2014年度第3回GSC-セミナーの要旨 - Department of Materials

Seminar on Green Sustainable
Chemistry in Tottori (2014-3)
日時：2014 年 12 月 5 日（金） 13：00〜場所：鳥取大学大学院工学研究科大講義室鳥取市湖山町南 4-101 主催鳥取大学グリーン・サスティナブル・ケミストリー (GSC)研究センタープログラム開会挨拶センター長伊藤敏幸 13:20-14:20：座長伊藤敏幸大野弘幸（東京農工大学工学研究院長工学研究院生命機能科学部
門教授）
「Design and control of phase state of ionic liquid/water mixtures」 14:20-14:30 休憩 14:30-14:45：座長深谷幸信鶴巻晃子（東京農工大学大学院工学府博士後期課程）「 Design of ionic liquids to enhance excellent and sustainable antistatic properties for polyether-based polyurethanes」 14:45-15:15：座長溝端知宏 Yuan Lu（東京大学大学院工学研究科，清華大学生物化工研究所）「Application of cell-free synthetic biology in the synthesis of highly stable virus-like particles」 15:15-15:45：座長大城隆八木寿梓（鳥取大学大学院工学研究科，GSC センター）「 Direct observation of amyloid fibril growth by total internal reflection fluorescence microscopy」 15:45-16:00 休憩 16:00-1７:00：座長河田康志 Rita P.-Y. Chen（Academia Sinica, Taiwan）「Application of Biophysics Tools in the Studies of Protein Misfolding Diseases」閉会
1
Hiroyuki Ohno
Professor Hiroyuki Ohno is known as one of leading scientists on ionic liquids. He
has reported several notable results on ionic liquids such as amino acid ionic liquids,
cellulose dissolution, phase behavior of ionic liquid/water mixture, and dimension
control of ionic liquids.
He was born in Chiba-city Chiba prefecture in 1953. He received B.S. (in 1976) and
M.S. (in 1978) degrees from Waseda University under the direction of Prof. Eishun
Tsuchida in Polymer Chemistry. He received his Ph. D. degree from Waseda
University in 1981. After working in Waseda University as a research associate, he
has been in Mainz University (Germany) and Case Western Reserve University
(USA) as visiting scientist and post-doctoral research fellow, respectively. Then, he
was invited to Tokyo University of Agriculture and Technology as an associate
professor in 1988. In 1997, he was promoted to be a full professor in the same
university. He was elected and has served for the university as a vice dean of the
graduate school from 2007 to 2012. Since 2013, he is a dean at the Graduate School
of Engineering, Tokyo University of Agriculture and Technology. He is a Fellow of
Royal Society of Chemistry since 2008.
He is working on ionic materials such as polyelectrolyte complexes, ion conductive
polymers, and ionic liquids. He has published 402 original papers in major journals
and 175 reviews and books. His h-index is now 55. He is the first winner of the
Paul Walden Award from DFG (German Research Foundation) in 2008.
2
Design and control of phase state of ionic liquid/water mixtures
Hiroyuki Ohno
Department of Biotechnology,
Tokyo University of Agriculture and Technology,
[email protected]
Ionic liquids are organic liquids composed of only ions. They show unique
physico-chemical properties such as negligible vapour pressure, wide temperature
range to be liquids, and very high ionic conductivity. Among these, the most
noteworthy property is their designability. There are still increasing numbers of
papers on ionic liquids. For the functionalization of ionic liquids, it is important to
control the physic-chemical properties of these ionic liquids. Study on the pure ionic
liquids is the first generation and the second one is their mixtures. Mixtures of ionic
liquids and water are the third generation topic on the ionic liquids. Because the
mixtures of ionic liquids and water have large potential as functional solvents for
many materials including biomolecules such as proteins. One of their important
properties is the state of water molecules. There is no free water in the ionic
liquid/water mixture when the added water content is not so large. Among many
kinds of ionic liquids, there are some ionic liquids showing variable affinity with
water deeply depending on temperature. Throughout our researches, we have found
interesting phase behavior of ionic liquid/water mixtures. Here I would like to
introduce unique phase changes of the mixtures of some of ionic liquids and water.
