Übersicht über die laufenden Studien

Neurologie – Klinische Forschung, Stand 14. März 2016
Laufende klinische Versuche
Aim
Principal
Investigator
Kamm
Status
Research Area
Insel-ID
KeK-Nr.
Recruiting
MS
2525
054/14
1
Teriflunomide in RRMS patients Assessing Clinical benefit and patient reported Outcomes in real-life practice
2
Influencing implicit task sequence learning and consolidation with transcranial stimulation
Müri
Recruiting
Neurorehabilitation
2694
179/14
3
Interactions between attentional networks and their influence on perception: a project in healthy subjects and hemispatial patients (AtNet)
AUTOREST 1: To compare daytime and nighttime autonomic function and cardiovascular risk markers in patients with RLS to healthy control subjects
AUTOREST 2: The effects of Pramipraxole versus Placebo on daytime and nigthtime autonomic function and selected markers of cardiovascular risk in
patients with RLS
eSATIS: Investigation of the impact of obstructive, central and mixed SBD and its early treatment with Adaptive Servo-Ventilation (ASV) on patients’
rehabilitation from stroke within the first 3 month following stroke onset.
Thrombolysis or anticoagulation for cerebral venous thrombosis (TO-ACT)
Müri
Recruiting
Neurorehabilitation
2764
36/15
Bassetti
Recruiting
Sleep
2590
183/14
Bassetti
Recruiting
Sleep
2734
016/15
Arnold
Recruiting
Stroke
2434
159/13
Arnold
Recruiting
Stroke
2478
192/13
4
5
6
7
Arnold
Recruiting
Stroke
2911
247/15
9
Biomarkers and antithrombotic treatment in cervical artery dissection (TREAT-CAD)
Multicenter, randomized, double-blind, double-dummy, active-comparator, event-driven, superiority phase III study of secondary prevention of stroke
and prevention of systemic embolism in patients with a recent Embolic Stroke of Undetermined Source (ESUS), comparing rivaroxaban 15 mg once
daily with aspirin 100 mg (NAVIGATE ESUS)
Randomized trial comparing best medical treatment vs. decompressive hemicraniecotmy in spontaneoaus intracerebral hemorrhage (SWITCH)
Fischer
Recruiting
Stroke
2577
163/14
10
Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH 2)
Fischer
Recruiting
Stroke
2970
363/15
8
Laufende Forschungsprojekte
Aim
11
Multi-scale intracranial EEG dynamics during wakefulness and sleep: implications for seizure generation.
12
Spike-getriggertes Reaktionszeit-EEG, ein zusätzliches Entscheidungsinstrument für die Beurteilung der Fahreignung bei Epilepsie?
Gezielte "next-generation" Sequenzierung von Kandidatengenen und selektiertem Transkriptom in der Temporalllappenepilepsie - Ausdehnung von
genomischen Methoden auf die RNA Pharmakotherapie-resistenter Epilepsien
Die Rolle mediotemporaler Ripples in der Konsolidierung von bewusst und unbewusst enkodierten episodischen Gedächtnisspuren.
13
14
15
Project
Leader(s)
Gast
Status
Research Area
Insel-ID
KeK-Nr.
Recruiting
Epilepsy
2510
034/10
Krestel
Recruiting
Epilepsy
1979
165/10
Krestel
Recruiting
Epilepsy
2360
038/13
Schindler
Recruiting
Epilepsy
2431
154/13
Schindler
Recruiting
Epilepsy
2521
051/14
Meier
Recruiting
Movement
2712
285/14
Schüpbach
Recruiting
Movement
2365
021/13
17
A Bayesian Inference Approach to Intracranial EEG Seizure Dynamics.
International, multicenter, non-interventional, prospective, longitudinal study to investigate the effictiveness of Botulinum Toxin A (Dysport®) injections
in patients suffering from post-stroke arm spacticity with respect to early, medium or late start of treatment (AS-NIS early BIRD)
Study of mechanism of deep brain stimulation for tremor by means of peri- and posoperative accelerometric recordings.
