DRAFT – Final program available online by August 15 SYMPOSIUM PROGRAM VENUE: The 6th Symposium on Biodegradable Metals will be held at the Hotel Villa del Mare, in Acquafredda di Maratea, Italy. Please note the phone number of the hotel, for emergency (0973 878 007 from Italy, +39 from outside Italy). PRESENTATIONS: All oral communications will be on Power-Point. A computer, audiovisual equipment (microphone, laser-point, etc.) and projector will be available to presenters. Tutorial, Keynote (K) and Oral (O) presenters will dispose of 70, 30, and 20 minutes respectively, including discussions. Short-Oral/Poster (SOP) presenters are invited to present 5 to 10 slides in 5 minutes (strict!) during oral session, while discussions will be held during Poster Session or individually with interested colleagues. Poster presenters are invited to prepare a 1m x 1m poster, display it on Monday Aug 25 and remove it on Thursday Aug 28. Posters will be displayed all along the conference, and delegates can access posters at any time. Oral presenters or other attendees are also invited to bring a poster without prior notice and display it to foster discussions, exchanges and share their expertise. Diego’s suggestions to survive Italy Please note that Maratea is located in Basilicata region, one of the smallest and most ancient region of Italy, also called Lucania (land of the light …). It is a green region, covered by trees, of around 10 000 square km, with only some 600 000 inhabitants. As soon as you land in Rome, please remember you are in Italy. Triple check your baggage and wallet 110% of the time. You are in Italy. Enjoy the life and remember that nothing has to be taken too seriously. This includes trains and departure/arrival times. Even if strong improvements have been done in the last decade, remember, timetables here are only … indicative! Please remain calm, sit down and enjoy … Page vi DRAFT – Final program available online by August 15 Sunday, Aug. 24th, 2014 Check-in at Hotel Villa del Mare on arrival, preferred arrival time after 13h30. Please make arrangements to arrive in Sapri Train station (4 hours from Rome Termini Train Station, 2 hours from Naples). You can find the timetable of the Italian trains online at http://www.ferroviedellostato.it/. Please make sure to buy, in Roma Termini Train Station, BOTH your train tickets TO and FROM Sapri. This will facilitate your travel back to Rome. Sapri si a small town and train tickets can only be bought at limited hours of the day … The Organizing Committee does NOT encourage you to buy tickets online. Please communicate to [email protected] your expected arrival time. A shuttle (identified Hotel Villa del Mare) will pick up you and drive you to the hotel (6 km). Please note the phone number of the hotel, for emergency (from Italy: 0973 878 007, from outside add +39). If you intend to arrive at the Hotel Villa del Mare with your own car, please make an itinerary from your location. The area around Maratea is beautiful but with very low density population and few info-points. 18h00 – 20h00 Registration & Welcome Reception. Our staff will welcome you in Maratea at registration desk (bar level). Please note that the entire hotel is reserved for the 6th Biometal 2014 attendees. 