We have already reported extraordinary properties of ionic liquid/water mixtures
undergoing temperature-responsive lower critical solution temperature (LCST)-type
phase transition after mixing with water [1,2]. These ionic liquid/water mixtures
became miscible at given temperature, but stable liquid/liquid biphase was obtained
upon heating the solution slightly. Upon cooling they mixed homogeneously again.
This highly temperature-sensitive LCST transition was characterized by drastic
change in water content in the separated ionic liquid phase upon small temperature
change. To determine the suitable hydrophilicity, we proposed a new parameter
“(Nw)” which is the number of water molecules per ion pair in the separated ionic
liquid phase, and this value was calculated by measuring the water content in the ionic
liquid phase by Carl-Fischer titration method. Required Nw value for ionic liquids
to show the LCST-type phase transition was found to be no less than 7 [3] .
Through suitable design of component ions, design of such LCST-type phase
transition of ionic liquid/water mixtures was easily carried out. Also mixing of two
different ionic liquids is effective to finely control the phase transition temperature of
ionic liquid/water mixtures[4]. These unique phase change should be useful in many
different scientific and industrial applications.
References
1. K. Fukumoto and H. Ohno, Angew. Chem. Int. Ed., 2007, 46, 1852.
2. Y. Kohno, H. Arai, S. Saita, and H. Ohno, Aust. J. Chem., 2011, 64, 1560.
3. Y. Kohno and H. Ohno, Phys. Chem. Chem. Phys., 2012, 14, 4993.
4. Y. Kohno and H. Ohno, Chem. Commun., 2012, 48, 7119.
3
Akiko Tsurumaki
Tokyo University of Agriculture and Technology, Japan
Akiko Tsurumaki is a third-year Ph.D. student under the supervision of Prof. Hiroyuki
Ohno in Department of Biotechnology, Tokyo University of Agriculture and
Technology. She received B.Eng. (2010) and M.Eng. (2012) degrees from Tokyo
University of Agriculture and Technology. Her research is centered on functional
design of polymer materials with ionic liquids. Current activities include design of
ionic liquids as antistatic agents, dissolution of fluorinated polymers to ionic liquids,
and design of ion conductive materials based of fluorinated polymers. She
experienced visiting researcher student in the Sapienza University of Rome as a part
of“International Program for Training Pre-Tenure-Track. Young Researchers in
Nano-Materials” funded by Japan Society for the Promotion of Science (JSPS) and is
currently working as a research fellow (DC2) of Japan Society for the Promotion of
Science.
4
Design of ionic liquids to enhance excellent and sustainable antistatic
properties for polyether-based polyurethanes
Akiko Tsurumaki
Department of Biotechnology, Tokyo University of Agriculture and Technology
(TUAT),
2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Functional Ionic Liquid Laboratories, Graduate School of Engineering,
TUAT, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
*E-mail address: [email protected]
Ionic liquids (ILs) have been recognized as potential salts due to their low glass
transition temperature (Tg) [1]. IL/polyether composites have been reported to have
larger amount of free ions which contribute to ion conduction compared to the
composites with inorganic salts [2]. Polyurethanes have been applied to many fields
as important materials whose properties are tunable from rubber-like elasticity to
plastic-like toughness. Polyether-based polyurethanes (PUs) have been proposed as
flexible materials which are applicable in a wide range of temperature. However,
the PUs are insulative and they cause electrostatic discharge (ESD) damages.
