Giovanni Migliaccio - European Medicines Agency

Curriculum Vitae
PERSONAL INFORMATION
Giovanni Migliaccio
WORK EXPERIENCE
June 1984–February 1993
Researcher
Istituto Superiore di Sanità, (Italy)
Execution of research project, supervision of technicians
Planning of independent research activities
Data analysis
Manuscript preparation and submission
February 1993–January 1998
Senior Researcher
Istituto Superiore di Sanità , (Italy)
Execution of research project, supervision of technicians
Planning of independent research activities
Data analysis
Manuscript preparation and submission
Direction of a section
January 1998–Present
Director of Research
Istituto Superiore di Sanità , (Italy)
Planning of independent research activities
Data analysis
Manuscript preparation and submission
Direction of a section
EDUCATION AND TRAINING
September 1972–June 1977
Laurea Sperimentale in Scienze Biologiche
Università Federico II (Napoli) , (Italy)
Basic and advanced Biological sciences with 36 different course
Inclusion of two year experimental design for the thesis with final dissertation awarded cum laude
June 1986–December 1988
Post Doctoral Fellow
University of Washington, Seattle WA , (United States)
Growth factors in Hematopoiesis
Stem cells
January 1989–September 1993
Associate Member
New York Blood Center, (United States)
Hematopoiesis; Stem cells commitment, Synthetic growth media
ADDITIONAL INFORMATION
Expertise
29/12/14
Experimental Hematology with specialization in growth factor control of stem cell self-renewal and
differentiation.
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Curriculum Vitae
Giovanni Migliaccio
Hemoglobin gene regulation
Cell therapies and Tissue engineering
Clinical trial authorization
Good Laboratory practices
Publications
[1]van Dongen, G.A., Ussi, A.E., de Man, F.H. and Migliaccio, G. (2013). EATRIS, a European
initiative to boost translational biomedical research. Am J Nucl Med Mol Imaging 3, 166-74.
[2]Migliaccio, G. and Pintus, C. (2013). Role of the EU Framework in Regulation of Stem Cell-Based
Products. Adv Biochem Eng Biotechnol 130, 287-99.
[3]Migliaccio, G., de Man, F.H. and Ussi, A.E. (2013). Therapeutics: Boost to translational medicine in
Europe. Nature 497, 565.
[4]Varricchio, L., Dell'Aversana, C., Nebbioso, A., Migliaccio, G., Altucci, L., Bieker, J.J. and Migliaccio,
A.R.F. (2012). Identification of a New Functional HDAC Complex Composed by HDAC5, GATA1 and
EKLF in Human Erythroid Cells. Blood 120
[5]Migliaccio, G. and Pintus, C. (2012). Role of the EU Framework in Regulation of Stem Cell-Based
Products. Adv Biochem Eng Biotechnol
[6]Varricchio, L. et al. (2011). The dominant negative β isoform of the glucocorticoid receptor is
uniquely expressed in erythroid cells expanded from polycythemia vera patients. Blood 118, 425-436.
[7]Migliaccio, G., Masiello, F., Tirelli, V., Sanchez, M., Varricchio, L., Whitsett, C. and Migliaccio, A.R.
(2011). Under HEMA conditions, self-replication of human erythroblasts is limited by autophagic death.
Blood Cells Mol Dis 47, 182-97.
[8]Migliaccio, G. and Capone, F. (2011) Il farmaco di origine biologica In Alla ricerca del farmaco
perduto (Tomino, C., ed.^eds), pp. 131-160. Medi Service, Milano.
[9]Migliaccio, A.R., Whitsett, C. and Migliaccio, G. (2011) Red Blood Cells from Stem Cells. In
Chemistry and Biochemistry of Oxygen Therapeutics (Mozzarelli, A. and Bettati, S., ed.^eds), pp. 257271. John Wiley & Sons, Ltd., New York.
[10]Ghinassi, B. et al. (2011). Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts
Injected into NOD/SCID/IL2Rgamma mice. Stem Cells Int 2011, 673752.
[11]Capone, F., Lombardini, L., Pupella, S., Grazzini, G., Costa, A.N. and Migliaccio, G. (2011). Cord
blood stem cell banking: a snapshot of the Italian situation. Transfusion 51, 1985-94.
[12]Botta, R. and Migliaccio, G. (2011). Cell-based treatments: advanced therapies and transplants.
Transplant Proc 43, 338-40.
[13]Belardelli, F., Rizza, P., Moretti, F., Carella, C., Galli, M.C. and Migliaccio, G. (2011). Translational
research on advanced therapies. Ann Ist Super Sanita 47, 72-78.
[14]Schneider, C.K. et al. (2010). Challenges with advanced therapy medicinal products and how to
meet them. Nat Rev Drug Discov 9, 195-201.
[15]Migliaccio, G., Sanchez, M., Masiello, F., Tirelli, V., Varricchio, L., Whitsett, C. and Migliaccio, A.R.
(2010). Humanized culture medium for clinical expansion of human erythroblasts. Cell Transplant 19,
453-69.
[16]Migliaccio, G. and Migliaccio, A.R. (2010). Getting personal with B19 parvovirus. Blood 115, 922-3.
[17]Migliaccio, G. and Carella, C. (2010). Toward a European harmonisation of the requirements for
the first clinical use of Advanced Therapy Medicinal Products (ATMPs): Preclinical requirements for
cell based medicinal products. Pharmaceuticals Policy and Law Volume 12, 35-40.
[18]Kozma, G.T. et al. (2010). Dynamic regulation of Gata1 expression during the maturation of
conventional dendritic cells. Exp Hematol 38, 489-503 e1.
