Einladung zu einem Kolloquium

Laboratorium für Physikalische Chemie
Einladung zu einem Kolloquium
Hörsaal HCI J 3
ETH Zürich, Hönggerberg
Datum/Zeit:
Dienstag, 20. September 2016, 16.45 Uhr
Referent:
Prof. Frédéric Allain
Institute of Molecular Biology and Biophysics,
ETH Zürich, Schweiz
Thema:
Hybrid structural approaches to solve structures of
protein-nucleic acid complexes
Protein-RNA-complexes are central for the regulation of gene expression and thus
crucial for cellular function. While solving structures of protein-RNA complex with
NMR has been very successful owing to the low affinity of many RNA-protein
interactions, the size limitation of the complexes that could be tackled structurally
solely by NMR has remained an issue. Using EPR and more recently Massspectrometry (MS) in combination with NMR has allowed us to investigate the
structures of larger protein-RNA complexes.
G. Masliaha, G. Dorna, A. Leitnera, , M. Yulikovb, R, Aebersolda, G. Jeschkeb, F. Allaina
a
b
Department of Biology, ETH Zurich, 8093, Zurich, Switzerland
Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland
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