20h30 Welcome Dinner. Please communicate with us ([email protected]) any allergy, or food special request. Although we will do our best, please note we cannot guarantee to fulfil all your requests. Please be organised and plan your special dietary requests. Page vii DRAFT – Final program available online by August 15 Monday, Aug. 25th, 2014 Tutorial Day Time 09:00-09:20 09:20-10:30 10:30-10:50 10:50-12:00 12:00-17:00 17:00-18:10 18:10-19:20 19:20-19:50 20:00-21:00 Title Opening and introductory remarks Metals: element physiology and pathogenesis Coffee Break Iron metabolism in humans Lunch break and beach session Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations Challenges for the investigation of biometal degradation in vitro and in vivo by analytical methods General discussion and other remarks Dinner Tutor Frank Witte Aaron Barchowski Piera Valenti Arie Bruinink Carla Vogt Page viii DRAFT – Final program available online by August 15 Tuesday, 26th August 2014 Session 1: Metals Time Title 08:30-09:00 K1- Stiffness of metals, alloys and components 09:00-09:20 09:20-09:40 09:40-10:00 10:00-10:20 10:20-10:50 10:50-11:10 11:10-11:30 11:30-11:35 Presenter N. Hort O1- Cold-drawn ZM21 and WE43 wires exhibit exceptional strength and A.J. Griebel ductility O2- In situ synchrotron radiation diffraction during solidification of G. Szakács Mg15Gd O3- Thermodynamic calculation and experimental studies of phase relations A. Gil-Santos in the Mg-Si-Ca-Sr system for degradable biomaterials O4- In vitro study on novel Zn-ZnO composites with tunable degradation Y.F. Zheng rate Coffee Break O5 - Experiments and numerical simulations to evaluate peeling properties F. Migliavacca of polymeric coatings for degradable Mg stents O6 - Binder-jetting 3D printing (3DP) of customized patient specific P.N. Kumta craniofacial scaffolds of Fe-Mn based alloys SOP1 - Effect of Sc addition on microstructure, mechanical properties and T. Li in vitro corrosion behaviour of biodegradable Mg-1.5Zn-0.6Zr (ZK21) alloy 11:35-11:40 SOP2- Innovative biodegradable Zinc-based alloys for load-bearing biomedical implant applications SOP3- The prospects of EW62 Mg alloy as a structural material for 11:40-11:45 biodegradable implants SOP4 - Comparative studies of mechanical, corrosion and cytotoxity of 11:45-11:50 MgZnCa and MgZnCa-RES alloys O7- Benefits and limitations of biodegradable mg implants and parts, 11:50-12:10 produced by MIM (metal injection moulding) SOP5 - Submerged laser microcutting of Mg alloys with NS pulsed green 12:10-12:15 laser for biodegradable stents Affiliation Magnesium Innovation Centre, Helmholtz-Zentrum Geesthacht, Germany Fort Wayne Metals Research Products Corp., USA Page Helmholtz-Zentrum Geesthacht, Germany Katholieke Universiteit Leuven, Belgium Peking University, China Politecnico di Milano, Italy University of Pittsburgh, U.S.A Peking University, China J.G. Zhou Drexel University, USA O. Hakimi University of the Negev, Israel Z. Xu North Carolina State University, USA M. Wolff Helmholtz-Zentrum Geesthacht, Germany A.G. Demir Politecnico di Milano, Italy Page ix DRAFT – Final program available online by August 15 Z. Liu Helmholtz-Zentrum Geesthacht, Germany M. Inoue Fuji Light Metal Co., Japan P. N. Kumta University of Pittsburgh, USA 12:15-12:20 SOP6-Mechanical properties of extruded antimicrobial Mg-Ag alloys 12:20-12:25 12:25-12:30 SOP7-Precise extrusion processing of Magnesium alloy small tube for biodegradable stent application SOP8-Evaluation of magnesium alloys for tracheal stent application 12:30-16:00 Lunch break and Free time Tuesday, 26th August 2014 Session 2: Metals Time 16:00-16:20 16:20-16:40 16:40-17:00 Title Presenter O8-Biodegradable Mg alloy with modified nanoscale surface for stent G. Yuan applications O9-The effect of hot rolling on the microstructure and degradation M.V. Manuel behaviour of a Mg-Ca-Sr alloy O10-Synthesis and characterization of biodegradable magnesium-yttrium P. N. Kumta based alloys for musculoskeletal load-bearing medical implants Affiliation Shanghai Jiao Tong University, China University of Florida, USA University of Pittsburgh, USA 17:00-17:05 SOP9-Mechanical and corrosion properties of UFG Mg alloys E. Mostaed Politecnico di Milano, Italy 17:05-17:10 SOP10 -In vitro degradation of pure magnesium and WE43 alloy in human bile Y.F. Zheng Peking University, China 17:10-17:15 SOP11-Magnesium corrosion