Hoshi University
氏
名
清水孝恒
所
属
病態生理学教室
学
位
博士（医学）
最終学歴
教育活動
（担当授業科目）
職
位
准教授
慶應義塾大学医学部・内科系専攻内科学分野博士課程
免疫と疾患、疾患と薬物治療Ⅰ、病原微生物・悪性新生物、薬学英語 IIB、
総合薬学演習 I、II
研究活動
（研究テーマ）
腫瘍細胞生物学
骨肉腫（難治性間葉系悪性腫瘍）の病態解明と克服
所属学会
日本内科学会（認定内科医）
日本癌学会（評議員）
日本分子生物学会
日本血液学会
米国癌学会（American Association of Cancer Research (AACR)）
学内活動
保健管理副センター長
（役職・委員等）
紀要編集委員長
学外活動
（委員会委員等）
慶應義塾大学医学部・先端医科学研究所・訪問准教授
研究業績等
（受賞歴）
財団法人がん研究振興財団
（主な著書・論文）
第 44 回がん研究助成（ランフォーホープ記念課題：骨肉腫）
1. Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S,
Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A and Saya H: IGF2 preserves
osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.
Cancer Res, 74,6531-41 (2014)
2. Nobusue H, Onishi N, Shimizu T, Sugihara E, Oki Y, Sumikawa Y, Chiyoda T, Akashi K, Saya H, Kano K. Regulation of
MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation . Nature Commun, 5,3363 (2014)
3. Mori T, Sato Y, Miyamoto K, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Iwasaki R,
Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y, Miyamoto T. TNF  promotes osteosarcoma progression by
maintaining tumor cells in an undifferentiated state. Oncogene, 33,4236-41 (2014)
4. Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama
R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, M iyano S, Saya H. Twist2 functions as a tumor
suppressor in murine osteosarcoma cells. Cancer Sci, 104,880-8 (2013)
5. Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H.
IGF1 receptor signaling regulates adaptive radioprotection in Glioma stem cells. Stem Cells 4,627 -640 (2013)
6. Nishiyama-Fujita Y, Shimizu T, Sagawa M, Uchida H, Kizaki M. The role of TC -PTP (PTPN2) in modulating sensitivity
to imatinib and interferon- in CML cell line, KT-1 cells. Leukemia Res, 37,1150-5 (2013)
7. Ueki A, Shimizu T, Masuda K, Yamaguchi S, Ishikawa T, Sugihara E, Onishi N, Kuninaka S, Miyoshi K, Muto A,
Toyama Y, Banno K, Aoki D, Saya H. Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.
PLoS One, 7, e50621 (2012)
8. Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D,
Ishihama Y, Saya H, Kuninaka S. LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian
mitotic progression. J. Cell Biol. 197,625-641 (2012)
9. Shimizu T, Ishikawa T, Iwai S, Ueki A, Sugihara E, Onishi N, Kuninaka S, Miyamoto T, Toyama Y, Ijiri H, Mori H,
Matsuzaki Y, Yaguchi T, Nishio H, Kawakami Y, Ikeda Y, Saya H. Fibroblast growth facto r-2 is an important factor that
maintains cellular immaturity and contributes to aggressiveness of osteosarcoma. Mol. Cancer Res. 10,454 -468 (2012)
10. Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda H, Kanno M, M iwa M,
Okada S, Andreeff M, Saya H. Ink4a and Arf are crucial factors in the determination of the cell of origin and the
therapeutic sensitivity of Myc-induced mouse lymphoid tumor. Oncogene 23, 2849 -61 (2011)
11. Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka
S, Aoki D, Saya H. Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells
transduced with HRASV12. Am. J. Pathol. 179,1471-82 (2011)
12. Sagawa M, Shimizu T, Fukushima N, Kinoshita Y, Ohizumi I, Uno S, Kikuchi Y, Ikeda Y, Okabe H, Kizaki M. A new
disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant
cells via the hypoxia inducible factor-1 pathway. Cancer Sci. 102,1208-15 (2011)
13. Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T,
Shimizu T, Ishikawa T, Kai K, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H. CD44 varia nt regulates
redox status in camcer cells by stabilizing the xCT subunit of system xc( -) and thereby promotes tumor growth. Cancer
Cell 19,387-400 (2011)
14. Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H,
Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H.
c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by
loss of adipogenesis. Oncogene 29,5687-99 (2010)
15. Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H,
Kuninaka S. The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190
RhoGAP for degradation. Mol. Cell. Biol. 30,3994-4005 (2010)
16. Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T. M -CSF inhibition selectively targets
pathological angiogenesis and lymphangiogenesis. J. Exp. Med 206,1089 -1102 (2009)
17. Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakarata N, Takeya M, Saya H. Aurora A overexpression
induces cellular senescence in mammary gland hyperplastic tumors developed in p53 -deficient mice. Oncogene
27,4305-4314 (2008)
18. Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T,
Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N, Hara E. Visualizing the dynamics of p21(Waf1/Cip1)
cyclin-dependent kinase inhibitor expression in living animals. Proc Natl Acad Sci USA 104,15034 -15039 (2007)
19. Xian M, Ito K, Nakazato T, Shimizu T, Chen CK, Yamato K, Murakami A, Ohigashi H, Ikeda Y, Kizaki M. Zerumbone,
a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas - and
mitochondria-mediated pathway. Cancer Sci 98,118-126 (2007)
20. Sagawa M, Shimizu T, Shimizu T, Awaya N, Mitsuhashi T, Ikeda Y, Okamoto S, Kizaki M. Establishment of a new
human acute monocytic leukemia cell line TZ -1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15. Leukemia
20,1566-1571 (2006)
21. Iwata S, Souta-Kuribara A, Yamakawa A, Sasaki T, Shimizu T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Watanabe
T, Arima N, Morimoto C. HTLV-1 Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L).
Oncogene 24,1262-1271 (2005)
22. Shimizu T, Miyakawa Y, Iwata S, Kuribara A, Tiganis T, Morimoto C, Ikeda Y, Kizaki M. A novel mechanism for
imatinib mesylate (STI571) resistance in CML cell line KT-1: Role of TC-PTP in modulating signals downstream from the
BCR-ABL fusion protein. Exp Hematol. 32,1057-1063 (2004)
23. Shimizu T, Miyakawa Y, Oda A, Kizaki M, Ikeda Y : S TI571-resistant KT-1 cells are sensitive to IFN accompanied
by the loss of TC-PTP phosphatase and prolonged phosphorylation of STAT1; Exp Hemato l. 31,601-608 (2003)
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氏 名 清水孝恒 所 属 病態生理学教室 職 位 准教授 学 位 博士（医学

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