麻生論文12 .26.08 - 高知大学医学部

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原著
(1)
Yasukawa, T., Kamura, T., Kitajima, S., Conaway, R.C., Conaway, J.W., and Aso, T.
Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and
degradation of Rpb1.
EMBO J. 27, 3256-3266, 2008.
(2)
Kinoshita, K., Goryo, K., Takada, M., Tomokuni, Y, Aso, T., Okuda, H., Shuin, T., Fukumura,
H., and Sogawa, K. Ternary complex formation of pVHL, elongin B and elongin C visualized
in living cells by a FRET-FLIM technique.
FEBS J. 274, 5567-5575, 2007.
(3)
Miyata, K., Yasukawa, T., Fukuda, M., Takeuchi, T., Yamazaki, K., Sakumi, K.,
Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S., and
Aso, T. Induction of apoptosis and cellular senescence in mice lacking transcription
elongation factor, Elongin A.
Cell Death Differ. 14, 716-726, 2007.
(4)
Yasukawa, T., Sugimura, K., Fukuda, M., Yamazaki, K., Kitajima, S., Okumura, K., and Aso,
T. Functional characterization of a mammalian transcription factor, Elongin A.
Biochem. Biophys. Res. Commun. 352, 237-243, 2007.
(5)
Tamura, K., Miyata, K., Sugahara, K., Onishi, S., Shuin, T., and Aso, T. Identification of
EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.
Biochem. Biophys. Res. Commun. 276, 189-195, 2003.
(6)
Yamazaki, K., Aso, T., Ohnishi, Y., Ohno, M., Tamura, K., Shuin, T., Kitajima, S., and
Nakabeppu, Y. Mammalian Elongin A is not essential for cell viability but required for proper
cell-cycle progression with limited alteration of gene expression.
J. Biol. Chem. 278, 13585-13589, 2003.
(7)
Yamazaki, K., Guo, L., Sugahara, K., Zhang, C., Enzan, H., Nakabeppu, Y., Kitajima, S., and
Aso, T. Identification biochemical and characterization of a novel transcription elongation
factor, Elongin A3.
J. Biol. Chem. 277, 26444-26451, 2002.
(8)
Zhang, C., Yong, C., Adachi, M.T., Oshiro, S., Aso, T., Kaufman, R.J., and Kitajima, S.
Homocysteine induces programmed cell death in human vascular endothelial cells through
activation of the unfolded protein response.
J. Biol. Chem. 276, 35867-35874, 2001.
(9)
Zhang, C., Kawauchi, J., Adachi, M.T., Hashimoto, Y., Oshiro, S., Aso, T., and Kitajima, S.
c-Jun NH2-terminal kinase and transcriptional repressor ATF3/LRF-1 is activated through
endoplasmic reticulum stress and implicated in human vascular endothelial cell death by
homocysteine.
Biochem. Biophys. Res. Commun. 289, 718-724, 2001.
(10) Aso, T., Yamazaki, K., Aigaki, T., and Kitajima, S. Drosophila von Hippel-Lindau tumor
suppressor complex possesses E3 ubiquitin ligase activity.
Biochem. Biophys. Res. Commun. 276, 355-361, 2000.
(11) Cai, Y., Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., and Kitajima, S.
Homocysteine-responsive ATF3 gene expression in humanvascular endothelial cells: signal
transduction pathway and promoter responsive element.
Blood 96, 2140-2148, 2000.
(12) Aso, T., Yamazaki, K., Amimoto, K., Kuroiwa, A., Higashi, H., Matsuda, Y., Kitajima, S., and
Hatakeyama, M. Identification and characterization of Elongin A2, a new member of an
Elongin family of transcription elongation factors, specifically expressed in the testis.
J. Biol. Chem. 275, 6546-6552, 2000.
(13) Ohh, M., Takagi, Y., Aso, T., Stebbins, C.E., Pavletich, N.P., Zbar, B., Conaway, R.C.,
Conaway, J.W., and Kaelin, W.G. Synthetic peptides define critical contacts between elongin
C, elongin B, and the von Hippel-Lindau tumor suppressor protein.