under physiological conditions N.A. Agha Helmholtz-Zentrum-Geesthacht, Germany B.Y. Peng Xihua University, China 17:15-17:20 17:20-17:50 17:50-18:10 18:10-18:15 SOP12-Influence of deformation on the corrosion and cytocompatibility of biodegradable mg alloys Coffee Break O11- Inflammatory response to magnesium based biodegradable implant M. Costantino materials SOP13-Suitability of novel PLA/Magnesium composites for biodegradable S.C. Cifuentes implants Page Helmholtz-Zentrum Geesthacht, Germany CENIM-CSIC, Spain Page x DRAFT – Final program available online by August 15 18:15-18:20 18:20-18:25 18:25-18:30 SOP14-Metallic magnesium degradation products inhibit human breast cancer bone metastasis via multiple signaling pathways SOP15-Effects of extracellular magnesium extracts on the proliferation and differentiation of human osteoblast-osteoclast co-cultures SOP16-Behaviour of bone cells due to contact to magnesium implant material 18:30-18:50 O12-How does blood contact change magnesium degradation? 18:50-19:50 Meeting ad hoc (location 7th Biometal and BiometaBlog) XH. Qu L.L. Wu A. Burmester R. WillumeitRömer 20:00-21:00 Dinner 21:00-23:00 Poster session Hospital, Shanghai Jiaotong University China Helmholtz-Zentrum Geesthacht, Germany Helmholtz-Zentrum Geesthacht, Germany Helmholtz-Zentrum Geesthacht, Germany Wednesday, 27th August 2014 Session 3: Corrosion Time 08:30-09:00 09:00-09:20 09:20-09:40 09:40-10:00 10:00-10:30 10:30-10:50 10:50-10:55 10:55-11:00 Title K2-Influence of corrosion on mechanical properties of Mg5Gd wire Presenter P. Maier O13-Cyclic voltammetry for prediction of degradation of resorbable W.D. Muelle metallic biomaterials: possibilities and limitations O14-Electrochemical study of Mg-0.6Ca alloy under a constant strain H. Hermawan condition O15-Methodical Screening of Corrosion Mechanisms of Iron Alloys P. Quadbeck for the Manipulation of Degradation Rates Coffee Break O16-Bioactive coatings as a key for advanced biomedical applications SOP17-Corrosion protection of biocompatible HA/CAP composite coating on AZ60 alloy SOP18-Comparison of the degradation behaviour of binary Mg-Ag and Mg-Gd alloys in PBS and in physiological conditions Affiliation Page University of Applied Sciences Stralsund, Germany Charite Universitaetsmedicine Berlin, Germany Universiti Teknologi Malaysia, Malaysia IFAM, Branch LabDresden, Germany A. Eliezer Bialik/Basel Sts. Beer-Sheva, Israel Y. Su Jilin University, China I. Marco Katholieke Universiteit Leuven, Belgium Page xi DRAFT – Final program available online by August 15 11:00-11:05 11:05-11:10 11:10-11:30 12:00-20:00 20:00-23:30 SOP19-Study of magnesium fluoride and self-assembled organosilane T. Hassel Leibniz Universität Hannover, Germany coatings of AZ31 and MgCa0.8 alloys SOP20-Influence of different surface modifications of the magnesium C. Schille University Hospital Tuebingen, Germany alloy WE43 on the electrochemical behaviour O17-Different approaches for in vivo testing of absorbable metals in M. Bartosch Deutsches Herzzentrum Berlin, Germany blood vessels Lunch on the bus and guided excursion - Cilento National Park: Morigerati and Sicili. Casual dress, historical and natural sight visits, dress and shoes for walk Conference Dinner in Sapri (local food and folkloric environment, with possibility of dancing late in the night) Thursday, 28th August 2014 Session 4: In-Vitro Time Title K3-Application of proteomics for investigating the impact of magnesium 08:30-09:00 implants on bone tissue O18-In vitro and in vivo degradation of ultrahigh-pure magnesium 09:00-09:20 09:20-09:40 09:40-10:10 10:10-10:30 10:30-10:50 10:50-10:55 10:55-11:00 11:00-11:05 Presenter H. Schluter J. Hofstetter O19-Are biodegradable Mg-based implant materials suitable for the use in J. Reifenrath osteosynthesis systems? Coffee Break O20-Rational