Taking low Tg of both ILs and the PUs into account, ILs such as
1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C4mim][Tf2N])
have been proposed as antistatic agents for the PUs [3]. The Rs of the PU films has
been reduced from 2.1 × 1012 to 5.5 × 109 Ω sq-1 when only 500 ppm of
[C4mim][Tf2N] was doped. These IL-doped PUs have been evaluated to be
sufficient to avoid ESD. However, the IL-doped PU films might suffer from bleed
out of ILs when the films are washed under harsh conditions or the films are stored
for long periods. In the present study, fixation of ILs into the PUs is proposed to
improve sustainability of antistatic effects [4]. Since terminal hydroxyl groups are
expected
to
form
urethane
bonds
with
isocyanate,
(2-hydroxyethyl)trimethylammonium [Tf2N] ([ch][Tf2N]) having a hydroxyl group in
cation
and
N,N-diethyl-N-(2-methoxyethyl)-N-methylammonium
glycolate
([DEME][Glyco]) having a hydroxyl group in anion were chosen to prepare cation- or
anion-fixed PU films. There was little change of Rs before and after ultra-sonication
treatment of these films in methanol. The effect of fixation and fixed ion species on
these antistatic properties will be discussed.
[1] M. Armand, F. Endres, D. R. MacFarlane, H. Ohno, B. Scrosati, Nat Mater 2009,
8, 621-629.
[2] A. Tsurumaki, J. Kagimoto, H. Ohno, Polym. Adv. Technol., 2011, 22, 1223-1228.
[3] T. Iwata, A. Tsurumaki, S. Tajima and H. Ohno, Macromol. Mat. Eng., 2014, 299,
794-798.
[4] T. Iwata, A. Tsurumaki, S. Tajima and H. Ohno, Polymer, 2014, 55, 2501-2504.
5
Yuan Lu received his B.S. (2004) and Ph.D. (2009) in Chemical Engineering from
Tsinghua University, China. He was a postdoc in the Department of Biology at Johns
Hopkins University, USA, from 2009 to 2010. In the following four years
(2010-2014), he was a postdoc in the Department of Chemical Engineering at
Stanford University, USA, where he worked on the cell-free biotechnology. Currently
he is a researcher at the University of Tokyo, Japan.
His research interests include:
1) Application of cell-free synthetic biology in bioenergy fields and medical fields
2) DNA/RNA/peptide/protein based biomolecular materials
3) Construction of synthetic metabolism by the assembly and the delivery of genetic
circuits
4) High effective degradation and biotransformation of low added-value biomass wastes
6
Application of cell-free synthetic biology in the synthesis of highly stable
virus-like particles
Yuan Lu
Address: Department of Chemistry and Biotechnology, School of Engineering, The
University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
E-mail: [email protected]
Virus-like particles (VLPs) mimic the structural skeleton of real viruses, but are
non-infectious as they lack the viral genome. They are typically stable over wide ranges of
pH, temperature, and solvent and have repetitive surfaces that can display a high density of
intrinsic or attached molecules. Because of these unique features, VLPs are particularly
attractive as vaccines as they offer in vivo stability, trafficking to lymph nodes, and
stimulation of B and T cell responses to displayed epitopes.
Figure 1. Virus-like particle (VLP) platform for medical applications
In this study, we describe Escherichia coli-based cell-free protein synthesis (CFPS) as a
method to rapidly produce Hepatitis B core protein (HBc) VLPs that display unnatural
amino acids as unique conjugation sites. However, repeated observations indicated that
these nanoparticles were at least partially disassembled by the click conjugation conditions.
We therefore took advantage of the repetitive and modular nature of VLPs to introduce 240
new disulfide bonds to totally stabilize the nanoparticles with covalent connections. VLPs
have been successfully produced in different expression host systems (bacteria, yeast, insect,
plant and mammalian), but CFPS enables rapid production of VLPs at high yields (~0.5
g/L) in a few hours. This CFPS technology has been shown to be scalable from the
microliter to the liter scale. Taking advantage of the open CFPS environment and
post-expression processing, the virus capsid coat proteins self-assemble into stable VLPs
under reducing conditions and can then be cross-linked using a mild oxidizing agent.
