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S. 12 – 17: Update: Chronisch-entzündliche Darmerkrankungen Von Prof. Dr. Andreas de Weerth, PD Dr. Michael Bläker
1. Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, Benchimol EI, Panaccione R, Ghosh S, Barkema HW,
Kaplan GG..: Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic
review. Gastroenterology 2012; 142: 46–54
2. Langholz E, Munkholm P, Nielsen OH, Kreiner S, Binder V. Incidence and prevalence of ulcerative colitis in Copenhagen
county from 1962 to 1987. Scand J Gastroenterol 1991; 26:1247.
3. Loftus EV Jr, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Crohn‘s disease in Olmsted
County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology 1998; 114:1161.
4. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell
DP, Karban A, Loftus EV Jr, Peña AS, Riddell RH, Sachar DB, Schreiber S, Steinhart AH, Targan SR, Vermeire S, Warren
BF.Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a
Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19 Suppl A:5A-36A.
5. Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease:
controversies, consensus, and implications. Gut 2006; 55: 749-53.
6. Yamada. Textbook of Gastroenterology, 4, Vol 2.
7. Mekhjian HS, Switz DM, Melnyk CS, Rankin GB, Brooks RK.et al. Clinical features and natural history of Crohn‘s disease.
Gastroenterology 1979; 77:898-906
8. Schwartz DA, Loftus EV Jr, Tremaine WJ, et al. The natural history of fistulizing Crohn‘s disease in Olmsted County,
Minnesota. Gastroenterology 2002; 122:875-80
9. Lichtenstein GR, Hanauer SB, Sandborn WJ, Practice Parameters Committee of American College of Gastroenterology.
Management of Crohn‘s disease in adults. Am J Gastroenterol 2009; 104:465.483
10. Mosli MH, Zou G, Garg SK, Feagan SG, MacDonald JK, Chande N, Sandborn WJ, Feagan BG. C-reactive protein, fecal
calprotectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease
Patients: A systematic review and meta-analysis. Am J Gastroenterol 2015; 110: 802–819
11. Annese V, Daperno M, Rutter MD, Amiot A, Bossuyt P, East J, Ferrante M, Götz M, Katsanos KH, Kießlich R, Ordás I, Repici
A, Rosa B, Sebastian S, Kucharzik T, Eliakim R; European Crohn‘s and Colitis Organisation. European evidence based
consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis 2013; 7: 982–1018
12. Travis SP, Schnell D, Krzeski P, Abreu MT, Altman DG, Colombel JF, Feagan BG, Hanauer SB, Lémann M, Lichtenstein GR,
Marteau PR, Reinisch W, Sands BE, Yacyshyn BR, Bernhardt CA, Mary JY, Sandborn WJ. Developing an instrument to
assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). Gut 2012;
61:535-542
13. Wehkamp J, Fellermann K, Herrlinger KR, Bevins CL, Stange EF: Mechanisms of disease: defensins in gastrointestinal
diseases. Nat Clin Pract Gastroenterol Hepatol 2005; 2: 406–415
14. VanDussen KL, Liu TC Li D, Towfic F, Modiano N, Winter R, Haritunians T, Taylor KD, Dhall D, Targan SR, Xavier RJ,
McGovern DP, Stappenbeck TS.: Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of
Crohn’s disease. Gastroenterology 2014; 146: 200–209
15. de Souza HS, Fiocchi C. Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol. 2016
Jan;13(1):13-27
16. Zundler S, Neurath MF: Immunopathogenesis of inflammatory bowel diseases: functional role of T cells and T cell
homing. Clin Exp Rheumatol 2015; 33: 19–28.
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17. Petersen BS, Spehlmann ME, Raedler A, Stade B, Thomsen I, Rabionet R, Rosenstiel P, Schreiber S, Franke A.
Whole genome and exome sequencing of monozygotic twins discordant for Crohn‘s disease. BMC Genomics.
