTHBF-6). Proceedings of University of Southern
Maine’s 4th Annual Thinking Matters Conference: USM Research, Scholarship and Creativity
Symposium, 62, 2007.
47. Knight, T., Venkata, C. Wise, S.S., Mason, M., Thompson, D., Wise, Sr., J.P. and Ng, A.K.
Cytotoxic and Inflammatory Effects of 15 nm Gold Nanoparticles. Proceedings of University of
Southern Maine’s 4th Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 16, 2007.
48. Qin, Q., Wise, S.S, Mason, M.D., Xie H. and Wise, Sr., J.P. The Cytotoxicity and
Genotoxicity of Gold Nanoparticles in Human Lung Cells. Proceedings of University of Southern
Maine's 5th Annual Thinking Matters Conference: USM Research, Scholarship and Creativity
Symposium, 41, 2008.
49. Young, J.L., Holmes, A.L., Qin, Q., Xie, H. and Wise, Sr., J.P. Zinc Chromate Induces
Spindle Assembly Checkpoint Bypass and Chromosome Instability in Human Lung Cells.
Proceedings of University of Southern Maine's 5th Annual Thinking Matters Conference: USM
Research, Scholarship and Creativity Symposium, 156, 2008.
50. Keierleber, J., Xie, H. and Wise, Sr., J.P. Cytotoxic and Genotoxic Effects of Zinc Chromate
on Human Lung Cells. Proceedings of University of Southern Maine's 5th Annual Thinking
Matters Conference: USM Research, Scholarship and Creativity Symposium, 40, 2008.
51. LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Neoplastic
Transformation in Human Lung Epithelial Cells. Proceedings of University of Southern Maine's
5th Annual Thinking Matters Conference: USM Research, Scholarship and Creativity
Symposium, 45, 2008.
52. Martino, J., Li Chen, T., Wise, S., LaCerte, C., Keierleber, J., Kraus, S. and Wise, Sr., J.P.
Zinc Chromate Cytotoxicity on Human and Right Whale Cells. Proceedings of University of
Southern Maine's 5th Annual Thinking Matters Conference: USM Research, Scholarship and
Creativity Symposium, 155, 2008.
78
53. Goodale, B.C., Walter, R., Pelsue, S.R., Thompson, W.D., Wise, S.S., Winn, R.N., Mitani, H.
and Wise, Sr., J.P. Medaka Cell Lines as Tools for Mechanistic Toxicity Studies. Proceedings of
University of Southern Maine's 5th Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 106, 2008.
54. Shaffiey, F., Wise, S.S., Goertz C.E.C., LaCerte, C., Dunn, J.L., Gulland, F.M.D., Thompson
W.D., Zheng T. and Wise, Sr., J.P. Cytotoxicity and Clastogenicity of Hexavalent Chromium in
Steller Sea Lion Lung Cells. Proceedings of University of Southern Maine's 5th Annual Thinking
Matters Conference: USM Research, Scholarship and Creativity Symposium, 39, 2008.
55. Wise, Jr. J.P., Wise, S.S., Wise, J.T.F., Link, N., Courtemanche, A., Freedman, B., Browne,
M., Gianios, Jr., C., Mason, M. and Wise, Sr., J.P. DIRIGO: Maine's First Student Team in
Microgravity. Proceedings of University of Southern Maine's 5th Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 51, 2008.
56. Wise, Jr., J.P., Xie, H., Wallace, W., Hammond, D., Jeevarajan, A. and Wise, Sr., J.P. The
Toxicity of Lunar Dust in Human Lung Epithelial Cells. Proceedings of University of Southern
Maine's 5th Annual Thinking Matters Conference: USM Research, Scholarship and Creativity
Symposium, 151, 2008.
57. Wise, Jr., J.P., Wise, J.T.F., Ford, J. and Wise, Sr., J.P. Protocol Development: Cells in
Microgravity. Proceedings of University of Southern Maine's 5th Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 20, 2008.
58. Wise, J., LaCerte, C., Xie, H., Huang, J., Okeny, M. and Wise, Sr., J.P. Are Cellulose
Nanoparticles Toxic to Humans? Proceedings of University of Southern Maine's 5th Annual
Thinking Matters Conference: USM Research, Scholarship and Creativity Symposium, 8, 2008.
59. Wise S.S., Holmes A.L., Xie H., Pelsue S., Thompson W.D. and Wise, Sr., J.P. Repeated
exposure to particulate chromate induces a repair-deficient phenotype and chromosome instability
in human lung cells. Proceedings of University of Southern Maine's 5th Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 132, 2008.
60. Holmes, A.L., Wise, S.S., Qin, Q., Young, J.L., Keierleber, J., Xie, H., Cavas, T., Schuler,
J.H.C., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Thompson, W.D. and Wise, Sr., J.P.
Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human
bronchial cells. Proceedings of University of Southern Maine's 5th Annual Thinking Matters
Conference: USM Research, Scholarship and Creativity Symposium, 34, 2008.
