Neurologie – Klinische Forschung, Stand 14. März 2016 Laufende klinische Versuche Aim Principal Investigator Kamm Status Research Area Insel-ID KeK-Nr. Recruiting MS 2525 054/14 1 Teriflunomide in RRMS patients Assessing Clinical benefit and patient reported Outcomes in real-life practice 2 Influencing implicit task sequence learning and consolidation with transcranial stimulation Müri Recruiting Neurorehabilitation 2694 179/14 3 Interactions between attentional networks and their influence on perception: a project in healthy subjects and hemispatial patients (AtNet) AUTOREST 1: To compare daytime and nighttime autonomic function and cardiovascular risk markers in patients with RLS to healthy control subjects AUTOREST 2: The effects of Pramipraxole versus Placebo on daytime and nigthtime autonomic function and selected markers of cardiovascular risk in patients with RLS eSATIS: Investigation of the impact of obstructive, central and mixed SBD and its early treatment with Adaptive Servo-Ventilation (ASV) on patients’ rehabilitation from stroke within the first 3 month following stroke onset. Thrombolysis or anticoagulation for cerebral venous thrombosis (TO-ACT) Müri Recruiting Neurorehabilitation 2764 36/15 Bassetti Recruiting Sleep 2590 183/14 Bassetti Recruiting Sleep 2734 016/15 Arnold Recruiting Stroke 2434 159/13 Arnold Recruiting Stroke 2478 192/13 4 5 6 7 Arnold Recruiting Stroke 2911 247/15 9 Biomarkers and antithrombotic treatment in cervical artery dissection (TREAT-CAD) Multicenter, randomized, double-blind, double-dummy, active-comparator, event-driven, superiority phase III study of secondary prevention of stroke and prevention of systemic embolism in patients with a recent Embolic Stroke of Undetermined Source (ESUS), comparing rivaroxaban 15 mg once daily with aspirin 100 mg (NAVIGATE ESUS) Randomized trial comparing best medical treatment vs. decompressive hemicraniecotmy in spontaneoaus intracerebral hemorrhage (SWITCH) Fischer Recruiting Stroke 2577 163/14 10 Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH 2) Fischer Recruiting Stroke 2970 363/15 8 Laufende Forschungsprojekte Aim 11 Multi-scale intracranial EEG dynamics during wakefulness and sleep: implications for seizure generation. 12 Spike-getriggertes Reaktionszeit-EEG, ein zusätzliches Entscheidungsinstrument für die Beurteilung der Fahreignung bei Epilepsie? Gezielte "next-generation" Sequenzierung von Kandidatengenen und selektiertem Transkriptom in der Temporalllappenepilepsie - Ausdehnung von genomischen Methoden auf die RNA Pharmakotherapie-resistenter Epilepsien Die Rolle mediotemporaler Ripples in der Konsolidierung von bewusst und unbewusst enkodierten episodischen Gedächtnisspuren. 13 14 15 Project Leader(s) Gast Status Research Area Insel-ID KeK-Nr. Recruiting Epilepsy 2510 034/10 Krestel Recruiting Epilepsy 1979 165/10 Krestel Recruiting Epilepsy 2360 038/13 Schindler Recruiting Epilepsy 2431 154/13 Schindler Recruiting Epilepsy 2521 051/14 Meier Recruiting Movement 2712 285/14 Schüpbach Recruiting Movement 2365 021/13 17 A Bayesian Inference Approach to Intracranial EEG Seizure Dynamics. International, multicenter, non-interventional, prospective, longitudinal study to investigate the effictiveness of Botulinum Toxin A (Dysport®) injections in patients suffering from post-stroke arm spacticity with respect to early, medium or late start of treatment (AS-NIS early BIRD) Study of mechanism of deep brain stimulation for tremor by means of peri- and posoperative accelerometric recordings. 18 Weltweites Register zur Beobachtung von Schwangerschaften unter Gilenya. Kamm Recruiting MS 2248 081/11 19 Nicht-interventionelle Beobachtungsstudie von Patienten unter Gilenya und anderen DMTs Kamm Recruiting MS 2364 208/12 20 Schweizweites Register von MS-Patienten Kamm Recruiting MS 2456 131/12 21 Validierung eines Fragebogens für manuelle Geschicklichkeit bei MS-Patienten (AMSQ) in Deutsch Kamm Recruiting MS 2506 028/14 22 Analyse von Bewegungen von MS-Patienten mit Kinect Kamm Recruiting MS 2515 055/14 16 NCTU_laufende Studien Neurologie 14. März 2016 1 Laufende Forschungsprojekte Aim Project Leader(s) Kamm Status Research Area Insel-ID KeK-Nr. Recruiting MS 2627 214/14 23 BETAEVAL_GLOBAL - The new BETACONNECT TM auto-jector: Adherence and EVALuation of MS patients treated with Betaferon. 