ᲨٻᐂᓏƷ၏Ҿࣱƴ᧙ɨƢǔᢡˡ܇፭Ʒ ̬ஊܱ७ƴ᧙ƢǔѼਙႎᛦ௹ᄂᆮ ٤ ⑺ጊ↱⟤㧔ᐶ⋵┙ஜᐽ↢ᵴ⑼ቇ⎇ⓥᚲ㧕 ޤ⊛⋡ޣ ᐔᚑ ᐕߦޔ࿖ౝߢߪንጊ⋵ࠍਛᔃߦ⣺▤ⴊᕈᄢ⣺⩶ '*'%1 ߇ޔߚ߹ޔ᰷Ꮊߢ ߪ࠼ࠗ࠷ࠍਛᔃߣߒߡ '*'%1 ߇ේ࿃ߣߥࠆ㘩ਛᲥ߇⊒↢ߒⶄߦ߽ߣޔᢙߩᱫ⠪߇ࠆᄢ ⷙᮨ㓸࿅ߣߥߞߚߩࠄࠇߎޕߢߪޔᓥ᧪߆ࠄ⍮ࠄࠇߡߚࡌࡠᲥ⚛ 86↥↢ᕈߩ 1 ߦട߃ߡޔ86 ࠍ↥↢ߒߥ 1 ߽ᄙᢙᬌߐࠇߚޔߚ߹ޕ1 ߪ 86 ↥↢ᕈߢࠆ ߇ޔ᰷Ꮊߩߢߪ '*'% ߇৻⥸⊛ߦߔࠆ⣺▤߳ߩ㒢ዪ⊛ߥઃ⌕࿃ሶࠍᰳ߈ޔઍࠊࠅߦ ⣺▤ಝ㓸ઃ⌕ᕈᄢ⣺⩶ '#II'%߇ᜬߟઃ⌕࿃ሶࠍߔࠆߎߣ߇ࠄ߆ߦߥߞߚ ࠃߩߎޕ ߁ߥੱߦ∛ᕈࠍߔࠆਅ∯ේᕈᄢ⣺⩶ߢߪޔ᭽ߥޘㆮવሶ⟲߇⚵ߺวࠊߐߞߡ․ᓽ⊛ߥ ∝⁁ࠍ⊒ߐߖߡࠆ߇ߩࠄࠇߎޔㆮવሶ߇ࡈࠔࠫ߿࠻ࡦࠬࡐ࠱ࡦ╬ߦࠃߞߡ⩶ᩣ㑆 ࠍ⒖േߔࠆߎߣߢᣂߚߥᒻ⾰ࠍᜬߞߚ∛ේ⩶߇ߔࠆߣ⠨߃ࠄࠇࠆޔߚߩߎޕᄢ⣺⩶ ߩ∛ේᕈߩ⸃ߦߪⴊߩߢ߹ࠇߎޔᷡဳߦଐߒߚ․ቯㆮવሶߦട߃ߡޔ᭽∛ߥޘේㆮ વሶ߿ߘߩ↪ࠍჇᒝߔࠆ╬ߩ㑐ㅪㆮવሶߦߟߡ߽⺞ᩏኻ⽎ߣߔࠆߎߣ߇ᔅⷐߣߥߞߡ ࠆⶄޔߡߒߘޕᢙߩ∛ේ࿃ሶࠍ⚵ߺวࠊߖߚᣂߚߥਅ∯ේᕈᄢ⣺⩶ߩߦኻߒߡ⋙ޔ ⷞࠍᒝൻߔࠆߎߣ߇㘩ਛᲥ੍㒐ኻ╷ߣߒߡ㊀ⷐߢࠆޕ ߘߎߢޔᲥ⚛࿃ሶߦട߃ߡઃ⌕࿃ሶ╬ว⸘ ⒳ߩㆮવሶߩ⁁ᴫࠍㄦㅦߦࠄ߆ߦߢ ߈ࠆ◲ޔଢ߆ߟଔߥࡑ࡞࠴ࡊ࠶ࠢࠬࠦࡦࡌࡦ࡚ࠪ࠽࡞ 2%4 ᴺࠍ⏕┙ߒߚޔߦࠄߐޕஜ ᐽോᚲ߿㘩⡺ⴡ↢ᬌᩏࡦ࠲ߩදജࠍᓧߡ⋵ޔਅߢ⊒↢ߒߚ㘩ਛᲥߢಽ㔌ߒ ߚ⩶߿⋵ޔౝ㘺⢒‐ߦᏱߔࠆᄢ⣺⩶ߦߟߡ∛ޔේㆮવሶߩ൮⊛ታᘒ⺞ᩏࠍⴕߞߚޕ ᧚ޣᢱߣᣇᴺޤ 㧝㧚ࡑ࡞࠴ࡊ࠶ࠢࠬࠦࡦࡌࡦ࡚ࠪ࠽࡞ 2%4 ᴺ ਅ∯ේᕈᄢ⣺⩶߇ߔࠆਥⷐߥ ⒳ߩ∛ේㆮવሶࠍჇߔࠆࡊࠗࡑࠍޔԘᲥ⚛࿃ ሶ㧔UVZUVZ56R56J.6㧕ޔଚ࿃ሶ KPX'㧕ޔԙઃ⌕࿃ሶ GCGCII4㧕ޔಝ㓸ઃ⌕ᕈ ᄢ⣺⩶⠴ᾲᕈᲥ⚛ CUV#㧕ޔᢔઃ⌕ᕈᄢ⣺⩶ଚ࿃ሶ CHC&ޔԚ⚦⢩⥌ᱫᕈᲥ⚛ EFV㧕⚦ޔ ⢩უᱫᲥ⚛ EPHߩ ࠣ࡞ࡊߦಽߌߡᷙวߒߚࡑ࡞࠴ࡊ࠶ࠢࠬ 2%4 ᴺࠍታᣉߒߚ 㧕ޕ 2%4 ᔕ⹜⮎ߦߪ )Q6CS*QV5VCTV)TGGP/CUVGT/KZ 2TQOGICࠍ↪ޔᔕ᧦ઙߪ ͠ ಽߩᓟࡊ࡞ࠣ ͠ޔ⑽ ͠ޔԘ߹ߚߪ ͠ ࠣ࡞ࡊԙ߅ࠃ߮Ԛ ⑽ ͠ޔಽ ߩᔕࠍ ࠨࠗࠢ࡞ⴕߩߘޔᓟ ͠ߢ ಽჇߒߚ ߢߎߎޕEFV ߅ࠃ߮ EPH ߇ᬌߐ ࠇߚ⩶ᩣߪޔᣢႎߩࡊࠗࡑ߅ࠃ߮ᣂߚߦ⸳⸘ߒߚࡊࠗࡑ 㧝ߦࠃࠅဳޔࠍ ⴕߞߚޕ 㧙 㧙 䋱䇭䌣䌤䌴 䈍䉋䈶㪺㫅㪽 ㆮવሶ䈱ㆬᛯ⊛䈭Ⴧ䈮↪䈇䈢䊒䊤䉟䊙䊷 ᮡ⊛ 䊒䊤䉟䊙䊷 ㈩ (5'㸢3') ㆮવሶ cdt 㸉 cdt㸉-f782 GACACAAACGAGTCAACGAA cdt㸉-r GTGATCTCCTTCCATGAAAATATAGT 䍏䍤䍎䍶䍻䍖䍼 ᷷ᐲ (㷄) 54 Ⴧ䍙䍐䍛䍼 (bp) 782 cnf1 cnf1-f669 cnf1-r669 TATCGTAGTCCCGGAGGTATCTG TGCGGTAATTTTGGGTTTGTATCAG 60 669 cnf2 cnf2-f667 cnf2-r667 GTCGCAATTCCGGAGGTGTC GCGGTAGTTTTGGGGTCGAATTA 60 667 㧞㧚ੱ↱᧪ᩣߩ∛ේㆮવሶ⺞ᩏ ᐔᚑ ᐕ ߆ࠄᐔᚑ ᐕ ߦᐶ⋵ౝߢ⣺▤ⴊᕈᄢ⣺⩶ᗵᨴ∝ߩዯߌ߇ߞ ߚᖚ⠪߅ࠃ߮⩶⠪ߩଢ߆ࠄಽ㔌ߐࠇߚ '*'% ⩶ᩣޔ㘩ਛᲥߢᖚ⠪ଢ߆ࠄಽ㔌ߐࠇ ߚᄢ⣺⩶ ⩶ᩣ߮ࠃ߅ޔᖚ⠪ଢ ᬌࠍ∛ේㆮવሶߩ⺞ᩏኻ⽎ߣߒߚޕ 㧟㧚ஜᐽ‐↱᧪ᩣߩ∛ේㆮવሶ⺞ᩏ ᐶ⋵ౝߢ㘺⢒ߐࠇޔᐔᚑ ᐕ ߆ࠄᐔᚑ ᐕ ߦዼᲕߐࠇߚ‐ 㗡ߩ⣺ౝኈ ‛ࠍ '% ࡉ࡛ࠗࡦߢჇ⩶ᓟࠠࡦࠦ࠶ࡑޔኙᄤၭߦႣᏓߒ∛ޔේㆮવሶࠍߔࠆᄢ⣺⩶ ࠍត⚝ߒߚޔߜࠊߥߔޕᐔ᧼ߩࠦࡠ࠾ኒ㓸ㇱಽ߆ࠄ㓸⩶ߔࠆࠦࡠ࠾ࠬࠗࡊߢฦ‐ ߇ߒߡࠆ∛ේㆮવሶࠍ੍᷹ߒߚᓟ৻ޔ㗡ᒰߚࠅ એߩᄢ⣺⩶ࠦࡠ࠾ߦߟߡޔ ࠬࠢ࠾ࡦࠣߢ㓁ᕈߣߥߞߚㆮવሶߩᬌࠍⴕߞߚޕ ⚿ޣᨐޤ 㧝㧚ੱ↱᧪ᩣ߇ߔࠆ∛ේㆮવሶ ⣺▤ⴊᕈᄢ⣺⩶ᗵᨴ∝ߩᖚ⠪߅ࠃ߮⩶⠪ߩଢ߆ࠄಽ㔌ߐࠇߚ '*'% ߩ∛ේㆮવሶ ⁁ᴫࠍ㧞ߦ␜ߒߚޕ86 ↥↢ߦ㑐ਈߔࠆㆮવሶߪޔ1 ߆ࠄ UVZ ߣ UVZ ߇หᤨࠆޔ ߪ UVZ ߇න⁛ߢᬌߐࠇޔ1ޔ1ޔ1 ߆ࠄ UVZ ߇න⁛ߢޔ1ޔ1 ߆ࠄ UVZ ߇න⁛ߢᬌߐࠇߚ⚦ޔߚ߹ޕ⢩߳ߩዪઃ⌕ᕈߦ㑐ਈߔࠆࠗࡦ࠴ࡒࡦㆮવሶ GCG߇ޔ1 ࠍ㒰ߊ ᩣ߆ࠄᬌߐࠇߚޕCII4 ╬ߩߘߩઁߩ∛ේㆮવሶߪᬌߐࠇߥ߆ߞߚޕ ߹ߚޔ㘩ਛᲥᖚ⠪ଢ߆ࠄᰴ⊛ߦಽ㔌ߐࠇߚᄢ⣺⩶ߦߟߡ ޔ⒳ߩ∛ේㆮવሶ⺞ᩏࠍ ⴕߞߚ⚿ᨐޔGCGޔCUV# ߅ࠃ߮ EPH ࠍߔࠆ⩶߇ዋᢙߥ߇ࠄߟ߆ߞߚ 㧟ޕ 㧞᧪↱ੱޓ⣺▤ⴊᕈᄢ⣺⩶ߩ ∛ේㆮવሶ⁁ᴫ ㆮવሶ⩶ᩣᢙ ᬌᩏ䈚䈢 ⴊᷡဳ stx1 stx2 eae ⩶ᩣᢙ 1* 㪍㪇 㪋㪇 㪍㪇 㪍㪇 1* 㪉㪉 㪈㪎 㪉㪉 㪉㪉 1* 㪊㪍 㪊㪍 㪇 㪊㪍 1* 㪈 㪈 㪇 㪈 1* 㪈 㪇 㪈 㪇 1* 㪈 㪈 㪇 㪈 1* 㪈 㪇 㪈 㪈 1* 㪊 㪊 㪇 㪊 ว⸘ 㪈㪉㪌 㪐㪏 㪏㪋 㪈㪉㪋 㧟ޓ㘩ਛᲥᖚ⠪߆ࠄᰴ⊛ߦಽ㔌ߐࠇߚ ᄢ⣺⩶ߩ∛ේㆮવሶ ᬌ䈘䉏䈢 ⴊᷡဳ ⩶ᩣ䈱↱᧪ ㆮવሶ astA 1*76 䉦䊮䊏䊨䊋䉪䉺䊷㘩ਛᲥᖚ⠪ଢ cnf1 1* 䊨䉺䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ eae 1C* 䉰䊘䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ astA 1*76 䊉䊨䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ astA 176*76 䊉䊨䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ astA 176*76 䊉䊨䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ eae 1* 䊉䊨䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ eae 176* 䊉䊨䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ cnf1 1* 䊉䊨䉡䉟䊦䉴㘩ਛᲥᖚ⠪ଢ 㧙 㧙 㧠ߩ‐ޓਅ∯ේᕈᄢ⣺⩶⁁ᴫ EHEC ਅ∯ේᕈᄢ⣺⩶ ᬌᩏߒߚ 㓁ᕈ 㓁ᕈ ‐ߩᢙ 79 32 ว⸘ 100 % 79.0 32.0 57 20 74 % 77.0 27.0 22 12 㓽 26 % 84.6 46.2 ㆮવሶࠍߒߡߚ‐ߩᢙ stx1 stx2 10 10.0 7 9.5 3 11.5 