[19]Ghinassi, B., Martelli, F., Verrucci, M., D'Amore, E., Migliaccio, G., Vannucchi, A.M., Hoffman, R.
and Migliaccio, A.R. (2010). Evidence for organ-specific stem cell microenvironments. J Cell Physiol
223, 460-70.
[20]Stellacci, E., Di Noia, A., Di Baldassarre, A., Migliaccio, G., Battistini, A. and Migliaccio, A.R.
(2009). Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells.
Exp Hematol 37, 559-72.
[21]Migliaccio, A.R., Whitsett, C. and Migliaccio, G. (2009). Erythroid cells in vitro: from developmental
biology to blood transfusion products. Curr Opin Hematol 16, 259-68.
[22]Migliaccio, A.R. et al. (2008). Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and
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Curriculum Vitae
Giovanni Migliaccio
in the Gata1 low mouse model of the disease. Exp Hematol 36, 158-71.
[23]Martelli, F. et al. (2008). Thrombopoietin Inhibits Murine Mast Cell Differentiation. Stem Cells 26,
912-919.
[24]Mai, A. et al. (2007). Identification of two new synthetic histone deacetylase inhibitors that
modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.
Mol Pharmacol 72, 1111-23.
[25]Ghinassi, B., Verrucci, M., Jelicic, K., Di Noia, A., Migliaccio, G. and Migliaccio, A.R. (2007).
Interleukin-3 and erythropoietin cooperate in the regulation of the expression of erythroid-specific
transcription factors during erythroid differentiation. Exp Hematol 35, 735-47.
[26]Ghinassi, B., Sanchez, M., Martelli, F., Amabile, G., Vannucchi, A.M., Migliaccio, G., Orkin, S.H.
and Migliaccio, A.R. (2007). The hypomorphic Gata1low mutation alters the proliferation/differentiation
potential of the common megakaryocytic-erythroid progenitor. Blood 109, 1460-71.
[27]Di Baldassarre, A. et al. (2007). Protein kinase Calpha is differentially activated during neonatal
and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma
globin-promoter in cellular models of hemoglobin switching. J Cell Biochem 101, 411-24.
[28]Sanchez, M., Weissman, I.L., Pallavicini, M., Valeri, M., Guglielmelli, P., Vannucchi, A.M.,
Migliaccio, G. and Migliaccio, A.R. (2006). Differential amplification of murine bipotent
megakaryocytic/erythroid progenitor and precursor cells during recovery from acute and chronic
erythroid stress. Stem Cells 24, 337-48.
[29]Vannucchi, A.M. et al. (2005). A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF{beta}1 in the development of myelofibrosis. Blood 105, 3493-501.
[30]Migliaccio, G., Di Baldassarre, A., Di Rico, C., Di Noia, A., Nakamoto, B., Cao, H., Skarpidi, E. and
Migliaccio, A.R. (2005). Spontaneous switch from Agamma- to beta-globin promoter activity in a stable
transfected dual reporter vector. Blood Cells Mol Dis 34, 174-80.
[31]Migliaccio, A.R., Alfani, E., Di Giacomo, V., Cieri, M. and Migliaccio, G. (2005). Ex vivo
amplification of T cells from human cord blood. Pathol Biol (Paris) 53, 151-8.
[32]Martelli, F. et al. (2005). Variegation of the phenotype induced by the Gata1low mutation in mice of
different genetic backgrounds. Blood 106, 4102-13.
[33]di Giacomo, V. et al. (2005). Expression of signal transduction proteins during the differentiation of
primary human erythroblasts. J Cell Physiol 202, 831-8.
[34]Amabile, G., Di Noia, A., Alfani, E., Vannucchi, A.M., Sanchez, M., Bosco, D., Migliaccio, A.R. and
Migliaccio, G. (2005). Isolation of TPO-dependent subclones from the multipotent 32D cell line. Blood
Cells Mol Dis 35, 241-52.
[35]Vannucchi, A.M., Bianchi, L., Paoletti, F., Di Giacomo, V., Migliaccio, G. and Migliaccio, A.R.
(2004). Impaired GATA-1 expression and myelofibrosis in an animal model. Pathol Biol (Paris) 52,
275-9.
[36]Migliaccio, G., Novelli, G. and Cancellieri, E. (2004) Le nuove frontiere della ricerca clinica. In
Manuale tecnico-pratico sulla sperimentazione clinica dei medicinali (Tomino, C., ed.^eds), pp. 335389. Critical Medicine Publishing Editore, Roma.
[37]Sanchez, M., Alfani, E., Migliaccio, A.R., Bonfini, T. and Migliaccio, G. (2003). Amplification of T
cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7
and interleukin-2. Bone Marrow Transplant 31, 713-23.
[38]Migliaccio, A.R. et al. (2003). GATA-1 as a regulator of mast cell differentiation revealed by the
phenotype of the GATA-1low mouse mutant. J Exp Med 197, 281-96.
[39]Migliaccio, A.R., Lorenzini, R., Vannucchi, A.M., Spangrude, G.J. and Migliaccio, G. (2003).
Robust levels of long-term multilineage reconstitution in the absence of stem cell self-replication in
W/Wv mice transplanted with purified stem cells. J Hematother Stem Cell Res 12, 409-24.
[40]Vannucchi, A.M., Bianchi, L., Cellai, C., Paoletti, F., Rana, R.A., Lorenzini, R., Migliaccio, G. and
Migliaccio, A.R. (2002). Development of myelofibrosis in mice genetically impaired for GATA-1
expression (GATA-1(low) mice). Blood 100, 1123-32.
[41]Migliaccio, G., Di Pietro, R., di Giacomo, V., Di Baldassarre, A., Migliaccio, A.R., Maccioni, L.,
Galanello, R. and Papayannopoulou, T. (2002). In vitro mass production of human erythroid cells from
the blood of normal donors and of thalassemic patients. Blood Cells Mol Dis 28, 169-80.
