Spring meeting Section Medicinal Chemistry, Royal Netherlands Chemical Society Computers for Medicinal chemistry: Applying Nobel Prize Science to Drug Discovery? The 2013 Nobel Prize in Chemistry was awarded to three computational chemists, who integrated Newton’s classical physics with quantum physics to simulate chemistry behavior. The committee concluded: “Today, the computer is just as important a tool for chemists as the test tube. Simulations are so realistic that they predict the outcome of traditional experiments.” Some may question this statement, whereas others even doubt the actual value of computer methods completely. So, it’s about time to discuss computer-aided medicinal chemistry during a one-day symposium organized by the Section of Medicinal Chemistry of the Royal Netherlands Chemical Society. Friday, March 28th, 2014, Boothzaal, Universiteitsbibliotheek Uithof Heidelberglaan 3, 3584 CS, Utrecht, The Netherlands Sectie Farmacochemie Sponsors: Program: 09.45 – Registration and coffee 10.15 – Welcome and Opening symposium 10.30 – Luc Brunsveld (Technical University Eindhoven, The Netherlands) Nuclear receptor chemical biology and medicinal chemistry; teaming up with molecular modeling for insights in molecular mechanisms. 11.00 – Gerard van Westen (EBI, Hinxton, UK) CHEMBL as an indispensable source for drug discovery 11.30 – Herman van Vlijmen (Janssen Pharmaceutica, Beerse, Belgium) Case studies of computational approaches in Medicinal Chemistry at Janssen 12.00 – Chris de Graaf (VU University Amsterdam, The Netherlands) Putting it all together: Gaps and stepping-stones in protein-ligand interaction prediction 12.30 – Luncheon and General Assembly of the Sectie Farmacochemie (ALV) 14.00 – Dahlia Weiss (Heptares, UK) Water molecules in drug target structures 14.30 – Didier Rognan (Univ Strasbourg, France) Computer-assisted target profiling of bioactive compounds 15.00 – Jürgen Bajorath (University of Bonn, Germany) Data mining and computer-based SAR analysis 15.30 – Carlo Boutton (Ablynx, Ghent, Belgium) The use of computational tools in the discovery of Nanobodies 16.00 – Closure and Drinks Registration fee €30 for members, €60 non-members For registration go to: http://www.kncv.nl/fc-reg-2014