61. Li Chen, T., Martino, J., Wise, S.S., Holmes, A., Shaffiey, F., Popa, O., Goertz, C.E.C.,
Kraus, S., Dunn, J.L., Gulland, F.M., Thompson, W.D., Zheng, T. and Wise, Sr., J.P. ChromiumContaminated Environments Are a Health Concern for Humans and Wildlife. Proceedings of
University of Southern Maine's 5th Annual Thinking Matters Conference: USM Research,
Scholarship and Creativity Symposium, 31, 2008.
62. Qin, Q., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P.
Particulate Chromate Induced DNA Double Strand Breaks Are Associated with XPF Gene
Activity in Human Lung Cells. Proceedings of University of Southern Maine’s 6th Annual
Thinking Matters: USM Research, Scholarship and Creativity Symposium, April, 2009.
79
63. McKay, J., Wise, Jr., J.P. and Wise, Sr., J.P. Effects of Hypergravity on Chromate-Induced
Toxicity in Bowhead Whale Lung Cells. Proceedings of University of Southern Maine’s 6th
Annual Thinking Matters: USM Research, Scholarship and Creativity Symposium, April, 2009.
64. Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D. and
Wise, Sr., J.P. Toxic Effects of Lunar Dust in Human Skin Fibroblast Cells. Proceedings of
University of Southern Maine’s 6th Annual Thinking Matters: USM Research, Scholarship and
Creativity Symposium, April, 2009.
65. Xie, H., Braun, M., McGovern, D., Li Chen, T., Bellino, J., Bessey, J. and Wise, Sr., J.P.
Cytotoxicity and Genotoxicity of Titanium Oxide in Human Skin Epithelial Cells. Proceedings of
University of Southern Maine’s 6th Annual Thinking Matters: USM Research, Scholarship and
Creativity Symposium, April, 2009.
66. Wise, S.S., Li Chen, T., LaCerte, C., Martino, J., Doering, A., Martin, P., McGovern, D.,
Sample, A., Bickford, M., Goodwin, T.J., O’Hara, T. and Wise, Sr., J.P. Hexavalent Chromium
Is More Clastogenic to Human Cells than Bowhead Whale (Balaena mysticetus) Cells.
Proceedings of University of Southern Maine’s 6th Annual Thinking Matters: USM Research,
Scholarship and Creativity Symposium, April, 2009.
67. Martino, J., Li Chen, T., Duffy, R., Braun, M., Creisher, R., Rochester, B. and Wise, Sr., J.P.
Do Whale Cells Have Better DNA Repair Than Human Cells? Proceedings of University of
Southern Maine’s 6th Annual Thinking Matters: USM Research, Scholarship and Creativity
Symposium, April, 2009.
68. Li Chen, T., Wise, S.S., Shaffiey F., Xie H., Holmes A.L., Kraus S.D. and Wise, Sr., J.P.
Hexavalent Chromium Is More Clastogenic to Human Cells than Northern Right Whale Cells.
Proceedings of University of Southern Maine’s 6th Annual Thinking Matters: USM Research,
Scholarship and Creativity Symposium, April, 2009.
69. LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium is Cytotoxic, Clastogenic and
Induces Transformation in Human Bronchial Epithelial Cells. Proceedings of University of
Southern Maine’s 6th Annual Thinking Matters: USM Research, Scholarship and Creativity
Symposium, April, 2009.
70. Martino, J., Wise, Jr., J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T.
and Wise, Sr., J.P. Aluminum Is More Cytotoxic than Lunar Dust in Human Skin and Lung
Fibroblasts. Proceedings of University of Southern Maine’s 6th Annual Thinking Matters: USM
Research, Scholarship and Creativity Symposium, April, 2009.
71. Wise, Jr., J.P., Wise, S.S., Wise, J., McKay, J., Courtemanche, A., Freedman, B., Browne, M.,
Gianios, Jr., C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity
Exacerbates Chromate-Induced Genotoxicity. Proceedings of University of Southern Maine’s 6th
Annual Thinking Matters: USM Research, Scholarship and Creativity Symposium, April, 2009.
72. Joyce, K., Mason, M.D., Craig, G. and Wise, Sr., J.P. Cytotoxicity of Depleted Uranium and
Silver Nanoparticles in DNA Repair Deficient Cell Lines. Proceedings of University of Southern
Maine’s 6th Annual Thinking Matters: USM Research, Scholarship and Creativity Symposium,
April, 2009.
80
73. Young, J.L., Wise, Jr., J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T.
and Wise, Sr., J.P. Lunar Dust and its Components are Cytotoxic to Human Lung Cells.
Proceedings of University of Southern Maine’s 6th Annual Thinking Matters: USM Research,
Scholarship and Creativity Symposium, April, 2009.
74. Braun, M., Wise, J., Duffy, R., LaCerte, C., Hong, X., Huang, J., Mckay, J., Bickford, M.,
Bousfield, D., Mason, M. and Wise, Sr., J.P. Are Cellulose Nanoparticles Toxic to Human Lung
Fibroblast Cells? Proceedings of University of Southern Maine’s 6th Annual Thinking Matters:
USM Research, Scholarship and Creativity Symposium, April, 2009.
75. Wise, J., Wise, S.S., Wise, Sr., J.P., Gilliam, S. and Berquist, I. Development of Amphibian
Cell Lines for Toxicological Studies. Proceedings of University of Southern Maine’s 6th Annual
Thinking Matters: USM Research, Scholarship and Creativity Symposium, April, 2009.