References:
1) Yuan Lu, et al. PNAS, 2014, 111: 125-130
2) Yuan Lu, et al. Biotech. and Bioeng., 2013, 110(8): 2073-2085
John P. Welsh, Yuan Lu, et al. Biotech. and Bioeng., 2012, 109: 2962–2969
7
Hisashi Yagi received his B.S. degree from Faculty of Engineering, Department of
Biotechnology, Tottori University, Japan, in 2001, a M.S. degree from Graduate School of
Engineering, Department of Biotechnology, Tottori University, Japan, in 2003, and a Ph.D.
degree from Graduate School of Medical Sciences, Institute of Regenerative Medicine and
Biofunction, Tottori University, Tottori, in 2006. He was a postdoc in Institute for Protein
Research, Osaka University, Japan, from 2006-2009. In 2010 he became an Assistant
Professor in Institute for Protein Research, Osaka University. Currently he is an Assistant
Professor in Center for Research on Green Sustainable Chemistry at Tottori University,
Japan. He received the Merck Young Biochemist Award in 2008.
.
His research interests include:
1) Therapeutical strategies of Amyloidoses
2) Structural comparison of amyloid fibrils and elastin fibers
3) Molecular mechanisms of biosynthetic process of elastin
8
Direct Observation of Amyloid Fibril Growth by Total Internal
Reflection Fluorescence Microscopy
Hisashi Yagi
Address: Center for Research on Green Sustainable Chemistry,
Tottori University, 4-101 Koyamacho-minami, Tottori, Tottori, Japan
E-mail: [email protected]
Amyloid fibrils have been a critical subject in recent studies of proteins and
peptides because they were recognized to be associated with the pathology of more than 20
serious human diseases. Additionally, various proteins and peptides that are not related to
diseases can also form amyloid-like fibrils, implying that the formation of amyloid fibrils is
a generic property of polypeptides. Although no sequence or structural similarity has been
found among the amyloid precursor proteins, amyloid fibrils share several common
structural and spectroscopic properties. Irrespective of the protein spices, electron
microscopy and X-ray fiber diffraction indicate that amyloid fibrils are relatively rigid and
straight with a diameter of 10-15 nm and several layers of cross-β sheets. On the other
hand, about the molecular mechanism, amyloid fibrils form via a nucleation process,
followed by a growth process. To clarify the mechanism involved, direct observations are
important. We developed a unique approach to monitor amyloid fibril growth in real time
at single fibril level using total internal reflection fluorescence microscopy (TIRFM)
combined with thioflavin T, an amyloid-specific fluorescence dye. TIRFM is a powerful
tool for understanding the supramolecular structure and growth process of fibrils. We
succeeded in visualizing the fibril growth with various proteins and peptides. On the basis
of our TIRFM observations, we elucidated the branching model of amyloid fibril growth.
The monomers and oligomers not only specifically interact with the active end of fibrils but
Real-time observation of the growth of amyloid β (1-40) fibrils
by total internal reflection fluorescence microscopy.
also interact with the side of preformed fibrils. Moreover, amyloid growth is similar to the
surface diffusion-dependent growth of crystals. Our results give new insight into the
mechanisms of amyloid fibril formation.
9
Rita P.-Y. Chen received her B.S. degree from Department of Agricultural Chemistry,
National Taiwan University, Taiwan, in 1989, a M.S. degree from Institute of Biochemical
Sciences, National Taiwan University, Taiwan, in 1991, and a Ph.D. degree from
Department of Biochemistry, University of Cambridge, UK, in 1998. She was a postdoc
in Institute of Chemistry, Academia Sinica, Taiwan, from 1999-2003. In 2003 she became
an Assistant Rsearch Rellow in Institute of Biological Chemistry, Academia Sinica. In
2011 she was promoted as Associate Rsearch Rellow. She received Academia Sinica
Young Investigator Award in 2010 and The TSBMB Award for Innovative Young
Biotechnologist in 2012.
