[Corning SMC4][354357][2014/1/14] [1/7]
2014
1.
354357
Corning SMC4
11
44
03-3586-1996
2.
GHS
A
-1-
24
[Corning SMC4][354357][2014/1/14] [2/7]
(6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2yl)amino)ethyl)amino)nicotinonitrile
)
-2-
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3.
CAS
dimethyl sulfoxide
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin
-2-yl-1H-imidazol-2-yl]benzamide
N-Benzyl-2-(pyrimidin-4-ylamino)
thiazole-4-carboxamide
6-((2-((4-(2,4-Dichlorophenyl)-5-(4methyl-1H-imidazol-2-yl)pyrimidin2-yl)amino)ethyl)amino)nicotinonitr
ile
N-[(2R)-2,3-Dihydroxypropoxy]-3,4difluoro-2[(2-fluoro-4-iodophenyl)
amino]-benzamide
99.53
67-68-5
(2)-1553
-
<0.3
301836-41-9
-
-
<0.3
1226056-71-8
-
-
<0.1
252917-06-9
-
-
<0.1
391210-10-9
-
-
4.
5.
6.
-3-
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7.
8.
AIHA WEEL 8-hour TWA = 250ppm (dimethyl sulfoxide)
-4-
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9.
16 19
189
87
3.5Vol%
0.55hPa (20 )
1.1g/cm3 (20
42Vol%
)
n301
10.
11.
Rat
Rat
Rat
Rat
dimethyl sulfoxide
LD50 = 28300mg/kg (SIDS, 2008)
LD50 = 14500mg/kg (
SDS)
LD50 = 3300mg/kg (
SDS)
dimethyl sulfoxide
LD50 40000mg/kg (SIDS, 2008)
dimethyl sulfoxide
Rat LC50 > 5330mg/m3 (Mixture of vapors and
-5-
[Corning SMC4][354357][2014/1/14] [6/7]
aerosols) (SIDS, 2008)
dimethyl sulfoxide
Rabbit, 4hr application (OECD TG 404):
(SIDS, 2008)
dimethyl sulfoxide
Rabbit, slight irritation (SIDS, 2008)
dimethyl sulfoxide
Buehler test
maximization method
(SIDS, 2008)
dimethyl sulfoxide
OECD
CHO
in vivo
in vitro
DMSO
dimethyl sulfoxide
IARC ACGIH NTP EPA
dimethyl sulfoxide
(OECD TG 421)
NOEL
1000mg/kg
DMSO
90
2800mg/m3
(SIDS, 2008)
DMSO
NOAEL
NOAEL
bw/
1000 300mg/kg bw/
1000mg/kg
(SIDS, 2008)
dimethyl sulfoxide
(SIDS, 2008)
dimethyl sulfoxide
(ICSC, 2000)
12.
dimethyl sulfoxide
Oncorhynchus mykiss, 96h-LC50 = 32.3g/L (SIDS, 2008)
dimethyl sulfoxide
Daphnia magna, 48h-LC50 = 24.6g/L (SIDS, 2008)
dimethyl sulfoxide
3.1 by BOD 0.3
by GC (
)
dimethyl sulfoxide
logPow = -1.35, BCF < 4 (SIDS, 2008)
-6-
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13.
14.
15
PRTR
32
((6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-y
l)amino)ethyl)amino)nicotinonitrile
))
4000L
16
NITE
CHEMWATCH GHS-MSDS (2008)
BD Biosciences, Discovery Labware SDS
SIDS (2008)
(ICSC) (ICSC No.0459, IPCS, 1993)
-7-

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