approach for evaluating Mg alloys for their biocompatibility G.J. Dias O21-Study on in vitro biocompatibility and macrophage phagocytosis of Y. Ke Mg17Al12 in Mg-Al-Zn alloys SOP21-Effect of Mg-2Sr alloys on fracture healing in osteoporotic rats, X.H. Qu via smad1/5/8 signalling SOP22-In vitro study on the corrosion protective effect of cells adhesion F. Witte on biodegradable Mg-Nd-Zn-Zr alloy SOP23-Effect of magnesium extract on osteoblastic progenitor cells B.J.C. Luthringer differentiation Affiliation University Medical Center HamburgEppendorf, Germany Page ETH Zurich, Switzerland Veterinary University of Hannover, Germany University of Otago, New Zealand Chinese Academy of Sciences, China Shanghai Jiaotong University, China Julius Wolf Institute, Berlin, Germany Helmholtz-Zentrum Geesthacht, Germany Page xii DRAFT – Final program available online by August 15 11:05-11:10 11:10-11:30 11:30-11:35 11:35-11:40 11:40-11:45 11:45-11:50 11:50-12:15 12:15-16:30 SOP24-Endothelial growth on fluoride and collagen coated magnesium D. Zhu North Carolina State University, USA alloys O22-Magnesium alloys in implantology: the effects of high concentrations J.A.M Maier Università di Milano, Italy of magnesium on human osteoblasts SOP25-In vitro biocompatibility of novel magnesium-rare earth based D. Zhu North Carolina State University, USA stent materials SOP26-Proteomics study of mouse fibroblasts exposed to biodegradable Z. Zhen Peking University, China pure magnesium SOP27-In vivo characterization of brushite coated Mg–Nd–Zn–Zr alloy M. Xiong Fudan University, China for mandible bone repairing applications SOP28-Osseointegration of resorbable magnesium screws – a SRµCT G. Silvia Malmö University, Sweden study Photos session: please join to pass to the history as attendee of 6th Biometal 2014 Lunch and Free time Thursday, 28th August 2014 Session 5: In Vivo Time Title Presenter 16:30-17:00 K4 The application of biodegradable magnesium screw in hip surgery D. Zhao 17:00-17:20 17:20-17:40 17:40-18:10 18:10-18:30 18:30-18:50 O23-Long-term in vivo degradation behaviour of Mg alloys WZ21 and J. Eichler ZX50 – a micro CT study O24-In vivo degradation and biocompatibility of linear cutter staples S. Zhang made of high purity magnesium Coffee Break O25 To be announced O26-Degradable magnesium plates and screws for bone fracture fixation Affiliation Zhongshan Hospital of Dalian University, China Page Medical University Graz, Austria Suzhou Origin Medical Technology Co., China To be added To be added A. Chaya University of Pittsburgh, USA Page xiii DRAFT – Final program available online by August 15 18:50-19:10 19:10-19:30 19:30-19:35 19:35-19:40 19:40-20:00 O27-Magnesium/PLGA composite scaffolds for improved bone A.J. Brown regeneration O28-Embolic risk mitigation in absorbable implants by composite J.E. Schaffer design SOP29-Peri-implant assessment of Fe-HA composite for temporary H. Hermawan bone implants SOP30-Comparison of magnesium alloy and poly-L-lactide screws as E. Marukawa degradable implant in canine fracture model Closing Remarks 20:00-23:30 University of Pittsburgh, USA Fort Wayne Metals Research Products Co., USA Universiti Teknologi Malaysia, Malaysia Tokyo Medical and Dental University, Japan Dinner and Farewell Party Friday, 29th August 2014 9:00-12:00 Standardization meeting. Free attendance, welcome to all 6th Biometal2014 delegates. 