氏名清水孝恒所属病態生理学教室職位准教授学位博士（医学

Hoshi University
氏
名
清水孝恒
所
属
病態生理学教室
学
位
博士（医学）
職
位
准教授
最終学歴
慶應義塾大学医学部・内科系専攻内科学分野博士課程
教育活動
（担当授業科目）
免疫と疾患、疾患と薬物治療Ⅰ、病原微生物・悪性新生物
研究活動
（研究テーマ）
腫瘍細胞生物学
難治性間葉系悪性腫瘍（骨肉腫）の病態解明と克服
所属学会
日本内科学会
日本癌学会
日本血液学会
American Association of Cancer Research (AACR)
学内活動
（役職・委員等）
学外活動
（委員会委員等）
慶應義塾大学医学部・先端医科学研究所共同研究員
東京大学医科学研究所共同研究員
研究業績等
（受賞歴）
財団法人がん研究振興財団第 44 回がん研究助成金（ランフォーホープ記念課題：骨肉腫）
（主な著書・論文）
1. Ueki A, Shimizu T, Masuda K, Yamaguchi S, Ishikawa T, Sugihara E, Onishi N, Kuninaka S, Miyoshi K, Muto
A, Toyama Y, Banno K, Aoki D, Saya H. Up-regulation of Imp3 confers in vivo tumorigenicity on murine
osteosarcoma cells. PLoS One, in press, (2012)
2. Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki
D, Ishihama Y, Saya H, Kuninaka S. LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate
mammalian mitotic progression. J. Cell Biol. 197,625 -641 (2012)
3. Shimizu T, Ishikawa T, Iwai S, Ueki A, Sugihara E, Onishi N, Kuninaka S, Miyamoto T, Toyama Y, Ijiri H, Mori
H, Matsuzaki Y, Yaguchi T, Nishio H, Kawakami Y, Ikeda Y, Saya H. Fibroblast growth factor -2 is an important
factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma. Mol. Cancer Res.
10,454-468 (2012)
4. Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda H, Kanno M,
Miwa M, Okada S, Andreeff M, Saya H. Ink4a and Arf are crucial factors in the determination of the cell of origin
and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor. Oncogene 23, 2849-61 (2011)
5. Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K,
Kuninaka S, Aoki D, Saya H. Establishment of a choriocarcinoma model from immortal ized normal extravillous
trophoblast cells transduced with HRASV12. Am. J. Pathol. 179,1471 -82 (2011)
6. Sagawa M, Shimizu T, Fukushima N, Kinoshita Y, Ohizumi I, Un o S, Kikuchi Y, Ikeda Y, Okabe H, Kizaki M. A
new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid
malignant cells via the hypoxia inducible factor-1 pathway. Cancer Sci. 102,1208-15 (2011)
7. Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko
T, Shimizu T, Ishikawa T, Kai K, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H. CD44 variant
regulates redox status in camcer cells by stabilizing the xCT subunit of system xc( -) and thereby promotes tumor
growth. Cancer Cell 19,387-400 (2011)
8. Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F,
Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda
T, Saya H. c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma
accompanied by loss of adipogenesis. Oncogene 29,5687 -99 (2010)
9. Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H,
Kuninaka S. The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190
RhoGAP for degradation. Mol. Cell. Biol. 30,3994 -4005 (2010)
10. Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T. M -CSF inhibition selectively
targets pathological angiogenesis and lymphangiogenesis. J. Exp. Med 206,1089 -1102 (2009)
11. Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakarata N, Takeya M, Saya H. Aurora A
overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Oncogene 27,4305-4314 (2008)
12. Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu
T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuk i N, Hara E. Visualizing the dynamics of
p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals. Proc Natl Acad Sci USA
104,15034-15039 (2007)
13. Xian M, Ito K, Nakazato T, Shimizu T, Chen CK, Yamato K, Murakami A, Ohigashi H, Ikeda Y, Kizaki M.
Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas - and
mitochondria-mediated pathway. Cancer Sci 98,118-126 (2007)
14. Sagawa M, Shimizu T, Shimizu T, Awaya N, Mitsuhashi T, Ikeda Y, Okamoto S, Kizaki M. Establishment of a
new human acute monocytic leukemia cell line TZ -1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15. Leukemia
20,1566-1571 (2006)
15. Iwata S, Souta-Kuribara A, Yamakawa A, Sasaki T, Shimizu T, Hosono O, Kawasaki H, Tanaka H, Dang NH,
Watanabe T, Arima N, Morimoto C. HTLV-1 Tax induces and associates with Crk-associated substrate lymphocyte
type (Cas-L). Oncogene 24,1262-1271 (2005)
16. Shimizu T, Miyakawa Y, Iwata S, Kuribara A, Tiganis T, Morimoto C, Ikeda Y, Kizaki M. A novel mechanism for
imatinib mesylate (STI571) resistance in CML cell line KT-1: Role of TC-PTP in modulating signals downstream
from the BCR-ABL fusion protein. Exp Hematol. 32,1057-1063 (2004)
17. Shimizu T, Miyakawa Y, Oda A, Kizaki M, Ikeda Y : S TI571-resistant KT-1 cells are sensitive to IFN
accompanied by the loss of TC-PTP phosphatase and prolonged phosphorylation of STAT1; Exp Hemato l.
31,601-608 (2003)
18. Tsukada Y, Nagayama H, Mori T, Shimizu T, Sato N, Takayama N, Ishida A, Handa M, Ikeda Y, Okamoto S.
Granulocyte transfusion as a treatment for enterococcal meningoencephalitis after allogeneic bone marrow
transplantation from an unrelated donor. Bone Marrow Transplant 31,69 -72 (2003)
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