[42]Migliaccio, A.R., Migliaccio, G., Di Baldassarre, A. and Eddleman, K. (2002). Circulating
hematopoietic progenitor cells in a fetus with alpha thalassemia: comparison with the cells circulating
in normal and non-thalassemic anemia fetuses and implications for in utero transplantations. Bone
Marrow Transplant 30, 75-80.
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Curriculum Vitae
Giovanni Migliaccio
[43]Vannucchi, A.M. et al. (2001). Accentuated response to phenylhydrazine and erythropoietin in
mice genetically impaired for their GATA-1 expression (GATA-1(low) mice). Blood 97, 3040-3050.
[44]Migliaccio, A.R., Campisi, S. and Migliaccio, G. (2001). Standardization of progenitor cell assay for
cord blood banking. Annali dell'Istituto Superiore di Sanità 37, 595-600.
[45]Vannucchi, A.M. et al. (2000). Identification and characterization of a bipotent (erythroid and
megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Blood 95, 25592568.
[46]Migliaccio, A.R. et al. (2000). Stable and unstable transgene integration sites in the human
genome: extinction of the Green Fluorescent Protein transgene in K562 cells. Gene 256, 197-214.
[47]Forte, L., Migliaccio, G., Sanchez, M., Migliaccio, A.R., Passarelli, A.M. and Amadori, S. (2000).
Effects of cell banking manipulations on ex vivo amplification of umbilical cord blood. Annali dell'Istituto
Superiore di Sanità 36, 333-342.
[48]Carta, C., Campisi, S., Migliaccio, G. and Migliaccio, A.R. (2000). Erythropoietin-dependent
suppression of the expression of the beta subunits of the interleukin-3 receptor during erythroid
differentiation. Blood Cells Molecules & Diseases 26, 467-478.
[49]Alfani, E., Migliaccio, A.R., Sanchez, M., Passarelli, A.M. and Migliaccio, G. (2000).
Characterization of the T cell receptor repertoire of neonatal T cells by RT-PCR and single strand
conformation polymorphism analysis. Bone Marrow Transplantation 26, 83-89.
[50]Tanosaki, R., Ashihara, E., Alessandrini, L., Migliaccio, G. and Migliaccio, A.R. (1999).
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and leukemia inhibitory factor (LIF) protect
the repopulating ability of purified murine hematopoietic stem cells in serum-deprived cultures
stimulated with SCF and IL-3. Annali dell'Istituto Superiore di Sanità 35, 553-562.
[51]Migliaccio, A.R., Carta, C. and Migliaccio, G. (1999). In vivo expansion of purified hematopoietic
stem cells transplanted in nonablated W/Wv mice. Experimental Hematology 27, 1655-1666.
[52]Cancedda, R. et al. (1999). Linee guida per l'ingegneria dei tessuti e la terapia cellulare. Notiziario
dell'Istituto Superiore di Sanità 12, 1-8.
[53]Bassini, A. et al. (1999). Lineage-restricted expression of protein kinase C isoforms in
hematopoiesis. Blood 93, 1178-1188.
[54]Sanchez, M., Alfani, E., Visconti, G., Passarelli, A.M., Migliaccio, A.R. and Migliaccio, G. (1998).
Thymus-independent T-cell differentiation in vitro. British Journal of Haematology 103, 1198-1205.
[55]Migliaccio, A.R. and Migliaccio, G. (1998). The making of an erythroid cell. Molecular control of
hematopoiesis. [Review] [223 refs]. Biotherapy 10, 251-268.
[56]Kurata, H., Mancini, G.C., Alespeiti, G., Migliaccio, A.R. and Migliaccio, G. (1998). Stem cell factor
induces proliferation and differentiation of fetal progenitor cells in the mouse. British Journal of
Haematology 101, 676-687.
[57]Sirchia, G. and Migliaccio, G. (1997). Il trapianto di cellule staminali emopoietiche e il network
GRACE delle banche di sangue placentare. Notiziario dell'Istituto Superiore di Sanità 10, 1-4.
[58]Moroni, E., Cairns, L., Ottolenghi, S., Giglioni, B., Ashihara, E., Migliaccio, G. and Migliaccio, A.R.
(1997). Expression in hematopoietic cells of GATA-1 transcripts from the alternative "testis" promoter
during development and cell differentiation. Biochemical & Biophysical Research Communications
231, 299-304.
[59]Migliaccio, A.R. and Migliaccio, G. (1997) Erythroid cells. In Hematopoietic lineages in Health and
Disease (Testa, N.G., Lord, B. and Dexter, M., ed.^eds), pp. 107-128. Marcell Dekker, inc
[60]Cianfriglia, M., Galli, M.C., Migliaccio, G., Care', A., Testa, U. and Proietti, E. (1997). Linee guida
per l'avvio degli studi clinici di fase I/II con cellule umane viventi per la terapia cellulare somatica.
Notiziario dell'Istituto Superiore di Sanità 10, 1-8.
[61]Ashihara, E., Vannucchi, A.M., Migliaccio, G. and Migliaccio, A.R. (1997). Growth factor receptor
expression during in vitro differentiation of partially purified populations containing murine stem cells.
Journal of Cellular Physiology 171, 343-356.
[62]Sanchez, M., Pascuccio, M., Barca, A., Migliaccio, A.R. and Migliaccio, G. (1996). Amplification of
the lymphoid compartments in serum-deprived cultures of human cord blood cells. Experimental
Hematology
[63]Sanchez, M., Pascuccio, M., Barca, A., Migliaccio, A.R. and Migliaccio, G. (1996). In vitro
amplification of the lymphoid compartments in serum deprived cultures of human cord blood. Blood
[64]Sanchez, M., Pascuccio, M., Barca, A., Migliaccio, A.R. and Migliaccio, G. (1996). Amplification of
the lymphoid compartments in serum-deprived cultures of human cord blood stimulated with SCF, IL7, IL-4 and IL-2. British Journal of Haematology 93, 293.