2014 Jul 5;15:564 15-564.
18. Farraye FA, Odze RD, Eaden J, Itzkowitz SH, McCabe RP, Dassopoulos T, Lewis JD, Ullman TA, James T 3rd, McLeod R,
Burgart LJ, Allen J, Brill JV. AGA medical position statement on the diagnosis and management of colorectal neoplasia
in inflammatory bowel disease. Gastroenterology 2010; 138:738.
19. Jess T, Loftus EV Jr, Velayos FS, et al. Risk of intestinal cancer in inflammatory bowel disease: a population-based study
from olmsted county, Minnesota. Gastroenterology 2006; 130:1039.
20. Hemminki K, Li X, Sundquist J, Sundquist K. Cancer risks in Crohn disease patients. Ann Oncol 2009; 20:574-580
21. Abraham BP. Cancer surveillance in ulcerative colitis and Crohn‘s disease: new strategies. Curr Opin Gastroenterol. 2016
Jan; 32(1):32-37
22. Weterman IT, Biemond I, Peña AS. Mortality and causes of death in Crohn‘s disease. Review of 50 years‘ experience in
Leiden University Hospital. Gut 1990; 31:1387-90
23. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP.
Colonoscopy is associated with a reduced risk for colon cancer and mortality in patients with inflammatory bowel
diseases. Clin Gastroenterol Hepatol 2015; 13:322-329
24. Solberg IC, Vatn MH, Høie O, Stray N, Sauar J, Jahnsen J, Moum B, Lygren I; IBSEN Study Group.Clinical course in Crohn‘s
disease: results of a Norwegian population-based ten-year follow-up study. Clin Gastroenterol Hepatol 2007; 5:1430-1438
25. Beaugerie L, Seksik P, Nion-Larmurier I, Gendre JP, Cosnes J. Predictors of Crohn‘s disease. Gastroenterology 2006;
130:650-656
26. Cosnes J, Bourrier A, Nion-Larmurier I, Sokol H, Beaugerie L, Seksik P. Factors affecting outcomes in Crohn‘s disease over
15 years. Gut 2012; 61:1140-1445
27. Thia KT, Sandborn WJ, Harmsen WS, Zinsmeister AR, Loftus EV Jr.Risk factors associated with progression to intestinal
complications of Crohn‘s disease in a population-based cohort. Gastroenterology 2010; 139:1147.1455
28. Dignass A, Preiss JC, Aust DE, Autschbach F, Ballauff A, Barretton G, Bokemeyer B, Fichtner-Feigl S, Hagel S, Herrlinger KR,
Jantschek G, Kroesen A, Kruis W, Kucharzik T, Langhorst J, Reinshagen M, Rogler G, Schleiermacher D, Schmidt C,
Schreiber S, Schulze H, Stange E, Zeitz M, Hoffmann JC, Stallmach A. [Updated German guideline on diagnosis and
treatment of ulcerative colitis, 2011]. Z Gastroenterol. 2011 Sep;49(9):1276-341.
29. Preiß JC, Bokemeyer B, Buhr HJ, Dignaß A, Häuser W, Hartmann F, Herrlinger KR, Kaltz B, Kienle P, Kruis W, Kucharzik T,
Langhorst J, Schreiber S, Siegmund B, Stallmach A, Stange EF, Stein J, Hoffmann JC; [Updated German clinical practice
guideline on „Diagnosis and treatment of Crohn‘s disease“ 2014]. Z Gastroenterol. 2014 Dec;52(12):1431-84.
30. Ardizzone S, Cassinotti A, Duca P, Mazzali C, Penati C, Manes G, Marmo R, Massari A, Molteni P, Maconi G, Porro GB.
Mucosal healing predicts late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitis.