76. Holmes, A.L., Buehler, D., Young, J., Wise, S.S., Jeevarajan, A., Wallace, W., Hammond, D.
and Wise, Sr., J.P. Arsenic Synergistically Increases Zinc Chromate-Induced Aneuploidy and
Spindle Assembly Checkpoint Bypass in Human Lung Cells. Proceedings of the University of
Southern Maine's 6th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2009
77. Li Chen, T., LaCerte, C., Shaffiey, F., Wise, S.S., Payne, R., Kerr, I., Thompson, W.D. and
Wise, Sr., J.P. Hexavalent Chromium is More Clastogenic to Human Skin Fibroblasts than to
Sperm Whale Skin Fibroblasts. Proceedings of the University of Southern Maine’s 7th Annual
Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April,
2010.
78. Savery, L.C., O’Brien, T.J., Holmes, A.L., Wise, Sr., J.P. and Patierno, S.R. Nucleotide
Excision Repair Contributes to Hexavalent Chromium-Induced Double Strand Breaks and
Chromosomal Damage. Proceedings of the University of Southern Maine’s 7th Annual Thinking
Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.
79. Doering, A., Wise, S.S, LaCerte, C., Chen, T.L, Martino, J., Martin, P., McGovern, D.,
Sample, A., Bickford, M, Goodwin, T.J., O’Hara, T. and Wise, Sr., J.P. Bowhead (Balaena
mysticetus) Lung Cells are Resistant to Chromium-Induced Damage. Proceedings of the
University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research,
Scholarship, and Creativity Symposium, April, 2010.
80. Doucette, C.R., Holmes, A.L. and Wise, Sr., J.P. Mitotic Arrest Deficient (MAD) Protein
Localization during Chromate-Induced Spindle Assembly Checkpoint Bypass. Proceedings of the
University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research,
Scholarship, and Creativity Symposium, April, 2010.
81. Karri, N.D., Holmes, A.L. and Wise, Sr., J.P. Role of Cdc20 and BubR1 Spindle Assembly
Checkpoint Proteins in Chromate-Induced Spindle Assembly Checkpoint Bypass. Proceedings of
the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research,
Scholarship, and Creativity Symposium, April, 2010.
82. LaCerte, C., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. During Which Division Does
Chronic Exposure to Hexavalent Chromium Induce Chromosome Instability in Human Lung
81
Cells? Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters
Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.
83. Martino, J., Wise, S.S., Holmes, A.L., Xie, H. and Wise, Sr., J.P. Bowhead Whale Lung
Cells Are Resistant to Cr-induced Genotoxicity Potential Mechanisms. Proceedings of the
University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research,
Scholarship, and Creativity Symposium, April, 2010.
84. Qin, Q., Holmes, A.L., Xie, H., Wise, S.S. and Wise, Sr., J.P. Chronic Exposure to Zinc
Chromate Induces DNA Double Strand Breaks in Human Lung Cells. Proceedings of the
University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research,
Scholarship, and Creativity Symposium, April, 2010.
85. Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J., Gallagher, J. and Wise, Sr.,
J.P. Prolonged Exposure to Zinc Chromate Induces Numerical Chromosome Instability via
Centrosome Amplification in Human Lung Cells. Proceedings of the University of Southern
Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity
Symposium, April, 2010.
86. Wise, C.F., Wise, S.S., Li Chen, T., Mate, B.R., Kraus, S., Thompson, W.D. and Wise, Sr.,
J.P. A Tale of Two Whales: Toxic Effects of Hexavalent Chromium in Right Whale (Eubalaena
glacialis) and Blue Whale (Balaenoptera musculus). Cells Proceedings of the University of
Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2010.
87. Davenport, J.A., Li Chen, T., Wise, S.S., Payne, R., Kerr, I. and Wise, Sr., J.P. Trivalent
Chromium is Clastogenic to Sperm Whale Skin Fibroblasts. Proceedings of the University of
Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2010.
88. Wise, Jr., J.P., Wise, S.S., Wise, J., McKay, J., Browne, M., Joyce, K., Braun, M., Wise, C.F.,
Duffy, R., Estell, E., Brown, J., Gianios, Jr., C., Mason, M., Shehata, T., Hammond, D. and Wise,
Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity Proceedings of the
University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2010.
89. Kreps, D., Wise, C.F., Wise, S.S. and Wise, Sr., J.P. Using Blueberry Extract to Prevent
Arsenic Toxicity. Proceedings of the University of Southern Maine’s 7th Annual Thinking
Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.
90. Braun, M., Leighton, R., Xie, H., Bickford, M., Lake, G., Mason, M., Jeevarajan, A., Wallace,
W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Cytotoxicity and Genotoxicity of
Mars, Earth and Moon Dusts in Human Skin Epithelial Cells. Proceedings of the University of
Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2010.
91. Wise, J., Duffy, R., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond,
D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Lunar, Martian and Earth Dusts in
Human Skin Fibroblast Cells. Proceedings of the University of Southern Maine’s 7th Annual
82
Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April,
2010.
92. Joyce, K., LaCerte, C. and Wise, Sr., J.P. Depleted Uranium Induces Chromosome
Hypercondensation in Human Bronchial Epithelial Cells. Proceedings of the University of
Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2010.