.
Her research interests include:
1) Application of photolabile caging strategy and laser flash photolysis in early stage protein
folding study on a nanosecond time scale
2) Conformational dynamics of proteins by single molecule technique
3) Species barrier in prion transmission
4) Structural conversion mechanism of prion protein
5) Therapeutical strategies of Alzheimer’s disease
10
Application of Biophysics Tools in the Studies of Protein Misfolding
Diseases
Rita P.-Y. Chen
Address: Institute of Biological Chemistry, Academia Sinica, No128, Sec2, Academia Rd,
Nankang, Taipei 115, Taiwan
E-mail: [email protected]
A disulfide-removed full-length mouse recombinant prion protein can
spontaneously convert from α-helical-dominant conformer (α-state) to β-sheet-rich
conformer (β-state), which later on associates into β-oligomers, under non-denaturing
neutral pH conditions. The kinetics of this spontaneous conversion was found to depend
on dissolving buffer (salt concentration and pH), whereas the molecular details of the
structural conversion have never been reported due to the complexity of oligomer structure.
We introduced spin probes at different structural segments and employed a combined
approach of ESR spectroscopy and nanochannels to reveal local structural changes in the
process of the α-to-β transition. Nanochannel provides an environment, wherein prion
proteins are isolated from each other while the α-to-β transition still persists during the
observation. By measuring dipolar interactions between spin probes in the process of the
transition, our results showed that helix 1 and helix 3 retained their helicity while helix 2
was unfolded to an extended structure. Moreover, our pulsed ESR results provided
unambiguous discrimination between intra- and inter-molecular distances of spins labeled
on helix 2 in the β-oligomers, thereby corroborating that the unfolded helix 2 segment is in
the association interface of the β-oligomers.
Exploring the α-to-β transition of mouse prion protein
by a combined approach of ESR spectroscopy and
nanochannels
In addition, we developed two therapeutical strategies for Alzheimer’s disease
(AD): (1) diverting Aβ association pathway; (2) enhancing Aβ clearance. For the first
one, we have designed two peptide drugs which could decrease Aβ accumulation in the
brains of the AD transgenic mice by intranasal delivery. For the second one, we used
fluorescence quenching technique to design a quenched fluorogenic peptide substrate and
developed a cell-based assay system to screen drugs which could activate the most
important Aβ-degrading enzyme, neprilysin. Orally feeding the screened drug to the AD
transgenic mice could increase neprilysin expression and decrease Aβ burden in the