Clin Gastroenterol Hepatol 2011; 9:483-489
31. Colombel JF, Rutgeerts P, Reinisch W, Esser D, Wang Y, Lang Y, Marano CW, Strauss R, Oddens BJ, Feagan BG, Hanauer SB,
Lichtenstein GR, Present D, Sands BE, Sandborn WJ. Early mucosal healing with infliximab is associated with improved
long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011; 141:1194-1201
32. Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, Lichtiger S, D‘Haens G, Diamond RH,
Broussard DL, Tang KL, van der Woude CJ, Rutgeerts P; SONIC Study Group. Infliximab, azathioprine, or combination
therapy for Crohn‘s disease. N Engl J Med. 2010 Apr 15;362(15):1383-95.
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33. Panaccione R, Ghosh S, Middleton S, Márquez JR, Scott BB, Flint L, van Hoogstraten HJ, Chen AC, Zheng H, Danese S,
Rutgeerts P. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in
ulcerative colitis. Gastroenterology. 2014 Feb;146(2):392-400
34. Chaudrey K, Salvaggio M, Ahmed A, Mahmood S, Ali T. Updates in vaccination: recommendations for adult inflammatory
bowel disease patients. World J Gastroenterol. 2015 Mar 21;21(11):3184-96.
35. Rahier JF, Magro F, Abreu C, et al.: Second European evidence-based consensus on the prevention, diagnosis and
management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis 2014; 8: 443–468
36. Ott C, Schölmerich J. Extraintestinal manifestations and complications in IBD. Nat Rev Gastroenterol Hepatol. 2013
Oct;10(10):585-595.
37. Sifuentes H, Kane S. Monitoring for Extra-Intestinal Cancers in IBD. Curr Gastroenterol Rep. 2015 Nov;17(11):42
38. Dohan A, Faraoun SA, Barral M, Guerrache Y, Boudiaf M, Dray X, Hoeffel C, Allez M, Farges O, Beaugerie L, Aparicio T, Marteau P, Fishman EK, Lucidarme O, Eveno C, Pocard M, Dautry R, Soyer P. Extra-intestinal malignancies in inflammatory bowel diseases: An update with emphasis on MDCT and MR imaging features. Diagn Interv Imaging. 2015 Sep;96(9): 871-883.
39. Mikocka-Walus A, Knowles SR, Keefer L, Graff L. Controversies Revisited: A Systematic Review of the Comorbidity of
Depression and Anxiety with Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2016 Mar;22(3):752-762.
40. Wędrychowicz A, Zając A, Tomasik P. Advances in nutritional therapy in inflammatory bowel diseases: Review.World J
Gastroenterol. 2016 Jan 21;22(3):1045-66.
Anhang (aktuelle Leitlinien)
Preiss JC, Bokemeyer B, Buhr HJ, et al.: Updated German clinical practice guideline on „Diagnosis and treatment of Crohn’s
disease“. Z Gastroenterol 2014; 52: 1431–84
Dignass A, Preiss JC, Aust DE, et al.: Updated German guideline on diagnosis and treatment of ulcerative colitis.
Z Gastroenterol 2011; 49: 1276–341
van Assche G, Dignass A, Panes J, et al.: The second European evidence-based consensus on the diagnosis and management
of Crohn’s disease: definitions and diagnosis. J Crohns Colitis 2010; 4: 7–27
Dignass A, Van Assche G, Lindsay JO, et al.: The second European evidence-based consensus on the diagnosis and
management of Crohn’s disease: current management. J Crohns Colitis 2010; 4: 28–62 8.
Dignass A, Eliakim R, Magro, et al.: Second European evidence-based consensus on the diagnosis and management of
ulcerative colitis part 1: definitions and diagnosis. J Crohns Colitis 2012; 6: 965–90
Dignass A, Lindsay JO, Sturm A, et al.: Second European evidence-based consensus on the diagnosis and management of
ulcerative colitis part 2: current management. J Crohns Colitis 2012; 6: 991–1030
S. 28 – 30: Narben- und Bauchwandhernien: Milos-Technik – viele Vorteile Von Dr. Wolfgang Reinpold
1. Midline versus transverse incision in major abdominal surgery: a randomized, double-blind equivalence trial (POVATI:
ISRCTN60734227). Seiler CM, Deckert A, Diener MK, Knaebel HP, Weigand MA, Victor N, Büchler MW . Ann Surg. 2009
Jun; 249 (6):13-20.
2. Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions:
a multicenter r andomized trial (INSECT: ISRCTN24023541). Seiler CM, Bruckner T, Diener MK, Papyan A, Golcher H,
Seidlmayer C, Franck A, Kieser M, Büchler MW, Knaebel HP. Ann Surg. 2009 Apr; 249 (4): 576-82.
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3. Use of marlex mesh in the repair of incisional hernias. Usher FC, Ochsner J, Tuttle LL Jr., Am Surg. 1958 Dec; 24 (12): 969-74.
4. Treatment of large eventrations (apropos of 133 cases). Rives J, Pire JC, Flament JB, Convers G., Minerva Chir. 1977 Jun
15; 32 (11): 749-56.
5. Prosthetic surgical treatment of inguinal hernias. Parietalization of the spermatic cord. Stoppa R, Warlaumont C,
Chantriaux JF. Presse Med. 1984 Oct 27; 13 (38): 2317-8.
6. The use of Dacron in the repair of hernias of the groin. Stoppa RE, Rives JL, Warlaumont CR, Palot JP, Verhaeghe PJ,
Delattre JF. Surg Clin North Am. 1984 Apr; 64 (2): 269-85.
7. Narbenhernie – Wie ist zu verfahren? Chirurgische Standardversorgung. Conze J, Binnebösel M, Junge K, Schumpelick V.
Chirurg. 2010 Mar; 81 (3): 192-200.
8. Meta-analysis of randomized controlled trials comparing open and laparoscopic ventral and incisional hernia repair
with mesh. Forbes SS, Eskicioglu C, McLeod RS, Okrainec A. Br J Surg. 2009 Aug; 96 (8): 851-8.
9. Laparoscopic versus open repair of incisional/ventral hernia: a meta-analysis. Sajid MS, Bokhari SA, Mallick AS, Cheek E,
Baig MK., Am J Surg. 2009 Jan; 197 (1): 64-72. Epub 2008 Jul 9. Review.
10. Open versus laparoscopic incisional hernia repair: something different from a meta-analysis. Kapischke M, Schulz T,
Schipper T, Tensfeldt J, Caliebe A.,Surg Endosc. 2008 Oct; 22 (10): 2251-60. Epub 2008 Mar 5. Review
11. Classification of primary and incisional abdominal wall hernias. Muysoms FE, Miserez M, Berrevoet F, Campanelli G,
Champault GG, Chelala E, Dietz UA, Eker HH, El Nakadi I, Hauters P, Hidalgo Pascual M, Hoeferlin A, Klinge U, Montgomery A, Simmermacher RK, Simons MP, Smietański M, Sommeling C, Tollens T, Vierendeels T, Kingsnorth A. Hernia. 2009
Aug; 13 (4): 407-14. Epub 2009 Jun 3.
12. Retromuscular alloplasty of large scar hernias: a simple staple attachment technique. Amid PK, Lichtenstein IL., Chirurg.
1996 Jun; 67 (6): 648-52
13. Laparoscopic component separation in the single-stage treatment of infected abdominal wall prosthetic removal.
Rosen MJ, Jin J, McGee MF, Williams C, Marks J, Ponsky JL., Hernia. 2007 Oct; 11 (5): 435-40. Epub 2007 Jul 24.
14. Open surgical procedures for incisional hernias. den Hartog D, Dur AH, Tuinebreijer WE, Kreis RW., Cochrane Database
Syst Rev. 2008 Jul 16; (3): CD006438. Review
15. Laparoscopic transperitoneal sublay mesh repair: a new technique for the cure of ventral and incisional hernias.
Schroeder AD, Debus ES, Schroeder M, Reinpold WM. Surg Endosc. 2013 Feb; 27(2): 648-54.
16. Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia
Society (IEHS)-part 1. Surg Endosc. 2014 Jan; 28 (1): 2-29. Epub 2013 Oct 11. Bittner R, Bingener-Casey J, Dietz U, Fabian
M, Ferzli GS, Fortelny RH, Köckerling F, Kukleta J, Leblanc K, Lomanto D, Misra MC, Bansal VK, Morales-Conde S, Ramshaw
B, Reinpold W, Rim S, Rohr M, Schrittwieser R, Simon T, Smietanski M, Stechemesser B, Timoney M, Chowbey P;
International Endohernia Society (IEHS).
S. 32 – 33: Schmerztherapie mit Zementoplastie und Radiofrequenzablation
Von Dr. Hendryk Vieweg, Dr. Matthias Werner, Dr. Friederike Helmich, Dr. Ralf Gehrckens, Dr. Ernst Malzfeldt
1. Iannessi A, Amoretti N. Diagn Interv Imaging 2012; 93(11): 859–870
2. Masala S, Volpi T. Support Care Cancer 2011; 19(7): 957–962
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S. 34 – 36: Modellsammlung: Lehrreiche „Spielereien“
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Von Henrik Eßler
Hendrik van den Bussche: Die Hamburger Universitätsmedizin im Nationalsozialismus: Forschung, Lehre,
Krankenversorgung. Berlin 2014, S. 464-467.
Christiane Rothmaler: Die Sammlung des Anatomischen Instituts der „Hansischen Universität“ in Hamburg:
didaktisches Konzept und Aufbau 1919 bis 1945, in: Deutsche Gesellschaft für Geschichte der Medizin, Naturwissenschaft und Technik (Hg.): Ideologie der Objekte - Objekte der Ideologie: Naturwissenschaft, Medizin und Technik in
Museen des 20. Jahrhunderts ; Vorträge von der 73. Jahrestagung in Mannheim, 2. - 5. Oktober 1990. - Kassel 1991, S.
55-62.
Christiane Rothmaler: Gutachten und Dokumentation über das Anatomische Institut des Universitäts-Krankenhauses
Eppendorf der Universität Hamburg 1933 – 1945, in 1999: Zeitschrift für Sozialgeschichte des 19. und 21. Jahrhunderts
5 (1990), 2, S. 78-95.
Johannes Brodersen: Erfahrungen in einem anatomischen Modellierkurs, in: Deutsche Medizinische Wochenschrift 25
(1926), S. 1052-1053.
Johannes Brodersen: Die Einführung der Modellierübungen in den anatomischen Unterricht, in: Anatomischer Anzeiger.
Centralblatt für die gesamte wissenschaftliche Anatomie 63 (1927), S. 37-43.
Johannes Brodersen: Das Modellieren im anatomischen Unterricht, in: DMW 53 (1927), 7, S. 287.
Johannes Brodersen: Farbe im anatomischen Unterricht, in: Anatomischer Anzeiger. Centralblatt für die gesamte
wissenschaftliche Anatomie 71 (1930), S. 342-345.
Johannes Brodersen: Der Aufbau der anatomischen Sammlungen, in: Anatomischer Anzeiger. Centralblatt für die
gesamte wissenschaftliche Anatomie 84 (1935), S. 268-272.
Ferdinand Tegtmeier: Der Weg des Modellbaues am Anatomischen Institut der Hansischen Universität.
Unveröffentlichtes Manuskript 1937. Archiv des Medizinhistorischen Museums Hamburg.
Ilka Schwoon: „Als Bildhauer in der Anatomie“. Ferdinand Tegtmeier (1884-1980), in: Jahrbuch des Freundes- und
Förderkreises des UKE. Hamburg 2011, S. 115-116.
Adolf Friedrich Holstein: Modelle für den anatomischen Unterricht, ebenda, S. 117-118.

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