12:00 Departure of delegates Page xiv DRAFT – Final program available online by August 15 Poster Session Tuesday 21:00-23:00 Poster Title Presenter Affiliation SOP1 - Effect of Sc addition on microstructure, mechanical properties and in vitro corrosion behaviour of biodegradable Mg-1.5Zn-0.6Zr (ZK21) alloy T. Li University of Science and Technology Beijing, China J.G. Zhou Drexel University, USA O. Hakimi University of the Negev, Beer-Sheva, Israel North Carolina A&T State University, USA SOP2- Innovative biodegradable Zinc-based alloys for load-bearing biomedical implant applications SOP3- The prospects of EW62 Mg alloy as a structural material for biodegradable implants SOP4 - Comparative studies of mechanical, corrosion and cytotoxity of MgZnCa and MgZnCa-RES alloys SOP5 - Submerged laser microcutting of Mg alloys with NS pulsed green laser for biodegradable stents SOP6-Mechanical properties of extruded antimicrobial Mg-Ag alloys Metals SOP7-Precise extrusion processing of Magnesium alloy small tube for biodegradable stent application SOP8-Evaluation of magnesium alloys for tracheal stent application SOP9-Mechanical and corrosion properties of UFG Mg alloys SOP10 -In vitro degradation of pure magnesium and WE43 alloy in human bile SOP11-Magnesium corrosion under physiological conditions SOP12- Influence of deformation on the corrosion and cytocompatibility of biodegradable mg alloys SOP13-Suitability of novel PLA/Magnesium composites for biodegradable implants SOP14-Metallic magnesium degradation products inhibit human breast cancer bone metastasis via multiple signaling pathways Z. Xu Page A.G. Demir Politecnico di Milano, Italy Z. Liu Helmholtz-Zentrum Geesthacht, Germany M. Inoue Fuji Light Metals, Japan P. N. Kumta University of Pittsburgh, USA E. Mostaed Politecnico di Milano, Italy Y.F. Zheng Peking University, China N.A. Agha Helmholtz-Zentrum-Geesthacht, Germany. B.Y. Peng Xihua University, Chengdu China S.C. Cifuentes CENIM-CSIC, Spain X.H. Qu Shanghai Jiaotong University School of Medicine, China Page xv DRAFT – Final program available online by August 15 SOP15-Effects of extracellular magnesium extracts on the proliferation and differentiation of human osteoblast-osteoclast co-cultures Corrosion SOP16-Behaviour of bone cells due to contact to magnesium implant material P1 - Preparation and antibacterial properties of Ag-loaded porous coatings on the Mg-3Nd-4Y-0.5Zr alloy by two-step electrochemical method P2 - Excellent mechanical properties and cytocompatibility of non-rare earth Mg-Zn-based alloys P3 - Characterization and wear behaviour of MAO on high pressure die cast AM50 magnesium alloy P4- Development of long-fine WE43 wire for biodegradable medical applications P5 - A comparative study of the degradation of pure Fe and Fe-20Mn-1.2C alloy in modified hanks’ solution for biodegradable cardiovascular devices SOP17-Corrosion protection of biocompatible HA/CAP composite coating on AZ60 alloy SOP18-Comparison of the degradation behaviour of binary Mg-Ag and MgGd alloys in PBS and in physiological conditions SOP19-Study of magnesium fluoride and self-assembled organosilane coatings of AZ31 and MgCa0.8 alloys SOP20-Influence of different surface modifications of the magnesium alloy WE43 on the electrochemical behaviour P6- Laser structured surfaces on AZ31 Mg alloy: influence on degradation behaviour and coating applicability P7- Combinatorial corrosion studies of Mg-Zn alloy coatings P8-In vitro study on the modified ZK60 alloy with the addition of 0.2wt.% Ca P9- Influence of binary magnesium alloys corrosion on morphology and adhesion of human undifferentiated cells P10- In vitro study on biodegradable Mg-1Ca-2Sr-XZn (X=2, 4, 6) alloys L.L. Wu Helmholtz-Zentrum Geesthacht, Germany A Burmester Helmholtz-Zentrum Geesthacht, Germany S. Yu Weiyang Road, Xi’an, China Y.J. Chen North Carolina State University, USA F. Mert Gazi University, Turkey K. Hanada National Institute (AIST), Japan M. SikoraJasinska Laval University, Canada Y.Su Jilin University, China I. Marco T. Hassel C. Schille Katholieke Universiteit Leuven, Belgium Leibniz Universität Hannover, Germany University Hospital Tuebingen, Germany A.G. Demir Politecnico di Milano, Italy R. Kotoka North Carolina State University, USA M. Zhou Peking