mouse brains.
11
鳥取大学 GSC セミナーの歴史 ○第 1 回（Seminar on Green and Sustainable Chemistry in Tottori）
，日本化学会・グ
リーンケミストリー研究会（17th Green Chemistry Forum）と共催，平成 20 年 12 月 10
日，とりぎん文化会館（鳥取県民文化会館）小ホール, 講師 3 名，出席者 187 名講師：上村明男（山口大学大学院医学系研究科教授）
，
「プラスチックの化学リサイクルに向
けた新しい方法」講師：丹羽幹（鳥取大学大学院工学研究科教授）
，
「Y ゼオライトのブレーンステッド酸性質
発現と触媒活性」講師：萩原久大（新潟大学大学院自然科学研究科教授）
「イオン液体固定化触媒（SILC）と
グリーンケミストリー」講師： Professor TECK PENG LOH（Nanyang Technological University,（Singapore）
）
“Ionic Liquids as Green Solvents & Catalysts for Organic Synthesis” ○第 2 回（Seminar on Green and Sustainable Chemistry in Tottori 2009 (1)）
（科研
費，特定領域研究「イオン液体の科学」
，触媒学会，石油学会と共催）
，Ｈ21 年 11 月 14 日，
工学研究科大講義室，講師 13 名，出席者 167 名講師：Professor Douglas MacFarlane( Monash Univ., Australia)” Ionic Liquids and Global Sustainability” 講師：Dr. Asako Narita (Kyoto University, Japan) “Ionic Liquid-modified Inorganic Nanoparticles and their Biomedical Applications” 講師：Dr. Hideo Midorikawa (Asahi Kasei Chemicals Corp., Japan), “Environmental Friendly Process for Producing Cyclohexanol from Benzene by Using Heterogeneous Catalysts” 講師： Dr. Kazu Okumura (Tottori Univ., Japan), “In situ X-ray Absorption Spectroscopic Study of Highly Dispersed Pd Species Active in the Suzuki-Miyaura Reactions” 講師：Professor Toshiyuki Itoh (Tottori Univ., Japan), “Iron Salt-catalyzed One-Pot Nazarov Cyclization / Michael Reaction of Pyrrole Derivatives 講師：Professor Bohari M. Yamin (Univ. Kebangsaan, Malaysia), “Structural and Complexation Studies of Fluorophenylthioureas” 講師：Dr. Hyunjoo Lee (KIST, Korea),” Alkyl Polyfluoroalkyl Imidazolium Ionic liquids: Synthesis and Characterization” 講師：Dr. Hisashi Shimakoshi (Kyushu Univ., Japan), “Bio-related Tetrapyrrole Catalyst with Ionic Liquid” 講師： Professor Kenji Takahashi, (Kanazawa Univ., Japan),” ormation of Anhydrosugars from Cellobiose in Ionic Liquids” 講師：Dr. Mayumi Nishida (Koei Chemical Co. Ltd., Japan), ” The Development of Koei’s Ionic Liquids” 講師：Professor Seiji Suga, (Okayama Univ., Japan), ” Electroorganic Synthesis Using Micro Reaction Systems” 講師：Professor Toshio Fuchigami (Tokyo Institute of Technology, Japan),” Highly Selective Fluorination of Organic Molecules and Macromolecules in Ionic Liquids” 講師： Professor Junko N. Kondo (Tokyo Institute of Technology, Japan), “Crystalline Mesoporous Ta2O5 Photocatalyst for Overall Water Splitting” ○第 3 回（Seminar on Green and Sustainable Chemistry in Tottori 2009 (2)）Ｈ21
年 12 月 1 日，工学研究科大講義室, 講師 2 名，出席者 154 名講師：Professor Pedro Lozano (University of Murcia, Spain), “Enzymatic Catalysis in Ionic Liquids and sc-CO2 Biphasic Systems” 12
講師：Professor Joe Chappell (University of Kentucky, USA),“Evolving the Catalytic Specificity of Terpene Biosynthetic Enzymes and the Development of Sustainable, Robust Production Platforms in Yeast and Plants” ○第 4 回（2010 年度 GSC in Tottori（1）