24 A prospective, multicenter, observational study to assess the correlation of EDSS with quality of life in MS patients treated with natalizumab Kamm Recruiting MS 2707 254/14 25 REAL-Life long-Term Effectiveness of fingolinod (Gilenya) in patients with reapsing-remitting multiple sclerosis Kamm Recruiting MS 2863 147/15 26 Stellenwert der „Cutaneous silent period“ für die Diagnostik der distalen Small fiber Neuropathie im Vergleich zu Hautbiopsie und QSART Kugler Recruiting Neuromuscular 1840 012/10 27 Swiss Pompe Registry Rösler Recruiting Neuromuscular 2121 119/11 28 Einsatz bildgebenden Ultraschalles zur Positionierung von Nadelelektroden bei der sensiblen Neurographie. Einfluss der kontraläsionellen Hemisphäre auf die sprachlichen Leistungen der aphasischen Patienten – eine Transkranielle Magnetstimulation (TMS) Studie. Motion and spatial neglect: Visuelle Aufmerksamkeit und Bewegungswahrnehmung bei Patienten mit Neglektsymptomatik. Rösler Recruiting Neuromuscular 2195 097/08 Müri Recruiting Neurorehabilitation 1842 002/10 Müri Recruiting Neurorehabilitation 2184 076/12 Aphasie und Gestik. Rehabilitation kombiniert mit bihemispahrischer transkranieller Gleichstromstimulation in subakuten Hirnschlagpatienten mit dem Ziel, den motorischen Rückgewinn der oberen Extremitäten zu fördern. Improving dexterous skills in Parkinson’s disease: A randomized controlled trial. Neurokognitive Mechanismen der mentalen Vorstellung: okulomotorische und repräsentationale Aspekte. Projekt 1: Einfluss von mentaler Vorstellung auf die kortikale Erregbarkeit. Projekt 2: Vorstellung und Augenbewegungen. Projekt 3: Einfluss von transkranieller Gleichstromstimulation auf die mentale Arithmetik. Signifikanz eines Rechts-Links-Shuntes bei rezidivierenden Vasovagalen Synkopen. Sleep Deficiency and Stroke Outcome: Investigation of the impact of sleep loss and sleep disorders on patients’ rehabilitation and quality of life and on the risk for further cardiovascular events within the 12 months following stroke onset. Müri Recruiting Neurorehabilitation 2208 083/12 Müri Recruiting Neurorehabilitation 2350 042/13 Müri Recruiting Neurorehabilitation 2426 131/13 Müri Recruiting Neurorehabilitation 2484 220/13 Humm Recruiting other 1655 238/08 Bassetti Recruiting Sleep 2765 014/15 Recruiting Sleep 2835 054/15 Recruiting Sleep 1267 185/06 29 30 31 32 33 34 35 36 37 Etiopathology of Narcolpsy-Cataplexy: Autoimmunity and Neurodegeneration (ENaCAN) 38 Diagnostic study in order to differentiate between organic- and non-organic causes of daytime sleepiness by use of vigilance tests (retrospective part) Bassetti Kallweit Mathis 39 Untersuchung eines funktionellen Zusammenhangs zwischen genetischen Markern und Narkolepsie. Mathis Recruiting Sleep 1637 214/08 40 European Narcolepsy Network Mathis Recruiting Sleep 1909 107/10 41 Swiss Intravenous and Intra-arterial Thrombolysis for Treatment of Acute Ischemic Stroke Registry (SWISS) Arnold Recruiting Stroke 1446 233/07 42 The Role of Factor XIII Activation Peptide and D-dimer Values for the Diagnosis of Cerebral Venous Thrombosis. Arnold Recruiting Stroke 1710 112/09 43 BioCad 2 Arnold Recruiting Stroke 1739 112/12 44 Contrast Enhanced MRI in Spontaneous and Traumatic Cervicocerebral Artery Dissection (MRI-CAD) Arnold Recruiting Stroke 2251 099/12 45 Symptomatic Atherothrombotic Vertebral Artery Stenosis (SAVAS)-Study Arnold Recruiting Stroke 2287 093/11 46 Thrombolysis or anticoagulation for cerebral venous thrombosis (TO-ACT) Arnold Recruiting Stroke 2434 159/13 47 Biomarkers and antithrombotic treatment in cervical artery dissection (TREAT-CAD) Arnold Recruiting Stroke 2478 192/13 48 Korrelation von klinischen und bildmorphographischen Parametern mit dem Outcome bei akuten zerebrovaskulären Erkrankungen. Arnold Active Stroke 2611 231/14 49 Biomarker Signature of Stroke Aetiology Study (BIOSIGNAL). Studie zur Untersuchung der Wertigkeit von Biomarkern in der Schlaganfall-Ätiologie. Arnold Recruiting Stroke 2667 269/14 50 Role of carotid anatomy, distension and displacement in the pathogenesis of carotid artery dissection (CADD-CAD) Fischer Recruiting Stroke 1775 186/09 51 BIO-STROKE Gralla Recruiting Stroke 2296 126/12 NCTU_laufende Studien Neurologie 14. März 2016 2 Laufende Forschungsprojekte Aim Project Leader(s) Status Research Area Insel-ID KeK-Nr. Jung Recruiting Stroke 2391 090/13 Jung Recruiting Stroke 2400 078/13 53 Prospective randomized, cross-over study to validate the effects of an outpatient secondary prevention program for stroke victims with minor or no residual deficits (Neurofit) Effect of epileptoform brain activity and spreading depression on penumbral evolution and outcome in acute stroke. 54 The brain heart interaction in acute stroke. Jung Recruiting Stroke 2561 155/14 55 Secondary Stroke Prevention In Patients With Patent Foramen Ovale: The Swiss PFO Consortium. Mono Recruiting Stroke 1575 117/08 56 In vivo Detection of Vulnerable Carotid Atherosclerotic Plaques: Co-Registration of Colour Mapped GSM Ultrasound Data and 3 Tesla MRI Images Die Bedeutung der Endothel- und Blutplättchenaktivierung, Entzündung und Plaque-Morphologie in der Behandlung der Stenose der A. carotis interna mit Stent oder Endarteriektomie (BIO-PLAQUE) Obesity paradox Mono Recruiting Stroke 2340 184/12 Mono Recruiting Stroke 2377 080/13 Sarikaya Recruiting Stroke 2738 367/14 52 57 58 NCTU_laufende Studien Neurologie 14. März 2016 3
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