Natural products chemistry

Natural products chemistry
instructors: 佐竹真幸 (Masayuki Satake, Natural Product Chemistry Lab.)
菅裕明 (Hiroaki Suga, Bioorganic Chemistry Lab.)
後藤佑樹 (Yuki Goto, Bioorganic Chemistry Lab.)
Tentative lecture schedule:
date
9/29
No. instructor subject
1 Goto
Overview of natural products
10/6
2
Goto
Terpenoids
10/13 3
Goto
Amino acids and peptides
10/20 4
Goto
TOPIC: Ribosomal synthesis of pseudo-natural peptides
10/27 5
“self study”
11/8
“self study”
6
11/10 7
Suga
TOPIC: Discovery and application of pseudo-natural peptides
11/17 8
Suga
TOPIC: Quorum sensing controlled by auto inducers
11/24 9
Satake
polyketides
12/1
10 Satake
polyketides
12/8
11 Satake
polyketides
12/15 12 Satake
chikimic acid pathway and its products
12/22 13 Satake
chikimic acid pathway and its products
1/5
chikimic acid pathway and its products
14 Satake
Grading:
Final exam + attendance
Suggested reference textbooks:
医薬品天然物化学（南江堂）、海老塚豊監訳
マクマリー生化学反応機構（東京化学同人）、長野哲雄監訳
Medicinal Natural Products: A Biosynthetic Approach, Paul M. Dewick
The Organic Chemistry Of Biological Pathways, John E. McMurry & Tadhg P. Begley
Natural product chemistry
＃1 – Overview of natural product chemistry
Table of contents –1/4–
What is natural product?
What are primary and secondary metabolites?
Natural product chemistry
＃1 – Overview of natural product chemistry
Table of contents –2/4–
Typical flow in natural product chemistry
Natural product chemistry
＃1 – Overview of natural product chemistry
Table of contents –3/4–
Drug development using artificial compounds (comparison with natural products)
Power of natural products (examples of natural products that made huge impacts)
Natural product chemistry
＃1 – Overview of natural product chemistry
Table of contents –4/4–
Major categories of natural products
Major categories of natural products
alkaloids
(highly modified amino acids)
cocaine
caffeine
terpenoids (oligomerized isoprenes)
menthol
cholesterol
kanamycin
polyketide (oligomerized malonic acid)
sesamin
erythromycin
peptides (amino acid oligomers)
cyclosporin
testosterone
glycoside (highly modified sugars)
salicin
retinol
polyphenol
catechin
steroids (terpenes with a specific ring system)
vancomycin
tetracycline

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