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Curriculum Vitae
Giovanni Migliaccio
[65]Migliaccio, G. and Galli, M.C. (1996) Le interleuchine. In Atti del VII Congresso dell'Ordine dei
Biologi ed.^eds), pp. 385-409
[66]Migliaccio, G., Baiocchi, M., Hamel, N., Eddleman, K. and Migliaccio, A.R. (1996). Circulating
progenitor cells in human ontogenesis: response to growth factors and replating potential. Journal of
Hematotherapy 5, 161-170.
[67]Migliaccio, G., Baiocchi, M., Adamson, J.W. and Migliaccio, A.R. (1996). Isolation and biological
characterization of two classes of blast-cell colony-forming cells from normal murine marrow. Blood
87, 4091-9.
[68]Migliaccio, A.R., Vannucchi, A.M. and Migliaccio, G. (1996). Molecular control of erythroid
differentiation. [Review] [270 refs]. International Journal of Hematology 64, 1-29.
[69]Migliaccio, A.R., Migliaccio, G., Rubinstein, P. and Adamson, J.W. (1996). Standardization of
assays for progenitor cells in placental/umbilical cord blood. Haematologica 81, 170.
[70]Migliaccio, A.R., Migliaccio, G., Ashihara, E., Moroni, E., Giglioni, B. and Ottolenghi, S. (1996).
Erythroid-specific activation of the distal (testis) promoter of GATA1 during differentiation of purified
normal murine hematopoietic stem cells. Acta Haematologica 95, 229-235.
[71]Migliaccio, A.R., Alespeiti, G., Burderi, E. and Migliaccio, G. (1996). Extensive self-replication
capacity of isolated hematopoietic stem cells in non-myeloablated W/Wv mice. Blood
[72]Kurata, H., Mancini, G.C., Migliaccio, G. and Migliaccio, A.R. (1996) Hematopoietic progenitor cells
purified from the murine fetal liver proliferate in serum-deprived cultures stimulated with stem cell
factor (SCF) alone. In Blood ed.^eds)
[73]Eddleman, K.A., Chervenak, F.A., George-Siegel, P., Migliaccio, G. and Migliaccio, A.R. (1996).
Circulating hematopoietic stem cell populations in human fetuses: implications for fetal gene therapy
and alterations with in utero red cell transfusion. Fetal Diagnosis & Therapy 11, 231-240.
[74]Alespeiti, G., Kajumo, F., Tanosaki, R., Migliaccio, G. and Migliaccio, A.R. (1996). Bone Marrow
reconstitution in non-myeloablated W/Wv mice. Experimental Hematology
[75]Rubinstein, P., Stevens, C.E., Adamson, J.W. and Migliaccio, G. (1995). Umbilical cord blood cells:
informed consent [letter; comment]. Bone Marrow Transplantation 15, 160.
[76]Rubinstein, P., Dobrila, L., Rosenfield, R.E., Adamson, J.W., Migliaccio, G., Migliaccio, A.R., Taylor,
P.E. and Stevens, C.E. (1995). Processing and cryopreservation of placental/umbilical cord blood for
unrelated bone marrow reconstitution. Proceedings of the National Academy of Sciences of the United
States of America 92, 10119-10122.
[77]Ashany, D., Elkon, K.B., Migliaccio, G. and Migliaccio, A.R. (1995). Functional characterization of
lymphoid cells generated in serum-deprived culture stimulated with stem cell factor and interleukin 7
from normal and autoimmune mice. Journal of Cellular Physiology 164, 562-570.
[78]Rubinstein, P. et al. (1994). Unrelated placental blood for bone marrow reconstitution: organization
of the placental blood program. Blood Cells 20, 587-596.
[79]Migliaccio, G. and Migliaccio, A.R. (1994) Serum-deprived cultures of primary haemopoietic cells.
In Culture of haemopoietic cells (Freshney, R.I., Pragnell, I.B. and Freshney, M.G., ed.^eds), pp. 8198, Wiley-Liss.
[80]Migliaccio, G., Mancini, G.C., Jiang, Y.J., Ashihara, E., Sotiropoulos, D., Migliaccio, A.R. and
Adamson, J.W. (1994). Purified murine stem cells: their colonization potential and the expression of
hemopoietic growth factor receptor genes during in vitro differentiation. J.Cell.Biochem. 18b, 184.
[81]Migliaccio, G., Baiocchi, M., Jiang, Y.J., Sotiropoulos, D. and Migliaccio, A.R. (1994). 5-Azacytine
(5-AzaC) reactivates the erythroid potential in a myeloid restricted murine cell line. Experimental
Hematology suppl.
[82]Migliaccio, A.R., Migliaccio, G. and Adamson, J.W. (1994). Expansion of human neonatal
progenitor cells in vitro under serum-deprived conditions. Blood Cells 20, 424-428.
[83]Migliaccio, A.R., Jiang, Y.J., Winardi, R., Migliaccio, G. and Adamson, J.W. (1994). Coordinate
regulation of the a-chain of the IL-3 receptor (aIL- 3) and Id gene expression during erythroid
differentiation. Experimental Hematology 22, 722.
[84]Migliaccio, A.R., Jiang, Y., Migliaccio, G., Nicolis, S., Crotta, S., Ronchi, A., Ottolenghi, S. and
Adamson, J.W. (1994). GATA-1-independent regulation of the expression of the erythropoietin
receptor (EPO-R) gene in a human EPO-dependent cell line, UT-7 EPO. Annals of the New York
Academy of Sciences 718, 359-361.
