PROGRAMME Journées du Département de Microbiologie 30 juin – 1er juillet 2014 Auditorium -‐ CIS Institut Pasteur, 28 rue du Dr Roux -‐ 75015 Paris Monday, June 30 rd, 2014 09.00 - 09.10 Patrick TRIEU-CUOT Introduction REGULATION Chairpersons : Nadia BENAROUDJ & Sarah DUBRAC 09.10 - 09.30 The role of the global regulator RfaH in Yerinia pestis and Yersinia pseudotuberculosis physiology and pathogenicity. Aurélien LEROY – Unité Yersinia 09.30 - 09.50 Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile. Pierre BOUDRY – Laboratoire Pathogenèse des bactéries anaérobies 09.50 - 10.10 Transcription Activator-‐Like Effectors (TALEs) are effective modulators of transcription in Leptospira spp. Christopher PAPPAS – Unité Biologie des Spirochètes 10.10 - 10.30 Mechanism of interaction between Crl and σS of Salmonella. Paola CAVALIERE – Unité Génétique moléculaire 10.30 - 11.00 Coffee break (Auditorium hall) 11.00 - 11.20 The Institut Pasteur International network: a breeding ground for collaborations. Marc JOUAN – Division International HOST PATHOGEN INTERACTIONS AND VIRULENCE FACTORS Chairpersons : Catherine WERTS & Nienke BUDDELMEIJER Binding of the LipL21 lipoprotein to peptidoglycan impairs Leptospira recognition by Nod receptors. Gwendoline RATET – Unité Biologie et génétique de la paroi bactérienne 11.40 - 12.00 Deciphering the haemorrhagic nature of plague. Guillain MIKATY – Unité Yersinia 11.20 - 11.40 12.00 - 12.20 Mitochondria biogenesis is induced in response to Helicobacter pylori infection in a partially VacA-‐dependent manner. Eliette TOUATI – Unité Pathogenèse de Helicobacter 12.20 - 14.00 Lunch at your convenience – poster session (Auditorium hall) 14.00 - 14.20 RORgt+ cells and symbiotic microbiota. Gérard EBERL – Unité Développement des tissus lymphoïdes 14.20 - 14.40 Ecological and molecular characterisation of colonisation resistance against pathogen infection in a zebrafish model. Franziska STRESSMANN – Unité Génétique des Biofilms 14.40 - 15.00 25 juin 2014 -‐ 16:00 Two-‐photon microscopy of inhalational anthrax infection reveals novel immunological contacts between dendritic cells and alveolar macrophages. Jean Nicolas TOURNIER – Laboratoire Pathogénie et toxi-‐infections bactériennes 3 15.00 - 15.20 Dynamic lipid A acylation in Leptospira. Azad ESHGHI – Unité Biologie des Spirochètes 15.20 - 15.50 Coffee break – poster session (Auditorium hall) PHYLOGENY, GENOMICS AND PHAGES Chairperson : Carmen BUCHRIESER 15.50 - 16.10 Casposons: a new superfamily of DNA transposon-‐like elements at the origin of prokaryotic CRISPR-‐Cas immunity. Mart KRUPOVIC – Unité Biologie moléculaire du gène chez les extrêmophiles 16.10 - 16.30 Discovery of a novel phage defense mechanism in Staphylococci. David BIKARD – G5 Biologie de synthèse 16.30 - 16.50 MIRRI -‐ Microbial Resource Research Infrastructure: A large-‐scale research infrastructure for microbiological services. Raquel HURTADO-‐ORTIZ – Centre de ressources biologiques de l’Institut Pasteur 16.50 - 17.10 17.10 - 17.30 Firmicutes with an outer membrane: towards new models to study the diversity and evolution of bacterial cell envelopes. Luisa ANTUNES – Unité Biologie moléculaire du gène chez les extrêmophiles Whole-‐genome comparison of Group B Streptococcus strains uncovers genomic differences between infected newborns and their mothers. Alexandre ALMEIDA – Unité Biologie des bactéries pathogènes à Gram-‐positif Tuesday, July 1st, 2014 MEMBRANES AND SURFACE PROTEINS Chairpersons : Olivera FRANCETIC & Christophe BELOIN 09.00 - 09.20 Pyrophosphate-‐mediated iron acquisition from transferrin in Neisseria meningitidis does not require TonB activity. Francis BIVILLE – Unité des Infections bactériennes invasives 09.20 - 09.40 Common cell shape evolution of nasopharyngeal pathogens. Frédéric VEYRIER – Unité Biologie et génétique de la paroi bactérienne 09.40 - 10.00 Characterization of the Yad bundle-‐forming fimbriae in Escherichia coli. Fanny LARSONNEUR – Unité Génétique des Biofilms 10.00 - 10.20 Heme iron utilization in Staphylococcus aureus. Antoine RACHID – ex-‐Unité Membranes bactériennes 10.20 - 11.00 Coffee break – poster session (Auditorium hall) 11.00 - 11.20 Control and constraints of bacterial cell shape. Sven VAN TEEFFELEN – G5 Morphogenèse et croissance microbiennes Cyclic di-‐AMP signalling in Group B Streptococcus. Arnaud FIRON -‐ Unité Biologie des bactéries pathogènes à Gram-‐positif 11.20 - 11.40 25 juin 2014 -‐ 16:00 4 11.40 - 12.00 Type 4 Secretion System: bacterial secretion at first sight. Francesca GUBELLINI – G5 Biologie structurale de la sécrétion bactérienne 12.00 - 12.20 Histopathological characterisation of early stages of host-‐pathogen interaction. Grégory JOUVION -‐ Unité Histopathologie humaine et modèles animaux 12.20 - 14.00 Lunch at your convenience – poster session (Auditorium hall) ANTIBIOTICS, TOXINS AND THEIR TARGETS Chairpersons : Laurent DEBARBIEUX & Bruno DUPUY 14.00 - 14.20 Aminoglycoside modifying enzyme Aph(3’)-‐VI originates in Acinetobacter guillouiae. Eun-‐Jeong YOON – Unité Agents antibactériens 14.20 - 14.40 A novel class of toxin-‐antitoxin modules in Helicobacter pylori. Lamya EL MORTAJI – Unité Pathogenèse de Helicobacter 14.40 - 15.00 Secondary metabolite toolbox to dominate freshwater bodies. Claire PANCRACE – Collection des Cyanobactéries 15.00 - 15.20 Clostridial glucosylating toxin binding to cell membrane: structural and functional aspects. Carolina VARELA-‐CHAVEZ – Unité Bactéries anaérobies et toxines 15.20 - 15.40 Detection of botulinum neurotoxins by endoprotease test, an alternative to the standard mouse bioassay. Marie VOILLEQUIN – Unité Bactéries anaérobies et toxines 15.40 - 16.00 Genome architecture in yeast: from 1D to 3D and back. Christophe ZIMMER – Unité Imagerie et modélisation 16.00 - 16.20 Conclusions : Hilde DE REUSE 17:00 - … Closing cocktail and Prize-‐giving 'New England Biolabs' (Bar, Auditorium hall) Comité d’organisation : C. Beloin, H. De Reuse, J.-M. Ghigo, C. Le Bouguénec, P. Trieu-Cuot Contact : [email protected] 25 juin 2014 -‐ 16:00 5
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