）
（日本化学会，第 53 回中国四国産学連携化学
フォーラムと共同開催）Ｈ22 年 9 月 20 日，工学研究科大講義室，講師 5 名，出席者 177 特別講演： J-E. Bäckvall（ストックホルム大学教授）” A Biomimetic Approach to Green Organic Transformations” 特別講演： B. K. Mihovilovic（ウイーン工業大学教授）“Bioorganic Chemistry in Sustainable Synthesis” 講師：國信洋一郎（岡山大学大学院自然科学研究科助教）
「不活性結合の切断を鍵とする新規
有機合成反応の開発」講師：米山公啓（広島大学大学院工学研究科助教）
「安全・安価な金属触媒を活用した有機合
成反応」講師：依馬正（岡山大学大学院自然科学研究科准教授）
「多重水素結合部位を有するキラル大
環状化合物の不斉識別機能」 ○第 5 回（2010 年度 GSC in Tottori (2)）(日本化学会，触媒学会，石油学会，化学工学会
と共催)，H22 年 11 月 13 日工学研究科大講義室，講師 4 名，出席者 188 名講師：Suk Bong HONG (Pohang University of Science and Technology, Korea) “Zeolite Syntheses via a CDM Approach” 講師：Shinji INAGAKI (Toyota Central R&D Labs, Inc., Japan) “Synthesis of Optically Active Periodic Mesoporous Organosilicas toward the Construction of Artificial Photosynthesis” 講師：Akira MIYAMOTO (Tohoku University, Japan) “Multi-level Computational Chemistry Methods for Green and Sustainable Chemistry” 講師：German SASTRE (Instituto de Tecnologia Quimica UPV-CSIC, Spain) “Synthesis of Octahedral Metal Oxides with Pore Structures” ○第 6 回（2010 年度 GSC in Tottori(3)）
，
（第 1 回イオン液体討論会（イオン液体研究会）
と共催）平成23年1月17日,18日，とりぎん文化会館，参加者186名特別講演：R. Rogers（アラバマ大学教授，米国）“Ionic Liquid Solvents for the Grand Challenge Inherent in a Biorefinery: Extraction and Separation of Lignin, Cellulose, and Hemicellulose”
特別講演：M-J. KOO（インハ大学教授，韓国，韓国生物工学会会長）“Application of Ionic Liquids in Bioconversion Process” ○第7回（2011 Green Sustainable Chemistry Seminar in Tottori (1)） 2011年12月15日（木）
，共通教育棟A20講義室，出席者93名，講師3名講師：久枝良雄（九州大学大学院工学研究院教授）「Bio-inspired Catalysts for Degradation of Environmental Pollutants: Lessons from Metalloenzyme（バイオイン
スパイアード触媒の創製と環境浄化への応用）
」講師：稲永純二（九州大学先導物質化学研究所教授）
「Green Asymmetric Catalysis with Diionic Chiral Sc-Complex in Ionic Liquid: An Organic Solvent-Free Catalytic Asymmetric Reaction Process（有機溶媒フリーの不斉反応プロセスの構築）
」講師：Suojiang Zhang （中国科学院(北京)教授，プロセス工学研究所長）
「Hydrogen Bonds: A New Insight Into Ionic Liquids」 13
○第 8 回（2011 Green Sustainable Chemistry Seminar in Tottori (2)） 2012年2月14日（火曜）
，工学研究科大講義室，出席者193名，講師3名講師：小川順（京都大学大学院農学研究科教授）
「Valuable microbial functions pioneering bio-based industry- development of bio-lipid platform and biotransformation 」講師：酒井貴志（岡山大学大学院自然科学研究科教授）
「New and Efficient Catalysts for Activation of Carbon Dioxide and Epoxide to Produce Cyclic Carbonate」講師：Xin-Hui Xing（中国，清華大学教授）
「Microbial Evolution Engineering for Microbial Strain Improvement」 ○第 9 回（2012 Green Sustainable Chemistry Seminar in Tottori (1)） GSC 研究センター設置記念講演会 2012 年 10 月 14 日（火曜）