[85]Migliaccio, A.R., Baiocchi, M., Durand, B., Eddleman, K., Migliaccio, G. and Adamson, J.W.
(1994). Stem cell factor and the amplification of progenitor cells from CD34+ cord blood cells. Blood
Cells 20, 129-138.
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Giovanni Migliaccio
[86]Durand, B., Migliaccio, G., Yee, N.S., Eddleman, K., Huima-Byron, T., Migliaccio, A.R. and
Adamson, J.W. (1994). Long-term generation of human mast cells in serum-free cultures of CD34+
cord blood cells stimulated with stem cell factor and interleukin-3. Blood 84, 3667-3674.
[87]Durand, B., Migliaccio, A.R., Adamson, J.W. and Migliaccio, G. (1994) Long-term culture of human
mast cells from neonatal CD34+ cells stimulated with stem cell factor (SCF) and interleukin-3 (IL-3). In
Molecular Biology of Haematopoiesis. Vol 3 (Abraham, N., Shadduck, R.K., Levine, A.S. and Takaku,
F., ed.^eds), pp. 191-200. Intercept, Andover.
[88]Barron, C., Migliaccio, A.R., Migliaccio, G., Jiang, Y., Adamson, J.W. and Ottolenghi, S. (1994).
Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell
lines and bone marrow. Gene 147, 263-268.
[89]Ashihara, E., Migliaccio, A.R., Jiang, Y.J., Sotiropoulos, D., Adamson, J.W. and Migliaccio, G.
(1994). Expression of hematopoietic growth factor (GF) receptor genes in purified murine stem cells
during in vitro differentiation. Experimental Hematology 22, 748.
[90]Adamson, J.W., Migliaccio, G., Stevens, C.E. and Rubinstein, P. (1994) Placental/umbilical cord
blood as a source of stem and progenitor cells for marrow reconstitution in man. In Molecular Biology
of Haematopoiesis. Vol 3 (Abraham, N., Shadduck, R.K., Levine, A.S. and Takaku, F., ed.^eds), pp.
211-214. Intercept, Andover.
[91]Shimada, Y., Migliaccio, G., Ralph, H., Migliaccio, A. and Shaw H$[corrected to Ralph, H. (1993).
Erythropoietin-specific cell cycle progression in erythroid subclones of the interleukin-3-dependent cell
line 32D [published erratum appears in Blood 1993 Jun 1;81(11):3168]. Blood 81, 935-941.
[92]Nicolis, S., Ottolenghi, S., Papayannopoulou, T., Baiocchi, M., Migliaccio, G., Adamson, J. and
Migliaccio, A.R. (1993). Dependence for the proliferative response to erythropoietin on an established
erythroid differentiation program in a human hematopoietic cell line, UT-7. Experimental Hematology
21, 665-670.
[93]Migliaccio, G. and Migliaccio, A.R. (1993) Kinetics of hematopoiesis in the human yolk sac. In The
human yolk sac and yolk sac tumor (Nogales, F.F., ed.^eds), pp. 70-83. Heidelberg, Springer-Verlag.
[94]Migliaccio, A.R., Migliaccio, G., Mancini, G., Ratajczak, M., Gewirtz, A.M. and Adamson, J.W.
(1993). Induction of the murine "W phenotype" in long-term cultures of human cord blood cells by c-kit
antisense oligomers. Journal of Cellular Physiology 157, 158-163.
[95]Migliaccio, A.R., Migliaccio, G., Durand, B., Mancini, G.C. and Adamson, J.W. (1993). The
generation of colony-forming cells (CFC) and the expansion of hematopoiesis in cultures of human
cord blood cells is dependent on the presence of stem cell factor (SCF). Cytotechnology 11, 107-113.
[96]Migliaccio, A.R., Jiang, Y., Migliaccio, G., Nicolis, S., Crotta, S., Ronchi, A., Ottolenghi, S. and
Adamson, J.W. (1993). Transcriptional and posttranscriptional regulation of the expression of the
erythropoietin receptor gene in human erythropoietin-responsive cell lines. Blood 82, 3760-3769.
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(1993). Aspects of the biology of the neonatal hematopoietic stem cell. Stem Cells 11 Suppl 2, 56-64.
[98]Galli, M.C., Giardina, P.J., Migliaccio, A.R. and Migliaccio, G. (1993). The biology of stem cell
factor, a new hematopoietic growth factor involved in stem cell regulation. [Review] [43 refs].
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[99]Durand, B., Samal, B., Migliaccio, A.R., Migliaccio, G. and Adamson, J.W. (1993) Macrophage
inhibitory protein 1 (MIP-1a) and leukemia inhibitori factor (LIF) increase the number of colony-forming
cells (CFC) in long-term cultures of human CD34+ cord blood cells. In The negative regulation of
Hematopoiesis (Guigon, M., ed.^eds), pp. 155-157. Colloque INSERM/John Libbey Eurotext Ltd
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generation of colony-forming cells (CFC) from CD34+ human umbilical cord blood cells. Leukemia &
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[101]Shimada, Y., Migliaccio, G., Ruscetti, S., Adamson, J.W. and Migliaccio, A.R. (1992). Expression
of the interleukin-3 and granulocyte-macrophage colony-stimulating factor genes in Friend spleen
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[102]Migliaccio, G., Migliaccio, A.R., Druzin, M.L., Giardina, P.J.V., Zsebo, K.M. and Adamson, J.W.
(1992) The effect of the recombinant human stem cell factor (SCF) on cord blood progenitor cell
growth and the generation of colony forming cells (CFC) from pre-CFC in liquid culture. In Molecular
Biology of Haematopoiesis. Vol 2 (Abraham, N., Konwalinka, G., Marks, P., Sachs, L. and Tavassoli,
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(1992). Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the
presence of recombinant human stem cell factor. Blood 79, 2620-2627.