J. Clin. Invest. 104, 1583-1591, 1999.
(14) Aso, T., Amimoto, K., Takebayashi, K., Okumura, K., and Hatakeyama, M. Structural
organization and chromosome location of the mouse Elongin A gene (Tceb3).
Cytogenet. Cell Genet. 86, 259-262, 1999.
(15) Shinobu, N., Maeda, T., Aso, T., Ito, T., Kondo, T., Koike, K., and Hatakeyama, M. Physical
interaction and functional antagonism between the RNA polymerase II elongation factor ELL
and p53.
J. Biol. Chem. 274, 17003-17010, 1999.
(16) Aso, T., and Conrad, M.N. Molecular cloning of DNAs encoding the regulatory subunits of
Elongin from Saccharomyces cerevisiae and Drosophila melanogaster.
Biochem. Biophys. Res. Commun. 241, 334-340, 1997.
(17) Pan, G., Aso, T., and Greenblatt, J. Interaction of elongation factors TFIIS and elongin A with
a human RNA polymerase II holoenzyme capable of promoter-specific initiation and
responsive to transcriptional activators.
J. Biol. Chem. 272, 24563-24571, 1997.
(18) Aso, T., Haque, D., Barstead, R.J., Conaway, R.C., and Conaway, J.W. The inducible
elongin A elongation activation domain: structure, function and interaction with the elongin BC
complex.
EMBO J. 15, 5557-5566, 1996.
(19) Aso, T., Haque, D., Fukudome, K., Brower, C.S., Conaway, J.W. and Conaway, R.C. A
human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor
elongin.
Gene 168, 277-278, 1996.
(20) Aso, T., Lane, W.S., Conaway, J.W., and Conaway, R.C.
regulator of elongation by RNA polymerase II.
Science 269, 1439-1443, 1995.
Elongin (SIII) : A multisubunit
(21) Duan, D.R., Pause, A., Burgess, W.H., Aso, T., Chen, D.Y.T., Garrett, K.P., Conaway, R.C.,
Conaway, J.W., Linehan, W.M., and Klausner, R.D. Inhibition of transcription elongation by
the von Hippel-Lindau tumor suppressor protein.
Science 269, 1402-1406, 1995.
(22) Garrett, K.P., Aso, T., Bradsher, J.N., Foundling, S.I., Lane, W.S., Conaway, R.C., and
Conaway, J.W. Positive regulation of general transcription factor SIII by a tailed ubiquitin
homolog.
Proc. Natl. Acad. Sci. U. S. A. 92, 7172-7176, 1995.
(23) Aso, T., Makady, N., Haque, D., Conaway, R.C., and Conaway, J.W. Assignment of a human
gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to
chromosome 1p36.1.
Genomics 30, 393-394, 1995.
(24) Aso, T., Serizawa, H., Conaway, R.C., and Conaway, J.W. A TATA sequence-dependent
transcriptional repressor activity associated with mammalian transcription factor IIA.
EMBO J. 13, 435-445, 1994.
(25) Aso, T., Conaway, J.W., and Conaway, R.C.
the RNA polymerase II preinitiation complex.
J. Biol. Chem. 269, 26575-26583, 1994.
Role of core promoter structure in assembly of
(26) Tan, S, Aso, T., Conaway, R.C., and Conaway, J.W. Roles of both the RAP30 and RAP74
subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase
II.
J. Biol. Chem. 269, 25684-25691, 1994.
(27) Yonaha, M., Aso, T., Kobayashi, Y., Vasavada, H., Yasukochi, Y., Weissman, S.M., and
Kitajima, S. Domain structure of a human general transcription initiation factor, TFIIF.
Nucleic Acid Res. 21, 273-279, 1993.
(28) Aso, T., Tsai, P., Kawaguchi, T., Menninger, J.C., Kitajima, S., Yasukochi, Y., Ward, D.C., and
Weissman, S.M. Assignment of the human GTF2F1 gene to chromosome 19p13.3.