93. Lake, G., Xie, H., LaCerte, C., Martino, J., Leighton, R., Mason, M., Jeevarajan, A., Wallace,
W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Toxicity of Lunar Dust on Human Brain Cells.
Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference:
USM Research, Scholarship, and Creativity Symposium, April, 2010.
94. McKay, J. and Wise, Sr., J.P. Effects of Hypergravity on Chromate-Induced Toxicity in
Bowhead Whale Lung Cells and Medaka Fish Fin Cells. Proceedings of the University of
Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2010.
95. Duffy, R., Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond,
D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Short-Term and Chronic Exposure to
Lunar Dust and Its Component Particles in Human Skin Fibroblast Cells. Proceedings of the
University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2010.
96. Shively, B., Wise, Jr., J.P., Richardson, B., Krieg, E., Bickford, M. and Wise, Sr., J.P. Mars
Dust is Genotoxic to Human Lung Cells. Proceedings of the University of Southern Maine’s 7th
Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium,
April, 2010.
97. Wheeler, C., Wise, Jr., J.P. and Wise, Sr., J.P. Effects of Simulated Microgravity on
Chromate Toxicity in Human Cells. Proceedings of the University of Southern Maine’s 7th
Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium,
April, 2010.
98. Wise, S.S., Holmes, A.L, Xie, H., Pelsue, S., Thompson, W.D. and Wise, Sr., J.P. Repeated
Particulate Chromate Exposure Induces Chromosome Instability and a DNA Double Strand Break
Repair-Deficient Phenotype in Human Lung Cells. Proceedings of the University of Southern
Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2010.
99. Holmes, A., Wise S., Pelsue S., Lingle, W., Salisbury, J. and Wise, Sr., J.P. Chronic
Exposure to Particulate Chromate Induces Numerical Chromosome Instability and Centrosome
Amplification in Human Lung Cells. Proceedings of the University of Southern Maine’s 8th
Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium,
April, 2011.
100. Wise, S., Kerr, I, Wise, Jr., J.P., Wise, C.F., Wise, J., Gianios, Jr., C., Braun, M., Wallace,
R., Glass, I., Walker, R., LaCerte, C., McKay, J., Li Chen, T., Martino, J., Chapman, G., Duffy,
R., Leighton, R., Joyce, K. and Wise, Sr., J.P. The Gulf Oil Crisis: Impact on Whales.
83
Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:
USM Research, Scholarship, and Creativity Symposium, April, 2011.
101. Wise, Jr., J.P., Wise, S.S. and Wise, Sr., J.P. The Use of Sperm Whale Karyotype to Assess
the Potential Impacts of the Gulf of Mexico Oil Spill. Proceedings of the University of Southern
Maine’s 8th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2011.
102. Wise, Jr., J.P., Wheeler, C. and Wise, Sr., J.P. The Impact of Altered Gravity on Chromate
Genotoxicity: Using a Bioreactor to Simulate Microgravity in Cell Culture. Proceedings of the
University of Southern Maine’s 8th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2011.
103. Shively, E., Wise, Jr., J.P., McKay, J. and Wise, Sr., J.P. The Effect of Hypergravity on
Cr(VI)-induced Cytotoxicity and Genotoxicity. Proceedings of the University of Southern
Maine’s 8th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2011.
104. LaCerte, C., Li Chen, T., Holmes, A., Wise, S., Kraus, S., Gulland, F. and Wise, Sr., J.P.
Comparison of Chromium Toxicity on Human, Steller Sea Lion, Sperm Whale and Northern
Right Whale Skin Cells. Proceedings of the University of Southern Maine’s 8th Annual Thinking
Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2011.
105. Wise, C.F., Kreps, D., Wise, S.S. and Wise, Sr., J.P. Using Natural Products to Prevent the
Toxic Effects of Chemicals in Altered Gravity. Proceedings of the University of Southern
Maine’s 8th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2011.
106. Wise, C.F., Braun, M., Wise, Jr., J.P., Wise, J., Wise, S., Kerr, I., Xie, H. and Wise, Sr., J.P.
Developing a Whale Cell Line at Sea to Evaluate the Cytotoxicity and Genotoxicity of Chemical
Dispersants Used in the Gulf of Mexico Oil Crisis. Proceedings of the University of Southern
Maine’s 8th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2011.
107. Kreps, D., Wise. C., Wise, S.S. and Wise, Sr., J.P. Using Blueberry Extract to Prevent
Arsenic Toxicity. Proceedings of the University of Southern Maine’s 8th Annual Thinking
Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2011.
108. Kari, N., Holmes, A. and Wise, Sr., J.P. Role of Cdc20 Spindle Assembly Checkpoint
Protein in Chromate-Induced Spindle Assembly Checkpoint Bypass. Proceedings of the
University of Southern Maine’s 8th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2011.
109. Martino, J., Wise, S., Holmes, A., Xie, H. and Wise, Sr., J.P. Hexavalent Chromium
Genotoxicity in Human and Bowhead Whale Lung Cells. Proceedings of the University of
Southern Maine’s 8th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2011.