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cellular response to erythropoietin (Epo). In Molecular Biology of Haematopoiesis. Vol 2 (Abraham, N.,
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[105]Migliaccio, A.R., Migliaccio, G., Adamson, J.W. and Torok-Storb, B. (1992). Production of
granulocyte colony-stimulating factor and granulocyte/macrophage-colony-stimulating factor after
interleukin-1 stimulation of marrow stromal cell cultures from normal or aplastic anemia donors.
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switching (Stamatoyannopoulos, G. and Nienhuis, A.W., ed.^eds), pp. 358-364. The John Hopkins
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[107]Migliaccio, G., Migliaccio, A.R., Valinsky, J., Langley, K., Zsebo, K., Visser, J.W. and Adamson,
J.W. (1991). Stem cell factor induces proliferation and differentiation of highly enriched murine
hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of
America 88, 7420-7424.
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(1991). Effects of recombinant human stem cell factor (SCF) on the growth of human progenitor cells
in vitro. Journal of Cellular Physiology 148, 503-509.
[109]Migliaccio, G., Migliaccio, A.R. and Adamson, J.W. (1991). In vitro differentiation and proliferation
of human hematopoietic progenitors: the effects of interleukins 1 and 6 are indirectly mediated by
production of granulocyte-macrophage colony-stimulating factor and interleukin 3. Experimental
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and Adamson, J.W. (1991) Erythropoietin-responsiveness during erythroid differentiation is acquired
through post-transcriptional regulation of the expression of the erythropoietin receptor gene. In The
regulation of hemoglobin switching (Stamatoyannopoulos, G. and Nienhuis, A.W., ed.^eds), pp. 474489. The John Hopkins University Press, Baltimore.
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and Adamson, J.W. (1991). Response to erythropoietin in erythroid subclones of the factor-dependent
cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface.
Proceedings of the National Academy of Sciences USA 88, 11086-11090.
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factors: studies in vitro under serum-deprived conditions. [Review] [88 refs]. Experimental Hematology
18, 1049-1055.
[113]Migliaccio, A.R., Migliaccio, G., Johnson, G., Adamson, J.W. and Torok-Storb, B. (1990).
Comparative analysis of hematopoietic growth factors released by stromal cells from normal donors or
transplanted patients [see comments]. Blood 75, 305-312.
[114]Migliaccio, A.R. and Migliaccio, G. (1990). Il ruolo del GM-CSF nella regolazione dell'ematopoiesi.
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erythroid progenitors. [Review] [53 refs]. Biotherapy 2, 299-303.
[116]Migliaccio, A., Migliaccio, G., Dale, D. and Hammond, W. (1990). Hematopoietic progenitors in
cyclic neutropenia: effect of granulocyte colony-stimulating factor in vivo. Blood 75, 1951-1959.
[117]Migliaccio, A., Migliaccio, G., Brice, M., Constantoulakis, P., Stamatoyannopoulos, G. and
Papayannopoulou, T. (1990). Influence of recombinant hematopoietins and of fetal bovine serum on
the globin synthetic pattern of human BFUe. Blood 76, 1150-1157.
[118]Crotta, S., Nicolis, S., Ronchi, A., Ottolenghi, S., Ruzzi, L., Shimada, Y., Migliaccio, A.R. and
Migliaccio, G. (1990). Progressive inactivation of the expression of an erythroid transcriptional factor in
GM- and G-CSF-dependent myeloid cell lines. Nucleic Acids Research 18, 6863-6869.
[119]Migliaccio, G., Migliaccio, A.R., Kreider, B.L., Rovera, G. and Adamson, J.W. (1989). Selection of
lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the
murine cell line 32D. Journal of Cell Biology 109, 833-841.
[120]Migliaccio, G., Migliaccio, A.R., Kaushansky, K. and Adamson, J.W. (1989). Regulation of
differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived
conditions. Experimental Hematology 17, 110-115.
[121]Migliaccio, G., Migliaccio, A., Ruscetti, S. and Adamson, J. (1989). The growth of Rauscher
erythroleukemia cells is mediated by autocrine production of a factor with biological activity similar to
interleukin- 3. Blood 73, 1770-1777.
[122]Migliaccio, A.R., Migliaccio, G., Shimada, Y. and Adamson, J.W. (1989). Direct effects of IL-4 on
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the in vitro differentiation and proliferation of hematopoietic progenitor cells. Biotechnology
Therapeutics 1, 347-360.
[123]Migliaccio, G., Migliaccio, A.R. and Adamson, J.W. (1988). In vitro differentiation of human
granulocyte/macrophage and erythroid progenitors: comparative analysis of the influence of
recombinant human erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serumdeprived cultures. Blood 72, 248-256.
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interleukin-3 in the induction of hematopoietic stem cell proliferation and erythroid burst colony
formation. Blood 72, 944-951.
[125]Migliaccio, A.R. and Migliaccio, G. (1988). Human embryonic hemopoiesis: control mechanisms
underlying progenitor differentiation in vitro. Developmental Biology (Orlando) 125, 127-134.
[126]Migliaccio, A., Migliaccio, G. and Adamson, J. (1988). Effect of recombinant hematopoietic
growth factors on proliferation of human marrow progenitor cells in serum-deprived liquid culture.
Blood 72, 1387-1392.
[127]Peschle, C., Migliaccio, G., Migliaccio, A.R., Marinucci, M. and Mastroberardino, G. (1987)
Hemoglobin Switching in Humans. In Thalassemia Today (Sirchia, G. and Zanella, A., ed.^eds), pp. 317. Ospedale Maggiore. Policlinico di Milano, Milano.