18
Weltweites Register zur Beobachtung von Schwangerschaften unter Gilenya.
Kamm
Recruiting
MS
2248
081/11
19
Nicht-interventionelle Beobachtungsstudie von Patienten unter Gilenya und anderen DMTs
Kamm
Recruiting
MS
2364
208/12
20
Schweizweites Register von MS-Patienten
Kamm
Recruiting
MS
2456
131/12
21
Validierung eines Fragebogens für manuelle Geschicklichkeit bei MS-Patienten (AMSQ) in Deutsch
Kamm
Recruiting
MS
2506
028/14
22
Analyse von Bewegungen von MS-Patienten mit Kinect
Kamm
Recruiting
MS
2515
055/14
16
NCTU_laufende Studien Neurologie
14. März 2016
1
Laufende Forschungsprojekte
Aim
Project
Leader(s)
Kamm
Status
Research Area
Insel-ID
KeK-Nr.
Recruiting
MS
2627
214/14
23
BETAEVAL_GLOBAL - The new BETACONNECT TM auto-jector: Adherence and EVALuation of MS patients treated with Betaferon.
24
A prospective, multicenter, observational study to assess the correlation of EDSS with quality of life in MS patients treated with natalizumab
Kamm
Recruiting
MS
2707
254/14
25
REAL-Life long-Term Effectiveness of fingolinod (Gilenya) in patients with reapsing-remitting multiple sclerosis
Kamm
Recruiting
MS
2863
147/15
26
Stellenwert der „Cutaneous silent period“ für die Diagnostik der distalen Small fiber Neuropathie im Vergleich zu Hautbiopsie und QSART
Kugler
Recruiting
Neuromuscular
1840
012/10
27
Swiss Pompe Registry
Rösler
Recruiting
Neuromuscular
2121
119/11
28
Einsatz bildgebenden Ultraschalles zur Positionierung von Nadelelektroden bei der sensiblen Neurographie.
Einfluss der kontraläsionellen Hemisphäre auf die sprachlichen Leistungen der aphasischen Patienten – eine Transkranielle Magnetstimulation (TMS)
Studie.
Motion and spatial neglect: Visuelle Aufmerksamkeit und Bewegungswahrnehmung bei Patienten mit Neglektsymptomatik.
Rösler
Recruiting
Neuromuscular
2195
097/08
Müri
Recruiting
Neurorehabilitation
1842
002/10
Müri
Recruiting
Neurorehabilitation
2184
076/12
Aphasie und Gestik.
Rehabilitation kombiniert mit bihemispahrischer transkranieller Gleichstromstimulation in subakuten Hirnschlagpatienten mit dem Ziel, den motorischen
Rückgewinn der oberen Extremitäten zu fördern.
Improving dexterous skills in Parkinson’s disease: A randomized controlled trial.
Neurokognitive Mechanismen der mentalen Vorstellung: okulomotorische und repräsentationale Aspekte. Projekt 1: Einfluss von mentaler Vorstellung
auf die kortikale Erregbarkeit. Projekt 2: Vorstellung und Augenbewegungen. Projekt 3: Einfluss von transkranieller Gleichstromstimulation auf die
mentale Arithmetik.
Signifikanz eines Rechts-Links-Shuntes bei rezidivierenden Vasovagalen Synkopen.
Sleep Deficiency and Stroke Outcome: Investigation of the impact of sleep loss and sleep disorders on patients’ rehabilitation and quality of life and
on the risk for further cardiovascular events within the 12 months following stroke onset.
