Nontraditional cardiovascular risk factors in end

Cover Page
The handle http://hdl.handle.net/1887/29973 holds various files of this Leiden University
dissertation.
Author: Meuwese, Christiaan Lucas
Title: Nontraditional cardiovascular risk factors in end-stage renal disease : studies on
inflammatory markers and thyroid hormones
Issue Date: 2014-12-03
Nontraditional cardiovascular
risk factors in
end-stage renal disease
Studies on inflammatory markers and
thyroid hormones
Studies presented in this thesis were partially made possible by financial support from the Dutch
Kidney Foundation, the Jo Keur Foundation and an MD-PhD fellowship from the Leiden University Medical Centre.
Cover design by: Franck Nederstigt (.com) | Art Direction & Design
Printed by Ipskamp drukkers
Nontraditional cardiovascular riskfactors in end-stage renal disease, studies on inflammatory
markers and thyroid hormones
Christiaan Lucas Meuwese / Leiden University Medical Center, 2014 / Thesis
© Christiaan L Meuwese 2014
No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form
or by any means without permission of the author.
ISBN: 978-94-6259-323-7
Nontraditional cardiovascular risk factors
in end-stage renal disease
Studies on inflammatory markers and thyroid hormones
PROEFSCHRIFT
ter verkrijging van de graad van Doctor
aan de Universiteit Leiden
op gezag van Rector Magnificus
prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op woensdag 3 december 2014
klokke 15:00 uur
door
Christiaan Lucas Meuwese
geboren te Zeist in 1986
Promotiecommissie
Promotores: Prof. dr. F.W. Dekker
Prof. dr. P. Stenvinkel (Renal Department, Karolinska Institutet, Stockholm)
Co-promotor:
Dr. J.J. Carrero (Renal Department, Karolinska Institutet, Stockholm)
Overige leden:
Prof. dr. J.W. de Fijter
Prof. dr. A.M. Pereira Arias
Dr. J.H. Kirkels (Afdeling Cardiologie, UMCU, Utrecht)
The printing of this thesis was financially supported by Stichting Cardiovasculaire Biologie,
Karolinska Institutet, Amgen, Sanofi, Baxter, Fresenius, Bayer, Shire, and the Leurs Stichting.
Voor mijn ouders
Table of Contents
Contents
Chapter 1
General Introduction
Part I
Inflammatory markers
Chapter 2
Regular monitoring of C-reactive protein in the dialysis patient: forewarned
is forearmed
7
15
Nature Reviews Nephrology. 7, 166-176 (2011).
Chapter 3
Trimestral variation patterns of C-reactive protein, interleukin-6 and tumor
necrosis factor-α are similarly associated with survival in hemodialysis patients
37
Nephrology Dialysis & Transplantation. 26, 1313-1318 (2011).
Chapter 4
Variations in C-reactive protein during a single haemodialysis session do not
associate with mortality
51
Nephrology Dialysis & Transplantation. 25, 3717-3723 (2010).
Part II
Thyroid hormones
Chapter 5
Nonthyroidal illness and the cardio-renal syndrome
65
Nature Reviews Nephrology. 9, 599-609 (2013).
Chapter 6
Impact of baseline levels and trimestral variation of triiodothyronine and thyroxine on mortality in maintenance hemodialysis patients.
89
Clinical Journal of the American Society of Nephrology. 7, 131–138 (2012).
Chapter 7
Nonthyroidal illness: a risk factor for coronary calcification and arterial stiffness in patients undergoing peritonealdialysis?
103
Journal of Internal Medicine. 274, 584-593 (2013).
Chapter 8
Thyroid status and renal function in older persons in the general population.
117
Journal of Clinical Endocrinology & Metabolism. Epublication, (2014).
Chapter 9
Summary & General Discussion
131
Chapter 10
Dutch Summary
143
Chapter 11
Appendices
149
Chapter 12
Acknowledgements
155
Chapter 13
Curriculum Vitae & List of Publications
159

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