STp 31 31.0 19 25.7 12 46.2 21 21.0 14 18.9 7 26.9 eae 29 29.0 24 32.4 5 19.2 astA 52 52.0 37 50.0 15 57.7 cdt cnf 47 47.0 35 47.3 12 46.2 32 32.0 23 31.1 9 34.6 㧞㧚ஜᐽ‐ߩ∛ේㆮવሶ⁁ᴫ ⺞ᩏߒߚ‐ 㗡ਛޔ‐߇ 㗡ߢ㓽‐߇ 㗡ߩࠄࠇߎޔ㦂ߪ 㨪 ࡨ߇ 㗡ߢޔᱷࠅߪ ߩࡨ ޔ‐ߩࡨ ޔޔ㓽‐߇ฦ 㗡ߢߞߚޕ㧠ߦޔਅ ∯ේᕈᄢ⣺⩶ߩߘޔਛߢ '*'%ߦࠄߐޔฦ∛ේㆮવሶࠍߒߡߚ‐ߩᢙࠍᕈߦ␜ߒߚޕ ߎࠇࠄߩǿ ᬌቯߢߪޔ‐ߣ㓽‐ߩ㑆ߦ₸ߩᗧᏅ ᗧ᳓Ḱ 㧑㧕ߪࠄࠇߥ ߆ߞߚ∛ޕේㆮવሶ߇ᬌߐࠇߥ߆ߞߚߩߪ 㗡ߢ ޔ㗡߆ࠄࠄ߆ߩ∛ේㆮવሶࠍᜬ ߟਅ∯ේᕈᄢ⣺⩶ߩߴ ᩣ߇ᬌߐࠇߚ'*'ޕ% ߪ ‐ޔ㗡߆ࠄߩߴ ᩣ߇ᬌߐࠇߚޕ CUV# ࠍඨᢙએߩ‐߇ߒߡ߅ࠅޔᰴߢޔEFVޔEPHޔUVZ ߩ㗅ߢ₸߇㜞߆ߞߚޕ ߥ߅ဳ࠻ࡅޔ⠴ᾲᕈࠛࡦ࠹ࡠ࠻ࠠࠪࡦㆮવሶ 56Jޔᤃᾲᕈࠛࡦ࠹ࡠ࠻ࠠࠪࡦㆮવሶ .6ޔ KPX'ޔCII4ޔCHC& ߩฦㆮવሶߪᬌߐࠇߥ߆ߞߚޕ ᰴߦߩ᧪↱‐ޔਅ∯ේᕈᄢ⣺⩶ ᩣߩ∛ේㆮવሶ⁁ᴫࠍ㧡ߦ␜ߒߚ'*'ޕ% ᩣ ਛޔUVZ න⁛߇ ᩣޔUVZ ߣ UVZ ߩหᤨ߇ ᩣ ߚ߹ޔUVZ ߣ GCG ࠍߔࠆ 1* ߇ ᩣߟ߆ߞߚဳ࠲ࡉޔ߽ߦઁߩߘޕ⠴ᾲᕈࠛࡦ࠹ࡠ࠻ࠠࠪࡦㆮવሶ 56R߿ CUV# ╬ࠍหᤨߔࠆ⩶ᩣ߇ሽߒߚޕ56R ࠍߔࠆ⣺▤Ქ⚛ේᕈᄢ⣺⩶ '6'%ߪ ᩣޔGCG ࠍߔࠆ⣺▤∛ේᕈᄢ⣺⩶ '2'%ߪ ᩣಽ㔌ߐࠇߚޕCUV# ߪන⁛ ᩣࠍ ᩣ߇ߒߡߚޕEFV ߪ ᩣ߇ߒߡ߅ࠅဳޔߢߪޔEFVΣ߇ ᩣޔEFVΥ߇ ᩣޔ EFVΧ߇ ᩣߢߞߚޕEPH ߪ ᩣ߇ߒ ߡߴߔߪࠄࠇߎޔEPH ဳߢ ߩߜ߁ߩߎޔ ᩣߪ EFVΥߣ EPH ࠍหᤨߒߡߚߩ᧪↱‐ޕਅ∯ේᕈᄢ⣺⩶ߩ⚂ ഀߪⴊᷡဳਇ⢻ ߢߞߚ߇ޔቯߢ߈ߚਥߥⴊᷡဳࠍ㧡ߦ␜ߒߚޕ ޣ⠨ኤޤ ࿁ߩ⺞ᩏߢߪ ⒳ߩ∛ේㆮવሶࠍኻ⽎ߣߒߚ߇ޔᬌߐࠇߚߩߪ UVZޔUVZޔ56Rޔ GCGޔCUV#ޔEFV ߅ࠃ߮ EPH ߩ ⒳ߦ㒢ቯߐࠇߚ'*' ᧪↱ੱޕ% ߆ࠄߪޔᓥ᧪ㅢࠅ UVZޔUVZ ߅ࠃ߮ GCG ߩߺ߇ᬌߐࠇޔ86 ߣߩሽߦࠃࠅᒝᲥൻ߇ ᔨߐࠇࠆ 1 ߢᬌߐࠇߚಝ 㓸ઃ⌕࿃ሶ CII4㧕ߪᬌߐࠇߥ߆ߞߚ᧪↱ੱޕᄢ⣺⩶ߩਛߦߪⴕޔޔ㘩ਛᲥߩේ࿃ߣ ߪ್ቯߐࠇߥ߆ߞߚ߽ߩߩޔGCGޔCUV# ߅ࠃ߮ EPH ࠍන⁛ߢߔࠆ⩶ᩣ߇ሽߒߡ߅ࠅޔ ߎࠇࠄߩ∛ේᕈ߿ಽᏓ⁁ᴫߩ⺞ᩏ߇ᔅⷐߣᕁࠊࠇߚޕ ‐ߩਅ∯ේᕈᄢ⣺⩶ߩ₸ߪ 㧑ߣ㜞ߊ'*'ޔ% ߦ㒢ቯߔࠆߣ 㧑ߢߞߚޕಽ㔌ߒ ߚ‐↱᧪ '*'% ᩣਛߦ CII4 ࠍหᤨߔࠆ߽ߩߪߥ߆ߞߚ߇ ޔᩣߪ 56RޔCUV# ࠆ 㧙 㧙 䋵䇭‐↱᧪ਅ∯ේᕈᄢ⣺⩶䈱ㆮવሶ⁁ᴫ ᬌ䈘䉏䈢∛ේㆮવሶ䈱⚵䉂ว䉒䈞 ಽ㘃 ⣺▤ⴊᕈᄢ⣺⩶(EHEC) stx1 stx1 stx1 stx1 stx2 stx2 STp astA STp astA cdt 㸉 stx2 stx2 stx2 stx2 stx2 stx2 stx2 stx2 stx2 STp STp STp eae astA astA eae eae eae astA cnf2 cdt 㸋 astA cdt 㸋 ⣺▤Ქ⚛ේᕈᄢ⣺⩶(ETEC) STp STp STp STp eae eae astA astA ⣺▤∛ේᕈᄢ⣺⩶(EPEC) eae eae astA ઁ䈱ਅ∯ේᕈᄢ⣺⩶ astA astA astA astA astA cdt 㸉 cdt 㸇 cdt 㸉 cdt 㸋 cnf2 cdt 㸉 cdt 㸉 cdt 㸋 cnf2 cnf2 ว⸘ 11 45 29 35 68 55 34 ⩶ᩣᢙ 49 1 6 2 2 2 4 2 2 1 3 3 1 20 18 1 1 4 12 25 2 23 92 2 1 1 3 40 29 7 8 1 184 ቯ䈪䈐䈢ਥ䈭ⴊᷡဳ 1* 1* 1* 1*1* 1* 1* 1* 1*1* 1* 1*1* 1*1CE* 1* 1*1CE* 1*1* 1*1* 1*1* 1* ߪ EFV ࠍหᤨߒߡ߅ࠅ'*' ᧪↱ੱޔ% ߣ⇣ߥࠆะ߇ࠄࠇߚޕCUV# ߪ'*'ޔ% ߩߺ ߥࠄߕ '6'% ߿ '2'% ߆ࠄ߽ᬌߐࠇޔEFV ࠍหᤨߔࠆ ᩣ߽ᬌߐࠇߚޕCUV# ߪಽ㔌 ⩶ᩣਛߩ₸߇ 㧑ߣᦨ߽㜞ߊޔCUV# ߇ਅ∯ේᕈᄢ⣺⩶ߦᐢߊಽᏓߔࠆߣ߁ႎ๔ ࠍⵣઃߌࠆ࠺࠲߇ᓧࠄࠇߚޕCUV# ߩਅ∯ߣߩ㑐ㅪߪࠄ߆ߦߥߞߡߥ߇ޔCUV# ⩶߇ේ࿃ߣ⠨߃ࠄࠇࠆ㓸࿅㘩ਛᲥߩႎ๔ ߽ࠅޔᬌᩏࠍ⛮⛯ߔߴ߈ㆮવሶߢࠆޕ EFVΥߣ EPH ߪ R8KT ࡊࠬࡒ࠼ߦሽߒߩࠄࠇߎߪࠄ߆‐ޔหᤨᩣ߇ᄙߊಽ㔌ߐࠇ ࠆߎߣ߇ႎ๔ߐࠇߡ߅ࠅ ޔ࿁ߩ⺞ᩏߢ߽ห᭽ߩ⚿ᨐ߇ᓧࠄࠇߚࠄ߆‐ޔߚ߹ޕᬌߐ ࠇߚ EPH ߪߔߴߡ EPH ߢߞߚ߇ࠄ߆ੱޔᬌߐࠇߚߩߪ EPH ߢߞߚߎߣ߆ࠄޔᓟ ߽⺞ᩏࠍჇ߿ߒߡޔEFV ߿ EPH ߩ⒳㑆ߢߩㆮવሶဳߩ㆑ߣ∛ේᕈߣߩ㑐ㅪߦߟߡ ࠄ߆ߦߔࠆᔅⷐ߇ࠆߣ⠨߃ߡࠆޕ 㧙 㧙 ⻢ޣㄉޤ ᧄ⎇ⓥࠍታᣉߔࠆߦߚࠅ⎇ޔⓥഥᚑࠍߚߛ߈߹ߒߚ⋉⽷࿅ᴺੱᄢห↢ᬺ࿅ߦ ᔃࠃࠅᗵ⻢ߚߒ߹ߔߩ⩶ߩ‐ޔߚ߹ޕណขߦߏදജߚߛߚᐶ⋵㘩⡺ⴡ↢ᬌᩏ ࡦ࠲ߩ⊝᭽∝ߦ߮ࠄߥޔ⠪ଢ↱᧪ߩ⩶ᩣࠍߏឭଏߚߛߚᐶ⋵ஜᐽോᚲ ᬌᩏቶߩ⊝᭽ߦෘߊᓮ␞↳ߒߍ߹ߔޕ ޣෳ⠨ᢥ₂ޤ 1) ኹ᎑ ᷕ㧘ઁ㧦⣺▤ⴊᕈᄢ⣺⩶ᗵᨴ∝ߩᦨㄭߩേะ, 㘩ຠⴡ↢⎇ⓥ㧘61, 7-15 (2011) 2) ᐔᚑ 23 ᐕᐲᣂ⥝ౣ⥝ᗵᨴ∝ᛛⴚ⎇ୃ ⾗ᢱޟㆮવሶᬌᩏᴺޠ㧘࿖┙ᗵᨴ∝⎇ⓥᚲ 3) Toth, I. et al. 㧦 Production of Cytolethal Distending Toxins by Pathogenic Escherichia coli Strains Isolated from Human and Animal Sources: Establishment of the Existence of a New cdt Variant (Type IV), J. Clin. Microbiol., 41, 4285-4291 (2003) 4) Mehdipour, S. et al. Detection of cytolethal distending toxin (cdt) and cytotoxic necrotizing factor (cnf) genes among Escherichia coli isolates from Iranian sheep carcasses, Comp. Clin. Pathol., 21, 1683-1688 (2012) 5) Bielaszewska, M. et al.