110. Qin, Q., Holmes, A., Xie, H., Wise, S.S. and Wise, Sr., J.P. Particulate Chromate Induces
Chromosome Instability by Disrupting Normal DNA Double Strand Break Repair and Cell Cycle
84
Regulation in Human Lung Cells. Proceedings of the University of Southern Maine’s 8th Annual
Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April,
2011.
111. Li Chen, T., Martino, J., Wise, S., LaCerte, C., Shaffiey, F., Xie, H., Holmes, A.,
McPhearson, K., Kerr, I., Payne, R., Kraus, S. and Wise, Sr., J.P. The Toxic Effects of
Chromium Compounds in North Atlantic Right Whale and Sperm Whale Cells. Proceedings of
the University of Southern Maine’s 8th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2011.
112. Wise, J., Wise, S., Xie, H. and Wise, Sr., J.P. Using Nutraceuticals to Prevent Organic
Chemical Toxicity. Proceedings of the University of Southern Maine’s 8th Annual Thinking
Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2011.
113. Wise, J., Wise, S., Xie, H., Griffit, J. and Wise, Sr., J.P. Chemical Dispersants Used in the
Gulf of Mexico Are Cytotoxic and Genotoxic to Human Skin Fibroblasts. Proceedings of the
University of Southern Maine’s 8th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2011.
114. Lake, G., Xie, H., LaCerte, C., Martino, J., Leighton, R., Mason, M., Jeevarajan, A.,
Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Toxicity of Lunar Dust Simulant and
Lunar Dust Components on Human Brain Cells. Proceedings of the University of Southern
Maine’s 8th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2011.
115. Duffy, R., Wise, J., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and
Wise, Sr., J.P. Lunar Dust Simulant is Cytotoxic but Not Genotoxic to Human Skin Fibroblast
Cells. Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters
Conference: USM Research, Scholarship, and Creativity Symposium, April, 2011.
116. Merrill, N., McKay, J. and Wise, Sr., J.P. Does Elderberry Syrup Help Protect Human Lung
Cells From Chromate-Induced Toxicity? Proceedings of the University of Southern Maine’s 8th
Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium,
April, 2011.
117. Braun, M., Leighton, R., Xie, H., Bickford, M., Lake, F., Mason, M., Jeevarajan, A.,
Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Cytotoxicity and
Genotoxicity of Mars, Earth and Moon Dusts in Human Skin Epithelial Cells. Proceedings of the
University of Southern Maine’s 8th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2011.
118. Braun, M., Wheeler, C., Shehata, T. and Wise, Sr., J.P. Using Microcarriers and a
Bioreactor to Support Cell Growth in a Simulated Microgravity Environment. Proceedings of the
University of Southern Maine’s 8th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2011.
119. Joyce. K., LaCerte, C. and Wise, Sr., J.P. Particulate Depleted Uranium Induces Selective
X-Chromosome Fragmentation in Chinese Hamster Ovary Cells Dependent on XRCC3.
Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:
USM Research, Scholarship, and Creativity Symposium, April, 2011.
85
120. Duffy, R., Holmes, A. and Wise, Sr., J.P. Elucidating the Role of Nek2A in Zinc ChromateInduced Centrosome Amplification and Aneuploidy in Human Lung Fibroblasts. To be presented
at the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2012.
121. Karri, N.D. and Wise, Sr., J.P. Role of a Spindle Assembly Checkpoint Protein, Cdc20, in
Chromate-Induced Spindle Assembly Checkpoint Bypass. To be presented at the University of
Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2012.
122. Joyce, K., LaCerte, C. and Wise, Sr., J.P. Particulate Depleted Uranium Induces
Chromosome Hypercondensation in Human Bronchial Epithelial Cells. To be presented at the
University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2012.
123. LaCerte, C. and Wise, Sr., J.P. Hexavalent Chromium Exposure Decreases Shugoshin1
Localization in Human Lung Fibroblasts. To be presented at the University of Southern Maine’s
9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2012.
124. Qin, Q., Xie, H., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Particulate Chromate Induces
Persistent DNA Double Strand Breaks Resulting in Disruption of Homologous Recombination
Repair in Human Lung Cells. To be presented at the University of Southern Maine’s 9th Annual
Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April,
2012.
125. Smith, L.J., Holmes, A.L. and Wise, Sr., J.P. Chronic Exposure of Cobalt Induces
Cytotoxicity and Potential Genotoxicity in Human Lung Cells. To be presented at the University
of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2012.
126. Wise, S.S, Holmes, A.L., Xie, H., Thompson, W.D. and Wise, Sr., J.P. Hexavalent
Chromium Induces Chromosome Instability Resulting in a DNA Double Strand Break Repair
Deficient Phenotype and Neoplastic Transformation. To be presented at the University of
Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2012.
127. Li Chen, T., Wise, S.S., Xie, H. and Wise, Sr., J.P. Hexavalent Chromium Induces DNADouble Strand Breaks in North Atlantic Right Whale and Sperm Whale Cells. To be presented at
the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2012.
128. Martino, J., Wise, S.S., Perkins, C., Kerr, I., Rowntree, V., Sironi, M. and Wise, Sr., J.P.
Metal Levels in Southern Right Whale Skin Biopsies. To be presented at the University of
Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2012.