，共通教育棟 A20 講義室，出席者 152 名，講師 3 名講師：奥村和（鳥取大学大学院工学研究科准教授）「Structure and catalysis of layered NbW oxide catalysts constructed by the self-assembly of nanofibers」講師：Dae Yoon Chi（韓国 Sogang大学教授）「 New Concept Nucleophilic Fluorination Assisted by 1H-1,2,3-Triazol-3-ium Triflates」講師：吉田潤一（京都大学大学院工学研究科教授）「空間で時間を制御する合成化学」 ○第 10 回（2012 Green Sustainable Chemistry Seminar in Tottori (2)） 2012 年 12 月 3 日（月曜）
，工学研究科大講義室，出席者 156 名，講師 3 名講師：Franz Hollmann (オランダ，Delft 工科大学准教授)「Oxidoreductases for a greener organic synthesis – scope and challenges」講師：伊藤伸哉（富山県立大学教授，生物工学研究センター所長）「Development of novel biocatalysts for producing chiral compounds」講師：溝端知宏（鳥取大学大学院工学研究科准教授）「Elucidating the molecular mechanism of chaperonin- facilitated protein folding」 ○第 11 回（2013 Green Sustainable Chemistry Seminar in Tottori(1)）有機合成
化学協会中国四国支部（第 69 回パネル討論会）と共催 2013 年 6 月 13 日（木曜）
，工学研究科大講義室，出席者 105 名，講師 3 名講師：藤井郁雄(大阪府立大学大学院理学系研究科教授，生命環境科学域自然科学類・学類長)
「Molecular Basis for Transition-state Stabilization in Catalytic Antibodies」講師：宇梶裕（金沢大学理工研究域物質化学系教授）「Development of novel synthetic methods for heterocycles utilizing 1,3-dipoles」講師：三好徳和（徳島大学大学院教授・ソシオアーツ＆サイエンス研究部）「Development and Application for Unexpected Sr-mediated Reactions」 ○第 12 回（2013 Green Sustainable Chemistry Seminar in Tottori(2)）日本化学
会中国四国支部（平成 25 年度鳥取地区化学講演会）と共催 2013 年 10 月 25 日（金曜）
，工学研究科大講義室，出席者 160 名，講師 3 名講師：Peter Wasserscheid（ドイツフリードリヒ・アレクサンダー大学エアランゲン＝ニュ
ンベルク教授）「Ionic Liquid Thin Films in Catalysis - Fundamental Aspects and Applications」講師：秋山隆彦（学習院大学理学部化学科教授）「Recent Progress in the Chiral Phosphoric Acid Catalysis」講師：吉田勝（産業技術総合研究所博士）
「Gels and Photoresoponsive Compounds as Novel Smart Materials」 14
○第 1３回（2013 Green Sustainable Chemistry Seminar in Tottori(３)） 2014 年 1 月 30 日（木曜）
，工学研究科大講義室，出席者 118 名，講師 3 名講師：Jason A. C. Clyburne（セントメリー大学 (カナダ) 教授）「Unusual anions in ion-rich media and their implication in catalysis and in nature」講師：柳日馨（大阪府立大学大学院理学系研究科教授）
「Greener Synthetic Processes Based on Continuous Micro Flow Systems 」講師：松浦和則（鳥取大学大学院工学研究科教授）「Development of Self-assembled Synthetic Viral Capsids 」 ○第 1４回（201４ Green Sustainable Chemistry Seminar in Tottori(１)） 201４年５月２３日（金曜）
，工学研究科大講義室，出席者 1３８名，講師２名講師：小林修（東京大学大学院理学系研究科教授）「Immobilized Catalysts for Green Sustainable Chemistry」講師：伊原博隆（熊本大学大学院自然科学研究科（工学・化学系）教授，熊本大学副学長）「Supramolecular Gels」 ○第 15 回（201４ Green Sustainable Chemistry Seminar in Tottori(2)・第 1 回
テニュアトラックフォーラム）第 24 回グリーンケミストリーフォーラムと共催 201４年１１月１４日（金曜）
，工学研究科大講義室，出席者 1４９名，講師４名講師：菅沼学史（鳥取大学大学院工学研究科 GSC センター・テニュアトラック助教）「固体酸触媒によるグリーンプロセスの開発」講師：西形孝司（山口大学大学院理工研究科准教授・テニュアトラック）「銅-多座アミン触媒系が可能にする新しいアルキル化反応化学」講師：Shang-Bin Liu (中央研究院（台湾）) 「Heteropolyacid-based Ionic Liquids as Efficient Green Homogeneous Catalysts for Biomass Conversion」講師：石原一彰（名古屋大学大学院工学研究科教授）「遷移金属の代替元素としてヨウ素を利用した触媒的酸化的カップリング反応の開発」延べ参加者 2323 名，講師 56 名
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