[128]Migliaccio, G. and Migliaccio, A.R. (1987). Early hemopoietic differentiation: the action of multiCSF is complemented by lineage specific growth factors. Annals of the New York Academy of
Sciences 511, 39-49.
[129]Migliaccio, G. and Migliaccio, A.R. (1987). Cloning of human erythroid progenitors (BFU-E) in the
absence of fetal bovine serum. British Journal of Haematology 67, 129-133.
[130]Migliaccio, A., Bruno, M. and Migliaccio, G. (1987). Evidence for direct action of human
biosynthetic (recombinant) GM-CSF on erythroid progenitors in serum-free culture. Blood 70, 18671871.
[131]Migliaccio, G., Migliaccio, A.R., Russo, G. and Peschle, C. (1986). Embryionic-fetal
hematopoiesis in humans. Kinetics of hematopoietic progenitors in yolk-sac, liver and blood and initial
characterization of their in vitro growth factor requirements. Cell Biology International Report 10, 479.
[132]Migliaccio, G. et al. (1986). Human embryonic hemopoiesis. Kinetics of progenitors and
precursors underlying the yolk sac----liver transition. Journal of Clinical Investigation 78, 51-60.
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factor (CIL) from T-cell lines suppresses the prolferation of adult but not embryionic fetal hemopoietic
progenitors. In Biological regulation of cell proliferation (Baserga, R., Foa, P., Metcalf, D. and Polli,
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differenziazione emopoietica: aspetti ontogenetici e citogenetici. In La cellula neoplastica (Prodi, G.,
Alberghina, L., Colnaghi, M.I., Comoglio, P.M., Squartini, F., Calissano, P., Pontremoli, S. and Rotilio,
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model for reactivation of human fetal globin genes. Blood 68, 1036-1041.
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at the level of erythroblasts. Annals of the New York Academy of Sciences 445, 225-234.
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Marinucci, M. (1985). Erythropoietic development and hemoglobin switching in human embryos:
cellular and molecular aspects. Progress in Clinical & Biological Research 191, 383-396.
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and epsilon----gamma-globin switches in primitive and definite erythropoietic lineage. Nature 313, 2358.
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generated by embryonic progenitors from yolk sac and liver. Proc Natl Acad Sci U S A 81, 2416-20.
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yolk sac, liver and circulating blood. In New trends in experimental hematology. Oncogenes, Stem
cells, Bone Marrow transplantation (Peschle, C. and Rizzoli, C., ed.^eds), pp. 77-82. Serono
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[143]Migliaccio, G. et al. (1984) A new human erythroleukemic line: initial characterization and hemininduced erythroid differentiation. In Genetic and phenotypic markers of tumors (Aaronson, S.A., Frati,
L. and Verna, R., ed.^eds), pp. 323-331. Plenum Press, New York.
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leukemia cels in suspension cultures. In New trends in experimental hematology, Oncogenes, Stem
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bromodeoxy uridine treatment. In New Trend in experimental Hematology. oncogenes, Stem cells,
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[147]Peschle, C., Rossi, G.B., Migliaccio, G., Migliaccio, A.R. and Mastroberardino, G. (1983) Friend
virus erythroleukemia. A temptative model for the erythropoietic preleukemic stage. In Frontiers in
experimental hematology (Torelli, U., Bagnara, G.P., Brunelli, M.A., Castaldini, C. and Di Prisco, A.U.,
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[148]Peschle, C., Rossi, G.B., Covelli, A., Migliaccio, G., Migliaccio, A.R. and Mastroberardino, G.
(1983). The early stage of Friend virus erythroleukemias: mechanisms underlying BPA-"independent"
in vitro growth of BFU-E. Hamatologie und Bluttransfusion 28, 403-406.
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Mastroberardino, G. (1983) Hemoglobin switching in humans. In Current Concept in Erythropoiesis
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embryios. In Frontiers in experimental hematology (Torelli, U., Bagnara, G.P., Brunelli, M.A.,
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Mastroberardino, G. and Peschle, C. (1983) Differential release of hemopoietins (GM-CSF,BPA) by
selected murine T-lymphocyte cell lines. In Frontiers in experimental hematology (Torelli, U., Bagnara,
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[153]Mavilio, F., Giampaolo, A., Marinucci, M., Migliaccio, G., Care', A., Mastroberardino, G. and
Peschle, C. (1983) DNA methylation and globin gene expression in human ontogenetic development.
In Frontiers in experimental hematology (Torelli, U., Bagnara, G.P., Brunelli, M.A., Castaldini, C. and Di
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undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts.
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Modulation of the kinetics of erythroid progenitors in hemopoietic microenvironment: possible role of
PGE. In Frontiers in experimental hematology (Torelli, U., Bagnara, G.P., Brunelli, M.A., Castaldini, C.
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(1982). The early stage of friend virus erythroleukemias: a tentative model. Progress in Clinical &
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Comi, P. (1982) The Hb swithches in ontogenesis and erythropoietic differentiation: a unifying model.
In Advances in red blood cell biology (Weatherall, D.J. and Fiorelli, G., ed.^eds), pp. 203-214. Raven
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[158]Peschle, C., Migliaccio, A.R., Migliaccio, G., Mastroberardino, G., Gianni, A.M., Comi, P.,
Ottolenghi, S. and Giglioni, B. (1982). In vitro regulation of Hb synthesis: studies in normal subjects
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erythropoietic component of the Friend virus erythroleukemias: role of the hormone(s) ans SFFV
genome. In Expression of differentiated function in cancer cells (Revoltella, R., Pontieri, G., Rovera,
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differentiated function in cancer cells (Revoltella, R., Pontieri, G., Rovera, G., Basilico, C., Gallo, R.
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differentiation. In vitro studies on fetal liver, cord blood, adult blood or marrow, and in HPFH patients. In
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progenitors in human fetal liver. Blood 58, 565-572.