86
129. Wise, J., Wise, S.S., Xie, H. and Wise, Sr., J.P. Using Nutraceuticals to Prevent Organic
Chemical Toxicity. To be presented at the University of Southern Maine’s 9th Annual Thinking
Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.
130. Sacco, J., Braun, M., Falank, L. and Wise, Sr., J.P. Nutraceuticals Protect Against
Particulate Ni(II)-Induced Cytotoxicity to Human Lung Fibroblast Cells. To be presented at the
University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2012.
131. Browning, C.L., Holmes, A.L., Mason, M., Kandpal, S. and Wise, Sr., J.P. Assessing the
Toxicity of an Emerging Environmental Pollutant: Titanium Dioxide Nanoparticles. To be
presented at the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM
Research, Scholarship, and Creativity Symposium, April, 2012.
132. Wise, C.F., Wise, S.S., Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of Mexico
Are Cytotoxic to Sperm Whale Skin Fibroblasts. To be presented at the University of Southern
Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2012.
133. Wise, Jr., J.P., Wise, C.F., Keim, E., Wise, Sr., J.P. Comparison of Observed Nickel Levels
and Nickel Toxicity in Whales. To be presented at the University of Southern Maine’s 9th Annual
Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April,
2012.
134. Braun, M., Sacco, J., Falank, L. and Wise, Sr., J.P. Nutraceuticals Protect Against
Chromium(VI)-Induced Cytotoxicity and Genotoxicity in Human Lung Fibroblast Cells. To be
presented at the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM
Research, Scholarship, and Creativity Symposium, April, 2012.
135. Keim, E., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of
Nickel Compounds on Marine Mammal and Human Fibroblasts. To be presented at the University
of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2012.
136. Martino, J., Holmes, A.L., Wise, Sr., J.P. Investigating the Effects of Particulate Hexavalent
Chromium on the Centrosome Cycle in Human Lung Cells. To be presented at the University of
Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2013.
137. Raph, S., Xie, H. and Wise, Sr., J.P. Hexavalent Chromium Exposure Decreases Mad1 and
Mad2 Localization and Interaction in Human Lung Fibroblasts. To be presented at the University
of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2013.
138. Smith, L.J., Holmes, A.L. and Wise, Sr., J.P. Chronic Exposure of Cobalt Induces
Cytotoxicity and Genotoxicity in Human Lung Cells. To be presented at the University of
Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2013.
87
139. Thompson, K., Wise, S.S. and Wise, Sr., J.P. Investigating if Large Whale Species and
Humans have differential rates of DNA Double Strand Break Repair. To be presented at the
University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2013.
140. Stewart, J., Xie, H. and Wise, Sr., J.P. Arsenic and Hexavalent Chromium Co-treatment
Toxicity in Human Lung Cells. To be presented at the University of Southern Maine’s 10th
Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium,
April, 2013.
141. Wise, J., Wise, S.S., Xie, H., Griffitt, J. and Wise, Sr., J.P. Chemical Dispersants Used in
the Gulf of Mexico Are Cytotoxic to Human Lung and Skin Fibroblasts. Toxicological Sciences,
132: 32, 2013. To be presented at the University of Southern Maine’s 10th Annual Thinking
Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.
142. Falank, C. and Wise, Sr., J.P. Chronic Exposure to Particulate Hexavalent Chromium
Disrupts Shugoshin1 Localization in Human Lung Cells. To be presented at the University of
Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2013.
143. Braun, M., Sacco, J., Lechner, J. and Wise, Sr., J.P. E162 Protects Against Chromium (VI)Induced Cytotoxicity and Genotoxicity in Human Lung Fibroblast Cells. To be presented at the
University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research,
Scholarship, and Creativity Symposium, April, 2013.
143. Smith, A., Martino, J., Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. Lead Chromate Induces
Persistent Centrosome Amplification in Human Lung Cells. To be presented at the University of
Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and
Creativity Symposium, April, 2013.
144. Keim, E., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Nickel Compounds Are Cytotoxic
and Genotoxic to Sperm Whale Skin Fibroblasts. To be presented at the University of Southern
Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity
Symposium, April, 2013.
Research Grants:
Current Grants
As Principal Investigator
SG-14-23
Wise (PI)
01/01/14 - 12/31/14
Maine Space Grant Consortium
$40,000
“Multidisciplinary Balloon Payloads”
The goal of this research is to use high altitude scientific ballooning as a platform for examining
the reactions of living cells and simple organisms to the rigors of extreme temperatures, radiation
and pressures encountered in space flight.
955-12-02
Wise (PI)
01/01/12 - 09/30/13
Prince William Sound Regional Citizens’ Advisory Council
$102,686
"Toxicology of Chemical Dispersants in Alaskan Whales"
The goal of this research is to study the cytotoxicity and genotoxicity of chemical dispersants and
Alaskan crude oil on humpback and sperm whales.
88
W911NF-09-1-0296
Wise (PI)
06/01/09 - 06/30/15
Army Research Office (ARO)
$1,552,000
“Toxicity of Gold Nanoparticles in Human Lung Cells”
The objective of this research is to investigate determine the effects of gold nanoparticles in
human lung cells.