Genomics 16, 252-253, 1993.
(29) Aso, T., Vasavada, H., Kawaguchi, T., Germino, F.J., Ganguly, S., Kitajima, S., Weissman,
S.M., and Yasukochi, Y. Characterization of cDNA for the large subunit of the transcription
initiation factor TFIIF.
Nature 355, 461-464, 1992.
(30) Aso, T., Okamura, S., Matsuguchi, T., Sakamoto, N., Sata, T., and Niho, Y.
organization of the α-chain of the human C4b-binding protein gene.
Biochem. Biophys. Res. Commun. 174, 222-227, 1991.
Genomic
(31) Matsuguchi, T., Okamura, S., Aso, T., Takahashi, K., and Niho, Y. Interleukin-6 and tumor
necrosis factor alpha fully activate liver-specific gene expression of C4b-binding protein.
Biochem. Int. 23, 979-985, 1991.
(32) Matsuguchi, T., Okamura, S., Aso, T., Sata, T., and Niho, Y. Molecular cloning of the cDNA
coding for proline-rich protein (PRP) : identity of PRP as C4b-binding protein.
Biochem. Biophys. Res. Commun. 165, 138-144, 1989.
著書・総説
(1) 田村賢司，宮田恵吉，管原和宣，麻生悌二郎 .
転写症候群：転写装置近傍の因子病．
臨床検査: 48: 223-231, 2004.
(2) 麻生悌二郎．(2002) 癌と遺伝子.（健康と先端医療, 相良祐輔編）, pp 15-24. 高知医
科大学附属病院, 高知.
(3) 北嶋繁孝，麻生悌二郎，山崎勝久．(2000) 転写伸長因子の機能 - TFIIF とエロンガン．
蛋白質核酸酵素 45, 1513-1522.
(4) 麻生悌二郎，山崎勝久．(1999) 転写伸長因子と発癌．
化学と生物 37, 713-717.
(5) 麻生悌二郎．(1999) VHL - エロンガン BC 複合体と von Hippel-Lindau 病．
医学のあゆみ 190, 677-679.
(6) 麻生悌二郎．(1999) 複数の細胞内機能を制御するエロンガン BC 複合体．
生化学 71, 278-282.
(7) 麻生悌二郎．(1998) VHL 癌抑制蛋白と転写伸長因子エロンガンによる複合体の形成.
臨床化学 27, 87-92.
(8) Aso, T. (1998) The Elongin complex: A target for regulation by the VHL tumor suppressor
protein. (in Molecular and Genetic Approaches to Diseases - Immunology, Hematology,
Oncology-, ed Niho Y.), pp.37-47, Kyushu University Press, Fukuoka.
(9) 麻生悌二郎．(1997) von Hippel-Lindau 癌抑制蛋白の標的分子としての転写伸長因子
elongin .
医学のあゆみ 182, 33-37.
(10) 麻生悌二郎．(1997) 転写伸長因子 elongin と von Hippel-Lindau 病.
実験医学 15, 460-464.
(11) Pause, A., Aso, T., Linehan, W.M., Conaway, J.W., Conaway, R.C., and Klausner, R.D. (1996)
Interaction of the von Hippel-Lindau tumor suppressor gene product with elongin. Methods
Enzymol. 274, 436-441.
(12) Aso, T., Shilatifard, A., Conaway, J.W., and Conaway, R.C. (1996) Transcription syndromes
and the role of RNA polymerase II general transcription factors in human disease.
J. Clin. Invest. 97, 1561-1569.
(13) 麻生悌二郎 , Conaway, J.W., and Conaway, R.C. (1996)
る elongin (SIII) の活性制御.
実験医学 14, 649-652 .
von Hippel-Lindau 癌抑制蛋白によ
(14) Aso, T., Conaway, J.W., and Conaway, R.C. (1995) The RNA polymerase II elongation
complex. FASEB J. 9, 1419-1428.