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(1981) Proliferation and differentiation of stem and progenitor cells in long-term cultures: studies in
normal and á-thalassemic subjects. In Hemolymphopoiesis: normal and pathological cell
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(1981) Identification and characterization of three classes of fetal erythroidprogenitors in humans:
comparative studies on fetal liver vs adult marrow, and fetal-neonatal vs adult blood. In
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FLV erythroleukemias. I. Erythropoietic progenitors from FLV-P-infectdd mice exhibit partial or total
independence from hemopoietic hormones. In Hemolymphopoiesis: normal and pathological cell
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Peschle, C. (1981) Clonogenic growth of murine and human erythromonocytic progenitors in serumfree cultures. In Hemolymphopoiesis: normal and pathological cell differentiation (Gavosto, F.,
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M. (1980) Modulation of in vitro hemopoiesis by PGE and cAMP: species dependent influences on
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precursori emopoietici. In Atti del XXIV congresso nazionale della societa italiana di
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(Brunelli, M.A., ed.^eds), pp. 59-72. Bologna
[183]Peschle, C., Cillo, C., Rappaport, I.A., Magli, M.C., Migliaccio, G., Pizzella, F. and
Mastroberardino, G. (1979). Early fluctuations of BFU-E pool size after transfusion or erythropoietin
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[184]Peschle, C., Barba, P., Cillo, C., Magli, M.C., Migliaccio, G., Pizzella, F. and Rappaport, I.A.
(1979). Testosterone action on BFU-E and CFU-E: correlation between enhancement of proliferative
rate and amplification of pool size. Life Sciences 24, 1165-1172.
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M.A., ed.^eds), pp. 341-353. Bologna
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(1978). Erythroid stem cell kinetics: experimental and clinical aspects. Blood Cells 4, 233-252.
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Projects
Head of the project “Identification of lineage specific regulatory sequences in the hematopoietic
system” Progetto Finalizzato Ingegneria Genetica, CNR
1992-1995
Head of the project "Ex-vivo amplification of human B- and T- cells for supportive or genetic
immunization of HIV positive subjects"; Progetto Nazionale AIDS
1994-1998
Head of the project “Large scale production of human hemopoietic progenitors and cells in vitro” Primo
Progetto di Ricerca “Sangue”, Fondi Art. 12 bis, comma 6, D.Lgs.229/99 del Ministero della Sanità
1996-1997
Partner of the CEE ERBBIO4CT960646 Contract “Bioreactor Production of Human Hemopoietic
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Curriculum Vitae
Giovanni Migliaccio
Cells” Progetto BIOTEC- CEE
1997-1999
Head of Section in the Project “Studies for the optimization of the organ and tissue transplants.” Fondi
Art. 12 bis, comma 6, D.Lgs.229/99 del Ministero della Sanità
1999-2000
Head of the Project “The plasticity of post-natal hemopoietic stem cells” Fondi Art. 12 bis, comma 6,
D.Lgs.229/99 del Ministero della Sanità
2002-2003
Head of Unit “Optimization of the ex-vivo expansion of human hematopoietic stem and progenitor
cells” Progetti FIRB, Ministero della Istruzione, Università e Ricerca.
2002-2005
Head of Unit “Role and function of TRAIL receptors in the erythroid differentiation” Progetti FIRB,
Ministero della Istruzione, Università e Ricerca.
2007-2010
PI of the project “Italian Network of Oncology BioBanks (RIBBO) for Alliance against Cancer (ACC)
Special Program for Oncology Research 2006
2007-2008
Head of Unit for the project “Italian Network for Clinical trials and GMP structures for Tumours
Biotherapies” for Alliance against Cancer (ACC) Special Program for Oncology Research 2006
2007-2009
Head of Unit for the project “Integrated Oncology Program – Theme 4: “Cellular Pharmaceuticals,
vaccines and innovative biotherapies against cancer”
2007-2009
Memberships
Head of the Section of Cellular Physiology, Cell Biology Laboratory, Istituto Superiore di Sanità, Rome
– Italy 1995 to 2004
Expert of the Good Laboratory Practices on Cell Culture for the Health Ministry 1997 to 2011
Member of the drafting group for the guidelines on Cell Therapy for the Istituto Superiore di Sanità
1997
Member of the drafting group for the guidelines on Cell Therapy of the Bioethical Committee of the
Cabinet of the Prime Minister 1999
Member of the drafting group for the Cell Therapy Guidelines for EMEA, London UK
1999 to 2000
Member of the Sub-Committee on Clinical Experimentation of the Italian Medicines Agency (AIFA )
from 2001
Head of the drafting group for the Guidelines on Cell Therapy for the Istituto Superiore di Sanità 2003
Member of the Cell Therapy Group of the European Pharmacopeia 2003 to 2004
Member of the Cell Product Working Party of the European Medicines
Agency (EMEA, London UK) 2005-2012
Member of the commission for the authorization of Phase I clinical studies on Innovative Medicinal
Products, Istituto Superiore di Sanità 2005-2014
Head of the section “Gene and Cell therapy” Istituto Superiore di Sanità from 2004
Member of the Committee for Orphan Disease’s Clinical Trial funding, AIFA 2006-2008
Member of the Committee “Stem Cells from Umbilical Cord Blood” Health Ministry, Rome Italy 2007
Advanced Medicinal Product’s Expert for the Consiglio Superiore di Sanità, Rome, Italy from 2008
Member of the Committee for the Advanced Therapies (CAT), EMEA London 2009-2011
Chair of the Cell Therapy Working Group for the EDQM (European Pharmacopeia)
From 2010
Scientific Director for EATRIS From 2011
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Curriculum Vitae
Giovanni Migliaccio
Other Relevant Information
29/12/14
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