1R01ES016893
NIH/NIEHS
Wise (PI)
07/01/09 - 03/31/19
$1,809,090 ($3,459,852
All years total)
"Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts"
The major goal of this project is to determine the mechanisms of Cr(VI)-induced chromosome
instability focusing on the spindle assembly checkpoint and centrosome amplification.
As Co-Investigator
MA-917393
Environmental Protection Agency
EPA Undergraduate Research Opportunity
C. Wise (PI) 09/01/11 – 05/31/14
$48,516
Pending Grants
None
Completed Grants
As Principal Investigator
SG-13-23
Wise (PI)
01/01/13 - 12/31/13
Maine Space Grant Consortium
$20,000
“Multidisciplinary Balloon Payloads”
The goal of this research is to use high altitude scientific ballooning as a platform for examining
the reactions of living cells and simple organisms to the rigors of extreme temperatures, radiation
and pressures encountered in space flight.
Wise (PI)
08/01/11 - 07/31/12
The Gulf Restoration Fund/The Ocean Foundation
$9,574
"Caribbean Marine Toxicology Laboratory "
The goal of this research was to study the possible development of a marine toxicology field
research laboratory in the Caribbean.
SG-12-23
Wise (PI)
10/01/11 - 09/30/12
Maine Space Grant Consortium
$40,000
“Multidisciplinary Balloon Payloads”
The goal of this research is to use high altitude scientific ballooning as a platform for examining
the reactions of living cells and simple organisms to the rigors of extreme temperatures, radiation
and pressures encountered in space flight.
ACD FSB-2009
Wise (PI)
06/01/09 - 05/31/12
National Aeronautics and Space Administration (NASA)
$257,502
"Mechanisms of Altered Gravity Potentiation of Metal-Induced Genotoxicity"
The major goal of this project is to develop a model of the effects of microgravity on the cellular
response to genotoxicity.
89
W911NF-08-1-0333
Wise (PI)
08/01/08 - 07/31/12
Army Research Office (ARO)
$885,674
"Genotoxicity and Carcinogenicity of Particulate Depleted Uranium"
The long-term objective of this research is to investigate and develop a model of depleted
uranium-induced carcinogenesis and genotoxicity in human bronchial cells.
EP-09-05
Wise (PI)
10/01/08 - 09/30/11
National Aeronautics and Space Administration (NASA)
$1,462,012
"Toxicology of Metal and Lunar Particles in Biological Systems"
This project determined the cytotoxicity and genotoxicity of lunar dusts in human cells.
SG-11-23
Wise (PI)
02/01/11 - 08/31/11
Maine Space Grant Consortium
$75,000
“Multidisciplinary Balloon Payloads”
This project developed high altitude scientific ballooning as a research platform.
Wise (PI)
06/01/09 - 05/31/10
Maine Space Grant Consortium
$5,000
“Effects of Hypergravity and Microgravity on DNA Damage, Repair and Cellular Uptake in Lung
Cells”
This project studied the effects of hyper and micro-gravity on the toxicity of particulates for cells
in culture.
Wise (PI)
04/01/08 - 03/31/09
Maine Space Grant Consortium
$5,760
“Effects of Hypergravity and Microgravity on DNA Damage, Repair and Cellular Uptake in Lung
Cells”
This project studied the effects of hyper and micro-gravity on the toxicity of particulates for cells
in culture.
Forest Bioproducts Research Initiative
Wise (PI)
National Science Foundation (NSF), Maine EPSCoR
This project studied the toxicity of cellulose nanoparticles.
11/01/06 - 03/31/08
$109,631
W911NF-04-1-0240
Wise (PI)
06/01/04 - 05/31/07
Army Research Office (ARO)
$850,000
“Genotoxicity of Depleted Uranium in Human Bronchial Cells”
This project studied depleted uranium carcinogenesis and genotoxicity in human lung cells.
ESO10838
Wise (PI)
07/01/01 - 12/31/06
NIH/NIEHS
$1,501,650
"Toxicology of Particulate Cr(VI) in Human Lung Cells"
The project studied the genotoxic mechanisms for particulate hexavalent chromium.
NA03NMF4721270
Wise (PI)
09/01/05 - 08/31/06
National Oceanic and Atmospheric Administration (NOAA)
$100,000
“Establishing a National Resource of Marine Mammal Cell Lines for Toxicological, Infections
Disease and Other Biomedical Research”
This project continued the establishment of a cell repository of marine mammal cell lines.
90
Wise (PI)
01/01/05 - 12/31/05
U.S. Department of Energy
$1,157,000
“Expansion of the Center for Integrated and Applied Environmental Toxicology at the University
of Southern Maine”
This project provided funds to buy equipment and build out the Wise Laboratory.
NA03NMF4720478
Wise (PI)
09/30/03 - 09/29/06
National Oceanic and Atmospheric Administration (NOAA)
$497, 249
“The Genetic Effects of Environmental Contaminants on the Reproductive Systems of the North
Atlantic Right Whale (Eubalaena glacialis)”
This project studied the genetic toxicology of environmental contaminants to right whales.
NA03NMF4390398
Wise (PI)
12/01/03 - 11/30/04
National Oceanic and Atmospheric Administration (NOAA)
$100,000
“Establishing a National Resource of Marine Mammal Cell Lines for Toxicological, Infections
Disease and Other Biomedical Research”
This project established a cell repository of marine mammal cell lines.