University, China F. Cecchinato Faculty of Odontology, Sweden. Y. H. Wu Peking University, China Page xvi DRAFT – Final program available online by August 15 SOP21-Effect of Mg-2Sr alloys on fracture healing in osteoporotic rats, via smad1/5/8 signalling SOP22-In vitro study on the corrosion protective effect of cells adhesion on biodegradable Mg-Nd-Zn-Zr alloy SOP23-Effect of magnesium extract on osteoblastic progenitor cells differentiation SOP24-Endothelial growth on fluoride and collagen coated magnesium alloys SOP25-In vitro biocompatibility of novel magnesium-rare earth based stent materials SOP26-Proteomics study of mouse fibroblasts exposed to biodegradable pure magnesium SOP27-In vivo characterization of brushite coated Mg–Nd–Zn–Zr alloy for mandible bone repairing applications SOP28-Osseointegration of resorbable magnesium screws – a SRµCT study In Vitro P11- Effect of Mg particles on MC3T3-E1 and J774 cellular cycle; influence of fluoride treatment P12-The electrophysiological effects of magnesium-based biomaterials on nerve cells P13- Cytotoxicity evaluation of ions released by a Mg-based alloy (ZEK100) in vitro: Comparison of the results obtained with different assays P14-Novel magnesium-based stent biomaterials with anti-corrosion and drugeluting coatings P15-Effect of magnesium extracts on the chondrogenic differentiation of hucpv cells P16-Effect of magnesium particle shape on in-vitro degradation kinetics of novel PLA/magnesium composites P17-Influence of SaOS-2 cells on corrosion behaviour of cast ZM21 magnesium alloy P18-Proteomic approaches for studying bone tissue sections P19- Evaluation of cell damage produced by Fe ions released as degradation products of biomaterials. Influence of pH changes X.H. Qu Shanghai Jiaotong University School of Medicine, China F. Witte Julius Wolf Institute Berlin, Germany B.J.C. Luthringer Helmholtz-Centre Geesthacht, Germany D. Zhu North Carolina State University, USA D. Zhu University Greensboro, USA Z. Zhen Peking University, China M. Xiong Fudan University, China Galli, Silvia Malmö University, Sweden F. Alvarez Universidad Nacional de La Plata, Argentina T.F. Xi Peking University, Beijing, China. C.A. Grillo Universidad Nacional de La Plata, Argentina J. Ma University Greensboro, USA A.H. MartínezSánchez Helmholtz-Zentrum Geesthacht, Germany S.C. Cifuentes CENIM-CSIC, Spain A. Witecka NIMS, Japan M. Omidi N. S. Fagali University Medical Center Hamburg, Germany Universidad Nacional de La Plata, Argentina. Page xvii DRAFT – Final program available online by August 15 P20-Recommendation for modification of current cytotoxicity testing standards for biodegradable magnesium materials SOP29-Peri-implant assessment of Fe-HA composite for temporary bone implants SOP30-Comparison of magnesium alloy and poly-L-lactide screws as degradable implant in canine fracture model P21-The evaluation of histological methods for biodegradable magnesium In Vivo J. Wang H. Hermawan E. Marukawa H-S. Han The Chinese University of HongKong, China Universiti Teknologi Malaysia, Malaysia Tokyo Medical and Dental University, Japan Korea Institute of Science and Technology, Korea P22-Biodegradable Mg-Cu alloy implants with antibacterial and osteostimulatory activity for the treatment of osteomyelitis: in vitro and in vivo evaluation Y. Li Shanghai Jiaotong University, China. P23- The effect of metallic magnesium degradation products on osteoclastinduced osteolysis and attenuation of NF-κB and NFATc1 signaling Z.J. Zhai Shanghai Jiaotong University, China E.Martinelli University Graz, Austria H. Nygren University of Gothenburg, Sweden P24- Ultra-pure magnesium alloys for use as biodegradable paediatric osteosynthetic material P25-Increase of compact bone mass is the endpoint effect of MgO implants Pagexviii
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