㧦Characterization of Cytolethal Distending Toxin Genes and Expression in Shiga Toxin-Producing Escherichia coli Strains of Non-O157 Serogroups, Infect. Immun. 72, 1812-1816 (2004) 6) Savarino, S. J. et al.㧦Enteroaggregative Escherichia coli Heat-Stable Enterotoxin Is Not Restricted to Enteroaggregative E. coli, J. Infect. Dis., 173, 1019-1022 (1996) 7) Zhou, Z. et al.㧦An outbreak of gastroenteritis in Osaka, Japan due to Escherichia coli serogroup O166:H15 that had a coding gene for enteroaggregative E. coli heat-stable enterotoxin 1(EAST1), Epidemiol. Infect., 128, 363-371 (2002) 8) Clark, C. G. et al.㧦PCR for Detection of cdt-III and The Relative Frequencies of Cytolethal Distending Toxin Variant-Producing Escherichia coli Isolates from Humans and Cattle, J. Clin. Microbiol., 40, 2671-2674 (2002) ⾌⚻ޣㅜ⚦ޤ ⚦⩶ၭ㙃ᶖ⠻ຠ㧔ၭ╬ࡖࠪޔ㧕 2%4 ↪⹜⮎ౕེ߮㧔2%4 ↪ࡑࠬ࠲ࡒ࠶ࠢࠬ╬ࡓࠦޔ㧕 ㆮવሶ⸃ᨆ↪⹜⮎㧔ࠪࠢࠛࡦࠬࠠ࠶࠻㧕 శᾲ᳓⾌ ᣏ⾌ ว⸘㧔ഥᚑ㊄ ਁޔㅢ⾌ ߅ࠃ߮㗍㊄ᕷ ࠍ㧕 㧙 㧙
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