NA16FX1412
Wise (PI)
07/01/01 - 06/30/05
National Marine Fisheries Service (NMFS)
$1,096,715
"Metal toxicity in Steller Seal Lion (Eumetopias jubatus) Tissues and Cell Lines."
This project studied the toxicity of metals in sea lion cell lines.
Wise (PI)
07/01/04 - 06/30/05
Maine Cancer Foundation
$45,745
"Mechanisms of Arsenic Induced Human Lung and Bladder Cancer"
This project studied metal-induced carcinogenesis in human bronchial and bladder cells.
Wise (PI)
01/01/01 - 12/31/01
Patterson Trust
$66,000
"Carcinogenicity of Cr(VI) in Human Bronchial Epithelial Cells"
This project studied the clastogenicity of hexavalent chromium in human lung cells.
Wise (PI)
11/01/00 - 10/31/01
American Cancer Society
$20,000
"Carcinogenicity of Particulate and Soluble Hexavalent Chromium in Human Bronchial Cells"
This project studied the genotoxicity of hexavalent chromium in human lung cells.
Wise (PI)
01/01/01 - 12/31/01
$20,000
Yale University
"Toxicology of Soot and Precursor Soot"
This project studied the genotoxicity of ambient particles in human lung cells.
Wise (PI)
12/01/99 - 12/31/00
Patterson Trust
$48,000
"Carcinogenicity of Cr(V1) in Human Bronchial Epithelial Cells"
This project established human lung cells in culture with telomerase.
Wise (PI)
91
03/01/00 - 02/28/01
Colgate Palmolive
"Metals and the Comet Assay"
This project established the comet assay in the Wise laboratory.
$20,000
Wise (PI)
06/01/01 - 09/04/01
Maine Sea Grant
$1,000
"Undergraduate Training in Marine Toxicology"
This project provided a stipend for undergraduate education in marine toxicology.
Wise (PI)
06/01/01 - 09/04/01
$8,000
Mount Desert Island Biological Laboratory
"Toxicology of Hexavalent Chromium in Marine Animals"
This project investigated the toxicity of hexavalent chromium in shark and skate cells.
Wise (PI)
06/01/00 - 09/04/00
$8,000
Mount Desert Island Biological Laboratory
"Toxicology of Hexavalent Chromium in Marine Animals"
This project investigated the toxicity of hexavalent chromium in shark and skate cells.
Wise (PI)
01/01/00 - 12/31/02
Yale Cancer Center:
$230,000
"Molecular Epidemiology Shared Resource"
This project provided genotyping service to the Yale Cancer Center.
Completed Grants (continued)
As Co-Investigator
MA-916977
Young (PI) 09/01/08 - 08/31/10
U.S. Environmental Protection Agency
$63,693
“Arsenic Potentiates the Carcinogenicity of Hexavalent Chromium by Inhibiting the Repair of
Cr(VI)-Induced DNA Double Strand Breaks”
This project studied the ability of arsenic to potentiate hexavalent chromium carcinogenicity.
Role: Faculty Participant
MA-916854
Holmes (PI) 09/01/07 - 08/31/10
U.S. Environmental Protection Agency
$63,693
“The Interactive and Carcinogenic Effects of Hexavalent Chromium and Arsenic in Human Lung
Cells”
This project studied the ability of arsenic to potentiate hexavalent chromium genotoxicity.
Role: Faculty Participant
NA04NOS4260202
Walter (PI) 09/01/05 - 8/31/09
National Oceanic and Atmospheric Administration (NOAA)
$250,000
“The modulating effects of hypoxia on the cytotoxicity and genotoxicity of hexavalent chromium
and methylmercury in medaka cells”
This project studied the interactions of hypoxia, chromate and methylmercury in fish cells.
Role: Co-Investigator
FP-916543
U.S. Environmental Protection Agency
Savery (PI)
92
09/01/05 - 05/31/09
$63,693
“Interaction of Chromium and Arsenic in Human Lung Cells and the Role of the Fanc Pathway”
This project studied the ability of arsenic to potentiate hexavalent chromium genotoxicity.
Role: Faculty Participant
R21
Katz (PI)
07/01/03 - 06/30/05
NIH
$300,279
"Chromium as Adjuvant Therapy for Type II Diabetes & Impaired Glucose Tolerance"
This project investigated the use of chromium treatments in diabetes.
1 R01 CA95788-01
Zheng (PI)
07/01/01 - 06/30/03
NIH/NIEHS
$737,907
"PCBs, CYP1A1 Polymorphism and Breast Cancer Risk in CT"
This project investigated genetics and PCB exposure in breast cancer.
Jones (PI)
01/01/02 - 12/31/04
$180,000
Donaghue Medical Research Foundation
"GSTM1, GSTT1, Chemotherapy, Race and Survival in Cancer"
This project investigated genetic polymorphisms in chemotherapy in breast cancer.
U13ES09483-04
de Peyster (PI) 03/01/01 - 02/28/04
NIH/NIEHS
$45,000
"Paracelsus Goes to School"
This project provided training in toxicology to K-12 teachers.
93

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