Müri
Recruiting
Neurorehabilitation
2208
083/12
Müri
Recruiting
Neurorehabilitation
2350
042/13
Müri
Recruiting
Neurorehabilitation
2426
131/13
Müri
Recruiting
Neurorehabilitation
2484
220/13
Humm
Recruiting
other
1655
238/08
Bassetti
Recruiting
Sleep
2765
014/15
Recruiting
Sleep
2835
054/15
Recruiting
Sleep
1267
185/06
29
30
31
32
33
34
35
36
37
Etiopathology of Narcolpsy-Cataplexy: Autoimmunity and Neurodegeneration (ENaCAN)
38
Diagnostic study in order to differentiate between organic- and non-organic causes of daytime sleepiness by use of vigilance tests (retrospective part)
Bassetti
Kallweit
Mathis
39
Untersuchung eines funktionellen Zusammenhangs zwischen genetischen Markern und Narkolepsie.
Mathis
Recruiting
Sleep
1637
214/08
40
European Narcolepsy Network
Mathis
Recruiting
Sleep
1909
107/10
41
Swiss Intravenous and Intra-arterial Thrombolysis for Treatment of Acute Ischemic Stroke Registry (SWISS)
Arnold
Recruiting
Stroke
1446
233/07
42
The Role of Factor XIII Activation Peptide and D-dimer Values for the Diagnosis of Cerebral Venous Thrombosis.
Arnold
Recruiting
Stroke
1710
112/09
43
BioCad 2
Arnold
Recruiting
Stroke
1739
112/12
44
Contrast Enhanced MRI in Spontaneous and Traumatic Cervicocerebral Artery Dissection (MRI-CAD)
Arnold
Recruiting
Stroke
2251
099/12
45
Symptomatic Atherothrombotic Vertebral Artery Stenosis (SAVAS)-Study
Arnold
Recruiting
Stroke
2287
093/11
46
Thrombolysis or anticoagulation for cerebral venous thrombosis (TO-ACT)
Arnold
Recruiting
Stroke
2434
159/13
47
Biomarkers and antithrombotic treatment in cervical artery dissection (TREAT-CAD)
Arnold
Recruiting
Stroke
2478
192/13
48
Korrelation von klinischen und bildmorphographischen Parametern mit dem Outcome bei akuten zerebrovaskulären Erkrankungen.
Arnold
Active
Stroke
2611
231/14
49
Biomarker Signature of Stroke Aetiology Study (BIOSIGNAL). Studie zur Untersuchung der Wertigkeit von Biomarkern in der Schlaganfall-Ätiologie.
Arnold
Recruiting
Stroke
2667
269/14
50
Role of carotid anatomy, distension and displacement in the pathogenesis of carotid artery dissection (CADD-CAD)
Fischer
Recruiting
Stroke
1775
186/09
51
BIO-STROKE
Gralla
Recruiting
Stroke
2296
126/12
NCTU_laufende Studien Neurologie
14. März 2016
2
Laufende Forschungsprojekte
Aim
Project
Leader(s)
Status
Research Area
Insel-ID
KeK-Nr.
Jung
Recruiting
Stroke
2391
090/13
Jung
Recruiting
Stroke
2400
078/13
53
Prospective randomized, cross-over study to validate the effects of an outpatient secondary prevention program for stroke victims with minor or no
residual deficits (Neurofit)
Effect of epileptoform brain activity and spreading depression on penumbral evolution and outcome in acute stroke.
54
The brain heart interaction in acute stroke.
Jung
Recruiting
Stroke
2561
155/14
55
Secondary Stroke Prevention In Patients With Patent Foramen Ovale: The Swiss PFO Consortium.
Mono
Recruiting
Stroke
1575
117/08
56
In vivo Detection of Vulnerable Carotid Atherosclerotic Plaques: Co-Registration of Colour Mapped GSM Ultrasound Data and 3 Tesla MRI Images
Die Bedeutung der Endothel- und Blutplättchenaktivierung, Entzündung und Plaque-Morphologie in der Behandlung der Stenose der A. carotis interna
mit Stent oder Endarteriektomie (BIO-PLAQUE)
Obesity paradox
Mono
Recruiting
Stroke
2340
184/12
Mono
Recruiting
Stroke
2377
080/13
Sarikaya
Recruiting
Stroke
2738
367/14
52
57
58
NCTU_laufende Studien Neurologie
14. März 2016
3