臨床関連論文
(1) Hirota, Y., Matsumoto, I., Aso, T., Kondo, S., Ikematsu, W., Hino, H., Nishiura, S., Yoneda, K.,
and Shiraishi, T. (1990) Hepatocellular carcinoma and bladder cancer as complications
following five years of chemotherapy for acute myeloblastic leukemia. Jpn. J. Med. 29, 203-207.
(2) 池松渉, 麻生悌二郎 , 広田雄一, 岡村秀樹, 松本勲, 綾部俊一郎, 松坂俊光, 岩下明徳. (1990)
心タンポナーデを合併し, 外科的切除と化学療法により長期寛解を維持している Burkitt's
lymphoma の１例. 臨床血液 31, 1731-1735.
(3) 広田雄一, 近藤誠司, 岡村秀樹, 池松渉, 麻生悌二郎 , 高上悦志, 松本勲, 桑島恵一, 梶山憲治.
(1990) 多発性骨髄腫の疼痛および血清カルシウム濃度に対する合成ウナギ Calcitonin 誘導体
製剤 (Elcatonin) の効果. 癌と化学療法 17, 1059-1063.
(4) 古郷功, 高上悦志, 広田雄一, 池松渉, 麻生悌二郎 , 梶山憲治, 松本勲. (1990) 血小板減少に
PA-IgG が関連していたと考えられた多発性骨髄腫の１例. 最新医学 45, 1455-1458.
(5) 麻生悌二郎 , 広田雄一, 松本勲, 鐘ケ江秀明, 八並淳. (1990) 急性骨髄性白血病の寛解導入療
法中に合併した肺アスペルギルス症の１例. 内科 65, 519.
(6) Aso, T., Asano, Y., Harada, M., Kudo, J., Fujimoto, K., Okamura, T., Tsuda, Y., and Niho, Y.
(1989) Fatal graft-versus-host disease following transfusion during open heart surgery. Acta
Haematol. Jpn. 52, 1064-1071.
(7) Aso, T., Okamura, T., Shibuya, T., Harada, M., Niho, Y., and Kikuchi, M. (1989) A case of hybrid
phenotypic chronic myelomonocytic leukemia transformed from aplastic anemia. Jpn. J. Med.
28, 385-389.
(8) Aso, T., Hirota, Y., Matsumoto, I., Kajiyama, K., Ohshima, K., and Kikuchi, M. (1989) Acute
lymphoblastic leukemia of Burkitt's type (L3-ALL) without chromosome abnormality and lacking
surface and cytoplasmic immunoglobulins. Jpn. J. Med. 28, 632-635.
(9) 麻生悌二郎 , 広田雄一, 松本勲, 岡村秀樹, 池松渉. (1989) 当科における高齢者急性非リンパ
性白血病 (ANLL) １６例の検討. 愛媛医学 8, 472-476.
(10) 麻生悌二郎 , 広田雄一, 近藤誠司, 松本勲, 松坂俊光, 岩下明徳. (1989) 直腸癌の化学・放射
線療法後に発症した急性骨髄性白血病の１例. 愛媛医学 8, 104-108.
(11) 広田雄一 , 松本勲 , 高田清式 , 近藤誠司 , 麻生悌二郎 , 日野寿子 , 西浦三郎 , 幕内雅敏 .
(1989) 完全寛解導入後５年間を経過して肝細胞癌を発見され, 治癒切除可能であった急性骨髄
性白血病の１例. 癌の臨床 35, 1073-1076.
(12) 梶山憲治, 松本勲, 広田雄一, 麻生悌二郎 , 池松渉, 古郷功. (1988) 全身性エリテマトーデ
スにおける methylprednisolone パルス療法の有用性 - 経口副腎皮質ステロイド剤療法との比
較. 愛媛医学 7, 421-427.
(13) 多田芳史, 松尾俊和, 松原不二夫, 麻生悌二郎 , 村田光宏, 清田正司, 高橋康一, 大森柱二.
(1988) 長期透析患者において顎骨の著明な膨隆を呈した二次性副甲状腺機能亢進症の１例. 臨
床と研究 65, 845-848.

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