Treat PE with the only FDA cleared endovascular device PULMONARY EMBOLISM - Reduces Right Ventricular/ Left Ventricular ratio by ~25%1 1 - Reduces PA pressures by ~30% ACCESS PTS Study - 76% less thrombolytic drug dosage than standard treatment1 - Minimized risk of bleeding2 DEEP VEIN THROMBOSIS - 50% of DVT patients have PE3 - Removes thrombus more completely compared to CDT4 - Reduces Post Thrombotic Syndrome5 PERIPHERAL ARTERIAL OCCLUSION - Lower 30-day amputation rate6 - Lower bleeding rates when compared to CDT6 - Higher complete dissolution rate of thrombus6 EkoSonic® Endovascular System 1 Piazza, G., et al., “A Prospective, Single-Arm, Multicenter Trial of Ultrasound-Facilitated, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism (Seattle II).” American College of Cardiology 63rd Annual Scientific Session, Washington, D.C., March 30, 2014. 2 Kucher, N., et al., “Randomized, Controlled Trial of Ultrasound-Assisted Catheter-Directed Thrombolysis for Acute Intermediate-Risk Pulmonary Embolism.” Circulation, Vol. 129, No. 4, 2014, 479–486. 3 Kahn, Sr. Shrier I. Julien, JA., et al., “Determinants and Time Course of the Post-thrombotic Syndrome After Acute Deep Venous Thrombosis.” Annals of Internal Medicine, 149, 2008, 698–707. 4 Mewissen, et al. Catheter-directed Thrombolysis for Lower Extremity Deep Venous Thrombosis: Report of a National Multicenter Registry, Radiology. 1999 Apr;211(1):39-49. 5 Engelberger, R., et al., “Fixed, Low-Dose Ultrasound-Assisted Catheter-Directed Thrombolysis Followed by Routine Stenting of Risidual Stenosis for Acute Ilio-Femoral Deep-Vein Thrombosis.” Journal of Thrombosis and Haemostasis, 2014, 111.6. 6 Lin, P. et al., “Catheter-Directed Thrombectomy and Thrombolysis for Symptomatic Lower-Extremity Deep Vein Thrombosis: Review of Current Interventional Treatment Strategies.” Perspectives in Vascular Surgery and Endovascular Therapy, 2010, 22(3): 152–163. FDA CLEARED INDICATIONS: The EkoSonic® Endovascular System is indicated for the ultrasound facilitated, controlled and selective infusion of physician-specified fluids, including thrombolytics, into the vasculature for the treatment of pulmonary embolism; the controlled and selective infusion of physician-specified fluids, including thrombolytics, into the peripheral vasculature; and the infusion of solutions into the pulmonary arteries. Instructions for Use, including warnings, precautions, potential complications, and contraindications can be found at www.ekoscorp.com. Caution: Federal (USA) law restricts these devices to sale by or on the order of a physician. EKOS® and EkoSonic® are registered trademarks of EKOS Corporation, a BTG International group company. BTG and the BTG roundel logo are registered trademarks of BTG International Ltd. US-EKO-2014-1031